The Experts below are selected from a list of 84 Experts worldwide ranked by ideXlab platform
Timothy I. Murphy - One of the best experts on this subject based on the ideXlab platform.
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Expanding Nielsen's Covert Rem model, questioning solms's approach to dreaming and Rem Sleep, and reinterpreting the vertes & Eastman view of Rem Sleep and memory
Behavioral and Brain Sciences, 2000Co-Authors: Robert D. Ogilvie, Tomoka Takeuchi, Timothy I. MurphyAbstract:Nielsen's covert REM process model explains much of the mentation found in REM and NREM Sleep, but stops short of postulating an interaction of waking cognitive processes with the dream mechanisms of REM Sleep. It ranks with the Hobson et al. paper as a major theoretical advance. The Solms article does not surmount the ever-present problem of defining dreams in a manner conducive to advancing dream theory. Vertes & Eastman review the REM Sleep and Learning literature, but make questionable assumptions in doing so.[Hobson et al.; Nielsen; Solms; Vertes & Eastman]
Robert D. Ogilvie - One of the best experts on this subject based on the ideXlab platform.
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Expanding Nielsen's Covert Rem model, questioning solms's approach to dreaming and Rem Sleep, and reinterpreting the vertes & Eastman view of Rem Sleep and memory
Behavioral and Brain Sciences, 2000Co-Authors: Robert D. Ogilvie, Tomoka Takeuchi, Timothy I. MurphyAbstract:Nielsen's covert REM process model explains much of the mentation found in REM and NREM Sleep, but stops short of postulating an interaction of waking cognitive processes with the dream mechanisms of REM Sleep. It ranks with the Hobson et al. paper as a major theoretical advance. The Solms article does not surmount the ever-present problem of defining dreams in a manner conducive to advancing dream theory. Vertes & Eastman review the REM Sleep and Learning literature, but make questionable assumptions in doing so.[Hobson et al.; Nielsen; Solms; Vertes & Eastman]
József Topál - One of the best experts on this subject based on the ideXlab platform.
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The interrelated effect of Sleep and Learning in dogs ( Canis familiaris ); an EEG and behavioural study
Scientific reports, 2017Co-Authors: Anna Kis, Sára Szakadát, Márta Gácsi, Enikő Kovács, Péter Simor, Csenge Török, Ferenc Gombos, Róbert Bódizs, József TopálAbstract:The active role of Sleep in memory consolidation is still debated, and due to a large between-species variation, the investigation of a wide range of different animal species (besides humans and laboratory rodents) is necessary. The present study applied a fully non-invasive methodology to study Sleep and memory in domestic dogs, a species proven to be a good model of human awake behaviours. Polysomnography recordings performed following a command Learning task provide evidence that Learning has an effect on dogs' Sleep EEG spectrum. Furthermore, spectral features of the EEG were related to post-Sleep performance improvement. Testing an additional group of dogs in the command Learning task revealed that Sleep or awake activity during the retention interval has both short- and long-term effects. This is the first evidence to show that dogs' human-analogue social Learning skills might be related to Sleep-dependent memory consolidation.
Paul J. Shaw - One of the best experts on this subject based on the ideXlab platform.
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Sleep restores place Learning to the adenylyl cyclase mutant rutabaga
Journal of Neurogenetics, 2020Co-Authors: Paul J. Shaw, Stephane Dissel, Ellen Morgan, Vincent Duong, Dorothy Chan, Bruno Van Swinderen, Troy ZarsAbstract:Sleep plays an important role in regulating plasticity. In Drosophila, the relationship between Sleep and Learning and memory has primarily focused on mushroom body dependent operant-Learning assays such as aversive phototaxic suppression and courtship conditioning. In this study, Sleep was increased in the classic mutant rutabaga (rut) and dunce (dnc) by feeding them the GABA-A agonist gaboxadol (Gab). Performance was evaluated in each mutant in response to social enrichment and place Learning, tasks that do not require the mushroom body. Gab-induced Sleep did not restore behavioral plasticity to either rut or dnc mutants following social enrichment. However, increased Sleep restored place Learning to rut mutants. These data extend the positive effects of enhanced Sleep to place Learning and highlight the utility of Gab for elucidating the beneficial effects of Sleep on brain functioning.
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notch signaling modulates Sleep homeostasis and Learning after Sleep deprivation in drosophila
Current Biology, 2011Co-Authors: Laurent Seugnet, Yasuko Suzuki, Gabriel Merlin, Laura Gottschalk, Stephen P Duntley, Paul J. ShawAbstract:Summary The role of the transmembrane receptor Notch in the adult brain is poorly understood. Here, we provide evidence that bunched , a negative regulator of Notch , is involved in Sleep homeostasis. Genetic evidence indicates that interfering with bun c hed activity in the mushroom bodies (MBs) abolishes Sleep homeostasis. Combining bunched and Delta loss-of-function mutations rescues normal homeostasis, suggesting that Notch signaling may be involved in regulating sensitivity to Sleep loss. Preventing the downregulation of Delta by overexpressing a wild-type transgene in MBs reduces Sleep homeostasis and, importantly, prevents Learning impairments induced by Sleep deprivation. Similar resistance to Sleep loss is observed with Notch spl-1 gain-of-function mutants. Immunohistochemistry reveals that the Notch receptor is expressed in glia, whereas Delta is localized in neurons. Importantly, the expression in glia of the intracellular domain of Notch , a dominant activated form of the receptor, is sufficient to prevent Learning deficits after Sleep deprivation. Together, these results identify a novel neuron-glia signaling pathway dependent on Notch and regulated by bunched . These data highlight the emerging role of neuron-glia interactions in regulating both Sleep and Learning impairments associated with Sleep loss.
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New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008Co-Authors: Thomas S. Kilduff, Ed S. Lein, Horacio O. De La Iglesia, Takeshi Sakurai, Paul J. ShawAbstract:Understanding the mechanisms that underlie the control of Sleep and wakefulness is a major research area in neuroscience. This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field. The studies discussed below use organisms ranging from flies to humans and focus on the interaction between the Sleep homeostatic and circadian systems, the consequences of mutations in genes involved in the circadian clock on Sleep timing, the effects of Sleep deprivation on brain gene expression, the discovery of "Sleep active" neurons in the cerebral cortex, the role of the hypocretin/orexin system in the maintenance of Sleep and wakefulness, and the interaction between Sleep and Learning.
Robert Stickgold - One of the best experts on this subject based on the ideXlab platform.
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Sleep and school education
Trends in Neuroscience and Education, 2014Co-Authors: Sidarta Ribeiro, Robert StickgoldAbstract:Sleep has emerged in the past decades as a key process for memory consolidation and restructuring. Given the universality of Sleep across cultures, the need to reduce educational inequality, the low implementation cost of a Sleep-based pedagogy, and its global scalability, it is surprising that the potential of improved Sleep as a means of enhancing school education has remained largely unexploited. Students of various socio-economic status often suffer from Sleep deficits. In principle, the optimization of Sleep schedules both before and after classes should produce large positive benefits for Learning. Here we review the biological and psychological phenomena underlying the cognitive role of Sleep, present the few published studies on Sleep and Learning that have been performed in schools, and discuss potential applications of Sleep to the school setting. Translational research on Sleep and Learning has never seemed more appropriate.