The Experts below are selected from a list of 16218 Experts worldwide ranked by ideXlab platform
Graham L Collingridge - One of the best experts on this subject based on the ideXlab platform.
-
Synaptic plasticity in the hippocampal Slice Preparation.
Current protocols in neuroscience, 2011Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L CollingridgeAbstract:Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal Slice Preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain Slice Preparations.
-
Current Protocols in Neuroscience - Synaptic plasticity in the hippocampal Slice Preparation
Current protocols in protein science, 2011Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L CollingridgeAbstract:Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal Slice Preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain Slice Preparations.
-
The brain Slice Preparation: a tribute to the pioneer Henry McIlwain.
Journal of Neuroscience Methods, 1995Co-Authors: Graham L CollingridgeAbstract:Abstract Henry McIlwain is usually remembered for his major contributions to the discipline of neurochemistry. He also had a profound infuence on electrophysiology by inventing and establishing the brain Slice technique. This article describes some of his pioneering studies where he devised ways of preparing, both manually and mechanically (using the McIlwain tissue chopper), viable Slices of mammalian cortical tissue and showed how these could be maintained in a brain Slice chamber. His work with Choh-Luh Li (Li and McIlwain, 1957) on the first intracellular recording from brain Slices and his work with Chosaburo Yamamoto (Yamamoto and McIlwain, 1966) describing the first study of synaptic transmission in brain Slices are highlighted. In these studies, McIlwain started the use of brain Slices to investigate functional anatomy, to study the effects of hypoxia and hypoglycaemia, to perform quantitative pharmacological analyses and to study synaptic plasticity: investigations which continue today to provide important insights into the functioning of the brain in health and disease.
Andrea Nistri - One of the best experts on this subject based on the ideXlab platform.
-
Current and Voltage Clamp Studies of the Spike Medium Afterhyperpolarization of Hypoglossal Motoneurons in a Rat Brain Stem Slice Preparation
Journal of neurophysiology, 2000Co-Authors: Remigijus Lape, Andrea NistriAbstract:Whole-cell patch clamp recordings were performed on hypoglossal motoneurons (HMs) in a brain stem Slice Preparation from the neonatal rat. The medium afterhyperpolarization (mAHP) was the only afte...
-
Voltage-Activated K+ Currents of Hypoglossal Motoneurons in a Brain Stem Slice Preparation From the Neonatal Rat
Journal of neurophysiology, 1999Co-Authors: Remigijus Lape, Andrea NistriAbstract:Lape, Remigijus and Andrea Nistri. Voltage-activated K+ currents of hypoglossal motoneurons in a brain stem Slice Preparation from the neonatal rat. J. Neurophysiol. 81: 140–148, 1999. Whole cell, ...
-
Modulation by TRH of NMDA-elicited responses of CA1 neurones of the rat hippocampal Slice Preparation
Neuroscience letters, 1994Co-Authors: Gabriella Stocca, Andrea NistriAbstract:Intracellular recording from CA1 neurones of the rat hippocampal Slice Preparation was carried out to assess the ability of the endogenously-occurring neuropeptide thyrotropin-releasing hormone (TRH) to modulate responses elicited by the excitatory amino acid agonist N-methyl-D-aspartate (NMDA). TRH (5 microM) produced no change in resting membrane potential or input resistance but facilitated on-going synaptic activity. In the continuous presence of the peptide responses to NMDA were selectively enhanced for about 20 min. In approximately 50% of cells the potentiating effect of TRH persisted in tetrodotoxin (TTX) solution and was associated with removal of the apparent voltage-dependent increase in input resistance usually found during the NMDA-induced depolarization. It is suggested that TRH evoked a transient upregulation of NMDA responses which might account for the reported facilitation by this peptide of long term potentiation in the hippocampus.
Zuner A Bortolotto - One of the best experts on this subject based on the ideXlab platform.
-
Synaptic plasticity in the hippocampal Slice Preparation.
Current protocols in neuroscience, 2011Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L CollingridgeAbstract:Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal Slice Preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain Slice Preparations.
-
Current Protocols in Neuroscience - Synaptic plasticity in the hippocampal Slice Preparation
Current protocols in protein science, 2011Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L CollingridgeAbstract:Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal Slice Preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain Slice Preparations.
Remigijus Lape - One of the best experts on this subject based on the ideXlab platform.
-
Current and Voltage Clamp Studies of the Spike Medium Afterhyperpolarization of Hypoglossal Motoneurons in a Rat Brain Stem Slice Preparation
Journal of neurophysiology, 2000Co-Authors: Remigijus Lape, Andrea NistriAbstract:Whole-cell patch clamp recordings were performed on hypoglossal motoneurons (HMs) in a brain stem Slice Preparation from the neonatal rat. The medium afterhyperpolarization (mAHP) was the only afte...
-
Voltage-Activated K+ Currents of Hypoglossal Motoneurons in a Brain Stem Slice Preparation From the Neonatal Rat
Journal of neurophysiology, 1999Co-Authors: Remigijus Lape, Andrea NistriAbstract:Lape, Remigijus and Andrea Nistri. Voltage-activated K+ currents of hypoglossal motoneurons in a brain stem Slice Preparation from the neonatal rat. J. Neurophysiol. 81: 140–148, 1999. Whole cell, ...
John T R Isaac - One of the best experts on this subject based on the ideXlab platform.
-
Synaptic plasticity in the hippocampal Slice Preparation.
Current protocols in neuroscience, 2011Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L CollingridgeAbstract:Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal Slice Preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain Slice Preparations.
-
Current Protocols in Neuroscience - Synaptic plasticity in the hippocampal Slice Preparation
Current protocols in protein science, 2011Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L CollingridgeAbstract:Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal Slice Preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain Slice Preparations.
