The Experts below are selected from a list of 13008 Experts worldwide ranked by ideXlab platform
Reginald Birngruber - One of the best experts on this subject based on the ideXlab platform.
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filtering bleb evaluation with Slit Lamp adapted 1310 nm optical coherence tomography
Current Eye Research, 2006Co-Authors: M Muller, Reginald Birngruber, Hans Hoerauf, Gerd Geerling, Stefanie Pape, Christian Winter, Gereon Huttmann, Horst LaquaAbstract:Purpose: Investigation of Slit-Lamp-adapted 1310-nm optical coherence tomography (OCT) as an in vivo imaging device in the postoperative course of glaucoma surgery. Methods: Postoperative images of filtering blebs and deep sclerectomies and their healing processes were qualitatively evaluated with a Slit-Lamp-adapted anterior segment OCT (AS-OCT; Heidelberg Engineering, Heidelberg, Germany) in 28 patients. Ophthalmologic examinations included Slit-Lamp examination, applanation tonometry, and Slit-Lamp photography. The OCT scans were qualitatively correlated with the morphologic and functional outcome of the filtering bleb. Results: 1310-nm OCT was able to demonstrate the internal structure and the dimensions of filtering blebs, as well as the scleral flap and the deep sclerectomy location including Descemet membrane. Functioning filtering blebs showed a low OCT signal, small fluid-filled cysts, superficial microcystic layer, and a slack internal texture. High internal reflectivity indicated an earlier sca...
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Noncontact corneal pachymetry with Slit Lamp-adapted optical coherence tomography.
American Journal of Ophthalmology, 2002Co-Authors: Christopher Wirbelauer, Christian Schölz, Hans Hoerauf, Horst Laqua, Duy Thoai Pham, Reginald BirngruberAbstract:Abstract PURPOSE: The purpose of this study was to determine the accuracy, the reproducibility, and the limits of agreement of noncontact central corneal thickness measurement with Slit Lamp-adapted optical coherence tomography (OCT). DESIGN: Nonrandomized comparative clinical trial. METHODS: In a prospective comparative observational study, a total of 108 consecutive patients (108 eyes) with normal corneas (92 eyes) and different corneal alterations (16 eyes) participated. Six sequential measurements of the central corneal thickness with Slit Lamp-adapted OCT and with ultrasound (US) pachymetry at 1640 ms −1 were performed. The main outcome measures were accuracy, reproducibility assessed with precision and coefficient of variation (CV), and limits of agreement of central corneal thickness measurement. RESULTS: The mean central corneal thickness values were 541 ± 43 μm (OCT) and 549 ± 44 μm (US) with a mean precision of ± 5.8 μm (CV 1.08%) and of ± 4.0 μm (CV 0.73%), respectively. The method comparison revealed equivalence (± 2SD) in the 5% range with a mean difference between both methods of 7.9 μm (1.45%). The relative error was 8.7 μm (1.6%), which corresponded to limits of agreement (± 2SD) ranging from −9.5 μm to 25.3 μm. CONCLUSIONS: Central corneal pachymetry with Slit Lamp-adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Thus, the presented OCT system seems to be a promising diagnostic modality to objectively measure corneal thickness in a convenient noncontact mode.
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Slit-Lamp-adapted optical coherence tomography of the anterior segment
Graefe's Arch Clin Exp Ophthalmol, 2000Co-Authors: Hans Hoerauf, Peter Koch, Christopher Wirbelauer, Ralf Engelhardt, Christian Schölz, Horst Laqua, Reginald BirngruberAbstract:q Purpose: To evaluate the diagnostic potential of a Slit-Lamp-adapted optical coherence tomogra-phy (OCT) system as an in vivo im-aging device for routine clinical ex-amination of the anterior segment of the eye. q Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a Slit-Lamp-adapted OCT system using 100–200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue. q Results: The Slit-Lamp-adapted OCT system allowed direct biomicroscopic imaging of the mea-sured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epitheli-um could be visualized with high ac-curacy. Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possi-ble. Complete demonstration of the chamber angle was difficult due to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris. q Conclu-sions: Slit-Lamp-adapted OCT is a useful diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular struc-tures.
Hans Hoerauf - One of the best experts on this subject based on the ideXlab platform.
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filtering bleb evaluation with Slit Lamp adapted 1310 nm optical coherence tomography
Current Eye Research, 2006Co-Authors: M Muller, Reginald Birngruber, Hans Hoerauf, Gerd Geerling, Stefanie Pape, Christian Winter, Gereon Huttmann, Horst LaquaAbstract:Purpose: Investigation of Slit-Lamp-adapted 1310-nm optical coherence tomography (OCT) as an in vivo imaging device in the postoperative course of glaucoma surgery. Methods: Postoperative images of filtering blebs and deep sclerectomies and their healing processes were qualitatively evaluated with a Slit-Lamp-adapted anterior segment OCT (AS-OCT; Heidelberg Engineering, Heidelberg, Germany) in 28 patients. Ophthalmologic examinations included Slit-Lamp examination, applanation tonometry, and Slit-Lamp photography. The OCT scans were qualitatively correlated with the morphologic and functional outcome of the filtering bleb. Results: 1310-nm OCT was able to demonstrate the internal structure and the dimensions of filtering blebs, as well as the scleral flap and the deep sclerectomy location including Descemet membrane. Functioning filtering blebs showed a low OCT signal, small fluid-filled cysts, superficial microcystic layer, and a slack internal texture. High internal reflectivity indicated an earlier sca...
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Noncontact corneal pachymetry with Slit Lamp-adapted optical coherence tomography.
American Journal of Ophthalmology, 2002Co-Authors: Christopher Wirbelauer, Christian Schölz, Hans Hoerauf, Horst Laqua, Duy Thoai Pham, Reginald BirngruberAbstract:Abstract PURPOSE: The purpose of this study was to determine the accuracy, the reproducibility, and the limits of agreement of noncontact central corneal thickness measurement with Slit Lamp-adapted optical coherence tomography (OCT). DESIGN: Nonrandomized comparative clinical trial. METHODS: In a prospective comparative observational study, a total of 108 consecutive patients (108 eyes) with normal corneas (92 eyes) and different corneal alterations (16 eyes) participated. Six sequential measurements of the central corneal thickness with Slit Lamp-adapted OCT and with ultrasound (US) pachymetry at 1640 ms −1 were performed. The main outcome measures were accuracy, reproducibility assessed with precision and coefficient of variation (CV), and limits of agreement of central corneal thickness measurement. RESULTS: The mean central corneal thickness values were 541 ± 43 μm (OCT) and 549 ± 44 μm (US) with a mean precision of ± 5.8 μm (CV 1.08%) and of ± 4.0 μm (CV 0.73%), respectively. The method comparison revealed equivalence (± 2SD) in the 5% range with a mean difference between both methods of 7.9 μm (1.45%). The relative error was 8.7 μm (1.6%), which corresponded to limits of agreement (± 2SD) ranging from −9.5 μm to 25.3 μm. CONCLUSIONS: Central corneal pachymetry with Slit Lamp-adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Thus, the presented OCT system seems to be a promising diagnostic modality to objectively measure corneal thickness in a convenient noncontact mode.
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Slit-Lamp-adapted optical coherence tomography of the anterior segment
Graefe's Arch Clin Exp Ophthalmol, 2000Co-Authors: Hans Hoerauf, Peter Koch, Christopher Wirbelauer, Ralf Engelhardt, Christian Schölz, Horst Laqua, Reginald BirngruberAbstract:q Purpose: To evaluate the diagnostic potential of a Slit-Lamp-adapted optical coherence tomogra-phy (OCT) system as an in vivo im-aging device for routine clinical ex-amination of the anterior segment of the eye. q Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a Slit-Lamp-adapted OCT system using 100–200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue. q Results: The Slit-Lamp-adapted OCT system allowed direct biomicroscopic imaging of the mea-sured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epitheli-um could be visualized with high ac-curacy. Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possi-ble. Complete demonstration of the chamber angle was difficult due to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris. q Conclu-sions: Slit-Lamp-adapted OCT is a useful diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular struc-tures.
Christopher Wirbelauer - One of the best experts on this subject based on the ideXlab platform.
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Noncontact corneal pachymetry with Slit Lamp-adapted optical coherence tomography.
American Journal of Ophthalmology, 2002Co-Authors: Christopher Wirbelauer, Christian Schölz, Hans Hoerauf, Horst Laqua, Duy Thoai Pham, Reginald BirngruberAbstract:Abstract PURPOSE: The purpose of this study was to determine the accuracy, the reproducibility, and the limits of agreement of noncontact central corneal thickness measurement with Slit Lamp-adapted optical coherence tomography (OCT). DESIGN: Nonrandomized comparative clinical trial. METHODS: In a prospective comparative observational study, a total of 108 consecutive patients (108 eyes) with normal corneas (92 eyes) and different corneal alterations (16 eyes) participated. Six sequential measurements of the central corneal thickness with Slit Lamp-adapted OCT and with ultrasound (US) pachymetry at 1640 ms −1 were performed. The main outcome measures were accuracy, reproducibility assessed with precision and coefficient of variation (CV), and limits of agreement of central corneal thickness measurement. RESULTS: The mean central corneal thickness values were 541 ± 43 μm (OCT) and 549 ± 44 μm (US) with a mean precision of ± 5.8 μm (CV 1.08%) and of ± 4.0 μm (CV 0.73%), respectively. The method comparison revealed equivalence (± 2SD) in the 5% range with a mean difference between both methods of 7.9 μm (1.45%). The relative error was 8.7 μm (1.6%), which corresponded to limits of agreement (± 2SD) ranging from −9.5 μm to 25.3 μm. CONCLUSIONS: Central corneal pachymetry with Slit Lamp-adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Thus, the presented OCT system seems to be a promising diagnostic modality to objectively measure corneal thickness in a convenient noncontact mode.
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Slit-Lamp-adapted optical coherence tomography of the anterior segment
Graefe's Arch Clin Exp Ophthalmol, 2000Co-Authors: Hans Hoerauf, Peter Koch, Christopher Wirbelauer, Ralf Engelhardt, Christian Schölz, Horst Laqua, Reginald BirngruberAbstract:q Purpose: To evaluate the diagnostic potential of a Slit-Lamp-adapted optical coherence tomogra-phy (OCT) system as an in vivo im-aging device for routine clinical ex-amination of the anterior segment of the eye. q Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a Slit-Lamp-adapted OCT system using 100–200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue. q Results: The Slit-Lamp-adapted OCT system allowed direct biomicroscopic imaging of the mea-sured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epitheli-um could be visualized with high ac-curacy. Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possi-ble. Complete demonstration of the chamber angle was difficult due to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris. q Conclu-sions: Slit-Lamp-adapted OCT is a useful diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular struc-tures.
Jennifer Rosenussbaumer - One of the best experts on this subject based on the ideXlab platform.
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multimodal assessment of corneal thinning using optical coherence tomography scheimpflug imaging pachymetry and Slit Lamp examination
Cornea, 2017Co-Authors: Julius T Oatts, Jeremy D Keenan, Tova Mannis, Thomas M Lietman, Jennifer RosenussbaumerAbstract:Author(s): Oatts, Julius T; Keenan, Jeremy D; Mannis, Tova; Lietman, Tom M; Rose-Nussbaumer, Jennifer | Abstract: To assess the relationship between corneal thinning measured by clinician-graded Slit-Lamp examination compared with ultrasound pachymetry (USP), anterior segment optical coherence tomography (AS-OCT), and the Pentacam.Patients with corneal thinning underwent USP, AS-OCT, Pentacam measurements and standardized clinical grading by 2 cornea specialists estimating thinning on Slit-Lamp examination. Reproducibility of each testing modality was assessed using the intraclass correlation coefficient. Bland-Altman plots were used to determine precision and limits of agreement (LOA) between imaging modalities and clinical grading.We included 22 patients with corneal thinning secondary to infectious or inflammatory keratitis. Mean percent stromal thinning estimated by grader 1 was 51% (SD 31) and grader 2 was 49% (SD 33). The intraclass correlation coefficient between the masked examiners was 0.95 (95% confidence interval, 0.88-0.98). Graders were more similar to each other than to any other modality with 2% difference and 4.6% of measurements outside the LOA. When measuring the area of maximum thinning, AS-OCT measured approximately 10% thicker than human graders while the Pentacam measured approximately 10% thinner than human graders with 16.7% outside the LOA. USP measured approximately 20% thinner than human graders with 5.6% outside the LOA.Trained corneal specialists have a high degree of agreement in location and degree of corneal thinning when measured in a standardized fashion on the same day. Other testing modalities had acceptable reproducibility and agreement with clinical examination and each other, although Scheimpflug imaging fared worse for corneal thinning, particularly in the periphery, than the other modalities.
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multimodal assessment of corneal thinning using optical coherence tomography scheimpflug imaging pachymetry and Slit Lamp examination
Cornea, 2017Co-Authors: Julius T Oatts, Jeremy D Keenan, Tova Mannis, Thomas M Lietman, Jennifer RosenussbaumerAbstract:Author(s): Oatts, Julius T; Keenan, Jeremy D; Mannis, Tova; Lietman, Tom M; Rose-Nussbaumer, Jennifer | Abstract: PurposeTo assess the relationship between corneal thinning measured by clinician-graded Slit-Lamp examination compared with ultrasound pachymetry (USP), anterior segment optical coherence tomography (AS-OCT), and the Pentacam.MethodsPatients with corneal thinning underwent USP, AS-OCT, Pentacam measurements and standardized clinical grading by 2 cornea specialists estimating thinning on Slit-Lamp examination. Reproducibility of each testing modality was assessed using the intraclass correlation coefficient. Bland-Altman plots were used to determine precision and limits of agreement (LOA) between imaging modalities and clinical grading.ResultsWe included 22 patients with corneal thinning secondary to infectious or inflammatory keratitis. Mean percent stromal thinning estimated by grader 1 was 51% (SD 31) and grader 2 was 49% (SD 33). The intraclass correlation coefficient between the masked examiners was 0.95 (95% confidence interval, 0.88-0.98). Graders were more similar to each other than to any other modality with 2% difference and 4.6% of measurements outside the LOA. When measuring the area of maximum thinning, AS-OCT measured approximately 10% thicker than human graders while the Pentacam measured approximately 10% thinner than human graders with 16.7% outside the LOA. USP measured approximately 20% thinner than human graders with 5.6% outside the LOA.ConclusionsTrained corneal specialists have a high degree of agreement in location and degree of corneal thinning when measured in a standardized fashion on the same day. Other testing modalities had acceptable reproducibility and agreement with clinical examination and each other, although Scheimpflug imaging fared worse for corneal thinning, particularly in the periphery, than the other modalities.
Horst Laqua - One of the best experts on this subject based on the ideXlab platform.
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filtering bleb evaluation with Slit Lamp adapted 1310 nm optical coherence tomography
Current Eye Research, 2006Co-Authors: M Muller, Reginald Birngruber, Hans Hoerauf, Gerd Geerling, Stefanie Pape, Christian Winter, Gereon Huttmann, Horst LaquaAbstract:Purpose: Investigation of Slit-Lamp-adapted 1310-nm optical coherence tomography (OCT) as an in vivo imaging device in the postoperative course of glaucoma surgery. Methods: Postoperative images of filtering blebs and deep sclerectomies and their healing processes were qualitatively evaluated with a Slit-Lamp-adapted anterior segment OCT (AS-OCT; Heidelberg Engineering, Heidelberg, Germany) in 28 patients. Ophthalmologic examinations included Slit-Lamp examination, applanation tonometry, and Slit-Lamp photography. The OCT scans were qualitatively correlated with the morphologic and functional outcome of the filtering bleb. Results: 1310-nm OCT was able to demonstrate the internal structure and the dimensions of filtering blebs, as well as the scleral flap and the deep sclerectomy location including Descemet membrane. Functioning filtering blebs showed a low OCT signal, small fluid-filled cysts, superficial microcystic layer, and a slack internal texture. High internal reflectivity indicated an earlier sca...
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Noncontact corneal pachymetry with Slit Lamp-adapted optical coherence tomography.
American Journal of Ophthalmology, 2002Co-Authors: Christopher Wirbelauer, Christian Schölz, Hans Hoerauf, Horst Laqua, Duy Thoai Pham, Reginald BirngruberAbstract:Abstract PURPOSE: The purpose of this study was to determine the accuracy, the reproducibility, and the limits of agreement of noncontact central corneal thickness measurement with Slit Lamp-adapted optical coherence tomography (OCT). DESIGN: Nonrandomized comparative clinical trial. METHODS: In a prospective comparative observational study, a total of 108 consecutive patients (108 eyes) with normal corneas (92 eyes) and different corneal alterations (16 eyes) participated. Six sequential measurements of the central corneal thickness with Slit Lamp-adapted OCT and with ultrasound (US) pachymetry at 1640 ms −1 were performed. The main outcome measures were accuracy, reproducibility assessed with precision and coefficient of variation (CV), and limits of agreement of central corneal thickness measurement. RESULTS: The mean central corneal thickness values were 541 ± 43 μm (OCT) and 549 ± 44 μm (US) with a mean precision of ± 5.8 μm (CV 1.08%) and of ± 4.0 μm (CV 0.73%), respectively. The method comparison revealed equivalence (± 2SD) in the 5% range with a mean difference between both methods of 7.9 μm (1.45%). The relative error was 8.7 μm (1.6%), which corresponded to limits of agreement (± 2SD) ranging from −9.5 μm to 25.3 μm. CONCLUSIONS: Central corneal pachymetry with Slit Lamp-adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Thus, the presented OCT system seems to be a promising diagnostic modality to objectively measure corneal thickness in a convenient noncontact mode.
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Slit-Lamp-adapted optical coherence tomography of the anterior segment
Graefe's Arch Clin Exp Ophthalmol, 2000Co-Authors: Hans Hoerauf, Peter Koch, Christopher Wirbelauer, Ralf Engelhardt, Christian Schölz, Horst Laqua, Reginald BirngruberAbstract:q Purpose: To evaluate the diagnostic potential of a Slit-Lamp-adapted optical coherence tomogra-phy (OCT) system as an in vivo im-aging device for routine clinical ex-amination of the anterior segment of the eye. q Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a Slit-Lamp-adapted OCT system using 100–200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue. q Results: The Slit-Lamp-adapted OCT system allowed direct biomicroscopic imaging of the mea-sured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epitheli-um could be visualized with high ac-curacy. Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possi-ble. Complete demonstration of the chamber angle was difficult due to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris. q Conclu-sions: Slit-Lamp-adapted OCT is a useful diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular struc-tures.