The Experts below are selected from a list of 7902 Experts worldwide ranked by ideXlab platform
Harjoh Nurulaini - One of the best experts on this subject based on the ideXlab platform.
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Sustained-Release alginate-chitosan pellets prepared by melt pelletization technique
Drug Development and Industrial Pharmacy, 2012Co-Authors: Tin Wui Wong, Harjoh NurulainiAbstract:Context: Alginate-chitosan pellets prepared by extrusion-spheronization technique exhibited fast Drug dissolution.Objective: This study aimed to design sustained-Release alginate pellets through rapid in situ matrix coacervation by chitosan during dissolution.Methods: Pellets made of alginate with chitosan and/or calcium acetate were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and allowed such reaction to occur only in dissolution phase.Results: Drug Release was retarded in pH 2.2 medium when pellets were formulated with calcium acetate or chitosan till a change in medium pH to 6.8. The sustained-Release characteristics of calcium alginate pellets were attributed to pellet dispersion and rapid cross-linking by soluble Ca2+ during dissolution. The Slow Drug Release characteristics of alginate-chitosan pellets were attributed to polyelectrolyte complexation and pellet aggregation into swollen structures with reduced eros...
Klaus K. Unger - One of the best experts on this subject based on the ideXlab platform.
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Gravimetric characterisation of the surface properties of a porous Drug carrier
Journal of Thermal Analysis and Calorimetry, 1995Co-Authors: Erich Robens, A. Brenner, Alexander V Neimark, Klaus K. UngerAbstract:The gas adsorption method is the most common means to characterise the topology of solid surfaces with regard to its use as an adsorbent. Adsorption isotherms are determined advanta-geously using a vacuum microbalance: Thermogravimetric techniques allow the observation of sample degassing and its optimization. The dry mass is determined in situ, the mass of gas adsorbed is measured directly and different gases can be used without calibration. From the isotherm the pore size distributions, specific surface area, fractal dimension and density can be derived. Commercially available gravimetric sorption apparata and vacuum balances as well as software for data evaluation are reviewed in tables. The sorption analysis of an aluminum oxide is presented. The porous material was used as a matrix for a Slow Drug Release.
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Gravimetric characterisation of the surface properties of a porous Drug carrier
Journal of thermal analysis, 1995Co-Authors: Erich Robens, A. Brenner, Alexander V Neimark, Klaus K. UngerAbstract:Die Gasadsorptionsmethode ist das weitverbreitetste Mittel zur Charakterisierung der Topologie von Feststoffoberflächen in Bezug auf die Verwendung als Adsorbens. Adsorptionsisothermen werden vorteilhafterweise unter Verwendung einer Vakuum-Mikrowaage ermittelt: Thermogravimetrische Techniken erlauben die Verfolgung der Probenentgasung und deren Optimierung. Die Trockenmasse wird in situ bestimmt, die Masse des adsorbierten Gases wird direkt gemessen und ohne Kalibrierung können verschiedene Gase verwendet werden. Anhand der Isothermen können Porengrößenverteilung, spezifische Oberfläche, Fraktaldimension und Dichte hergeleitet werden. In Tabellen wird ein Überblick über handelsübliche gravimetrische Sorptionsgeräte und Vakuumwaagen als auch über die Software zur Datenauswertung gegeben. Darstellung findet die Sorptionsanalyse eines Aluminiumoxides. Dieses poröse Material wurde als Matrix für eine langsame Wirkstoffreisetzung benutzt. The gas adsorption method is the most common means to characterise the topology of solid surfaces with regard to its use as an adsorbent. Adsorption isotherms are determined advanta-geously using a vacuum microbalance: Thermogravimetric techniques allow the observation of sample degassing and its optimization. The dry mass is determined in situ, the mass of gas adsorbed is measured directly and different gases can be used without calibration. From the isotherm the pore size distributions, specific surface area, fractal dimension and density can be derived. Commercially available gravimetric sorption apparata and vacuum balances as well as software for data evaluation are reviewed in tables. The sorption analysis of an aluminum oxide is presented. The porous material was used as a matrix for a Slow Drug Release.
Arnobio Antonio Da Silvajunior - One of the best experts on this subject based on the ideXlab platform.
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designing structural features of novel benznidazole loaded cationic nanoparticles for inducing Slow Drug Release and improvement of biological efficacy
Materials Science and Engineering: C, 2017Co-Authors: Alaine Dos M Santossilva, Lilia Basilio De Caland, Ana Luiza C De S L Oliveira, Raimundo F De Araujojunior, Matheus F Fernandespedrosa, Alianda Maira Cornelio, Arnobio Antonio Da SilvajuniorAbstract:Abstract Several polymers have been investigated for producing cationic nanocarriers due to their ability to cross biological barriers. Polycations such as copolymers of polymethylmethacrylate are highlighted due to their biocompatibility and low toxicity. The purpose of this study was to produce small and narrow-sized cationic nanoparticles able to overcome cell membranes and improve the biological activity of benznidazole (BNZ) in normal and cancer cells. The effect of composition and procedure parameters of the used emulsification-solvent evaporation method were controlled for this purpose. The experimental approach included particle size, polydispersity index, zeta potential, atomic force microscopy (AFM), attenuated total reflectance Fourier transforms infrared spectroscopy (ATR– FTIR), Drug loading efficiency, and physical stability assays. Spherical and stable (over six weeks) sub 150 nm cationic nanoparticles were optimized, with the encapsulation efficiency > 80%. The used Drug/copolymer ratio modulated the Slow Drug Release, which was adjusted by the parabolic diffusion mathematical model. In addition, the ability of the cationic nanoparticles improve the BNZ uptake in the normal kidney cells (HEK 293) and the human colorectal cancer cells (HT 29) demonstrate that this novel BNZ-loaded cationic has great potential as a chemotherapeutic application of benznidazole.
Tin Wui Wong - One of the best experts on this subject based on the ideXlab platform.
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Sustained-Release alginate-chitosan pellets prepared by melt pelletization technique
Drug Development and Industrial Pharmacy, 2012Co-Authors: Tin Wui Wong, Harjoh NurulainiAbstract:Context: Alginate-chitosan pellets prepared by extrusion-spheronization technique exhibited fast Drug dissolution.Objective: This study aimed to design sustained-Release alginate pellets through rapid in situ matrix coacervation by chitosan during dissolution.Methods: Pellets made of alginate with chitosan and/or calcium acetate were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and allowed such reaction to occur only in dissolution phase.Results: Drug Release was retarded in pH 2.2 medium when pellets were formulated with calcium acetate or chitosan till a change in medium pH to 6.8. The sustained-Release characteristics of calcium alginate pellets were attributed to pellet dispersion and rapid cross-linking by soluble Ca2+ during dissolution. The Slow Drug Release characteristics of alginate-chitosan pellets were attributed to polyelectrolyte complexation and pellet aggregation into swollen structures with reduced eros...
Erich Robens - One of the best experts on this subject based on the ideXlab platform.
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Gravimetric characterisation of the surface properties of a porous Drug carrier
Journal of Thermal Analysis and Calorimetry, 1995Co-Authors: Erich Robens, A. Brenner, Alexander V Neimark, Klaus K. UngerAbstract:The gas adsorption method is the most common means to characterise the topology of solid surfaces with regard to its use as an adsorbent. Adsorption isotherms are determined advanta-geously using a vacuum microbalance: Thermogravimetric techniques allow the observation of sample degassing and its optimization. The dry mass is determined in situ, the mass of gas adsorbed is measured directly and different gases can be used without calibration. From the isotherm the pore size distributions, specific surface area, fractal dimension and density can be derived. Commercially available gravimetric sorption apparata and vacuum balances as well as software for data evaluation are reviewed in tables. The sorption analysis of an aluminum oxide is presented. The porous material was used as a matrix for a Slow Drug Release.
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Gravimetric characterisation of the surface properties of a porous Drug carrier
Journal of thermal analysis, 1995Co-Authors: Erich Robens, A. Brenner, Alexander V Neimark, Klaus K. UngerAbstract:Die Gasadsorptionsmethode ist das weitverbreitetste Mittel zur Charakterisierung der Topologie von Feststoffoberflächen in Bezug auf die Verwendung als Adsorbens. Adsorptionsisothermen werden vorteilhafterweise unter Verwendung einer Vakuum-Mikrowaage ermittelt: Thermogravimetrische Techniken erlauben die Verfolgung der Probenentgasung und deren Optimierung. Die Trockenmasse wird in situ bestimmt, die Masse des adsorbierten Gases wird direkt gemessen und ohne Kalibrierung können verschiedene Gase verwendet werden. Anhand der Isothermen können Porengrößenverteilung, spezifische Oberfläche, Fraktaldimension und Dichte hergeleitet werden. In Tabellen wird ein Überblick über handelsübliche gravimetrische Sorptionsgeräte und Vakuumwaagen als auch über die Software zur Datenauswertung gegeben. Darstellung findet die Sorptionsanalyse eines Aluminiumoxides. Dieses poröse Material wurde als Matrix für eine langsame Wirkstoffreisetzung benutzt. The gas adsorption method is the most common means to characterise the topology of solid surfaces with regard to its use as an adsorbent. Adsorption isotherms are determined advanta-geously using a vacuum microbalance: Thermogravimetric techniques allow the observation of sample degassing and its optimization. The dry mass is determined in situ, the mass of gas adsorbed is measured directly and different gases can be used without calibration. From the isotherm the pore size distributions, specific surface area, fractal dimension and density can be derived. Commercially available gravimetric sorption apparata and vacuum balances as well as software for data evaluation are reviewed in tables. The sorption analysis of an aluminum oxide is presented. The porous material was used as a matrix for a Slow Drug Release.