The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
José Biller - One of the best experts on this subject based on the ideXlab platform.
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Language Impairment and Right Hemiparesis in a 54-Year-Old Woman
Frontiers in neurology, 2011Co-Authors: Alexander Venizelos, John W. Lee, José BillerAbstract:A 54 year-old woman presented to the emergency room with 3 months of Slurred Speech, language problems, and right hemiparesis. Initial impression based on history, exam and imaging was brain abscess versus primary or metastatic neoplasm. Brain biopsy of the lesion and pathologic specimens were obtained. Below is a description of her presentation, hospital course, imaging, and pathology, as well as a short discussion of the final diagnosis.
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Memory Loss, Behavioral Changes, and Slurred Speech in a 49-Year-Old Man
Frontiers in neurology, 2011Co-Authors: Chandril Chugh, John M. Lee, José BillerAbstract:A 49-year-old man presented with Slurred Speech, memory loss, and behavioral changes. His clinical course was marked by decline in functional status and cognition. He had poorly controlled hypertension and hyperlipidemia. Neuroimaging was remarkable for multiple subcortical white matter lesions. We discuss the diagnostic and therapeutic approach of rapidly progressing cognitive decline in the given clinical setting.
Matthew P. Frosch - One of the best experts on this subject based on the ideXlab platform.
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Case records of the Massachusetts General Hospital. Case 9-2010. A 37-year-old woman with paresthesias and ataxia.
The New England journal of medicine, 2010Co-Authors: Misha L. Pless, Yi-bin Chen, William A. Copen, Matthew P. FroschAbstract:A 37-year-old right-handed woman was admitted to this hospital because of a 7-month history of intermittent paresthesias, followed by Slurred Speech, headaches, ataxia, and cognitive difficulties. Treatment with corticosteroids, verapamil, and azathioprine resulted in little improvement. Imaging studies showed lesions in the cerebral and cerebellar white matter. Gait imbalance, unsteadiness, and visual hallucinations developed. A diagnostic procedure was performed.
Mary H Maddox - One of the best experts on this subject based on the ideXlab platform.
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1231 Slurred Speech- Unusual Presentation of Cataplexy in Childhood Narcolepsy
Sleep, 2020Co-Authors: Abhishek Reddy, Mary H MaddoxAbstract:Abstract Introduction Narcolepsy, a chronic neurological disorder of excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic/hypnopompic hallucinations, frequently presents in late childhood/early adolescence. Cataplexy, the most specific symptom, presents as transient loss of muscle tone causing weakness. Approximately 80% of children with narcolepsy present with cataplexy1. Report of Case Eight year old African American boy presented to sleep clinic with concerns for excessive daytime sleepiness and Slurred Speech. Teachers initially referred to Speech therapy because of Slurred Speech. There, Speech got noticeably worse with frustration. Subsequently, sleepiness developed, and his pediatrician referred him for polysomnogram (PSG) and Mean Sleep Latency test (MSLT). After unremarkable PSG, MSLT demonstrated mean sleep latency of 10 minutes with no SOREM sleep. Patient came for evaluation in Sleep Medicine clinic where family reported worsening Speech with extreme emotions and profound sleepiness, Epworth of 20. Because of the presentation and lack of REM sleep on MSLT, brain MRI was ordered and was normal. HLA typing for narcolepsy positively showed HLA haplotype associated with narcolepsy. Patient was diagnosed with narcolepsy with cataplexy and started on Modafinil 50 mg. Modafinil was progressively increased to 200 mg in a.m. and 100 mg at noon. To address cataplexy symptoms, he started Venlafaxine 12.5 mg and increased to 25 mg. Epworth score improved on Modafinil, his cataplexy symptoms, including Speech difficulties, subsided on Venlafaxine. Patient’s communication improved, as did school performance and social life, and patient is currently thriving in 10th grade. Current Epworth is 5 and current medications include Modafinil 200 mg in the morning, 100 mg at noon and Venlaflaxine 25 mg at night. Conclusion This case report highlights the importance of recognizing unusual presentations of cataplexy and the impact of treatment. These symptoms can be easily missed and erroneously attributed to developmental delay or behavioral issues.
Lee H. Schwamm - One of the best experts on this subject based on the ideXlab platform.
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Case 16-2006
The New England journal of medicine, 2006Co-Authors: Stephen H. Thomas, Lee H. Schwamm, Michael H. LevAbstract:A 72-year-old woman had a sudden onset of Slurred Speech and left hemiparesis. Emergency medical services were called, and she was airlifted to a hospital. A multidisciplinary team of physicians discuss the emergency management of acute stroke.
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Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5-2004 - a 57-year-old man with Slurred Speech and left hemiparesis.
The New England journal of medicine, 2004Co-Authors: Bob S. Carter, James D. Rabinov, Rolf Pfannl, Lee H. SchwammAbstract:A 57-year-old right-handed man was admitted to the hospital because of the sudden onset of Slurred Speech and left hemiparesis. Imaging studies revealed an infarct in the area of the right middle cerebral artery. With thrombolysis, recanalization of the vessels was achieved, but the patient's condition continued to worsen.
Melinda F. Lerwill - One of the best experts on this subject based on the ideXlab platform.
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Case 4-2007: A 56-Year-Old Woman with Rapidly Progressive Vertigo and Ataxia
The New England journal of medicine, 2007Co-Authors: Josep Dalmau, R. Gilberto Gonzalez, Melinda F. LerwillAbstract:A 56-year-old woman had dizziness and nausea, followed by Slurred Speech and ataxia; 2 months later she was unable to walk. Neurologic examination disclosed severe ataxia. Imaging studies of the brain did not show discrete parenchymal lesions or vascular occlusion; there was cerebellar atrophy. A diagnostic procedure was performed.
