The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jihad H Kaouk - One of the best experts on this subject based on the ideXlab platform.
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robotic partial nephrectomy with intracorporeal renal hypothermia using ice Slush
Urology, 2014Co-Authors: Jihad H Kaouk, Dinesh Samarasekera, Jayram Krishnan, Riccardo Autorino, Oktay Acka, Luis Felipe Brando, Humberto Laydner, Homayoun ZargarAbstract:Objective To outline our technique for intracorporeal cooling with ice Slush during robotic partial nephrectomy (RPN), with real-time parenchymal temperature monitoring. Materials and Methods Eleven consecutive patients with enhancing solid renal masses suitable for treatment with RPN between September 2013 and January 2014 were included in the analysis. Institutional review board approval and informed consent were obtained. Preoperative patient characteristics, intraoperative surgical parameters including patient body temperature and ipsilateral kidney temperature with real-time monitoring, and short-term functional outcomes were analyzed. Results Median age was 55 years (range, 39-75 years) and American Society of Anesthesiologists score was 3 (range, 2-4). Median tumor size was 4 cm (range, 2.3-7.1) and RENAL nephrometry score was 9 (range, 5-11). One patient had a solitary kidney. During cooling, the lowest median renal parenchymal temperature was 17.05°C (range, 11°C-26°C) and cold ischemia time was 27.17 minutes (range, 18-49 minutes). Median time to latest postoperative estimated glomerular filtration rate was 12 days (range, 2-30 days). Median glomerular filtration rate preservation was 81% (range, 47.9%-126%). There was one positive margin. There were no postoperative complications, and no patients experienced a prolonged ileus. The limitations of this study include a small number of patients and short-term follow-up. Conclusion RPN with renal hypothermia using intracorporeal ice Slush is technically feasible. Our simplified method of introducing the ice Slush was free of complications and highly reproducible. The use of a needle temperature probe allowed us to monitor in real time cooling of the renal parenchyma.
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laparoscopic ice Slush renal hypothermia for partial nephrectomy the initial experience
The Journal of Urology, 2003Co-Authors: Inderbir S Gill, Sidney C Abreu, Mihir M Desai, Andrew P Steinberg, Anup P Ramani, N G Christopher, Kevin L W Banks, Andrew C Novick, Jihad H KaoukAbstract:ABSTRACTPurpose: We describe a novel technique of laparoscopic renal hypothermia with intracorporeal ice Slush during partial nephrectomy as well as clinical experience with the initial 12 patients.Materials and Methods: A total of 12 select patients with an infiltrating renal tumor who were candidates for nephron sparing surgery underwent transperitoneal laparoscopic partial nephrectomy with renal hypothermia. An Endocatch II (United States Surgical Corp., Norwalk, Connecticut) bag was placed around the mobilized kidney and its drawstring was cinched around the intact renal hilum. The renal artery and vein were occluded en bloc with a Satinsky clamp. The bottom of the engaged bag was retrieved through a 12 mm port site and opened, and ice Slush was introduced within the bag to completely surround the kidney. After renal hypothermia was achieved laparoscopic partial nephrectomy was performed by duplicating open surgical techniques. Renal parenchymal temperature was measured using a thermocouple needle in ...
Y.y. Jiang - One of the best experts on this subject based on the ideXlab platform.
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forced convective heat transfer of Slush nitrogen in a horizontal pipe
International Journal of Heat and Mass Transfer, 2014Co-Authors: Peng Zhang, Y.y. JiangAbstract:Abstract In the present study, the flow and heat transfer characteristics of Slush nitrogen in a horizontal pipe of 10.0 mm in diameter were investigated experimentally and theoretically. The flow velocity was in the range of 0.9–3.4 m/s, and the solid volume fraction was up to 30.0%, and the Slush Reynolds number ranged from 1.89 × 104 to 1.01 × 105. The Eulerian–Eulerian multiphase model incorporated with the kinetic theory of granular flow was employed to investigate the forced convective heat transfer of Slush nitrogen by taking into account of the heat and mass transfer between the solid and liquid phases. It was found that the pressure drop of Slush nitrogen was higher than that of subcooled liquid nitrogen and increased with the solid volume fraction due to the existence of solid particles, and it showed different dependences on the flow velocity in the heterogeneous and pseudo-homogenous flows. Due to the latent heat involved in the solid–liquid phase change, the local heat transfer coefficients of Slush nitrogen were higher than that of subcooled liquid nitrogen. The heat transfer between solid and liquid phases was enhanced as the solid volume fraction increased, leading to higher local heat transfer coefficient and lower and more stable fluid temperature of Slush nitrogen. Although the dependences of the local heat transfer coefficient on the velocity and solid volume fraction were similar in both the homogeneous and heterogeneous flows, the distribution of the fluid temperature on the cross-section was found to vary with the flow patterns because of the non-uniform distribution of solid particles. The heat transfer correlation was proposed based on the experimental results for predicting the heat transfer performance of the heterogeneous and pseudo-homogenous Slush nitrogen flows with various solid volume fractions.
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Numerical investigation of Slush nitrogen flow in a horizontal pipe
Chemical Engineering Science, 2012Co-Authors: Y.y. Jiang, Pengfei ZhangAbstract:Slush nitrogen is a cryogenic two-phase fluid containing solid particles in liquid nitrogen, and the flow of Slush nitrogen in a horizontal pipe is investigated using the 2D Eulerian–Eulerian multiphase approach. The per-phase k–e turbulence model is used in the study to model the turbulent two-phase flow, and the motion of solid phase is modeled by the kinetic theory of granular flow to account for both particle–particle and particle–wall interactions. The 2D multiphase model is firstly validated with solid volume fraction and velocity profile data of several different slurry flows from the open literature, and then is further applied to studying Slush nitrogen flow in a horizontal pipe, and the numerical solid velocity profiles are compared with the experimental data. The effects of the flow velocity and the mean solid volume fraction on the flow characteristics of Slush nitrogen are investigated numerically in this study.
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density determination of Slush nitrogen by the improved capacitance type densimeter
Experimental Thermal and Fluid Science, 2011Co-Authors: Y.y. Jiang, P ZhangAbstract:Abstract Slush nitrogen is considered to be a better coolant than subcooled liquid nitrogen for the high-temperature superconducting cable cooling because of its greater density and cooling capacity. The capacitance-type densimeter is utilized to determine the density of Slush nitrogen in this paper. In order to improve the densimeter performance, the bulk shielding method, based on the application of the double-shielded cables, is introduced, and the influence of the frequency of the applied voltage is investigated. The parasitic capacitance of the densimeter system is significantly reduced, and the fluctuation of the capacitance is depressed within ±2.0 × 10 −4 pF at a frequency of 1.0 MHz, and the typical sensitivity of the differential type densimeter is 3.718 pF and the high accuracy of within ±0.25% for density measurement is obtained. In process of producing Slush nitrogen by the freeze–thaw method, the discharge rate is 4 l/s and the time of the freeze and thaw cycles is 10 s and 5 s respectively to obtain Slush nitrogen with fine solid particles, and Slush density is measured by the densimeter system. According to the experimental results, the rotating speed, higher than 50 rpm in this study, is necessary to homogenize Slush nitrogen for the high accuracy of the density measurement.
Olcay Arslan - One of the best experts on this subject based on the ideXlab platform.
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an alternative multivariate skew slash distribution
Statistics & Probability Letters, 2008Co-Authors: Olcay ArslanAbstract:In this paper, we introduce an alternative skew-slash distribution in multivariate setting. This includes as a special case the symmetric multivariate slash distribution, and otherwise provides skew extension of the multivariate slash distribution. The distribution is potentially useful for empirical modeling and in robustness studies. Some properties of the new distribution are presented. An application is provided for illustrative reason.
Kazuhiro Suzuki - One of the best experts on this subject based on the ideXlab platform.
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chlormadinone acetate is effective for hot flush during androgen deprivation therapy
Prostate international, 2013Co-Authors: Hidekazu Koike, Yasuyuki Morikawa, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro SuzukiAbstract:Purpose To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy. Methods Our study included 32 prostate cancer patients who had severe hot flush after undergoing hormone therapy for more than 3 months. The average age of the patients was 72.5 years. In the beginning, patients received CMA at 100 mg orally per day. We defined the hot flush as disappeared, improved, or not improved. In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day. When hot flush appeared again at 25 mg per day, we returned the dose of CMA to 50 mg per day. In cases with no change for more than two months, we canceled the treatment of CMA. Results Hot flush disappeared in 17 patients, improved in 10 patients, and did not improve in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients. No patients had prostate-specific antigen failure in the treatment of CMA. Conclusions When hot flush appears during treatment with luteinizing hormone-releasing hormone agonist for prostate cancer, it seems that CMA can improve it immediately in most patients.
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Chlormadinone acetate is effective for hot flush during androgen deprivation therapy
Elsevier, 2013Co-Authors: Hidekazu Koike, Yasuyuki Morikawa, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro SuzukiAbstract:To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy. Methods: Our study included 32 prostate cancer patients who had severe hot flush after undergoing hormone therapy for more than 3 months. The average age of the patients was 72.5 years. In the beginning, patients received CMA at 100 mg orally per day. We defined the hot flush as disappeared, improved, or not improved. In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day. When hot flush appeared again at 25 mg per day, we returned the dose of CMA to 50 mg per day. In cases with no change for more than two months, we canceled the treatment of CMA. Results: Hot flush disappeared in 17 patients, improved in 10 patients, and did not improve in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients. No patients had prostate-specific antigen failure in the treatment of CMA. Conclusions: When hot flush appears during treatment with luteinizing hormone-releasing hormone agonist for prostate cancer, it seems that CMA can improve it immediately in most patients
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136 chlormadinone acetate is effective for hot flush in androgen deprivation therapy
European Urology Supplements, 2010Co-Authors: Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro SuzukiAbstract:Purpose: To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy. Methods: Our study included 32 prostate cancer patients who had severe hot flush after undergoing hormone therapy for more than 3 months. The average age of the patients was 72.5 years. In the beginning, patients received CMA at 100 mg orally per day. We defined the hot flush as disappeared, improved, or not improved. In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day. When hot flush appeared again at 25 mg per day, we returned the dose of CMA to 50 mg per day. In cases with no change for more than two months, we canceled the treatment of CMA. Results: Hot flush disappeared in 17 patients, improved in 10 patients, and did not improve in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients. No patients had prostate-specific antigen failure in the treatment of CMA. Conclusions: When hot flush appears during treatment with luteinizing hormone-releasing hormone agonist for prostate cancer, it seems that CMA can improve it immediately in most patients.
Pengfei Zhang - One of the best experts on this subject based on the ideXlab platform.
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Numerical investigation of Slush nitrogen flow in a horizontal pipe
Chemical Engineering Science, 2012Co-Authors: Y.y. Jiang, Pengfei ZhangAbstract:Slush nitrogen is a cryogenic two-phase fluid containing solid particles in liquid nitrogen, and the flow of Slush nitrogen in a horizontal pipe is investigated using the 2D Eulerian–Eulerian multiphase approach. The per-phase k–e turbulence model is used in the study to model the turbulent two-phase flow, and the motion of solid phase is modeled by the kinetic theory of granular flow to account for both particle–particle and particle–wall interactions. The 2D multiphase model is firstly validated with solid volume fraction and velocity profile data of several different slurry flows from the open literature, and then is further applied to studying Slush nitrogen flow in a horizontal pipe, and the numerical solid velocity profiles are compared with the experimental data. The effects of the flow velocity and the mean solid volume fraction on the flow characteristics of Slush nitrogen are investigated numerically in this study.
