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Emery N. Brown - One of the best experts on this subject based on the ideXlab platform.

  • The Smallest Concentration
    Clinical chemistry, 1997
    Co-Authors: Robert F. Moran, Emery N. Brown
    Abstract:

    Brown et al. (1) reported on the different analytical approaches used to characterize and quantify “the Smallest analyte Concentration an immunoassay can measure.” While in agreement with the excellent science of the report, I take issue with certain aspects of some of the basic terminology and definitions used. Given that a definition is a “statement of meaning” (2)(3), and a term is “a spoken or written representation of a concept” (2)(3), the title seems to put the cart before the definitive horse, in that the term being “defined” by the report is actually the “minimal detectable Concentration (MDC),” by which the authors mean “the Smallest analyte Concentration an immunoassay can measure.” The concept embodied in the author’s definition is synonymous with “quantitation limit” or “limit of quantitation (LOQ)”—terms already defined by at least two …

Robert F. Moran - One of the best experts on this subject based on the ideXlab platform.

  • The Smallest Concentration
    Clinical chemistry, 1997
    Co-Authors: Robert F. Moran, Emery N. Brown
    Abstract:

    Brown et al. (1) reported on the different analytical approaches used to characterize and quantify “the Smallest analyte Concentration an immunoassay can measure.” While in agreement with the excellent science of the report, I take issue with certain aspects of some of the basic terminology and definitions used. Given that a definition is a “statement of meaning” (2)(3), and a term is “a spoken or written representation of a concept” (2)(3), the title seems to put the cart before the definitive horse, in that the term being “defined” by the report is actually the “minimal detectable Concentration (MDC),” by which the authors mean “the Smallest analyte Concentration an immunoassay can measure.” The concept embodied in the author’s definition is synonymous with “quantitation limit” or “limit of quantitation (LOQ)”—terms already defined by at least two …

Davor Antanasijević - One of the best experts on this subject based on the ideXlab platform.

  • Review: the approaches for estimation of limit of detection for ICP-MS trace analysis of arsenic.
    Talanta, 2012
    Co-Authors: Ljubinka V. Rajaković, Dana D. Marković, Vladana N. Rajaković-ognjanović, Davor Antanasijević
    Abstract:

    The analytical properties of an analytical method must be evaluated through validation protocols. Beside specificity and/or selectivity, linearity of calibration, repeatability and accuracy, the most important parameters are: LOD (limit of detection) and LOQ (limit of quantification). Through these limits, it is possible to define the Smallest Concentration of analyte that can be reliably detected and quantified. To establish these limits, an analyst should apply several estimation methods and test a large number of sample replicates. It is difficult to make a compromise between complex statistical programs and the simple analytical demand to have reliable analytical parameters. The differences and equivalency of estimation methods and approaches for analytical limits could be overcome by an experimental comparison. In this paper, the focus is the LOD of inductively coupled plasma-mass spectrometry (ICP-MS) measurements employed for the determination of arsenic. The current approaches for the calculation of the LOD are summarized and critically discussed.

Ljubinka V. Rajaković - One of the best experts on this subject based on the ideXlab platform.

  • Review: the approaches for estimation of limit of detection for ICP-MS trace analysis of arsenic.
    Talanta, 2012
    Co-Authors: Ljubinka V. Rajaković, Dana D. Marković, Vladana N. Rajaković-ognjanović, Davor Antanasijević
    Abstract:

    The analytical properties of an analytical method must be evaluated through validation protocols. Beside specificity and/or selectivity, linearity of calibration, repeatability and accuracy, the most important parameters are: LOD (limit of detection) and LOQ (limit of quantification). Through these limits, it is possible to define the Smallest Concentration of analyte that can be reliably detected and quantified. To establish these limits, an analyst should apply several estimation methods and test a large number of sample replicates. It is difficult to make a compromise between complex statistical programs and the simple analytical demand to have reliable analytical parameters. The differences and equivalency of estimation methods and approaches for analytical limits could be overcome by an experimental comparison. In this paper, the focus is the LOD of inductively coupled plasma-mass spectrometry (ICP-MS) measurements employed for the determination of arsenic. The current approaches for the calculation of the LOD are summarized and critically discussed.

D. Yu. Tsvetkov - One of the best experts on this subject based on the ideXlab platform.

  • Distributions of supernovae of different types along the radius and in z coordinate of galaxies
    Astronomy Letters, 2016
    Co-Authors: N. N. Pavlyuk, D. Yu. Tsvetkov
    Abstract:

    The distributions of supernovae of different types and subtypes along the radius and in z coordinate of galaxies have been studied. We show that among the type Ia supernovae (SNe Ia) in spiral galaxies, SNe Iax and Ia-norm have, respectively, the largest and Smallest Concentration to the center; the distributions of SNe Ia-91bg and Ia-91T are similar. A strong Concentration of SNe Ib/c to the central regions has been confirmed. In spiral galaxies, the supernovae of all types strongly concentrate to the galactic plane; the slight differences in scale height correlate with the extent to which the classes of supernovae are associated with star formation.