The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Jing Dong - One of the best experts on this subject based on the ideXlab platform.
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estimating 24 hour Sodium excretion from spot urine samples in chinese adults can spot urine substitute 24 hour urine samples
Nutrients, 2020Co-Authors: Jiyu Zhang, Min Liu, Yamin Bai, Xiaolei Guo, Jing DongAbstract:Several estimating equations for predicting 24-h urinary Sodium (24-hUNa) excretion using spot urine (SU) samples have been developed, but have not been readily available to Chinese populations. We aimed to compare and validate the six existing methods at population level and individual level. We extracted 1671 adults eligible for both 24-h urine and SU sample collection. Mean biases (95% CI) of predicting 24-hUNa excretion using six formulas were 58.6 (54.7, 62.5) mmol for Kawasaki, -2.7 (-6.2, 0.9) mmol for Tanaka, -24.5 (-28.0, -21.0) mmol for the International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT) with potassium, -26.8 (-30.1, -23.3) mmol for INTERSALT without potassium, 5.9 (2.3, 9.6) mmol for Toft, and -24.2 (-27.7, -20.6) mmol for Whitton. The proportions of relative difference >40% with the six methods were nearly a third, and the proportions of absolute difference >51.3 mmol/24-h (3 g/day salt) were more than 40%. The misclassification rate were all >55% for the six methods at the individual level. Although the Tanaka method could offer a plausible estimation for surveillance of the population Sodium excretion in Shandong province, caution remains when using the Tanaka formula for other provincial populations in China. However, these predictive methods were inadequate to evaluate individual Sodium excretion.
Alan G Jardine - One of the best experts on this subject based on the ideXlab platform.
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urinary Sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease
Nephrology Dialysis Transplantation, 2013Co-Authors: Emily P Mcquarrie, Ellen Marie Freel, Patrick B Mark, R Fraser, John M Connell, Alan G JardineAbstract:Background. Blockade of the mineralocorticoid receptor (MR) in patients with chronic kidney disease (CKD) improves surrogate cardiovascular outcomes, such as left ventricular mass. Animal models of renal disease support a pathological role of mineralocorticoids, in the context of a high Sodium intake. We aimed to assess the regulation of mineralocorticoid biosynthesis in patients with CKD. Methods. Seventy patients with CKD stages 3/4 and 30 patients with essential hypertension (EH) were recruited. Patients underwent detailed clinical phenotyping, drug history and biochemical assessment. Patients completed a 24-h urine collection for measurement of urinary tetrahydroaldosterone (THALDO) and tetrahydrocorticosterone (THDOC) excretion rates (measured using gas chromatography-mass spectrometry) and urinary electrolytes. The factors which correlated significantly with THALDO and THDOC excretion were entered into linear regression models. Results. Patients with EH and CKD were well matched with no significant differences in gender, age or weight. The mean estimated glomerular filtration rate (eGFR) in CKD patients was 38.6/min/1.73 m 2 . The mean urinary excretion rates of THALDO, THDOC and 24-h urinary Sodium (24-h USod) were not significantly different between CKD and EH patients. The level of renal function did not correlate with THALDO or THDOC excretion. In patients with CKD, 24-h USodium (r= 0.614, P < 0.001) and 24-h UPotassium (r= 0.538, P < 0.001) were positively correlated with THALDO excretion. On multivariate linear regression analysis, 24-h USod was the strongest independent predictor (P = 0.004) of THALDO and THDOC excretion in CKD. In patients with EH, no relationship was seen between mineralocorticoid excretion and 24-h urinary Sodium excretion. Conclusions. In patients with CKD, 24-h urinary Sodium excretion is the strongest positive predictor of urinary mineralocorticoid excretion. The nature of this relationship is unexpected, novel, not seen in patients with EH and may explain the association seen between high urinary Sodium excretion, mineralocorticoids and poor outcomes in patients with CKD.
Jiyu Zhang - One of the best experts on this subject based on the ideXlab platform.
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estimating 24 hour Sodium excretion from spot urine samples in chinese adults can spot urine substitute 24 hour urine samples
Nutrients, 2020Co-Authors: Jiyu Zhang, Min Liu, Yamin Bai, Xiaolei Guo, Jing DongAbstract:Several estimating equations for predicting 24-h urinary Sodium (24-hUNa) excretion using spot urine (SU) samples have been developed, but have not been readily available to Chinese populations. We aimed to compare and validate the six existing methods at population level and individual level. We extracted 1671 adults eligible for both 24-h urine and SU sample collection. Mean biases (95% CI) of predicting 24-hUNa excretion using six formulas were 58.6 (54.7, 62.5) mmol for Kawasaki, -2.7 (-6.2, 0.9) mmol for Tanaka, -24.5 (-28.0, -21.0) mmol for the International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT) with potassium, -26.8 (-30.1, -23.3) mmol for INTERSALT without potassium, 5.9 (2.3, 9.6) mmol for Toft, and -24.2 (-27.7, -20.6) mmol for Whitton. The proportions of relative difference >40% with the six methods were nearly a third, and the proportions of absolute difference >51.3 mmol/24-h (3 g/day salt) were more than 40%. The misclassification rate were all >55% for the six methods at the individual level. Although the Tanaka method could offer a plausible estimation for surveillance of the population Sodium excretion in Shandong province, caution remains when using the Tanaka formula for other provincial populations in China. However, these predictive methods were inadequate to evaluate individual Sodium excretion.
Emily P Mcquarrie - One of the best experts on this subject based on the ideXlab platform.
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urinary Sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease
Nephrology Dialysis Transplantation, 2013Co-Authors: Emily P Mcquarrie, Ellen Marie Freel, Patrick B Mark, R Fraser, John M Connell, Alan G JardineAbstract:Background. Blockade of the mineralocorticoid receptor (MR) in patients with chronic kidney disease (CKD) improves surrogate cardiovascular outcomes, such as left ventricular mass. Animal models of renal disease support a pathological role of mineralocorticoids, in the context of a high Sodium intake. We aimed to assess the regulation of mineralocorticoid biosynthesis in patients with CKD. Methods. Seventy patients with CKD stages 3/4 and 30 patients with essential hypertension (EH) were recruited. Patients underwent detailed clinical phenotyping, drug history and biochemical assessment. Patients completed a 24-h urine collection for measurement of urinary tetrahydroaldosterone (THALDO) and tetrahydrocorticosterone (THDOC) excretion rates (measured using gas chromatography-mass spectrometry) and urinary electrolytes. The factors which correlated significantly with THALDO and THDOC excretion were entered into linear regression models. Results. Patients with EH and CKD were well matched with no significant differences in gender, age or weight. The mean estimated glomerular filtration rate (eGFR) in CKD patients was 38.6/min/1.73 m 2 . The mean urinary excretion rates of THALDO, THDOC and 24-h urinary Sodium (24-h USod) were not significantly different between CKD and EH patients. The level of renal function did not correlate with THALDO or THDOC excretion. In patients with CKD, 24-h USodium (r= 0.614, P < 0.001) and 24-h UPotassium (r= 0.538, P < 0.001) were positively correlated with THALDO excretion. On multivariate linear regression analysis, 24-h USod was the strongest independent predictor (P = 0.004) of THALDO and THDOC excretion in CKD. In patients with EH, no relationship was seen between mineralocorticoid excretion and 24-h urinary Sodium excretion. Conclusions. In patients with CKD, 24-h urinary Sodium excretion is the strongest positive predictor of urinary mineralocorticoid excretion. The nature of this relationship is unexpected, novel, not seen in patients with EH and may explain the association seen between high urinary Sodium excretion, mineralocorticoids and poor outcomes in patients with CKD.
Xiaolei Guo - One of the best experts on this subject based on the ideXlab platform.
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estimating 24 hour Sodium excretion from spot urine samples in chinese adults can spot urine substitute 24 hour urine samples
Nutrients, 2020Co-Authors: Jiyu Zhang, Min Liu, Yamin Bai, Xiaolei Guo, Jing DongAbstract:Several estimating equations for predicting 24-h urinary Sodium (24-hUNa) excretion using spot urine (SU) samples have been developed, but have not been readily available to Chinese populations. We aimed to compare and validate the six existing methods at population level and individual level. We extracted 1671 adults eligible for both 24-h urine and SU sample collection. Mean biases (95% CI) of predicting 24-hUNa excretion using six formulas were 58.6 (54.7, 62.5) mmol for Kawasaki, -2.7 (-6.2, 0.9) mmol for Tanaka, -24.5 (-28.0, -21.0) mmol for the International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT) with potassium, -26.8 (-30.1, -23.3) mmol for INTERSALT without potassium, 5.9 (2.3, 9.6) mmol for Toft, and -24.2 (-27.7, -20.6) mmol for Whitton. The proportions of relative difference >40% with the six methods were nearly a third, and the proportions of absolute difference >51.3 mmol/24-h (3 g/day salt) were more than 40%. The misclassification rate were all >55% for the six methods at the individual level. Although the Tanaka method could offer a plausible estimation for surveillance of the population Sodium excretion in Shandong province, caution remains when using the Tanaka formula for other provincial populations in China. However, these predictive methods were inadequate to evaluate individual Sodium excretion.