The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Ming Thau Sheu - One of the best experts on this subject based on the ideXlab platform.

  • swelling floating capability and drug release characterizations of gastroretentive drug delivery system based on a combination of hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose
    PLOS ONE, 2015
    Co-Authors: Ying Chen Chen, Der Zen Liu, Wen Shian Siow, Ming Thau Sheu
    Abstract:

    The aim of this study was to characterize the swelling and floating behaviors of gastroretentive drug delivery system (GRDDS) composed of hydroxyethyl Cellulose (HEC) and Sodium Carboxymethyl Cellulose (NaCMC) and to optimize HEC/NaCMC GRDDS to incorporate three model drugs with different solubilities (metformin, ciprofloxacin, and esomeprazole). Various ratios of NaCMC to HEC were formulated, and their swelling and floating behaviors were characterized. Influences of media containing various NaCl concentrations on the swelling and floating behaviors and drug solubility were also characterized. Finally, release profiles of the three model drugs from GRDDS formulation (F1-4) and formulation (F1-1) were examined. Results demonstrated when the GRDDS tablets were tested in simulated gastric solution, the degree of swelling at 6 h was decreased for each formulation that contained NaCMC in comparison to those in de-ionized water (DIW). Of note, floating duration was enhanced when in simulated gastric solution compared to DIW. Further, the hydration of tablets was found to be retarded as the NaCl concentration in the medium increased resulting in smaller gel layers and swelling sizes. Dissolution profiles of the three model drugs in media containing various concentrations of NaCl showed that the addition of NaCl to the media affected the solubility of the drugs, and also their gelling behaviors, resulting in different mechanisms for controlling a drug’s release. The release mechanism of the freely water-soluble drug, metformin, was mainly diffusion-controlled, while those of the water-soluble drug, ciprofloxacin, and the slightly water-soluble drug, esomeprazole, were mainly anomalous diffusion. Overall results showed that the developed GRDDS composed of HEC 250HHX and NaCMC of 450 cps possessed proper swelling extents and desired floating periods with sustained-release characteristics.

  • development of swelling floating gastroretentive drug delivery system based on a combination of hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose for losartan and its clinical relevance in healthy volunteers with cyp2c9 polymorphism
    European Journal of Pharmaceutical Sciences, 2010
    Co-Authors: Ray Neng Chen, Ming Thau Sheu
    Abstract:

    The aim of this study was to develop an optimal gastroretentive drug delivery system (GRDDS) for administering Losartan. Additionally, the influence of optimized GRDDS on the bioavailability of Losartan and the formation extent of active metabolite E3174 by CYP2C9 polymorphism was investigated. Swellable and floatable GRDDS tablets combining hydroxyethyl Cellulose (HEC), Sodium Carboxymethyl Cellulose (NaCMC), and Sodium bicarbonate were prepared at various compression pressures for evaluating swelling characteristics and floating capacity. Then Losartan was incorporated into optimized formulations for in vitro and in vivo characterizations. An appropriate ratio of HEC to NaCMC, addition of Sodium bicarbonate, and compression at lower pressures resulted in the tablets floating over SGF for more than 16 h and swelling to 2 cm in diameter within 3h. The release patterns of Losartan from these tablets were pH-dependent. Results of the clinical trials showed that the mean bioavailability from GRD-A (HEC 91.67%, Sodium bicarbonate 3.33% and Losartan 8.33%) was approximately 164%, relative to the immediate-release product (Cozaar). MRT and t(max) values were greater and C(max) values were lower for the GRDDS tablets compared with Cozaa. The lower bioavailability of Losartan in the CYP2C9*1/*1 subjects than CYP2C9*1/*3 subjects was found and could be due to the variety of enzymatic activity.

Hongshan Liang - One of the best experts on this subject based on the ideXlab platform.

  • improving the emulsifying property of gliadin nanoparticles as stabilizer of pickering emulsions modification with Sodium Carboxymethyl Cellulose
    Food Hydrocolloids, 2020
    Co-Authors: Hongshan Liang, Xuan Zhang, Xianling Wei
    Abstract:

    Abstract In the present work, Sodium Carboxymethyl Cellulose (CMCNa) was utilized to improve the emulsifying property of gliadin colloid particles (GCPs). We demonstrated the use of gliadin/CMCNa complex particles (GCCPs) as stabilizer to stabilize oil-in-water emulsions in a wide pH range (3.0–9.0) at a very low protein concentration (0.1%, w/v) which could be kept at room temperature for three months without oil-leakage. The effect of gliadin/CMCNa ratio, pH and ionic strength on emulsifying property of gliadin-based particles was investigated, and the stability of Pickering emulsions fabricated by GCCPs at a series of pH (3.0–9.0) to a four-week-long storage was evaluated. The optimized emulsifying property of particles was achieved at a gliadin/CMCNa ratio of 2:1, and Pickering emulsions stabilized by GCCPs at this ratio had a high tolerance for aqueous phase pH variation. Furthermore, the possible mechanisms were discussed by investigating the effect of gliadin/CMCNa ratio on wettability and adsorption behavior of particles at pH 4.0 and pH 7.0. Moderate wettability was achieved at the gliadin/CMCNa ratio of 1:1 at pH 4.0 and 2:1 at pH 7.0. The surface loading percentage of protein of Pickering emulsions increased from 70.28 ± 1.97% to 82.02 ± 6.20% and the surface protein loading (τ) decreased from 267.53 ± 5.31 mg/m2 to 149.17 ± 4.45 mg/m2 with the increase of CMCNa concentration, indicating the adsorption and emulsifying activity of particles could be enhanced by CMCNa addition.

  • folate functionalized assembly of low density lipoprotein Sodium Carboxymethyl Cellulose nanoparticles for targeted delivery
    Colloids and Surfaces B: Biointerfaces, 2017
    Co-Authors: Hongshan Liang, Bin Zhou
    Abstract:

    In this study, well-defined folate (FA)-functionalized low density lipoproteins (LDL)/Sodium Carboxymethyl Cellulose (CMC) nanoparticles (NP) were first formulated, utilized in tumor targeting and pH-triggered drug release. CMC was modified with FA before the preparation of NP. A model anti-tumor drug, doxorubicin (DOX), was effectively loaded into the LDL/CMC-FA NP by ionic bonding and hydrophobic interactions. To enhance non-covalent encapsulation stability, self-assembly of DOX-loaded LDL/CMC-FA NP (NP-DOX) was cross-linked by multivalent cations such as Ca2+ (Ca2+-NP-DOX). The active targeting efficiency of NP-DOX and Ca2+-NP-DOX was tested against KB cells (FA-receptor over-expressing cells, FR+) and A549 cells (FA-receptor negative-expressing cells, FR-), using FA non-modified DOX-loaded LDL/CMC NP (NG-DOX) as control. The competition assay proved that free FA molecules prevented the cellular uptake of the NP by competitive binding to the FA receptors on the surface of KB cells. This new pH-responsive and FA-targeted nanocarrier may be a promising efficient drug delivery system for potential cancer therapy.

  • self assembled zein Sodium Carboxymethyl Cellulose nanoparticles as an effective drug carrier and transporter
    Journal of Materials Chemistry B, 2015
    Co-Authors: Hongshan Liang, Bin Zhou, Qingrong Huang, Liufeng Lin, Shilin Liu, Yijie Chen
    Abstract:

    In this work, biodegradable nanoparticles (NPs) were assembled with Sodium Carboxymethyl Cellulose (CMC) and zein to produce zein–CMC NPs. Paclitaxel (PTX) was 95.5% encapsulated at a zein–CMC weight ratio of 1 : 3 and the NPs were spherical with an average particle size of approximately 159.4 nm, with the PTX concentration maintained at 80 μg mL−1. The NPs demonstrated good stability over a broad range of pH ranging from 3.7 to 11.0. The zein–CMC NPs were seen to provide a sustained release of PTX for up to 72 h, which led to an 80% release of the total loaded PTX in vitro. Confocal laser scanning microscopy (CLSM) and flow cytometry studies showed that the zein–CMC NPs could effectively transport encapsulated molecules into both drug-sensitive (HepG2 cells) and drug-resistant cancer cells (MCF-7 cells). Moreover, in vitro viability studies revealed that the PTX-loaded zein–CMC NPs had greater potency than free PTX in the PTX resistant MCF-7 cells at higher concentration. Furthermore, PTX-loaded NPs displayed obvious efficiency in the apoptosis of HepG2 cells. Zein–CMC NPs have shown significant potential as a highly versatile and potent platform for cancer therapy.

  • green step assembly of low density lipoprotein Sodium Carboxymethyl Cellulose nanogels for facile loading and ph dependent release of doxorubicin
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Hongshan Liang, Yijie Chen, Lei He, Bakht Ramin Shah, Yan Li
    Abstract:

    : In this study, a simple and green approach was developed to produce a novel nanogel via self-assembly of low density lipoproteins (LDL) and Sodium Carboxymethyl Cellulose (CMC), to efficiently deliver doxorubicin (DOX) to cancer cells. Under optimal conditions, the stable nanogels were of spherical shape with an average diameter of about 90 nm, PDI<0.3 and a zeta potential -35 mV. Furthermore, the cationic anticancer drug, doxorubicin (DOX) was effectively encapsulated into LDL/CMC nanogels with an exceptionally high encapsulation efficiency of ∼ 98%. The release of DOX from DOX-LDL/CMC nanogels was pH-dependent, and DOX was released at a quicker rate at pH 6.2 than at pH 7.4. Importantly, the DOX-LDL/CMC nanogels were shown to effectively kill cancer cells in vitro. The IC50 of the DOX-LDL/CMC nanogels in HeLa and HepG2 cells was approximately 2.45 and 1.72 times higher than that of free DOX. The slightly reduced antitumor efficacy was primarily due to the less cellular uptake of the DOX-LDL/CMC nanogels, which was confirmed by confocal laser scanning microscope (CLSM) and flow cytometry analysis. The high DOX payload and pH-dependent drug release rendered LDL/CMC nanogels as an efficient carrier for doxorubicin and possibly be used for other cationic drugs in different biomedical applications.

Yijie Chen - One of the best experts on this subject based on the ideXlab platform.

  • self assembled zein Sodium Carboxymethyl Cellulose nanoparticles as an effective drug carrier and transporter
    Journal of Materials Chemistry B, 2015
    Co-Authors: Hongshan Liang, Bin Zhou, Qingrong Huang, Liufeng Lin, Shilin Liu, Yijie Chen
    Abstract:

    In this work, biodegradable nanoparticles (NPs) were assembled with Sodium Carboxymethyl Cellulose (CMC) and zein to produce zein–CMC NPs. Paclitaxel (PTX) was 95.5% encapsulated at a zein–CMC weight ratio of 1 : 3 and the NPs were spherical with an average particle size of approximately 159.4 nm, with the PTX concentration maintained at 80 μg mL−1. The NPs demonstrated good stability over a broad range of pH ranging from 3.7 to 11.0. The zein–CMC NPs were seen to provide a sustained release of PTX for up to 72 h, which led to an 80% release of the total loaded PTX in vitro. Confocal laser scanning microscopy (CLSM) and flow cytometry studies showed that the zein–CMC NPs could effectively transport encapsulated molecules into both drug-sensitive (HepG2 cells) and drug-resistant cancer cells (MCF-7 cells). Moreover, in vitro viability studies revealed that the PTX-loaded zein–CMC NPs had greater potency than free PTX in the PTX resistant MCF-7 cells at higher concentration. Furthermore, PTX-loaded NPs displayed obvious efficiency in the apoptosis of HepG2 cells. Zein–CMC NPs have shown significant potential as a highly versatile and potent platform for cancer therapy.

  • green step assembly of low density lipoprotein Sodium Carboxymethyl Cellulose nanogels for facile loading and ph dependent release of doxorubicin
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Hongshan Liang, Yijie Chen, Lei He, Bakht Ramin Shah, Yan Li
    Abstract:

    : In this study, a simple and green approach was developed to produce a novel nanogel via self-assembly of low density lipoproteins (LDL) and Sodium Carboxymethyl Cellulose (CMC), to efficiently deliver doxorubicin (DOX) to cancer cells. Under optimal conditions, the stable nanogels were of spherical shape with an average diameter of about 90 nm, PDI<0.3 and a zeta potential -35 mV. Furthermore, the cationic anticancer drug, doxorubicin (DOX) was effectively encapsulated into LDL/CMC nanogels with an exceptionally high encapsulation efficiency of ∼ 98%. The release of DOX from DOX-LDL/CMC nanogels was pH-dependent, and DOX was released at a quicker rate at pH 6.2 than at pH 7.4. Importantly, the DOX-LDL/CMC nanogels were shown to effectively kill cancer cells in vitro. The IC50 of the DOX-LDL/CMC nanogels in HeLa and HepG2 cells was approximately 2.45 and 1.72 times higher than that of free DOX. The slightly reduced antitumor efficacy was primarily due to the less cellular uptake of the DOX-LDL/CMC nanogels, which was confirmed by confocal laser scanning microscope (CLSM) and flow cytometry analysis. The high DOX payload and pH-dependent drug release rendered LDL/CMC nanogels as an efficient carrier for doxorubicin and possibly be used for other cationic drugs in different biomedical applications.

Yan Bao - One of the best experts on this subject based on the ideXlab platform.

  • synthesis and swelling behaviors of Sodium Carboxymethyl Cellulose g poly aa co am co amps mmt superabsorbent hydrogel
    Carbohydrate Polymers, 2011
    Co-Authors: Yan Bao
    Abstract:

    Abstract Superabsorbents were synthesized by graft copolymerization of acrylic acid (AA)/acrylamide (AM)/2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) onto Sodium Carboxymethyl Cellulose (CMC) and montmorillonite (MMT) by using potassium persulfate (KPS) as a free radical initiator, in the presence of N,N′-methylenebisacrylamide (MBA) as a crosslinking agent. The structure and morphologies of the superabsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscope (SEM). Superabsorbent comprised a porous crosslink structure of MMT and CMC with side chains that carry carboxylate, carboxamide and sulfate. The swelling behaviors of the superabsorbent were dependant on the pH of external solutions, particle size and the concentration of the salt solution. The effect of four cationic salt solutions on the swelling had the following order: K+ > Na+ > Ca2+ > Mg2+.

Bin Zhou - One of the best experts on this subject based on the ideXlab platform.

  • folate functionalized assembly of low density lipoprotein Sodium Carboxymethyl Cellulose nanoparticles for targeted delivery
    Colloids and Surfaces B: Biointerfaces, 2017
    Co-Authors: Hongshan Liang, Bin Zhou
    Abstract:

    In this study, well-defined folate (FA)-functionalized low density lipoproteins (LDL)/Sodium Carboxymethyl Cellulose (CMC) nanoparticles (NP) were first formulated, utilized in tumor targeting and pH-triggered drug release. CMC was modified with FA before the preparation of NP. A model anti-tumor drug, doxorubicin (DOX), was effectively loaded into the LDL/CMC-FA NP by ionic bonding and hydrophobic interactions. To enhance non-covalent encapsulation stability, self-assembly of DOX-loaded LDL/CMC-FA NP (NP-DOX) was cross-linked by multivalent cations such as Ca2+ (Ca2+-NP-DOX). The active targeting efficiency of NP-DOX and Ca2+-NP-DOX was tested against KB cells (FA-receptor over-expressing cells, FR+) and A549 cells (FA-receptor negative-expressing cells, FR-), using FA non-modified DOX-loaded LDL/CMC NP (NG-DOX) as control. The competition assay proved that free FA molecules prevented the cellular uptake of the NP by competitive binding to the FA receptors on the surface of KB cells. This new pH-responsive and FA-targeted nanocarrier may be a promising efficient drug delivery system for potential cancer therapy.

  • self assembled zein Sodium Carboxymethyl Cellulose nanoparticles as an effective drug carrier and transporter
    Journal of Materials Chemistry B, 2015
    Co-Authors: Hongshan Liang, Bin Zhou, Qingrong Huang, Liufeng Lin, Shilin Liu, Yijie Chen
    Abstract:

    In this work, biodegradable nanoparticles (NPs) were assembled with Sodium Carboxymethyl Cellulose (CMC) and zein to produce zein–CMC NPs. Paclitaxel (PTX) was 95.5% encapsulated at a zein–CMC weight ratio of 1 : 3 and the NPs were spherical with an average particle size of approximately 159.4 nm, with the PTX concentration maintained at 80 μg mL−1. The NPs demonstrated good stability over a broad range of pH ranging from 3.7 to 11.0. The zein–CMC NPs were seen to provide a sustained release of PTX for up to 72 h, which led to an 80% release of the total loaded PTX in vitro. Confocal laser scanning microscopy (CLSM) and flow cytometry studies showed that the zein–CMC NPs could effectively transport encapsulated molecules into both drug-sensitive (HepG2 cells) and drug-resistant cancer cells (MCF-7 cells). Moreover, in vitro viability studies revealed that the PTX-loaded zein–CMC NPs had greater potency than free PTX in the PTX resistant MCF-7 cells at higher concentration. Furthermore, PTX-loaded NPs displayed obvious efficiency in the apoptosis of HepG2 cells. Zein–CMC NPs have shown significant potential as a highly versatile and potent platform for cancer therapy.