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Victor E. A. Gerdes - One of the best experts on this subject based on the ideXlab platform.
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The Longer-Term Effects of Roux-en-Y Gastric Bypass Surgery on Sodium Excretion
Obesity Surgery, 2013Co-Authors: Funda Celik, Mohamed Ahdi, Eelco W. Meesters, Arnold Laar, Dees P. M. Brandjes, Victor E. A. GerdesAbstract:Background Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of Sodium Excretion has been described. The aim of this work was to study the influence of bariatric surgery on Sodium Excretion at more than a year after the intervention. Methods Patients who have undergone Roux-en-Y gastric bypass (RYGB) and who had collected a 24-h urine sample before surgery more than 12 months ago were asked to participate. A second 24-h urine sample was collected. Blood pressure and weight were measured. The difference in Sodium Excretion before and after surgery was calculated, and the relationship with blood pressure and weight loss was investigated. Results We included 33 patients; the median follow-up time was 21 months (range 14–41). Sodium Excretion was high before surgery (median 195 mmol/day, IQR range 167–247) and decreased by 18 % after surgery (median 160 mmol/day, IQR range 118–205, p = 0.015), while there were significant improvements in body weight (% EWL 80.9 ± 21.8), systolic blood pressure (126 to 120 mmHg, p = 0.02), and diastolic blood pressure (84 to 77 mmHg, p = 0.002), even with a reduced number of antihypertensive drugs. Conclusions After RYGB and considerable weight loss, Sodium Excretion remains high in the longer term. The profound improvement in blood pressure cannot be explained by reductions in Sodium Excretion after RYGB.
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The longer-term effects of Roux-en-Y gastric bypass surgery on Sodium Excretion.
Obesity surgery, 2012Co-Authors: Funda Celik, Mohamed Ahdi, Eelco W. Meesters, Dees P. M. Brandjes, Arnold W. J. M. Van De Laar, Victor E. A. GerdesAbstract:Background Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of Sodium Excretion has been described. The aim of this work was to study the influence of bariatric surgery on Sodium Excretion at more than a year after the intervention.
Ho Jun Chin - One of the best experts on this subject based on the ideXlab platform.
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association of Sodium Excretion with metabolic syndrome insulin resistance and body fat
Medicine, 2015Co-Authors: Kum Hyun Han, Sang Youb Han, Ho Seok Koo, Suhnggwon Kim, Ho Jun ChinAbstract:Sodium intake was reported to be related to metabolic syndrome (MS). Although a strong association between Sodium intake and blood pressure (BP) has been reported, the relationship between Sodium intake and other components of MS is unknown. An observational study of 18,146 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008–2011) was performed. Estimates of 24-h Sodium Excretion were made from a single fasting urine sample. A significant positive association was found between Sodium Excretion and systolic BP and between Sodium Excretion and diastolic BP in participants with and without hypertension after adjusting for multiple covariates (P < 0.001 for trend). The relationship between triglyceride or glucose levels and Sodium Excretion was linear (P < 0.005). In both men and women, a positive relationship between Sodium Excretion and waist circumference and an inverse relationship between Sodium Excretion and high-density lipoprotein were found (P ≤ 0.001). Body fat percentage, body fat mass, and insulin level were positively related to Sodium Excretion (P ≤ 0.001), and HOMA-IR was significantly associated with Sodium Excretion (P < 0.05). The risk of MS was elevated 1.279-fold in the second quartile of Sodium Excretion (95% CI, 1.088–1.504, P = 0.003), 1.479-fold in the third quartile (95% CI, 1.262–1.734; P < 0.001), and 1.929-fold in the highest quartile (95% CI 1.654–2.249, P < 0.001) compared with the lowest quartile. Sodium intake is significantly associated with all components of MS, body fat, and insulin resistance. Therefore, a high-salt diet is a significant risk factor for MS.
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Association of Sodium Excretion With Metabolic Syndrome, Insulin Resistance, and Body Fat
Medicine, 2015Co-Authors: Kum Hyun Han, Sang Youb Han, Ho Seok Koo, Suhnggwon Kim, Ho Jun ChinAbstract:Sodium intake was reported to be related to metabolic syndrome (MS). Although a strong association between Sodium intake and blood pressure (BP) has been reported, the relationship between Sodium intake and other components of MS is unknown. An observational study of 18,146 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008–2011) was performed. Estimates of 24-h Sodium Excretion were made from a single fasting urine sample. A significant positive association was found between Sodium Excretion and systolic BP and between Sodium Excretion and diastolic BP in participants with and without hypertension after adjusting for multiple covariates (P
James D. Stockand - One of the best experts on this subject based on the ideXlab platform.
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Vasopressin regulation of renal Sodium Excretion
Kidney international, 2010Co-Authors: James D. StockandAbstract:Vasopressin promotes renal water reabsorption decreasing Excretion of free water to dilute plasma and lower serum osmolality. We have good understanding of the causes, mechanisms and consequences of this vasopressin-dependent renal water movement. In comparison, vasopressin actions on renal electrolytes including Sodium Excretion and its consequences have been less well understood. This is so for investigation and discussions of the renal actions of vasopressin are framed primarily around water metabolism rather than any direct effect on salt handling. The fact that water moves in biological systems, to include the mammalian kidney, only by osmosis passively down its concentration gradient is implicit in such discussion but often not overtly addressed. This can cause confusion. Moreover, although vasopressin action on renal Sodium Excretion via the V2 receptor is critical to water transport, it is masked easily being situational—for instance, dependent on hydration state. It is now clear that an increase in Sodium reabsorption along the distal nephron (CNT + CD) mediated by activation of the epithelial Na + channel (ENaC) by vasopressin makes an important contribution to maintenance of the axial corticomedullary osmotic gradient necessary for maximal water reabsorption. Thus, we need to modify slightly our understanding of vasopressin and its renal actions to include the idea that while vasopressin decreases free water Excretion to dilute plasma, it does this, in part, by promoting Sodium reabsorption and consequently decreasing Sodium Excretion via ENaC activated along the distal nephron.
Funda Celik - One of the best experts on this subject based on the ideXlab platform.
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The Longer-Term Effects of Roux-en-Y Gastric Bypass Surgery on Sodium Excretion
Obesity Surgery, 2013Co-Authors: Funda Celik, Mohamed Ahdi, Eelco W. Meesters, Arnold Laar, Dees P. M. Brandjes, Victor E. A. GerdesAbstract:Background Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of Sodium Excretion has been described. The aim of this work was to study the influence of bariatric surgery on Sodium Excretion at more than a year after the intervention. Methods Patients who have undergone Roux-en-Y gastric bypass (RYGB) and who had collected a 24-h urine sample before surgery more than 12 months ago were asked to participate. A second 24-h urine sample was collected. Blood pressure and weight were measured. The difference in Sodium Excretion before and after surgery was calculated, and the relationship with blood pressure and weight loss was investigated. Results We included 33 patients; the median follow-up time was 21 months (range 14–41). Sodium Excretion was high before surgery (median 195 mmol/day, IQR range 167–247) and decreased by 18 % after surgery (median 160 mmol/day, IQR range 118–205, p = 0.015), while there were significant improvements in body weight (% EWL 80.9 ± 21.8), systolic blood pressure (126 to 120 mmHg, p = 0.02), and diastolic blood pressure (84 to 77 mmHg, p = 0.002), even with a reduced number of antihypertensive drugs. Conclusions After RYGB and considerable weight loss, Sodium Excretion remains high in the longer term. The profound improvement in blood pressure cannot be explained by reductions in Sodium Excretion after RYGB.
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The longer-term effects of Roux-en-Y gastric bypass surgery on Sodium Excretion.
Obesity surgery, 2012Co-Authors: Funda Celik, Mohamed Ahdi, Eelco W. Meesters, Dees P. M. Brandjes, Arnold W. J. M. Van De Laar, Victor E. A. GerdesAbstract:Background Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of Sodium Excretion has been described. The aim of this work was to study the influence of bariatric surgery on Sodium Excretion at more than a year after the intervention.
Kum Hyun Han - One of the best experts on this subject based on the ideXlab platform.
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association of Sodium Excretion with metabolic syndrome insulin resistance and body fat
Medicine, 2015Co-Authors: Kum Hyun Han, Sang Youb Han, Ho Seok Koo, Suhnggwon Kim, Ho Jun ChinAbstract:Sodium intake was reported to be related to metabolic syndrome (MS). Although a strong association between Sodium intake and blood pressure (BP) has been reported, the relationship between Sodium intake and other components of MS is unknown. An observational study of 18,146 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008–2011) was performed. Estimates of 24-h Sodium Excretion were made from a single fasting urine sample. A significant positive association was found between Sodium Excretion and systolic BP and between Sodium Excretion and diastolic BP in participants with and without hypertension after adjusting for multiple covariates (P < 0.001 for trend). The relationship between triglyceride or glucose levels and Sodium Excretion was linear (P < 0.005). In both men and women, a positive relationship between Sodium Excretion and waist circumference and an inverse relationship between Sodium Excretion and high-density lipoprotein were found (P ≤ 0.001). Body fat percentage, body fat mass, and insulin level were positively related to Sodium Excretion (P ≤ 0.001), and HOMA-IR was significantly associated with Sodium Excretion (P < 0.05). The risk of MS was elevated 1.279-fold in the second quartile of Sodium Excretion (95% CI, 1.088–1.504, P = 0.003), 1.479-fold in the third quartile (95% CI, 1.262–1.734; P < 0.001), and 1.929-fold in the highest quartile (95% CI 1.654–2.249, P < 0.001) compared with the lowest quartile. Sodium intake is significantly associated with all components of MS, body fat, and insulin resistance. Therefore, a high-salt diet is a significant risk factor for MS.
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Association of Sodium Excretion With Metabolic Syndrome, Insulin Resistance, and Body Fat
Medicine, 2015Co-Authors: Kum Hyun Han, Sang Youb Han, Ho Seok Koo, Suhnggwon Kim, Ho Jun ChinAbstract:Sodium intake was reported to be related to metabolic syndrome (MS). Although a strong association between Sodium intake and blood pressure (BP) has been reported, the relationship between Sodium intake and other components of MS is unknown. An observational study of 18,146 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008–2011) was performed. Estimates of 24-h Sodium Excretion were made from a single fasting urine sample. A significant positive association was found between Sodium Excretion and systolic BP and between Sodium Excretion and diastolic BP in participants with and without hypertension after adjusting for multiple covariates (P
