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Anders Alvestrand - One of the best experts on this subject based on the ideXlab platform.

  • Short-term treatment with ramipril normalizes renal haemodynamics and the natriuretic response to a Sodium Load in type 1 diabetic patients with early nephropathy.
    Acta diabetologica, 1997
    Co-Authors: Peter Stenvinkel, J Bolinder, Anders Alvestrand
    Abstract:

    The objective of the present study was to determine whether acute inhibition of angiotensin converting enzyme (ACE) normalizes intrarenal Sodium handling, renal haemodynamics and renal dopamine output in response to an i.v. NaCl infusion in type 1 diabetic patients with early nephropathy. Nine diabetic patients (aged 28±3 years) with elevated urinary albumin excretion (173±39 mg ⋅ min–1) were studied. The effects of a 2-hour NaCl infusion (12.5 ml ⋅ kg–1⋅ h–1) on para-amino hippuric acid (PAH), inulin, lithium and Sodium clearances as well as the urinary dopamine excretion were studied before and after 2 days of acute ACE inhibition. Fifteen healthy subjects (aged 34±1 years) served as controls. The results showed that 2 days of ACE inhibition improved the natriuretic response significantly (P

  • short term treatment with ramipril normalizes renal haemodynamics and the natriuretic response to a Sodium Load in type 1 diabetic patients with early nephropathy
    Acta Diabetologica, 1997
    Co-Authors: Peter Stenvinkel, J Bolinder, Anders Alvestrand
    Abstract:

    The objective of the present study was to determine whether acute inhibition of angiotensin converting enzyme (ACE) normalizes intrarenal Sodium handling, renal haemodynamics and renal dopamine output in response to an i.v. NaCl infusion in type 1 diabetic patients with early nephropathy. Nine diabetic patients (aged 28±3 years) with elevated urinary albumin excretion (173±39 mg ⋅ min–1) were studied. The effects of a 2-hour NaCl infusion (12.5 ml ⋅ kg–1⋅ h–1) on para-amino hippuric acid (PAH), inulin, lithium and Sodium clearances as well as the urinary dopamine excretion were studied before and after 2 days of acute ACE inhibition. Fifteen healthy subjects (aged 34±1 years) served as controls. The results showed that 2 days of ACE inhibition improved the natriuretic response significantly (P<0.05) within the first 2 h following an i.v. NaCl Load due to a normalization of the proximal tubular Sodium handling. In control subjects urinary dopamine output increased by 14% (P<0.01) following i.v. NaCl infusion, whereas a blunted increase was seen in the diabetic patients, which tended to normalize following inhibition of ACE. In conclusion, this study demonstrates that patients with type 1 diabetes and early nephropathy display abnormalities in renal haemodynamics, natriuresis and urinary dopamine mobilization in response to a Sodium Load, which can be reversed by short-term inhibition of ACE.

Peter Stenvinkel - One of the best experts on this subject based on the ideXlab platform.

  • Short-term treatment with ramipril normalizes renal haemodynamics and the natriuretic response to a Sodium Load in type 1 diabetic patients with early nephropathy.
    Acta diabetologica, 1997
    Co-Authors: Peter Stenvinkel, J Bolinder, Anders Alvestrand
    Abstract:

    The objective of the present study was to determine whether acute inhibition of angiotensin converting enzyme (ACE) normalizes intrarenal Sodium handling, renal haemodynamics and renal dopamine output in response to an i.v. NaCl infusion in type 1 diabetic patients with early nephropathy. Nine diabetic patients (aged 28±3 years) with elevated urinary albumin excretion (173±39 mg ⋅ min–1) were studied. The effects of a 2-hour NaCl infusion (12.5 ml ⋅ kg–1⋅ h–1) on para-amino hippuric acid (PAH), inulin, lithium and Sodium clearances as well as the urinary dopamine excretion were studied before and after 2 days of acute ACE inhibition. Fifteen healthy subjects (aged 34±1 years) served as controls. The results showed that 2 days of ACE inhibition improved the natriuretic response significantly (P

  • short term treatment with ramipril normalizes renal haemodynamics and the natriuretic response to a Sodium Load in type 1 diabetic patients with early nephropathy
    Acta Diabetologica, 1997
    Co-Authors: Peter Stenvinkel, J Bolinder, Anders Alvestrand
    Abstract:

    The objective of the present study was to determine whether acute inhibition of angiotensin converting enzyme (ACE) normalizes intrarenal Sodium handling, renal haemodynamics and renal dopamine output in response to an i.v. NaCl infusion in type 1 diabetic patients with early nephropathy. Nine diabetic patients (aged 28±3 years) with elevated urinary albumin excretion (173±39 mg ⋅ min–1) were studied. The effects of a 2-hour NaCl infusion (12.5 ml ⋅ kg–1⋅ h–1) on para-amino hippuric acid (PAH), inulin, lithium and Sodium clearances as well as the urinary dopamine excretion were studied before and after 2 days of acute ACE inhibition. Fifteen healthy subjects (aged 34±1 years) served as controls. The results showed that 2 days of ACE inhibition improved the natriuretic response significantly (P<0.05) within the first 2 h following an i.v. NaCl Load due to a normalization of the proximal tubular Sodium handling. In control subjects urinary dopamine output increased by 14% (P<0.01) following i.v. NaCl infusion, whereas a blunted increase was seen in the diabetic patients, which tended to normalize following inhibition of ACE. In conclusion, this study demonstrates that patients with type 1 diabetes and early nephropathy display abnormalities in renal haemodynamics, natriuresis and urinary dopamine mobilization in response to a Sodium Load, which can be reversed by short-term inhibition of ACE.

J Bolinder - One of the best experts on this subject based on the ideXlab platform.

  • Short-term treatment with ramipril normalizes renal haemodynamics and the natriuretic response to a Sodium Load in type 1 diabetic patients with early nephropathy.
    Acta diabetologica, 1997
    Co-Authors: Peter Stenvinkel, J Bolinder, Anders Alvestrand
    Abstract:

    The objective of the present study was to determine whether acute inhibition of angiotensin converting enzyme (ACE) normalizes intrarenal Sodium handling, renal haemodynamics and renal dopamine output in response to an i.v. NaCl infusion in type 1 diabetic patients with early nephropathy. Nine diabetic patients (aged 28±3 years) with elevated urinary albumin excretion (173±39 mg ⋅ min–1) were studied. The effects of a 2-hour NaCl infusion (12.5 ml ⋅ kg–1⋅ h–1) on para-amino hippuric acid (PAH), inulin, lithium and Sodium clearances as well as the urinary dopamine excretion were studied before and after 2 days of acute ACE inhibition. Fifteen healthy subjects (aged 34±1 years) served as controls. The results showed that 2 days of ACE inhibition improved the natriuretic response significantly (P

  • short term treatment with ramipril normalizes renal haemodynamics and the natriuretic response to a Sodium Load in type 1 diabetic patients with early nephropathy
    Acta Diabetologica, 1997
    Co-Authors: Peter Stenvinkel, J Bolinder, Anders Alvestrand
    Abstract:

    The objective of the present study was to determine whether acute inhibition of angiotensin converting enzyme (ACE) normalizes intrarenal Sodium handling, renal haemodynamics and renal dopamine output in response to an i.v. NaCl infusion in type 1 diabetic patients with early nephropathy. Nine diabetic patients (aged 28±3 years) with elevated urinary albumin excretion (173±39 mg ⋅ min–1) were studied. The effects of a 2-hour NaCl infusion (12.5 ml ⋅ kg–1⋅ h–1) on para-amino hippuric acid (PAH), inulin, lithium and Sodium clearances as well as the urinary dopamine excretion were studied before and after 2 days of acute ACE inhibition. Fifteen healthy subjects (aged 34±1 years) served as controls. The results showed that 2 days of ACE inhibition improved the natriuretic response significantly (P<0.05) within the first 2 h following an i.v. NaCl Load due to a normalization of the proximal tubular Sodium handling. In control subjects urinary dopamine output increased by 14% (P<0.01) following i.v. NaCl infusion, whereas a blunted increase was seen in the diabetic patients, which tended to normalize following inhibition of ACE. In conclusion, this study demonstrates that patients with type 1 diabetes and early nephropathy display abnormalities in renal haemodynamics, natriuresis and urinary dopamine mobilization in response to a Sodium Load, which can be reversed by short-term inhibition of ACE.

Frej Fyhrquist - One of the best experts on this subject based on the ideXlab platform.

  • Sodium Load increases renal angiotensin type 1 receptors and decreases bradykinin type 2 receptors
    Hypertension Research, 2003
    Co-Authors: Pia Stewen, Eero Mervaala, Heikki Karppanen, Tuulikki Nyman, Outi Saijonmaa, Ilkka Tikkanen, Frej Fyhrquist
    Abstract:

    The regulation of both angiotensin receptors and bradykinin receptors during Sodium intake is poorly understood. We hypothesized that an altered balance between renal angiotensin type 1 (AT1) receptors and bradykinin type 2 (B2) receptors might contribute to an increase in blood pressure during periods of high-Sodium intake. We studied the effects of high-Sodium intake on renal AT1 receptors and B2 receptors in 5-6-week-old spontaneously hypertensive rats (SHR) receiving high-Sodium chloride (6% NaCl) or mineral salts (10.5%, composition: 57% NaCl, 28% KCl, 12% MgSO4) compared to those receiving a low-Sodium (NaCl 0.125%) diet for 10 weeks. Mineral salt intake was included due to its beneficial effects on blood pressure and cardiac hypertrophy. Receptor densities were measured by quantitative autoradiography. AT1 receptors were quantified using incubation with 125I-Sar1-Ile8-angiotensin II and displacement was measured with PD123319 (10μmol/l), whereas B2 receptors were quantified using 125I-HPP-icatibant and displacement was measured with icatibant (3μmol/l). Compared to the SHR controls, a further increase in blood pressure occurred after 2 weeks in the 6% NaCl group and after 6 weeks in the mineral salt group. AT1 receptor density increased in the renal cortex by 41% (p <0.01) in the 6% NaCl group and by 26% (p <0.05) in the mineral salt group. B2 receptor density decreased in the renal medulla by 26% (p <0.01) in the 6% NaCl group, and decreased even more i.e., by 45% (p <0.001), in the mineral salt group. It was shown that a 6% NaCl or a 10.5% mineral salt Loading was capable of increasing renal AT1 receptor density and decreasing renal B2 receptor density. An altered balance between these receptors might be associated with hypertension under conditions of Sodium Loading. (Hypertens Res 2003; 26: 583-589)

  • Sodium Load Increases Renal Angiotensin Type 1 Receptors and Decreases Bradykinin Type 2 Receptors
    Hypertension research : official journal of the Japanese Society of Hypertension, 2003
    Co-Authors: Pia Stewen, Eero Mervaala, Heikki Karppanen, Tuulikki Nyman, Outi Saijonmaa, Ilkka Tikkanen, Frej Fyhrquist
    Abstract:

    The regulation of both angiotensin receptors and bradykinin receptors during Sodium intake is poorly understood. We hypothesized that an altered balance between renal angiotensin type 1 (AT1) receptors and bradykinin type 2 (B2) receptors might contribute to an increase in blood pressure during periods of high-Sodium intake. We studied the effects of high-Sodium intake on renal AT1 receptors and B2 receptors in 5-6-week-old spontaneously hypertensive rats (SHR) receiving high-Sodium chloride (6% NaCl) or mineral salts (10.5%, composition: 57% NaCl, 28% KCl, 12% MgSO4) compared to those receiving a low-Sodium (NaCl 0.125%) diet for 10 weeks. Mineral salt intake was included due to its beneficial effects on blood pressure and cardiac hypertrophy. Receptor densities were measured by quantitative autoradiography. AT1 receptors were quantified using incubation with 125I-Sar1-Ile8-angiotensin II and displacement was measured with PD123319 (10μmol/l), whereas B2 receptors were quantified using 125I-HPP-icatibant and displacement was measured with icatibant (3μmol/l). Compared to the SHR controls, a further increase in blood pressure occurred after 2 weeks in the 6% NaCl group and after 6 weeks in the mineral salt group. AT1 receptor density increased in the renal cortex by 41% (p

Michael E Stillabower - One of the best experts on this subject based on the ideXlab platform.