The Experts below are selected from a list of 2982 Experts worldwide ranked by ideXlab platform
Zhaoguo Zhang - One of the best experts on this subject based on the ideXlab platform.
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Sodium Sulfite involved photocatalytic radical cascade cyclization of 2 isocyanoaryl thioethers access to 2 cf2 cf3 containing benzothiazoles
Organic Letters, 2019Co-Authors: Yao Yuan, Wuheng Dong, Zhaoguo ZhangAbstract:A visible-light-induced radical cascade cyclization of 2-isocyanoaryl thioethers for the synthesis of 2-CF2/CF3-containing benzothiazoles has been developed. Sodium Sulfite can participate in the photocatalytic cycle as a reductant that efficiently transforms Ir4+ into Ir3+ to promote the fluoroalkylation under mild reaction conditions.
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Sodium Sulfite-Involved Photocatalytic Radical Cascade Cyclization of 2‑Isocyanoaryl Thioethers: Access to 2‑CF2/CF3‑Containing Benzothiazoles
2018Co-Authors: Yao Yuan, Wuheng Dong, Xiaoshuang Gao, Xiaomin Xie, Zhaoguo ZhangAbstract:A visible-light-induced radical cascade cyclization of 2-isocyanoaryl thioethers for the synthesis of 2-CF2/CF3-containing benzothiazoles has been developed. Sodium Sulfite can participate in the photocatalytic cycle as a reductant that efficiently transforms Ir4+ into Ir3+ to promote the fluoroalkylation under mild reaction conditions
Xiaoming Zhao - One of the best experts on this subject based on the ideXlab platform.
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synthesis of allylic sulfonic acids via regioselective pd catalyzed allylic substitutions of na2so3
Tetrahedron Letters, 2015Co-Authors: Xiaoming ZhaoAbstract:Abstract Palladium-catalyzed allylic sulfonations of the linear allylic carbonates with Sodium Sulfite (Na 2 SO 3 ) were accomplished under mild conditions. This method gave allylic sulfonic acids in good to excellent yields with high level of regioselectivities.
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enantioselective transformation of na2so3 into allylic sulfonic acids under pd catalysis
Chemical Communications, 2015Co-Authors: Xiaoming Zhao, Hongbo Zhang, Liang ZhangAbstract:Pd-catalyzed asymmetric allylic sulfonation of di-aryl-substituted allylic acetates with Sodium Sulfite (Na2SO3) in THF–H2O at room temperature was described. This method directly provided allylic sulfonic acids in up to excellent yield and enantioselectivity.
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asymmetric synthesis of allylic sulfonic acids enantio and regioselective iridium catalyzed allylations of na2so3
Chemistry: A European Journal, 2014Co-Authors: Xiaoming Zhao, Hongbo Zhang, Liang Zhang, Mingzhu ZhaoAbstract:An enantioselective allylation reaction of allylic carbonates with Sodium Sulfite (Na2SO3) catalyzed by Ir complex was accomplished, providing allylic sulfonic acids in good to excellent yields with a high level of enantio- and regioselectivities. (R)-2-Phenyl-2-sulfoacetic acid, a key intermediate for the synthesis of Cefsulodin and Sulbenicillin, was synthesized as well.
Stefan Schneeberger - One of the best experts on this subject based on the ideXlab platform.
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Sodium Sulfite exacerbates allograft vasculopathy and affects tryptophan breakdown in murine heterotopic aortic transplantation
Oxidative Medicine and Cellular Longevity, 2019Co-Authors: Robert Sucher, Theresa Hautz, Elisabeth Mohr, Maximilian Mackowitz, Vanessa Mellitzer, Christina Maria Steger, Benno Cardini, Thomas Resch, Christian Margreiter, Stefan SchneebergerAbstract:Graft vasculopathy is the main feature of chronic rejection in organ transplantation, with oxidative stress being a major trigger. Inflammation-associated prooxidant processes may be controlled by antioxidants; however, interference with redox-regulated mechanisms is a complex endeavor. An essential feature of the cellular immune response is the acceleration of tryptophan (Trp) breakdown, leading to the formation of several bioactive catabolites. Long-term activation of this immunobiochemical pathway contributes to the establishment of a tolerogenic environment, thereby supporting allograft survival. Herein, the impact of the antioxidant Sodium Sulfite on the development of graft vasculopathy was assessed in murine aortic transplantation. Allogeneic (BALB/c to C57BL/6) heterotopic murine aortic transplantations were performed. Animals were left untreated or were treated with 10 μl of 0.1 M, of 0.01 M Sodium Sulfite, or of 0.1 M Sodium sulfate, intraperitoneally once/day, until postoperative day (POD) 100. Grafts were assessed by histology, immunohistochemistry, and adhesion molecule gene expression. Serum concentrations of tryptophan and its catabolite kynurenine (Kyn) were measured. On day 100, graft vasculopathy was significantly increased upon treatment with 0.1 M Sodium Sulfite, compared to allogeneic untreated controls (p = 0.004), which correlated with a significant increase of α-smooth-muscle-actin, Vcam-1, and P-selectin. Serum Kyn concentrations increased in the allogeneic control group over time (p < 0.05, POD ≥ 50), while low-dose Sodium Sulfite treatment (0.01 M) treatment resulted in a decrease in Kyn levels over time (p < 0.05, POD ≥ 10), compared to the respective baselines (p < 0.05). Longitudinal analysis of serum metabolite concentrations in the different treatment groups further identified an overall effect of Sodium Sulfite on Kyn concentrations. Antioxidative treatment may result in ambivalent consequences. Our data reveal that an excess of antioxidants like Sodium Sulfite can aggravate allograft vasculopathy, which further highlights the challenges associated with interventions that interfere with the complex interplay of redox-regulated inflammatory processes.
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Sodium Sulfite Exacerbates Allograft Vasculopathy and Affects Tryptophan Breakdown in Murine Heterotopic Aortic Transplantation
Hindawi Limited, 2019Co-Authors: Robert Sucher, Theresa Hautz, Elisabeth Mohr, Maximilian Mackowitz, Vanessa Mellitzer, Benno Cardini, Thomas Resch, Christian Margreiter, Christina Steger, Stefan SchneebergerAbstract:Graft vasculopathy is the main feature of chronic rejection in organ transplantation, with oxidative stress being a major trigger. Inflammation-associated prooxidant processes may be controlled by antioxidants; however, interference with redox-regulated mechanisms is a complex endeavor. An essential feature of the cellular immune response is the acceleration of tryptophan (Trp) breakdown, leading to the formation of several bioactive catabolites. Long-term activation of this immunobiochemical pathway contributes to the establishment of a tolerogenic environment, thereby supporting allograft survival. Herein, the impact of the antioxidant Sodium Sulfite on the development of graft vasculopathy was assessed in murine aortic transplantation. Allogeneic (BALB/c to C57BL/6) heterotopic murine aortic transplantations were performed. Animals were left untreated or were treated with 10 μl of 0.1 M, of 0.01 M Sodium Sulfite, or of 0.1 M Sodium sulfate, intraperitoneally once/day, until postoperative day (POD) 100. Grafts were assessed by histology, immunohistochemistry, and adhesion molecule gene expression. Serum concentrations of tryptophan and its catabolite kynurenine (Kyn) were measured. On day 100, graft vasculopathy was significantly increased upon treatment with 0.1 M Sodium Sulfite, compared to allogeneic untreated controls (p=0.004), which correlated with a significant increase of α-smooth-muscle-actin, Vcam-1, and P-selectin. Serum Kyn concentrations increased in the allogeneic control group over time (p
Yao Yuan - One of the best experts on this subject based on the ideXlab platform.
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Sodium Sulfite involved photocatalytic radical cascade cyclization of 2 isocyanoaryl thioethers access to 2 cf2 cf3 containing benzothiazoles
Organic Letters, 2019Co-Authors: Yao Yuan, Wuheng Dong, Zhaoguo ZhangAbstract:A visible-light-induced radical cascade cyclization of 2-isocyanoaryl thioethers for the synthesis of 2-CF2/CF3-containing benzothiazoles has been developed. Sodium Sulfite can participate in the photocatalytic cycle as a reductant that efficiently transforms Ir4+ into Ir3+ to promote the fluoroalkylation under mild reaction conditions.
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Sodium Sulfite-Involved Photocatalytic Radical Cascade Cyclization of 2‑Isocyanoaryl Thioethers: Access to 2‑CF2/CF3‑Containing Benzothiazoles
2018Co-Authors: Yao Yuan, Wuheng Dong, Xiaoshuang Gao, Xiaomin Xie, Zhaoguo ZhangAbstract:A visible-light-induced radical cascade cyclization of 2-isocyanoaryl thioethers for the synthesis of 2-CF2/CF3-containing benzothiazoles has been developed. Sodium Sulfite can participate in the photocatalytic cycle as a reductant that efficiently transforms Ir4+ into Ir3+ to promote the fluoroalkylation under mild reaction conditions
Liang Zhang - One of the best experts on this subject based on the ideXlab platform.
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enantioselective transformation of na2so3 into allylic sulfonic acids under pd catalysis
Chemical Communications, 2015Co-Authors: Xiaoming Zhao, Hongbo Zhang, Liang ZhangAbstract:Pd-catalyzed asymmetric allylic sulfonation of di-aryl-substituted allylic acetates with Sodium Sulfite (Na2SO3) in THF–H2O at room temperature was described. This method directly provided allylic sulfonic acids in up to excellent yield and enantioselectivity.
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asymmetric synthesis of allylic sulfonic acids enantio and regioselective iridium catalyzed allylations of na2so3
Chemistry: A European Journal, 2014Co-Authors: Xiaoming Zhao, Hongbo Zhang, Liang Zhang, Mingzhu ZhaoAbstract:An enantioselective allylation reaction of allylic carbonates with Sodium Sulfite (Na2SO3) catalyzed by Ir complex was accomplished, providing allylic sulfonic acids in good to excellent yields with a high level of enantio- and regioselectivities. (R)-2-Phenyl-2-sulfoacetic acid, a key intermediate for the synthesis of Cefsulodin and Sulbenicillin, was synthesized as well.