The Experts below are selected from a list of 31230 Experts worldwide ranked by ideXlab platform

V R Allegro - One of the best experts on this subject based on the ideXlab platform.

  • resistance of class c fly ash belite cement to simulated Sodium Sulphate radioactive liquid waste attack
    Journal of Hazardous Materials, 2009
    Co-Authors: A Guerrero, S Goni, V R Allegro
    Abstract:

    The resistance of class C fly ash belite cement (FABC-2-W) to concentrated Sodium Sulphate salts associated with low level wastes (LLW) and medium level wastes (MLW) is discussed. This study was carried out according to the Koch and Steinegger methodology by testing the flexural strength of mortars immersed in simulated radioactive liquid waste rich in Sulphate (48 000 ppm) and demineralised water (used as a reference), at 20 °C and 40 °C over a period of 180 days. The reaction mechanisms of Sulphate ion with the mortar was carried out through a microstructure study, which included the use of Scanning electron microscopy (SEM), porosity and pore-size distribution and X-ray diffraction (XRD). The results showed that the FABC mortar was stable against simulated Sulphate radioactive liquid waste (SSRLW) attack at the two chosen temperatures. The enhancement of mechanical properties was a result of the formation of non-expansive ettringite inside the pores and an alkaline activation of the hydraulic activity of cement promoted by the ingress of Sulphate. Accordingly, the microstructure was strongly refined.

  • resistance of class c fly ash belite cement to simulated Sodium Sulphate radioactive liquid waste attack
    Journal of Hazardous Materials, 2009
    Co-Authors: A Guerrero, S Goni, V R Allegro
    Abstract:

    The resistance of class C fly ash belite cement (FABC-2-W) to concentrated Sodium Sulphate salts associated with low level wastes (LLW) and medium level wastes (MLW) is discussed. This study was carried out according to the Koch and Steinegger methodology by testing the flexural strength of mortars immersed in simulated radioactive liquid waste rich in Sulphate (48,000 ppm) and demineralised water (used as a reference), at 20 degrees C and 40 degrees C over a period of 180 days. The reaction mechanisms of Sulphate ion with the mortar was carried out through a microstructure study, which included the use of Scanning electron microscopy (SEM), porosity and pore-size distribution and X-ray diffraction (XRD). The results showed that the FABC mortar was stable against simulated Sulphate radioactive liquid waste (SSRLW) attack at the two chosen temperatures. The enhancement of mechanical properties was a result of the formation of non-expansive ettringite inside the pores and an alkaline activation of the hydraulic activity of cement promoted by the ingress of Sulphate. Accordingly, the microstructure was strongly refined.

A Guerrero - One of the best experts on this subject based on the ideXlab platform.

  • resistance of class c fly ash belite cement to simulated Sodium Sulphate radioactive liquid waste attack
    Journal of Hazardous Materials, 2009
    Co-Authors: A Guerrero, S Goni, V R Allegro
    Abstract:

    The resistance of class C fly ash belite cement (FABC-2-W) to concentrated Sodium Sulphate salts associated with low level wastes (LLW) and medium level wastes (MLW) is discussed. This study was carried out according to the Koch and Steinegger methodology by testing the flexural strength of mortars immersed in simulated radioactive liquid waste rich in Sulphate (48 000 ppm) and demineralised water (used as a reference), at 20 °C and 40 °C over a period of 180 days. The reaction mechanisms of Sulphate ion with the mortar was carried out through a microstructure study, which included the use of Scanning electron microscopy (SEM), porosity and pore-size distribution and X-ray diffraction (XRD). The results showed that the FABC mortar was stable against simulated Sulphate radioactive liquid waste (SSRLW) attack at the two chosen temperatures. The enhancement of mechanical properties was a result of the formation of non-expansive ettringite inside the pores and an alkaline activation of the hydraulic activity of cement promoted by the ingress of Sulphate. Accordingly, the microstructure was strongly refined.

  • resistance of class c fly ash belite cement to simulated Sodium Sulphate radioactive liquid waste attack
    Journal of Hazardous Materials, 2009
    Co-Authors: A Guerrero, S Goni, V R Allegro
    Abstract:

    The resistance of class C fly ash belite cement (FABC-2-W) to concentrated Sodium Sulphate salts associated with low level wastes (LLW) and medium level wastes (MLW) is discussed. This study was carried out according to the Koch and Steinegger methodology by testing the flexural strength of mortars immersed in simulated radioactive liquid waste rich in Sulphate (48,000 ppm) and demineralised water (used as a reference), at 20 degrees C and 40 degrees C over a period of 180 days. The reaction mechanisms of Sulphate ion with the mortar was carried out through a microstructure study, which included the use of Scanning electron microscopy (SEM), porosity and pore-size distribution and X-ray diffraction (XRD). The results showed that the FABC mortar was stable against simulated Sulphate radioactive liquid waste (SSRLW) attack at the two chosen temperatures. The enhancement of mechanical properties was a result of the formation of non-expansive ettringite inside the pores and an alkaline activation of the hydraulic activity of cement promoted by the ingress of Sulphate. Accordingly, the microstructure was strongly refined.

Karen Madsen - One of the best experts on this subject based on the ideXlab platform.

  • cis-Urocanic Acid Attenuates Acute Dextran Sodium Sulphate-Induced Intestinal Inflammation
    2013
    Co-Authors: Eric Albert, John Walker, Aducio Thiesen, Thomas Churchill, Karen Madsen
    Abstract:

    On exposure to sunlight, urocanic acid (UCA) in the skin is converted from trans to the cis form and distributed systemically where it confers systemic immunosuppression. The aim of this study was to determine if administration of cis-UCA would be effective in attenuating colitis and the possible role of IL-10. Colitis was induced in 129/SvEv mice by administering 5% dextran Sodium sulfate (DSS) for 7 days in drinking water. During this period mice received daily subcutaneously injections of cis-UCA or vehicle. To examine a role for IL-10, 129/SvEv IL-10 2/2 mice were injected for 24 days with cis-UCA or vehicle. Clinical disease was assessed by measurement of body weight, stool consistency, and presence of blood. At sacrifice, colonic tissue was collected for histology and measurement of myeloperoxidase and cytokines. Splenocytes were analyzed for CD4+CD25+FoxP3+ T-regulatory cells via flow cytometry. Murine bone-marrow derived antigen-presenting cells were treated with lipopolysaccharide (LPS) 6 UCA and cytokine secretion measured. Our results demonstrated that cis-UCA at a dose of 50 mg was effective in ameliorating DSS-induced colitis as evidenced by reduced weight loss and attenuated changes in colon weight/length. This protection was associated with reduced colonic expression of CXCL1, an increased expression of IL-17A and a significant preservation of splenic CD4+CD25+FoxP3+ T-regulatory cells. cis-UCA decreased LPS induced CXCL1, but not TNFa secretion, from antigen-presenting cells in vitro. UCA reduced colonic levels of IFNc in IL-10 2/2 mice but did not attenuate colitis. In conclusion, this study demonstrates that cis-urocanic acid is effective i

  • cis urocanic acid attenuates acute dextran Sodium Sulphate induced intestinal inflammation
    PLOS ONE, 2010
    Co-Authors: Eric J Albert, John Walker, Aducio Thiesen, Thomas A Churchill, Karen Madsen
    Abstract:

    On exposure to sunlight, urocanic acid (UCA) in the skin is converted from trans to the cis form and distributed systemically where it confers systemic immunosuppression. The aim of this study was to determine if administration of cis-UCA would be effective in attenuating colitis and the possible role of IL-10. Colitis was induced in 129/SvEv mice by administering 5% dextran Sodium sulfate (DSS) for 7 days in drinking water. During this period mice received daily subcutaneously injections of cis-UCA or vehicle. To examine a role for IL-10, 129/SvEv IL-10−/− mice were injected for 24 days with cis-UCA or vehicle. Clinical disease was assessed by measurement of body weight, stool consistency, and presence of blood. At sacrifice, colonic tissue was collected for histology and measurement of myeloperoxidase and cytokines. Splenocytes were analyzed for CD4+CD25+FoxP3+ T-regulatory cells via flow cytometry. Murine bone-marrow derived antigen-presenting cells were treated with lipopolysaccharide (LPS) ± UCA and cytokine secretion measured. Our results demonstrated that cis-UCA at a dose of 50 µg was effective in ameliorating DSS-induced colitis as evidenced by reduced weight loss and attenuated changes in colon weight/length. This protection was associated with reduced colonic expression of CXCL1, an increased expression of IL-17A and a significant preservation of splenic CD4+CD25+FoxP3+ T-regulatory cells. cis-UCA decreased LPS induced CXCL1, but not TNFα secretion, from antigen-presenting cells in vitro. UCA reduced colonic levels of IFNγ in IL-10−/− mice but did not attenuate colitis. In conclusion, this study demonstrates that cis-urocanic acid is effective in reducing the severity of colitis in a chemically-induced mouse model, indicating that pathways induced by ultraviolet radiation to the skin can influence distal sites of inflammation. This provides further evidence for a possible role for sunlight exposure in modulating inflammatory disorders.

S Goni - One of the best experts on this subject based on the ideXlab platform.

  • resistance of class c fly ash belite cement to simulated Sodium Sulphate radioactive liquid waste attack
    Journal of Hazardous Materials, 2009
    Co-Authors: A Guerrero, S Goni, V R Allegro
    Abstract:

    The resistance of class C fly ash belite cement (FABC-2-W) to concentrated Sodium Sulphate salts associated with low level wastes (LLW) and medium level wastes (MLW) is discussed. This study was carried out according to the Koch and Steinegger methodology by testing the flexural strength of mortars immersed in simulated radioactive liquid waste rich in Sulphate (48 000 ppm) and demineralised water (used as a reference), at 20 °C and 40 °C over a period of 180 days. The reaction mechanisms of Sulphate ion with the mortar was carried out through a microstructure study, which included the use of Scanning electron microscopy (SEM), porosity and pore-size distribution and X-ray diffraction (XRD). The results showed that the FABC mortar was stable against simulated Sulphate radioactive liquid waste (SSRLW) attack at the two chosen temperatures. The enhancement of mechanical properties was a result of the formation of non-expansive ettringite inside the pores and an alkaline activation of the hydraulic activity of cement promoted by the ingress of Sulphate. Accordingly, the microstructure was strongly refined.

  • resistance of class c fly ash belite cement to simulated Sodium Sulphate radioactive liquid waste attack
    Journal of Hazardous Materials, 2009
    Co-Authors: A Guerrero, S Goni, V R Allegro
    Abstract:

    The resistance of class C fly ash belite cement (FABC-2-W) to concentrated Sodium Sulphate salts associated with low level wastes (LLW) and medium level wastes (MLW) is discussed. This study was carried out according to the Koch and Steinegger methodology by testing the flexural strength of mortars immersed in simulated radioactive liquid waste rich in Sulphate (48,000 ppm) and demineralised water (used as a reference), at 20 degrees C and 40 degrees C over a period of 180 days. The reaction mechanisms of Sulphate ion with the mortar was carried out through a microstructure study, which included the use of Scanning electron microscopy (SEM), porosity and pore-size distribution and X-ray diffraction (XRD). The results showed that the FABC mortar was stable against simulated Sulphate radioactive liquid waste (SSRLW) attack at the two chosen temperatures. The enhancement of mechanical properties was a result of the formation of non-expansive ettringite inside the pores and an alkaline activation of the hydraulic activity of cement promoted by the ingress of Sulphate. Accordingly, the microstructure was strongly refined.

Eric J Albert - One of the best experts on this subject based on the ideXlab platform.

  • cis urocanic acid attenuates acute dextran Sodium Sulphate induced intestinal inflammation
    PLOS ONE, 2010
    Co-Authors: Eric J Albert, John Walker, Aducio Thiesen, Thomas A Churchill, Karen Madsen
    Abstract:

    On exposure to sunlight, urocanic acid (UCA) in the skin is converted from trans to the cis form and distributed systemically where it confers systemic immunosuppression. The aim of this study was to determine if administration of cis-UCA would be effective in attenuating colitis and the possible role of IL-10. Colitis was induced in 129/SvEv mice by administering 5% dextran Sodium sulfate (DSS) for 7 days in drinking water. During this period mice received daily subcutaneously injections of cis-UCA or vehicle. To examine a role for IL-10, 129/SvEv IL-10−/− mice were injected for 24 days with cis-UCA or vehicle. Clinical disease was assessed by measurement of body weight, stool consistency, and presence of blood. At sacrifice, colonic tissue was collected for histology and measurement of myeloperoxidase and cytokines. Splenocytes were analyzed for CD4+CD25+FoxP3+ T-regulatory cells via flow cytometry. Murine bone-marrow derived antigen-presenting cells were treated with lipopolysaccharide (LPS) ± UCA and cytokine secretion measured. Our results demonstrated that cis-UCA at a dose of 50 µg was effective in ameliorating DSS-induced colitis as evidenced by reduced weight loss and attenuated changes in colon weight/length. This protection was associated with reduced colonic expression of CXCL1, an increased expression of IL-17A and a significant preservation of splenic CD4+CD25+FoxP3+ T-regulatory cells. cis-UCA decreased LPS induced CXCL1, but not TNFα secretion, from antigen-presenting cells in vitro. UCA reduced colonic levels of IFNγ in IL-10−/− mice but did not attenuate colitis. In conclusion, this study demonstrates that cis-urocanic acid is effective in reducing the severity of colitis in a chemically-induced mouse model, indicating that pathways induced by ultraviolet radiation to the skin can influence distal sites of inflammation. This provides further evidence for a possible role for sunlight exposure in modulating inflammatory disorders.