The Experts below are selected from a list of 2328 Experts worldwide ranked by ideXlab platform
Howard I. Maibach - One of the best experts on this subject based on the ideXlab platform.
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Topical cis-Urocanic Acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice
Acta Dermato-venereologica, 1995Co-Authors: A. I. Lauerma, Aioi A, Howard I. MaibachAbstract:Cis-Urocanic Acid, converted from trans-Urocanic Acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-Urocanic Acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-Urocanic Acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-Urocanic Acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-Urocanic Acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-Urocanic Acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwile to investigate.
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topical cis Urocanic Acid suppresses both induction and elicitation of contact hypersensitivity in balb c mice
Acta Dermato-venereologica, 1995Co-Authors: A. I. Lauerma, A Aioi, Howard I. MaibachAbstract:Cis-Urocanic Acid, converted from trans-Urocanic Acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-Urocanic Acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-Urocanic Acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-Urocanic Acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-Urocanic Acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-Urocanic Acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate.
A. I. Lauerma - One of the best experts on this subject based on the ideXlab platform.
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Topical cis-Urocanic Acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice
Acta Dermato-venereologica, 1995Co-Authors: A. I. Lauerma, Aioi A, Howard I. MaibachAbstract:Cis-Urocanic Acid, converted from trans-Urocanic Acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-Urocanic Acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-Urocanic Acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-Urocanic Acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-Urocanic Acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-Urocanic Acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwile to investigate.
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topical cis Urocanic Acid suppresses both induction and elicitation of contact hypersensitivity in balb c mice
Acta Dermato-venereologica, 1995Co-Authors: A. I. Lauerma, A Aioi, Howard I. MaibachAbstract:Cis-Urocanic Acid, converted from trans-Urocanic Acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-Urocanic Acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-Urocanic Acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-Urocanic Acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-Urocanic Acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-Urocanic Acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate.
John D. Simon - One of the best experts on this subject based on the ideXlab platform.
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The Origin of the Wavelength‐Dependent Photoreactivity of Trans‐Urocanic Acid
Photochemistry and Photobiology, 1998Co-Authors: Kerry M. Hanson, John D. SimonAbstract:Two-color, pulsed-laser photoacoustic calorimetry is used to distinguish between multiple rotamer or electronic state contributions to the absorption spectrum of the epidermal chromophore trans-Urocanic Acid. The data definitively show that the wavelength-dependent photochemistry of trans-Urocanic Acid results from the presence of two distinct, weakly coupled electronic states absorbing between 264 nm and 310 nm.
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Research Note The Origin of the Wavelength-Dependent Photoreactivity of Trans-Urocanic Acid
1998Co-Authors: Kerry M. Hanson, John D. SimonAbstract:Two-color, pulsed-laser photoacoustic calorimetry is used to distinguish between multiple rotarner or electronic state contributions to the absorption spectrum of the epidermal chromophore trans-Urocanic Acid. The data definitively show that the wavelength-dependent photochemistry of trans-Urocanic Acid results from the presence of two distinct, weakly coupled electronic states absorbing between 264 nm and 310 nm.
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The origin of the wavelength-dependent photoreactivity of trans-Urocanic Acid.
Photochemistry and Photobiology, 1998Co-Authors: Kerry M. Hanson, John D. SimonAbstract:Two-color, pulsed-laser photoacoustic calorimetry is used to distinguish between multiple rotamer or electronic state contributions to the absorption spectrum of the epidermal chromophore trans-Urocanic Acid. The data definitively show that the wavelength-dependent photochemistry of trans-Urocanic Acid results from the presence of two distinct, weakly coupled electronic states absorbing between 264 nm and 310 nm.
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Primary Processes of the Electronic Excited States of trans-Urocanic Acid
The Journal of Physical Chemistry A, 1997Co-Authors: Kerry M. Hanson, John D. SimonAbstract:The primary photoreactivity of the excited states of trans-Urocanic Acid (t-UA) is investigated by ultrafast transient-absorption spectroscopy. Fundamentally different photophysics were observed wh...
J.d. Simon - One of the best experts on this subject based on the ideXlab platform.
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Epidermal trans-Urocanic Acid and the UV-A-induced photoaging of the skin.
Proceedings of the National Academy of Sciences of the United States of America, 1998Co-Authors: K M Hanson, J.d. SimonAbstract:The premature photoaging of the skin is mediated by the sensitization of reactive oxygen species after absorption of ultraviolet radiation by endogenous chromophores. Yet identification of UV-A-absorbing chromophores in the skin that quantitatively account for the action spectra of the physiological responses of photoaging has remained elusive. This paper reports that the in vitro action spectrum for singlet oxygen generation after excitation of trans-Urocanic Acid mimics the in vivo UV-A action spectrum for the photosagging of mouse skin. The data presented provide evidence suggesting that the UV-A excitation of trans-Urocanic Acid initiates chemical processes that result in the photoaging of skin.
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Photochemistry of Urocanic Acid : Evidence that Urocanic Acid should be used with caution in cosmetic formulations
Journal of the society of cosmetic chemists, 1997Co-Authors: K M Hanson, J.d. SimonAbstract:Data from a previously reported spectroscopic investigation of Urocanic Acid are summarized. The data support the conclusion that Urocanic Acid should be used with caution as an ingredient in sunscreen and conditioning cosmetic formulations because reactive intermediates can be produced following absorption of the sun's lower UV-B wavelengths.
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A Femtosecond Absorption Study of Urocanic Acid
Springer Series in Chemical Physics, 1996Co-Authors: Bulang Li, K M Hanson, J.d. SimonAbstract:The excited state dynamics of trans-Urocanic Acid in vitro were studied with femtosecond and picosecond transient absorption spectroscopy.
A Aioi - One of the best experts on this subject based on the ideXlab platform.
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topical cis Urocanic Acid suppresses both induction and elicitation of contact hypersensitivity in balb c mice
Acta Dermato-venereologica, 1995Co-Authors: A. I. Lauerma, A Aioi, Howard I. MaibachAbstract:Cis-Urocanic Acid, converted from trans-Urocanic Acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-Urocanic Acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-Urocanic Acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-Urocanic Acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-Urocanic Acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-Urocanic Acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate.
