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Sung Ho Ghil - One of the best experts on this subject based on the ideXlab platform.
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prevention of postsurgical tissue adhesion by anti inflammatory drug loaded pluronic mixtures with sol gel Transition behavior
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Se Heang Oh, Kyu Sang Song, Sung Ho GhilAbstract:Sol–gel Transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The sol–gel Transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body. Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. The gelation temperatures of the Pluronic mixtures were not affected by the alginate but lowered by the addition of ibuprofen. The in vitro drug release behavior and in vivo peritoneal tissue adhesion of the Pluronic mixtures with the sol–gel Transition just below body temperatures were investigated. The drug release behavior from the ibuprofen (1 wt%)-loaded Pluronic mixture gels at 37°C was examined using a membrane-less dissolution model. The drug in the mixture gels was released continuously up to about 45–65% of the total loading amount during the first 7 days. For in vivo evaluation of tissue anti-adhesion potential, the Pluronic mixtures with/without drug were coated on the peritoneal wall defects of rats and their tissue adhesion extents and tissue reactions (inflammatory response, granulation tissue formation, and toxicity in organs) were compared. It was observed that ibuprofen has a positive effect for the peritoneal tissue anti-adhesion. The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res 72A: 306–316, 2005
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prevention of postsurgical tissue adhesion by anti inflammatory drug loaded pluronic mixtures with sol gel Transition behavior
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Jin Kyeong Kim, Kyu Sang Song, Sung Ho Ghil, Seung Moo Noh, Soon Hong Yuk, Jin Ho LeeAbstract:Sol-Gel Transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The Sol-Gel Transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body. Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. The gelation temperatures of the Pluronic mixtures were not affected by the alginate but lowered by the addition of ibuprofen. The in vitro drug release behavior and in vivo peritoneal tissue adhesion of the Pluronic mixtures with the Sol-Gel Transition just below body temperatures were investigated. The drug release behavior from the ibuprofen (1 wt%)-loaded Pluronic mixture gels at 37 degrees C was examined using a membrane-less dissolution model. The drug in the mixture gels was released continuously up to about 45-65% of the total loading amount during the first 7 days. For in vivo evaluation of tissue anti-adhesion potential, the Pluronic mixtures with/without drug were coated on the peritoneal wall defects of rats and their tissue adhesion extents and tissue reactions (inflammatory response, granulation tissue formation, and toxicity in organs) were compared. It was observed that ibuprofen has a positive effect for the peritoneal tissue anti-adhesion. The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel.
Ryo Yoshida - One of the best experts on this subject based on the ideXlab platform.
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precisely tunable sol gel Transition temperature by blending thermoresponsive abc triblock terpolymers
ACS Macro Letters, 2018Co-Authors: Michika Onoda, Takeshi Ueki, Timothy P Lodge, Ryota Tamate, Aya Mizutani Akimoto, Cecilia Hall, Ryo YoshidaAbstract:Here, we report a facile methodology to control the sol–gel Transition temperature (Tgel) of a physically cross-linked hydrogel by blending two kinds of ABC triblock terpolymers. Well-defined triblock terpolymers including thermosensitive N-isopropylacrylamide (NIPAAm), ABC1, and ABC2, were prepared by sequential reversible addition–fragmentation chain transfer polymerization. The chemical structure as well as the molecular weight of the A and B blocks for both polymers are identical, whereas the C blocks are different. The C block of ABC1 (C1) is a statistical copolymer of NIPAAm with hydrophobic n-butyl acrylate (BA), while that of ABC2 (C2) is a PNIPAAm homopolymer. Independently prepared ABC triblock terpolymer solutions exhibit well-defined sol–gel Transitions. The Tgel of ABC1 is lower than that of ABC2 since hydrophobic BA is copolymerized into block C1. Remarkably, the Tgel varies linearly within this temperature range by simply blending the two polymers, while the resultant gel strength (∼G′) rem...
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Precisely Tunable Sol–Gel Transition Temperature by Blending Thermoresponsive ABC Triblock Terpolymers
2018Co-Authors: Michika Onoda, Takeshi Ueki, Timothy P Lodge, Ryota Tamate, Aya Mizutani Akimoto, Cecilia C. Hall, Ryo YoshidaAbstract:Here, we report a facile methodology to control the sol–gel Transition temperature (Tgel) of a physically cross-linked hydrogel by blending two kinds of ABC triblock terpolymers. Well-defined triblock terpolymers including thermosensitive N-isopropylacrylamide (NIPAAm), ABC1, and ABC2, were prepared by sequential reversible addition–fragmentation chain transfer polymerization. The chemical structure as well as the molecular weight of the A and B blocks for both polymers are identical, whereas the C blocks are different. The C block of ABC1 (C1) is a statistical copolymer of NIPAAm with hydrophobic n-butyl acrylate (BA), while that of ABC2 (C2) is a PNIPAAm homopolymer. Independently prepared ABC triblock terpolymer solutions exhibit well-defined sol–gel Transitions. The Tgel of ABC1 is lower than that of ABC2 since hydrophobic BA is copolymerized into block C1. Remarkably, the Tgel varies linearly within this temperature range by simply blending the two polymers, while the resultant gel strength (∼G′) remains almost unchanged. Therefore, the Tgel can be precisely adjusted by the mixing ratio of the two polymers. This method for straightforward manipulation of Tgel has great potential for various soft material applications such as biomaterials for tissue engineering, drug delivery systems, and injectable gels
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amoeba like self oscillating polymeric fluids with autonomous sol gel Transition
Nature Communications, 2017Co-Authors: Michika Onoda, Takeshi Ueki, Ryota Tamate, Mitsuhiro Shibayama, Ryo YoshidaAbstract:Most polymeric materials that show Sol-Gel Transitions are unidirectional and stimuli-responsive systems. Here the authors show a block copolymer solution that undergoes autonomous and periodic Sol-Gel Transitions under constant conditions.
Jin Ho Lee - One of the best experts on this subject based on the ideXlab platform.
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prevention of postsurgical tissue adhesion by anti inflammatory drug loaded pluronic mixtures with sol gel Transition behavior
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Jin Kyeong Kim, Kyu Sang Song, Sung Ho Ghil, Seung Moo Noh, Soon Hong Yuk, Jin Ho LeeAbstract:Sol-Gel Transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The Sol-Gel Transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body. Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. The gelation temperatures of the Pluronic mixtures were not affected by the alginate but lowered by the addition of ibuprofen. The in vitro drug release behavior and in vivo peritoneal tissue adhesion of the Pluronic mixtures with the Sol-Gel Transition just below body temperatures were investigated. The drug release behavior from the ibuprofen (1 wt%)-loaded Pluronic mixture gels at 37 degrees C was examined using a membrane-less dissolution model. The drug in the mixture gels was released continuously up to about 45-65% of the total loading amount during the first 7 days. For in vivo evaluation of tissue anti-adhesion potential, the Pluronic mixtures with/without drug were coated on the peritoneal wall defects of rats and their tissue adhesion extents and tissue reactions (inflammatory response, granulation tissue formation, and toxicity in organs) were compared. It was observed that ibuprofen has a positive effect for the peritoneal tissue anti-adhesion. The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel.
Kyu Sang Song - One of the best experts on this subject based on the ideXlab platform.
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prevention of postsurgical tissue adhesion by anti inflammatory drug loaded pluronic mixtures with sol gel Transition behavior
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Se Heang Oh, Kyu Sang Song, Sung Ho GhilAbstract:Sol–gel Transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The sol–gel Transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body. Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. The gelation temperatures of the Pluronic mixtures were not affected by the alginate but lowered by the addition of ibuprofen. The in vitro drug release behavior and in vivo peritoneal tissue adhesion of the Pluronic mixtures with the sol–gel Transition just below body temperatures were investigated. The drug release behavior from the ibuprofen (1 wt%)-loaded Pluronic mixture gels at 37°C was examined using a membrane-less dissolution model. The drug in the mixture gels was released continuously up to about 45–65% of the total loading amount during the first 7 days. For in vivo evaluation of tissue anti-adhesion potential, the Pluronic mixtures with/without drug were coated on the peritoneal wall defects of rats and their tissue adhesion extents and tissue reactions (inflammatory response, granulation tissue formation, and toxicity in organs) were compared. It was observed that ibuprofen has a positive effect for the peritoneal tissue anti-adhesion. The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res 72A: 306–316, 2005
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prevention of postsurgical tissue adhesion by anti inflammatory drug loaded pluronic mixtures with sol gel Transition behavior
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Jin Kyeong Kim, Kyu Sang Song, Sung Ho Ghil, Seung Moo Noh, Soon Hong Yuk, Jin Ho LeeAbstract:Sol-Gel Transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The Sol-Gel Transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body. Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. The gelation temperatures of the Pluronic mixtures were not affected by the alginate but lowered by the addition of ibuprofen. The in vitro drug release behavior and in vivo peritoneal tissue adhesion of the Pluronic mixtures with the Sol-Gel Transition just below body temperatures were investigated. The drug release behavior from the ibuprofen (1 wt%)-loaded Pluronic mixture gels at 37 degrees C was examined using a membrane-less dissolution model. The drug in the mixture gels was released continuously up to about 45-65% of the total loading amount during the first 7 days. For in vivo evaluation of tissue anti-adhesion potential, the Pluronic mixtures with/without drug were coated on the peritoneal wall defects of rats and their tissue adhesion extents and tissue reactions (inflammatory response, granulation tissue formation, and toxicity in organs) were compared. It was observed that ibuprofen has a positive effect for the peritoneal tissue anti-adhesion. The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel.
Byeongmoon Jeong - One of the best experts on this subject based on the ideXlab platform.
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Thermogelling poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) disulfide multiblock copolymer as a thiol-sensitive degradable polymer.
Biomacromolecules, 2006Co-Authors: Kyung Hwa Sun, Youn Soo Sohn, Byeongmoon JeongAbstract:We report a reverse thermogelling poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) disulfide multiblock copolymer as a thiol-sensitive biodegradable polymer. The poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) aqueous solutions studied in this research underwent sol−gel−sol or sol−gel−sol−gel Transition depending on the molecular weight and concentration of the polymer, whereas the corresponding disulfide multiblock copolymer aqueous solutions underwent sol−gel Transition as the temperature increased in a range of 0−60 °C. The hydrophobic dye solubilization and dynamic light scattering of the polymer aqueous solution suggest that the poly(ethylene oxide-b-propylene oxide-b-ethylene oxide)s undergo unimer (3 nm) to micelle (12 nm) Transition, whereas the disulfide multiblock copolymers undergo unimer (6 nm) to aggregated polymer (600 nm) Transition as the temperature increases. The gel duration increased from 6 h (poly(ethylene oxide-b-propylene oxide-b-ethylene oxide)) to more than 12 days ...
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sol gel Transition temperature of plga g peg aqueous solutions
Biomacromolecules, 2002Co-Authors: Youngme Chung, Kevin L Simmons, And Anna Gutowska, Byeongmoon JeongAbstract:Aqueous solutions of poly(DL-lactic acid-co-glycolic acid)-g-poly(ethylene glycol) copolymers exhibited sol-to-gel Transition with increasing temperature. Further increase in temperature makes the system flow and form a sol phase again. Subcutaneous injection of a copolymer aqueous solution (0.5 mL) resulted in a formation of a hydrogel depot by temperature-sensitive sol-to-gel Transition in a rat model. The reliable determination and control of sol-to-gel Transition temperatures are the most important issues for this kind of Sol-Gel reversible hydrogel. The sol-to-gel Transition temperature determined by the test tube inverting method, falling ball method, and dynamic mechanical analysis coincided within 1-2 degrees C. Fine tuning of the sol-to-gel Transition temperature was achieved by varying the ionic strength of the polymer solutions and by mixing two polymer aqueous solutions with different sol-to-gel Transition temperatures. The sol-to-gel Transition temperature of polymer mixture aqueous solutions was well described by an empirical equation of miscible blends, indicating miscibility of the two polymer systems in water on the molecular level.