The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Wenbin Guo - One of the best experts on this subject based on the ideXlab platform.
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frequency specific alterations of the frontal cerebellar circuit in first episode drug naive Somatization Disorder
Journal of Affective Disorders, 2021Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Meiying Lei, Yongmei Jiang, Tiantian LuoAbstract:Abstract Background With the development of imaging techniques, evidence of abnormal neural activity has been implicated in patients with Somatization Disorder (SD). It remains unclear whether abnormal spontaneous neural activities are related to specific frequency bands. In this study, resting-state functional magnetic resonance imaging (fMRI) using the frequency-specific amplitude of low frequency fluctuation (ALFF) approach was applied to investigate changes in spontaneous neural activity in different frequency bands in patients with SD. Methods Twenty-five first-episode, medication-naive patients with SD and 28 age-, sex-, education-matched healthy controls (HCs) underwent resting-state fMRI. The ALFF method with the classical low-frequency (0.01 - 0.08 Hz), slow-5 (0.01 - 0.027 Hz) and slow-4 (0.027 - 0.08 Hz) bands was employed to analyze the data. Results With the classical low-frequency and slow-5 bands, patients with SD showed significantly increased ALFF in the left orbitofrontal cortex (OFC) and reduced ALFF in the right cerebellum compared with HCs. With the slow-4 band, patients with SD exhibited significantly reduced ALFF in the right cerebellum compared with HCs. However, no significant correlation was observed between the ALFF value in the left OFC or right cerebellum and clinical/cognitive variables. Conclusions Our findings indicate that there are abnormal regional activities of the left OFC and right cerebellum in first-episode, treatment-naive patients with SD, suggesting that these alterations occur early in the course of the disease and are independent of medication status. Our study provides novel evidence that different regional activities of the frontal-cerebellar circuit may be involved in the pathophysiology of SD.
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enhanced connectivity of thalamo cortical networks in first episode treatment naive Somatization Disorder
Frontiers in Psychiatry, 2020Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Jin Zhao, Ru Yang, Jingping ZhaoAbstract:ABSTRACT Background: Dysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with Somatization Disorder (SD). However, changes in the anatomical specificity of thalamo-cortical functional connectivity (FC) in SD remain unclear. Methods: Resting-state fMRI scans were collected in 25 first-episode, drug-naive patients with SD, as well as 28 sex-, age-, and education-matched healthy controls. We parcellated the thalamus with seven predefined regions of interest (ROIs) and used them as seeds to map whole-brain FC. Correlation analysis was conducted in the patients. Results: We found an increased pattern of thalamic ROI-cortex connectivity in patients with SD. Patients with SD demonstrated enhanced thalamic connectivity to the bilateral anterior/middle cingulum, motor/sensory cortex, visual cortex, and auditory cortex. A significantly negative correlation was found between the right occipital thalamic ROI to the anterior cingulum and EPQ extraversion scores (r=0.404, p=0.045) after the Benjamini-Hochberg correction. Conclusions: This study demonstrates that anatomical specificity of enhanced thalamo-cortical FCs exists in first-episode, drug-naive patients with SD. These findings further highlight the importance of the thalamic subregions in the pathophysiology of SD.
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abnormal functional asymmetry in the salience and auditory networks in first episode drug naive Somatization Disorder
Neuroscience, 2020Co-Authors: Feng Liu, Meijiao Deng, Wenbin GuoAbstract:Abstract Evidence of abnormal functional connectivity (FC) has been implicated in patients with Somatization Disorder (SD). Although the importance of damage to the functional asymmetry has been established, it remains unclear as to whether abnormal intra- and inter-hemispheric FCs are related to patients with SD. We applied resting-state functional magnetic resonance imaging to first-episode, medication-naive patients with SD (n = 25) and matched healthy controls (HCs) (n = 28). The data were analyzed using parameter of asymmetry (PAS) and support vector machine (SVM). Patients with SD showed significantly lower PAS values in the left inferior temporal gyrus (ITG) and higher PAS values in the right insula compared to HCs. A negative correlation was observed between the higher PAS values in the right insula and the Hamilton Depression Scale (HAMD) sleep subscale scores (r = −0.502, p = 0.011), and positive correlations were found between the lower PAS values in the left ITG and the Hamilton Anxiety Scale (HAMA) somatic anxiety subscale scores (r = 0.443, p = 0.027) and the HAMA total scores (r = 0.456, p = 0.022). Moreover, the increased PAS values in the right insula could distinguish patients with SD from HCs with acceptable accuracy (77.36%). First-episode, treatment-naive patients with SD show disrupted asymmetry of inter- and intra-hemispheric FCs. The pattern of disrupted functional asymmetry occurs early in the course of the disease and is independent of medication status, which suggests that disrupted functional asymmetry of salience and auditory networks may be applied as early biological markers for SD.
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increased nucleus accumbens connectivity in resting state patients with drug naive first episode Somatization Disorder
Frontiers in Psychiatry, 2019Co-Authors: Feng Liu, Zhikun Zhang, Jingping Zhao, Jindong Chen, Yudan Ding, Wenbin GuoAbstract:The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric Disorders including Somatization Disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed to explore the NAc connectivity in first-episode, drug-naive patients with SD using the bilateral NAc as seeds. Twenty-five first-episode, drug-naive patients with SD and twenty-eight healthy controls were recruited. Functional connectivity (FC) was designed to analyze the images. LIBSVM (a library for support vector machines) was used to identify whether abnormal FC could be utilized to discriminate the patients from the controls. The patients showed significantly increased FC between the left NAc and the right gyrus rectus and left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC), and between the right NAc and the left gyrus rectus and left MPFC/ACC compared with the controls. The patients could be separated from the controls through increased FC between the left NAc and the right gyrus rectus with a sensitivity of 88.00% and a specificity of 82.14%. The findings reveal that patients with SD have increased NAc connectivity with the frontal regions of the reward circuit. Increased left NAc-right gyrus rectus connectivity can be used as a potential marker to discriminate patients with SD from healthy controls. The study thus highlights the importance of the reward circuit in the neuropathology of SD.
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voxel based global brain functional connectivity alterations in first episode drug naive patients with Somatization Disorder
Journal of Affective Disorders, 2019Co-Authors: Pan Pan, Feng Liu, Jingping Zhao, Jindong Chen, Wenbin GuoAbstract:Abstract Background Altered functional connectivity (FC) is associated with the pathophysiology of patients with Somatization Disorder (SD). However, inconsistent results were obtained due to different selections of regions of interest (ROIs) in previous researches. This study aims to examine voxel-wise brain-wide FC alterations in patients with first-episode, drug-naive SD in an unbiased way. Methods A total of 25 patients with SD and 28 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging. Global-brain FC (GFC) was applied to analyze the images. Receiver operating characteristic curves and support vector machine were used to differentiate the patients from the controls. Results Compared with healthy controls, patients with SD exhibited increased GFC in the right inferior temporal gyrus (t-value = 4.0663, p Conclusions Our study indicates that patients with SD show abnormal GFC in the brain areas of insula-centered sensorimotor network, and thus providing a new perspective for understanding the pathological changes of FC in SD. Furthermore, a combination of the GFC values in the right insula and left superior occipital gyrus may be used as a potential biomarker to identify the patients from the controls.
Zhikun Zhang - One of the best experts on this subject based on the ideXlab platform.
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frequency specific alterations of the frontal cerebellar circuit in first episode drug naive Somatization Disorder
Journal of Affective Disorders, 2021Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Meiying Lei, Yongmei Jiang, Tiantian LuoAbstract:Abstract Background With the development of imaging techniques, evidence of abnormal neural activity has been implicated in patients with Somatization Disorder (SD). It remains unclear whether abnormal spontaneous neural activities are related to specific frequency bands. In this study, resting-state functional magnetic resonance imaging (fMRI) using the frequency-specific amplitude of low frequency fluctuation (ALFF) approach was applied to investigate changes in spontaneous neural activity in different frequency bands in patients with SD. Methods Twenty-five first-episode, medication-naive patients with SD and 28 age-, sex-, education-matched healthy controls (HCs) underwent resting-state fMRI. The ALFF method with the classical low-frequency (0.01 - 0.08 Hz), slow-5 (0.01 - 0.027 Hz) and slow-4 (0.027 - 0.08 Hz) bands was employed to analyze the data. Results With the classical low-frequency and slow-5 bands, patients with SD showed significantly increased ALFF in the left orbitofrontal cortex (OFC) and reduced ALFF in the right cerebellum compared with HCs. With the slow-4 band, patients with SD exhibited significantly reduced ALFF in the right cerebellum compared with HCs. However, no significant correlation was observed between the ALFF value in the left OFC or right cerebellum and clinical/cognitive variables. Conclusions Our findings indicate that there are abnormal regional activities of the left OFC and right cerebellum in first-episode, treatment-naive patients with SD, suggesting that these alterations occur early in the course of the disease and are independent of medication status. Our study provides novel evidence that different regional activities of the frontal-cerebellar circuit may be involved in the pathophysiology of SD.
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enhanced connectivity of thalamo cortical networks in first episode treatment naive Somatization Disorder
Frontiers in Psychiatry, 2020Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Jin Zhao, Ru Yang, Jingping ZhaoAbstract:ABSTRACT Background: Dysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with Somatization Disorder (SD). However, changes in the anatomical specificity of thalamo-cortical functional connectivity (FC) in SD remain unclear. Methods: Resting-state fMRI scans were collected in 25 first-episode, drug-naive patients with SD, as well as 28 sex-, age-, and education-matched healthy controls. We parcellated the thalamus with seven predefined regions of interest (ROIs) and used them as seeds to map whole-brain FC. Correlation analysis was conducted in the patients. Results: We found an increased pattern of thalamic ROI-cortex connectivity in patients with SD. Patients with SD demonstrated enhanced thalamic connectivity to the bilateral anterior/middle cingulum, motor/sensory cortex, visual cortex, and auditory cortex. A significantly negative correlation was found between the right occipital thalamic ROI to the anterior cingulum and EPQ extraversion scores (r=0.404, p=0.045) after the Benjamini-Hochberg correction. Conclusions: This study demonstrates that anatomical specificity of enhanced thalamo-cortical FCs exists in first-episode, drug-naive patients with SD. These findings further highlight the importance of the thalamic subregions in the pathophysiology of SD.
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increased nucleus accumbens connectivity in resting state patients with drug naive first episode Somatization Disorder
Frontiers in Psychiatry, 2019Co-Authors: Feng Liu, Zhikun Zhang, Jingping Zhao, Jindong Chen, Yudan Ding, Wenbin GuoAbstract:The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric Disorders including Somatization Disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed to explore the NAc connectivity in first-episode, drug-naive patients with SD using the bilateral NAc as seeds. Twenty-five first-episode, drug-naive patients with SD and twenty-eight healthy controls were recruited. Functional connectivity (FC) was designed to analyze the images. LIBSVM (a library for support vector machines) was used to identify whether abnormal FC could be utilized to discriminate the patients from the controls. The patients showed significantly increased FC between the left NAc and the right gyrus rectus and left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC), and between the right NAc and the left gyrus rectus and left MPFC/ACC compared with the controls. The patients could be separated from the controls through increased FC between the left NAc and the right gyrus rectus with a sensitivity of 88.00% and a specificity of 82.14%. The findings reveal that patients with SD have increased NAc connectivity with the frontal regions of the reward circuit. Increased left NAc-right gyrus rectus connectivity can be used as a potential marker to discriminate patients with SD from healthy controls. The study thus highlights the importance of the reward circuit in the neuropathology of SD.
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regional white matter volume abnormalities in first episode Somatization Disorder
International Journal of Psychophysiology, 2018Co-Authors: Jin Zhao, Feng Liu, Zhikun Zhang, Jingping Zhao, Furong Zhu, Wenbin GuoAbstract:Abstract Background Alterations of white matter integrity have been implicated in patients with Somatization Disorder (SD). However, changes of white matter volume (WMV) remain unclear. This study is designed to examine regional WMV in patients with SD and to investigate the potential relationships between WMV abnormalities and personality traits, cognitive function, and symptom severity. Methods We recruited 25 first-episode, drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls for the study. Personality traits, cognitive function, and symptom severity were assessed for all participants. Data were analyzed with the computational anatomy toolbox (CAT12) methods. Results Patients with SD exhibited a significantly increased WMV in the right inferior frontal gyrus (IFG) (t = 4.4009) and a significantly decreased WMV in the left inferior longitudinal fasciculus (ILF) (t = −3.4292) relative to healthy controls. No correlation was found between abnormal WMV and clinical/cognitive variables in the patients. Conclusions Our findings suggest the presence of significant regional WMV abnormalities in first-episode, drug-naive patients with SD, which might improve understanding the pathophysiology of SD.
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increased coherence based regional homogeneity in resting state patients with first episode drug naive Somatization Disorder
Journal of Affective Disorders, 2018Co-Authors: Feng Liu, Zhikun Zhang, Jingping Zhao, Jindong Chen, Pan Pan, Wenbin GuoAbstract:Abstract Background Abnormal neural activity has been observed in patients with Somatization Disorder (SD), especially in brain regions of the default-mode network (DMN). In this study, a coherence-based regional homogeneity (Cohe-ReHo) approach was used to detect abnormal regional synchronization in patients with SD, which might be used to differentiate the patients from the controls. Methods We recruited 25 patients with SD and 28 healthy controls. The imaging data of the participants were analyzed using the Cohe-ReHo approach. LIBSVM (a library for support vector machines) was utilized to verify whether abnormal Cohe-ReHo values could be applied to separate patients with SD from healthy controls. Results Compared with healthy controls, patients with SD showed an increased Cohe-ReHo in the left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC) (t = 5.5017, p Conclusions An increased Cohe-ReHo was observed in the anterior DMN of the patients and could be applied as a marker to distinguish patients from healthy controls. These results highlighted the importance of the DMN in the pathophysiology of SD.
Feng Liu - One of the best experts on this subject based on the ideXlab platform.
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frequency specific alterations of the frontal cerebellar circuit in first episode drug naive Somatization Disorder
Journal of Affective Disorders, 2021Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Meiying Lei, Yongmei Jiang, Tiantian LuoAbstract:Abstract Background With the development of imaging techniques, evidence of abnormal neural activity has been implicated in patients with Somatization Disorder (SD). It remains unclear whether abnormal spontaneous neural activities are related to specific frequency bands. In this study, resting-state functional magnetic resonance imaging (fMRI) using the frequency-specific amplitude of low frequency fluctuation (ALFF) approach was applied to investigate changes in spontaneous neural activity in different frequency bands in patients with SD. Methods Twenty-five first-episode, medication-naive patients with SD and 28 age-, sex-, education-matched healthy controls (HCs) underwent resting-state fMRI. The ALFF method with the classical low-frequency (0.01 - 0.08 Hz), slow-5 (0.01 - 0.027 Hz) and slow-4 (0.027 - 0.08 Hz) bands was employed to analyze the data. Results With the classical low-frequency and slow-5 bands, patients with SD showed significantly increased ALFF in the left orbitofrontal cortex (OFC) and reduced ALFF in the right cerebellum compared with HCs. With the slow-4 band, patients with SD exhibited significantly reduced ALFF in the right cerebellum compared with HCs. However, no significant correlation was observed between the ALFF value in the left OFC or right cerebellum and clinical/cognitive variables. Conclusions Our findings indicate that there are abnormal regional activities of the left OFC and right cerebellum in first-episode, treatment-naive patients with SD, suggesting that these alterations occur early in the course of the disease and are independent of medication status. Our study provides novel evidence that different regional activities of the frontal-cerebellar circuit may be involved in the pathophysiology of SD.
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enhanced connectivity of thalamo cortical networks in first episode treatment naive Somatization Disorder
Frontiers in Psychiatry, 2020Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Jin Zhao, Ru Yang, Jingping ZhaoAbstract:ABSTRACT Background: Dysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with Somatization Disorder (SD). However, changes in the anatomical specificity of thalamo-cortical functional connectivity (FC) in SD remain unclear. Methods: Resting-state fMRI scans were collected in 25 first-episode, drug-naive patients with SD, as well as 28 sex-, age-, and education-matched healthy controls. We parcellated the thalamus with seven predefined regions of interest (ROIs) and used them as seeds to map whole-brain FC. Correlation analysis was conducted in the patients. Results: We found an increased pattern of thalamic ROI-cortex connectivity in patients with SD. Patients with SD demonstrated enhanced thalamic connectivity to the bilateral anterior/middle cingulum, motor/sensory cortex, visual cortex, and auditory cortex. A significantly negative correlation was found between the right occipital thalamic ROI to the anterior cingulum and EPQ extraversion scores (r=0.404, p=0.045) after the Benjamini-Hochberg correction. Conclusions: This study demonstrates that anatomical specificity of enhanced thalamo-cortical FCs exists in first-episode, drug-naive patients with SD. These findings further highlight the importance of the thalamic subregions in the pathophysiology of SD.
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abnormal functional asymmetry in the salience and auditory networks in first episode drug naive Somatization Disorder
Neuroscience, 2020Co-Authors: Feng Liu, Meijiao Deng, Wenbin GuoAbstract:Abstract Evidence of abnormal functional connectivity (FC) has been implicated in patients with Somatization Disorder (SD). Although the importance of damage to the functional asymmetry has been established, it remains unclear as to whether abnormal intra- and inter-hemispheric FCs are related to patients with SD. We applied resting-state functional magnetic resonance imaging to first-episode, medication-naive patients with SD (n = 25) and matched healthy controls (HCs) (n = 28). The data were analyzed using parameter of asymmetry (PAS) and support vector machine (SVM). Patients with SD showed significantly lower PAS values in the left inferior temporal gyrus (ITG) and higher PAS values in the right insula compared to HCs. A negative correlation was observed between the higher PAS values in the right insula and the Hamilton Depression Scale (HAMD) sleep subscale scores (r = −0.502, p = 0.011), and positive correlations were found between the lower PAS values in the left ITG and the Hamilton Anxiety Scale (HAMA) somatic anxiety subscale scores (r = 0.443, p = 0.027) and the HAMA total scores (r = 0.456, p = 0.022). Moreover, the increased PAS values in the right insula could distinguish patients with SD from HCs with acceptable accuracy (77.36%). First-episode, treatment-naive patients with SD show disrupted asymmetry of inter- and intra-hemispheric FCs. The pattern of disrupted functional asymmetry occurs early in the course of the disease and is independent of medication status, which suggests that disrupted functional asymmetry of salience and auditory networks may be applied as early biological markers for SD.
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increased nucleus accumbens connectivity in resting state patients with drug naive first episode Somatization Disorder
Frontiers in Psychiatry, 2019Co-Authors: Feng Liu, Zhikun Zhang, Jingping Zhao, Jindong Chen, Yudan Ding, Wenbin GuoAbstract:The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric Disorders including Somatization Disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed to explore the NAc connectivity in first-episode, drug-naive patients with SD using the bilateral NAc as seeds. Twenty-five first-episode, drug-naive patients with SD and twenty-eight healthy controls were recruited. Functional connectivity (FC) was designed to analyze the images. LIBSVM (a library for support vector machines) was used to identify whether abnormal FC could be utilized to discriminate the patients from the controls. The patients showed significantly increased FC between the left NAc and the right gyrus rectus and left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC), and between the right NAc and the left gyrus rectus and left MPFC/ACC compared with the controls. The patients could be separated from the controls through increased FC between the left NAc and the right gyrus rectus with a sensitivity of 88.00% and a specificity of 82.14%. The findings reveal that patients with SD have increased NAc connectivity with the frontal regions of the reward circuit. Increased left NAc-right gyrus rectus connectivity can be used as a potential marker to discriminate patients with SD from healthy controls. The study thus highlights the importance of the reward circuit in the neuropathology of SD.
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voxel based global brain functional connectivity alterations in first episode drug naive patients with Somatization Disorder
Journal of Affective Disorders, 2019Co-Authors: Pan Pan, Feng Liu, Jingping Zhao, Jindong Chen, Wenbin GuoAbstract:Abstract Background Altered functional connectivity (FC) is associated with the pathophysiology of patients with Somatization Disorder (SD). However, inconsistent results were obtained due to different selections of regions of interest (ROIs) in previous researches. This study aims to examine voxel-wise brain-wide FC alterations in patients with first-episode, drug-naive SD in an unbiased way. Methods A total of 25 patients with SD and 28 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging. Global-brain FC (GFC) was applied to analyze the images. Receiver operating characteristic curves and support vector machine were used to differentiate the patients from the controls. Results Compared with healthy controls, patients with SD exhibited increased GFC in the right inferior temporal gyrus (t-value = 4.0663, p Conclusions Our study indicates that patients with SD show abnormal GFC in the brain areas of insula-centered sensorimotor network, and thus providing a new perspective for understanding the pathological changes of FC in SD. Furthermore, a combination of the GFC values in the right insula and left superior occipital gyrus may be used as a potential biomarker to identify the patients from the controls.
Jingping Zhao - One of the best experts on this subject based on the ideXlab platform.
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enhanced connectivity of thalamo cortical networks in first episode treatment naive Somatization Disorder
Frontiers in Psychiatry, 2020Co-Authors: Feng Liu, Zhikun Zhang, Wenbin Guo, Jin Zhao, Ru Yang, Jingping ZhaoAbstract:ABSTRACT Background: Dysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with Somatization Disorder (SD). However, changes in the anatomical specificity of thalamo-cortical functional connectivity (FC) in SD remain unclear. Methods: Resting-state fMRI scans were collected in 25 first-episode, drug-naive patients with SD, as well as 28 sex-, age-, and education-matched healthy controls. We parcellated the thalamus with seven predefined regions of interest (ROIs) and used them as seeds to map whole-brain FC. Correlation analysis was conducted in the patients. Results: We found an increased pattern of thalamic ROI-cortex connectivity in patients with SD. Patients with SD demonstrated enhanced thalamic connectivity to the bilateral anterior/middle cingulum, motor/sensory cortex, visual cortex, and auditory cortex. A significantly negative correlation was found between the right occipital thalamic ROI to the anterior cingulum and EPQ extraversion scores (r=0.404, p=0.045) after the Benjamini-Hochberg correction. Conclusions: This study demonstrates that anatomical specificity of enhanced thalamo-cortical FCs exists in first-episode, drug-naive patients with SD. These findings further highlight the importance of the thalamic subregions in the pathophysiology of SD.
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increased nucleus accumbens connectivity in resting state patients with drug naive first episode Somatization Disorder
Frontiers in Psychiatry, 2019Co-Authors: Feng Liu, Zhikun Zhang, Jingping Zhao, Jindong Chen, Yudan Ding, Wenbin GuoAbstract:The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric Disorders including Somatization Disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed to explore the NAc connectivity in first-episode, drug-naive patients with SD using the bilateral NAc as seeds. Twenty-five first-episode, drug-naive patients with SD and twenty-eight healthy controls were recruited. Functional connectivity (FC) was designed to analyze the images. LIBSVM (a library for support vector machines) was used to identify whether abnormal FC could be utilized to discriminate the patients from the controls. The patients showed significantly increased FC between the left NAc and the right gyrus rectus and left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC), and between the right NAc and the left gyrus rectus and left MPFC/ACC compared with the controls. The patients could be separated from the controls through increased FC between the left NAc and the right gyrus rectus with a sensitivity of 88.00% and a specificity of 82.14%. The findings reveal that patients with SD have increased NAc connectivity with the frontal regions of the reward circuit. Increased left NAc-right gyrus rectus connectivity can be used as a potential marker to discriminate patients with SD from healthy controls. The study thus highlights the importance of the reward circuit in the neuropathology of SD.
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voxel based global brain functional connectivity alterations in first episode drug naive patients with Somatization Disorder
Journal of Affective Disorders, 2019Co-Authors: Pan Pan, Feng Liu, Jingping Zhao, Jindong Chen, Wenbin GuoAbstract:Abstract Background Altered functional connectivity (FC) is associated with the pathophysiology of patients with Somatization Disorder (SD). However, inconsistent results were obtained due to different selections of regions of interest (ROIs) in previous researches. This study aims to examine voxel-wise brain-wide FC alterations in patients with first-episode, drug-naive SD in an unbiased way. Methods A total of 25 patients with SD and 28 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging. Global-brain FC (GFC) was applied to analyze the images. Receiver operating characteristic curves and support vector machine were used to differentiate the patients from the controls. Results Compared with healthy controls, patients with SD exhibited increased GFC in the right inferior temporal gyrus (t-value = 4.0663, p Conclusions Our study indicates that patients with SD show abnormal GFC in the brain areas of insula-centered sensorimotor network, and thus providing a new perspective for understanding the pathological changes of FC in SD. Furthermore, a combination of the GFC values in the right insula and left superior occipital gyrus may be used as a potential biomarker to identify the patients from the controls.
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regional white matter volume abnormalities in first episode Somatization Disorder
International Journal of Psychophysiology, 2018Co-Authors: Jin Zhao, Feng Liu, Zhikun Zhang, Jingping Zhao, Furong Zhu, Wenbin GuoAbstract:Abstract Background Alterations of white matter integrity have been implicated in patients with Somatization Disorder (SD). However, changes of white matter volume (WMV) remain unclear. This study is designed to examine regional WMV in patients with SD and to investigate the potential relationships between WMV abnormalities and personality traits, cognitive function, and symptom severity. Methods We recruited 25 first-episode, drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls for the study. Personality traits, cognitive function, and symptom severity were assessed for all participants. Data were analyzed with the computational anatomy toolbox (CAT12) methods. Results Patients with SD exhibited a significantly increased WMV in the right inferior frontal gyrus (IFG) (t = 4.4009) and a significantly decreased WMV in the left inferior longitudinal fasciculus (ILF) (t = −3.4292) relative to healthy controls. No correlation was found between abnormal WMV and clinical/cognitive variables in the patients. Conclusions Our findings suggest the presence of significant regional WMV abnormalities in first-episode, drug-naive patients with SD, which might improve understanding the pathophysiology of SD.
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increased coherence based regional homogeneity in resting state patients with first episode drug naive Somatization Disorder
Journal of Affective Disorders, 2018Co-Authors: Feng Liu, Zhikun Zhang, Jingping Zhao, Jindong Chen, Pan Pan, Wenbin GuoAbstract:Abstract Background Abnormal neural activity has been observed in patients with Somatization Disorder (SD), especially in brain regions of the default-mode network (DMN). In this study, a coherence-based regional homogeneity (Cohe-ReHo) approach was used to detect abnormal regional synchronization in patients with SD, which might be used to differentiate the patients from the controls. Methods We recruited 25 patients with SD and 28 healthy controls. The imaging data of the participants were analyzed using the Cohe-ReHo approach. LIBSVM (a library for support vector machines) was utilized to verify whether abnormal Cohe-ReHo values could be applied to separate patients with SD from healthy controls. Results Compared with healthy controls, patients with SD showed an increased Cohe-ReHo in the left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC) (t = 5.5017, p Conclusions An increased Cohe-ReHo was observed in the anterior DMN of the patients and could be applied as a marker to distinguish patients from healthy controls. These results highlighted the importance of the DMN in the pathophysiology of SD.
Hans Joergen Grabe - One of the best experts on this subject based on the ideXlab platform.
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complex post traumatic stress Disorder in patients with Somatization Disorder
Australian and New Zealand Journal of Psychiatry, 2009Co-Authors: Carsten Spitzer, Sven Barnow, Katja Wingenfeld, Matthias Rose, Bernd Lowe, Hans Joergen GrabeAbstract:Objective: Given the association between severe childhood trauma, adult Somatization and complex post-traumatic stress Disorder (cPTSD), the purpose of the present paper was to assess this syndrome and its clinical correlates in patients with Somatization Disorder (SD).Methods: A total of 28 patients (82% women, mean age = 41.7±10.1 years) meeting DSM-IV criteria for SD as confirmed by the Structured Clinical Interview for DSM-IV, Axis I were compared to 28 age- and gender-matched patients with major depression, but without a lifetime diagnosis of SD. They completed the Structured Interview for Disorders of Extreme Stress, the Brief Symptom Inventory, the Inventory of Interpersonal Problems–Circumplex Scales, and the SF-36 Health Survey.Results: Compared to the control group, SD patients had higher risks for current and lifetime diagnoses of cPTSD (odds ratio (OR) = 15.0, 95% confidence interval (CI) = 1.76–127.54; and OR = 8.33, 95%CI = 2.04–34.07, respectively). SD subjects with cPTSD had more psycholog...
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childhood maltreatment in patients with Somatization Disorder
Australian and New Zealand Journal of Psychiatry, 2008Co-Authors: Carsten Spitzer, Sven Barnow, Kay Gau, Harald J Freyberger, Hans Joergen GrabeAbstract:Objective: There is converging evidence indicating a close association between trauma, particularly childhood trauma, and adult Somatization, but studies using both structured interviews and self-report measures to assess childhood adversities in patients with Somatization Disorder are scarce.Methods: A total of 28 patients (82% women, mean age=41.7±10.1years) meeting DSM-IV criteria for Somatization Disorder as confirmed by the Structured Clinical Interview for DSM-IV, Axis I (SCID-I) underwent the Structured Trauma Interview (STI) and the Childhood Trauma Questionnaire (CTQ). The comparison group consisted of 28 patients with major depression, but without a lifetime diagnosis of Somatization Disorder matched for gender and age.Results: Univariate analyses of both the STI and the CTQ data showed that somatizing patients had been exposed to childhood sexual and physical abuse significantly more often than major depressive Disorder (MDD) patients. In logistic regression analysis with Somatization Disorder ...