The Experts below are selected from a list of 1158 Experts worldwide ranked by ideXlab platform
Orville A Levander - One of the best experts on this subject based on the ideXlab platform.
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relationship between serum Somatomedin c levels and tissue selenium content among adults living in a seleniferous area
Nutrition Research, 1993Co-Authors: Arline D Salbe, C H Hill, Claude Veillon, Sister Marmion Howe, Matthew P Longnecker, Philip R Taylor, Orville A LevanderAbstract:Abstract Depressed serum Somatomedin C levels have been suggested by others as an early indicator of selenium (Se) toxicity. In both human and animal studies, Somatomedin C levels were lower in Se supplemented as compared to control subjects. The present study examined Se and Somatomedin C levels in 44 adult long-term residents of seleniferous areas in South Dakota. Serum Se (SSe) and whole blood Se (WBSe) levels were analyzed by GC/MS. Toenail Se (TSe) was measured by neutron activation analysis. Somatomedin C was analyzed by RIA assay. Subjects were divided into 3 groups based on the following criteria: group I, SSe 240, WBSe >400 ng/ml. Data were pooled across gender (20 males, 24 females). Somatomedin C levels were not different despite greater than 50% differences in SSe, WBSe, and TSe levels among the groups. In these subjects, Somatomedin C was not a sensitive index of elevated Se exposure.
Carol S Burckhardt - One of the best experts on this subject based on the ideXlab platform.
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low levels of Somatomedin c in patients with the fibromyalgia syndrome a possible link between sleep and muscle pain
Arthritis & Rheumatism, 1992Co-Authors: Robert M Bennett, Sharon R Clark, Stephen M Campbell, Carol S BurckhardtAbstract:Objective Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue. Lacking distinctive tissue or laboratory correlations, it has often been considered a form of "psychogenic rheumatism." In the present study, the notion that the stage-4 sleep anomaly typically seen in the fibromyalgia syndrome may disrupt growth hormone secretion was tested. Because growth hormone has a very short half-life, serum levels of Somatomedin C were measured; Somatomedin C is the major mediator of growth hormone's anabolic actions and is a prerequisite for normal muscle homeostasis. Methods Serum levels of Somatomedin C were measured in 70 female fibromyalgia patients and 55 healthy controls, using a peptide-specific radioimmunoassay. Results Significantly lower levels of Somatomedin C were observed in the fibromyalgia patients compared with controls (mean +/- SD 124.7 +/- 47 ng/ml versus 175.2 +/- 60 ng/ml; P = 0.000001). These results could not be explained by concomitant therapy or by weight, and in a subset of 21 patients in whom this was investigated, there was no correlation with various indices of disease activity. Conclusion These findings indicate that there is a distinctive disruption of the growth hormone-Somatomedin C neuroendocrine axis in a majority of fibromyalgia patients. It is hypothesized that this abnormality may explain the link between disturbed sleep and predisposition to muscle pain.
Arline D Salbe - One of the best experts on this subject based on the ideXlab platform.
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relationship between serum Somatomedin c levels and tissue selenium content among adults living in a seleniferous area
Nutrition Research, 1993Co-Authors: Arline D Salbe, C H Hill, Claude Veillon, Sister Marmion Howe, Matthew P Longnecker, Philip R Taylor, Orville A LevanderAbstract:Abstract Depressed serum Somatomedin C levels have been suggested by others as an early indicator of selenium (Se) toxicity. In both human and animal studies, Somatomedin C levels were lower in Se supplemented as compared to control subjects. The present study examined Se and Somatomedin C levels in 44 adult long-term residents of seleniferous areas in South Dakota. Serum Se (SSe) and whole blood Se (WBSe) levels were analyzed by GC/MS. Toenail Se (TSe) was measured by neutron activation analysis. Somatomedin C was analyzed by RIA assay. Subjects were divided into 3 groups based on the following criteria: group I, SSe 240, WBSe >400 ng/ml. Data were pooled across gender (20 males, 24 females). Somatomedin C levels were not different despite greater than 50% differences in SSe, WBSe, and TSe levels among the groups. In these subjects, Somatomedin C was not a sensitive index of elevated Se exposure.
Robert M Bennett - One of the best experts on this subject based on the ideXlab platform.
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low levels of Somatomedin c in patients with the fibromyalgia syndrome a possible link between sleep and muscle pain
Arthritis & Rheumatism, 1992Co-Authors: Robert M Bennett, Sharon R Clark, Stephen M Campbell, Carol S BurckhardtAbstract:Objective Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue. Lacking distinctive tissue or laboratory correlations, it has often been considered a form of "psychogenic rheumatism." In the present study, the notion that the stage-4 sleep anomaly typically seen in the fibromyalgia syndrome may disrupt growth hormone secretion was tested. Because growth hormone has a very short half-life, serum levels of Somatomedin C were measured; Somatomedin C is the major mediator of growth hormone's anabolic actions and is a prerequisite for normal muscle homeostasis. Methods Serum levels of Somatomedin C were measured in 70 female fibromyalgia patients and 55 healthy controls, using a peptide-specific radioimmunoassay. Results Significantly lower levels of Somatomedin C were observed in the fibromyalgia patients compared with controls (mean +/- SD 124.7 +/- 47 ng/ml versus 175.2 +/- 60 ng/ml; P = 0.000001). These results could not be explained by concomitant therapy or by weight, and in a subset of 21 patients in whom this was investigated, there was no correlation with various indices of disease activity. Conclusion These findings indicate that there is a distinctive disruption of the growth hormone-Somatomedin C neuroendocrine axis in a majority of fibromyalgia patients. It is hypothesized that this abnormality may explain the link between disturbed sleep and predisposition to muscle pain.
Philip R Taylor - One of the best experts on this subject based on the ideXlab platform.
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relationship between serum Somatomedin c levels and tissue selenium content among adults living in a seleniferous area
Nutrition Research, 1993Co-Authors: Arline D Salbe, C H Hill, Claude Veillon, Sister Marmion Howe, Matthew P Longnecker, Philip R Taylor, Orville A LevanderAbstract:Abstract Depressed serum Somatomedin C levels have been suggested by others as an early indicator of selenium (Se) toxicity. In both human and animal studies, Somatomedin C levels were lower in Se supplemented as compared to control subjects. The present study examined Se and Somatomedin C levels in 44 adult long-term residents of seleniferous areas in South Dakota. Serum Se (SSe) and whole blood Se (WBSe) levels were analyzed by GC/MS. Toenail Se (TSe) was measured by neutron activation analysis. Somatomedin C was analyzed by RIA assay. Subjects were divided into 3 groups based on the following criteria: group I, SSe 240, WBSe >400 ng/ml. Data were pooled across gender (20 males, 24 females). Somatomedin C levels were not different despite greater than 50% differences in SSe, WBSe, and TSe levels among the groups. In these subjects, Somatomedin C was not a sensitive index of elevated Se exposure.