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Utpal Bora - One of the best experts on this subject based on the ideXlab platform.
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In situ generation of palladium nanoparticles using agro waste and their use as catalyst for copper‐, amine‐ and ligand‐free Sonogashira Reaction
Applied Organometallic Chemistry, 2016Co-Authors: Anindita Dewan, Utpal Bora, Manashi Sarmah, Ashim Jyoti ThakurAbstract:The use of water extract of waste papaya bark ash for the in situ generation of palladium nanoparticles (Pd NPs) as an efficient and environmentally friendly basic medium for the Sonogashira Reaction at room temperature is reported. This methodology follows green chemistry principles as the Reaction is performed using agro waste (natural feedstock) for the generation of the Pd NPs as well as for providing a basic medium for the Reaction in the absence of any additional organic or inorganic base, ligand and copper salt, giving excellent yield of cross-coupled product at room temperature. The Reaction conditions are compatible with electronically diverse aryl iodides and electronically diverse alkyne derivatives.
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A highly efficient copper and ligand free protocol for the room temperature Sonogashira Reaction
RSC Advances, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Utpal BoraAbstract:A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira Reaction of aryl iodides at room temperature.
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a highly efficient copper and ligand free protocol for the room temperature Sonogashira Reaction
RSC Advances, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Utpal BoraAbstract:A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira Reaction of aryl iodides at room temperature. The system provides a simple route to obtain polyfunctional alkynes under ligand and copper free conditions. The procedure is equally efficient for aliphatic alkynes and aryl bromides.
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A palladium salen complex: an efficient catalyst for the Sonogashira Reaction at room temperature
New Journal of Chemistry, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Geetika Borah, Utpal BoraAbstract:A tetradentate Schiff base derived palladium complex has been developed as a catalyst for the room temperature Sonogashira Reaction under copper free conditions. The main catalytic species, a Pd-complex was derived from Schiff base ligand N,N′-bis(salicylidene)-arylmethanediamine and Pd(OAc)2. Electron rich, electron deficient and sterically hindered aryl iodides underwent smooth coupling to afford good to excellent yield of diaryl alkynes in isopropanol at room temperature. The protocol is also suitable for aliphatic alkynes.
Ankur Gogoi - One of the best experts on this subject based on the ideXlab platform.
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A highly efficient copper and ligand free protocol for the room temperature Sonogashira Reaction
RSC Advances, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Utpal BoraAbstract:A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira Reaction of aryl iodides at room temperature.
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a highly efficient copper and ligand free protocol for the room temperature Sonogashira Reaction
RSC Advances, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Utpal BoraAbstract:A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira Reaction of aryl iodides at room temperature. The system provides a simple route to obtain polyfunctional alkynes under ligand and copper free conditions. The procedure is equally efficient for aliphatic alkynes and aryl bromides.
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A palladium salen complex: an efficient catalyst for the Sonogashira Reaction at room temperature
New Journal of Chemistry, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Geetika Borah, Utpal BoraAbstract:A tetradentate Schiff base derived palladium complex has been developed as a catalyst for the room temperature Sonogashira Reaction under copper free conditions. The main catalytic species, a Pd-complex was derived from Schiff base ligand N,N′-bis(salicylidene)-arylmethanediamine and Pd(OAc)2. Electron rich, electron deficient and sterically hindered aryl iodides underwent smooth coupling to afford good to excellent yield of diaryl alkynes in isopropanol at room temperature. The protocol is also suitable for aliphatic alkynes.
Anindita Dewan - One of the best experts on this subject based on the ideXlab platform.
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In situ generation of palladium nanoparticles using agro waste and their use as catalyst for copper‐, amine‐ and ligand‐free Sonogashira Reaction
Applied Organometallic Chemistry, 2016Co-Authors: Anindita Dewan, Utpal Bora, Manashi Sarmah, Ashim Jyoti ThakurAbstract:The use of water extract of waste papaya bark ash for the in situ generation of palladium nanoparticles (Pd NPs) as an efficient and environmentally friendly basic medium for the Sonogashira Reaction at room temperature is reported. This methodology follows green chemistry principles as the Reaction is performed using agro waste (natural feedstock) for the generation of the Pd NPs as well as for providing a basic medium for the Reaction in the absence of any additional organic or inorganic base, ligand and copper salt, giving excellent yield of cross-coupled product at room temperature. The Reaction conditions are compatible with electronically diverse aryl iodides and electronically diverse alkyne derivatives.
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A highly efficient copper and ligand free protocol for the room temperature Sonogashira Reaction
RSC Advances, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Utpal BoraAbstract:A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira Reaction of aryl iodides at room temperature.
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a highly efficient copper and ligand free protocol for the room temperature Sonogashira Reaction
RSC Advances, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Utpal BoraAbstract:A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira Reaction of aryl iodides at room temperature. The system provides a simple route to obtain polyfunctional alkynes under ligand and copper free conditions. The procedure is equally efficient for aliphatic alkynes and aryl bromides.
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A palladium salen complex: an efficient catalyst for the Sonogashira Reaction at room temperature
New Journal of Chemistry, 2015Co-Authors: Ankur Gogoi, Anindita Dewan, Geetika Borah, Utpal BoraAbstract:A tetradentate Schiff base derived palladium complex has been developed as a catalyst for the room temperature Sonogashira Reaction under copper free conditions. The main catalytic species, a Pd-complex was derived from Schiff base ligand N,N′-bis(salicylidene)-arylmethanediamine and Pd(OAc)2. Electron rich, electron deficient and sterically hindered aryl iodides underwent smooth coupling to afford good to excellent yield of diaryl alkynes in isopropanol at room temperature. The protocol is also suitable for aliphatic alkynes.
Xiang-yun Guo - One of the best experts on this subject based on the ideXlab platform.
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Photocatalytic Sonogashira Reaction over silicon carbide supported Pd–Cu alloy nanoparticles under visible light irradiation
Catalysis Science & Technology, 2018Co-Authors: Bing Wang, Yingyong Wang, Xiaoning Guo, Gailing Bai, Xili Tong, Guoqiang Jin, Xiang-yun GuoAbstract:The Sonogashira Reaction is an important Reaction for forming carbon–carbon bonds in organic synthesis, which is typically carried out under harsh Reaction conditions. We herein report that PdCu alloy nanoparticles supported on SiC can efficiently catalyze the Sonogashira Reaction by visible light irradiation under ligand-free and mild conditions. The addition of Cu enhanced the activity of the PdCu alloy nanoparticles. The Pd3Cu1/SiC catalyst exhibited the highest catalytic performance for the Sonogashira Reaction of iodobenzene with phenylacetylene, and the conversion of iodobenzene and selectivity of diphenylacetylene were 99.7% and 98.7%, respectively. The Sonogashira Reaction catalyzed over the SiC supported PdCu alloy is a light-driven process, and the Reaction rate was greatly influenced by the light intensity and wavelength. A possible Reaction mechanism for the photocatalytic Sonogashira Reaction over Pd3Cu1/SiC was proposed.
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Visible-light-enhanced photocatalytic Sonogashira Reaction over silicon carbide supported Pd nanoparticles
Catalysis Communications, 2017Co-Authors: Bing Wang, Xiaoning Guo, Guoqiang Jin, Xiang-yun GuoAbstract:Abstract Sonogashira Reaction of aryl halides with terminal alkynes can be realized by a visible-light-driven heterogeneous catalytic route using silicon carbide supported Pd nanoparticles as the catalyst under copper-, and ligand-free conditions. Under the irradiation of visible light, the photo-generated electrons excited in SiC can quickly transfer to Pd nanoparticles through the Mott-Schottky contact, and make them electron-rich. The electrons of Pd particles become energetic by absorbing the energy of visible light, and then transfer to halogen atoms to facilitate the cleavage of carbon-halogen bond in aryl halides. The final carbon-carbon formation is achieved by the substitution Reaction and reductive elimination processes.
Avelino Corma - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of the ortho/meta/para Isomers of Relevant Pharmaceutical Compounds by Coupling a Sonogashira Reaction with a Regioselective Hydration
ACS Catalysis, 2014Co-Authors: Antonio Leyva-pérez, Jose R. Cabrero-antonino, Paula Rubio-marqués, Saud I. Al-resayes, Avelino CormaAbstract:Aryl ketones substituted in ortho, meta, and para position are prepared by a palladium-catalyzed Sonogashira Reaction followed by a regioselective hydration of the so-formed alkyne with triflimidic acid or a gold catalyst, under catalytic conditions. This methodology opens a way to obtain substituted aryl alkyl ketones from readily available starting materials, haloarenes, and terminal alkynes. The syntheses of the different regioisomers of haloperidol, melperone, pipamperone, and ibuprofen are presented. Structure–activity relationships for these compounds are studied with dopaminergic and cyclooxigenase binding assays.
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synthesis of the ortho meta para isomers of relevant pharmaceutical compounds by coupling a Sonogashira Reaction with a regioselective hydration
ACS Catalysis, 2014Co-Authors: Antonio Leyvaperez, Jose R Cabreroantonino, Paula Rubiomarques, Saud I Alresayes, Avelino CormaAbstract:Aryl ketones substituted in ortho, meta, and para position are prepared by a palladium-catalyzed Sonogashira Reaction followed by a regioselective hydration of the so-formed alkyne with triflimidic acid or a gold catalyst, under catalytic conditions. This methodology opens a way to obtain substituted aryl alkyl ketones from readily available starting materials, haloarenes, and terminal alkynes. The syntheses of the different regioisomers of haloperidol, melperone, pipamperone, and ibuprofen are presented. Structure–activity relationships for these compounds are studied with dopaminergic and cyclooxigenase binding assays.
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Synthesis of the ortho/meta/para Isomers of Relevant Pharmaceutical Compounds by Coupling a Sonogashira Reaction with a Regioselective Hydration
2014Co-Authors: Antonio Leyva-pérez, Jose R. Cabrero-antonino, Saud I. Al-resayes, Paula Rubio-marqués, Avelino CormaAbstract:Aryl ketones substituted in ortho, meta, and para position are prepared by a palladium-catalyzed Sonogashira Reaction followed by a regioselective hydration of the so-formed alkyne with triflimidic acid or a gold catalyst, under catalytic conditions. This methodology opens a way to obtain substituted aryl alkyl ketones from readily available starting materials, haloarenes, and terminal alkynes. The syntheses of the different regioisomers of haloperidol, melperone, pipamperone, and ibuprofen are presented. Structure–activity relationships for these compounds are studied with dopaminergic and cyclooxigenase binding assays