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Maria J Jaroslavsky - One of the best experts on this subject based on the ideXlab platform.
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su1620 mast cells in the gastric antrum its relation with functional dyspepsia a multicenter study in a South American Country
Gastroenterology, 2012Co-Authors: Susana B Pignataro, Teresa Barcia, Esteban H Campitelli, Daniela Ibarra, Alicia Paszkiewich, Flavio O Pere, Santiago J Regnasco, Horacio W Rubio, Claudia Casco, Maria J JaroslavskyAbstract:INTRODUCTION:Mast cells might be involved in the pathogenesis of FD, but is still unclear how to evaluate their presence in the gastric mucosa,and their association with FD and H. pylori infection. AIM: to assess the presence of an increased number of mast cells in gastric mucosa (antrum) of patients with FD subtype postprandial distress, based on Rome III criteria, with and without HP infection. MATERIAL AND METHODS: an observational multicenter study, 53 patients were enrolled consecutively, 20(38%) male, mean age 52 years, who underwent an upper endoscopy to be compared with control group (n=56). For mast cells count, biopsy samples were taken from the antrum and they were detected by Giemsa stain, and HP status was defined as a positive urease test or histologic finding.Two blinded independent pathologists assessed the mast cells number, an a third one was called when in disagreement or when the difference of mast cells number was≥4.Statistical analysis: X2test was used to compare proportions, and the Mann-Whitney test to compare numerical variables in both groups.Odds ratios (OR)were calculated using logistic regression with a significance level of 0.05 in all cases. RESULTS:see Table I and II Forward Stepwise Multiple Logistic Regression was used to identify better predictors of mast cells> 6 among the following variables: age<45,sex male, H. pylori status and dyspepsia symptoms.This model included the age(OR=8,55; p=0,005) and dyspepsia(OR=7,19; p=0,013) CONCLUSION: an increased number of mast cells in the gastric antrum ,seems to be more related to age, to functional dyspepsia symptoms than to H. pylori infection.However furher studies are necessary to confirm these findings including a higher number of cases 1FD:Functional dyspepsia 2.HP: Helicobacter pylori Results: Case group vs Control Group
Jefferson Gomes Fernandes - One of the best experts on this subject based on the ideXlab platform.
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subarachnoid hemorrhage mortality in a South American Country
Arquivos De Neuro-psiquiatria, 2013Co-Authors: Jefferson Gomes FernandesAbstract:on-traumatic subarachnoid hemorrhage (SAH) usually caused by aneurysm rup-ture is a potentially devastating condition, feared both by patients and physicians. It is estimated that death from SAH occurs before hospital admission in 12% to 15% of cases¹. The epidemiology of SAH shows some particularities which profes-sionals involved with health policies and the care of people with this disorder should be aware of. Age, gender, income, race and ethnicity have a significant impact on SAH presentation.There is a wide variation in the annual incidence of SAH in different regions of the world, from 2 cases per 100 000 population in China to 22.5 cases per 100 000 in Finland as shown by the WHO MONICA Stroke Study². In South and Central America the SAH incidence is reported to be 4.2 per 100 000 person-years³ with studies from Chile and Barbados indicating incidences of 6.2 per 100 000 per year (3.0–9.3) and 3.0 per 100 000 per year (1.0–5.0), respectively
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subarachnoid hemorrhage mortality in a South American Country hemorragia subaracnoidea mortalidade em um pais sul Americano
2013Co-Authors: Jefferson Gomes Fernandes, Oswaldo Cruz, Rua Joao JuliaoAbstract:Non-traumatic subarachnoid hemorrhage (SAH) usually caused by aneurysm rupture is a potentially devastating condition, feared both by patients and physicians. It is estimated that death from SAH occurs before hospital admission in 12% to 15% of cases¹. The epidemiology of SAH shows some particularities which professionals involved with health policies and the care of people with this disorder should be aware of. Age, gender, income, race and ethnicity have a significant impact on SAH presentation. There is a wide variation in the annual incidence of SAH in different regions of the world, from 2 cases per 100 000 population in China to 22.5 cases per 100 000 in Finland as shown by the WHO MONICA Stroke Study². In South and Central America the SAH incidence is reported to be 4.2 per 100 000 person-years³ with studies from Chile and Barbados indicating incidences of 6.2 per 100 000 per year (3.0–9.3) and 3.0 per 100 000 per year (1.0–5.0), respectively 4 . SAH incidence increases with age, with an average age of onset in adults of ≥50 years, being 1.24 times higher in women than in men 3,5 . In a Brazilian study the age-adjusted incidence for SAH was higher among females and increased progressively with age 6 . Mortality data obtained from the city of Sao Paulo Health Statistic System (PRO-AIM) identified SAH as a much more frequent cause of death among women when compared to men 7 . Race and ethnicity are relevant factors in SAH with Blacks and Hispanics having a higher incidence than white Americans 8 . A study reviewing data on approximately one billion hospitalizations in the United States over a 30-year study period (1979-2008) identified 612 500 cases of SAH, which was more common in women and non-white persons9. The impact of income on SAH rates was reported in a recent systematic review of population-based studies, where the incidence of SAH ranged from 2 to 16 per 100 000, with a pooled age-adjusted incidence rate in low to middle-income countries almost double that found in high income countries 5 . Another study found a significant income–mortality association for SAH among US patients, which was absent among Canadian patients 10 . The preva lence of intracranial aneurysms in the general population appears to be 2–5% and the frequency of unruptured aneurysms in angiographic and prospective autopsy series is approximately 3–4% 11 . In population-based studies of Latin American and the Caribbean 2-5% of all strokes were subarachnoid hemorrhage 4 . In a study of 2418 consecutive patients from 19 hospitals in the city of Fortaleza, Brazil, the frequency of admissions of subarachnoid hemorrhage patients was 6.0% 12 .
Susana B Pignataro - One of the best experts on this subject based on the ideXlab platform.
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su1620 mast cells in the gastric antrum its relation with functional dyspepsia a multicenter study in a South American Country
Gastroenterology, 2012Co-Authors: Susana B Pignataro, Teresa Barcia, Esteban H Campitelli, Daniela Ibarra, Alicia Paszkiewich, Flavio O Pere, Santiago J Regnasco, Horacio W Rubio, Claudia Casco, Maria J JaroslavskyAbstract:INTRODUCTION:Mast cells might be involved in the pathogenesis of FD, but is still unclear how to evaluate their presence in the gastric mucosa,and their association with FD and H. pylori infection. AIM: to assess the presence of an increased number of mast cells in gastric mucosa (antrum) of patients with FD subtype postprandial distress, based on Rome III criteria, with and without HP infection. MATERIAL AND METHODS: an observational multicenter study, 53 patients were enrolled consecutively, 20(38%) male, mean age 52 years, who underwent an upper endoscopy to be compared with control group (n=56). For mast cells count, biopsy samples were taken from the antrum and they were detected by Giemsa stain, and HP status was defined as a positive urease test or histologic finding.Two blinded independent pathologists assessed the mast cells number, an a third one was called when in disagreement or when the difference of mast cells number was≥4.Statistical analysis: X2test was used to compare proportions, and the Mann-Whitney test to compare numerical variables in both groups.Odds ratios (OR)were calculated using logistic regression with a significance level of 0.05 in all cases. RESULTS:see Table I and II Forward Stepwise Multiple Logistic Regression was used to identify better predictors of mast cells> 6 among the following variables: age<45,sex male, H. pylori status and dyspepsia symptoms.This model included the age(OR=8,55; p=0,005) and dyspepsia(OR=7,19; p=0,013) CONCLUSION: an increased number of mast cells in the gastric antrum ,seems to be more related to age, to functional dyspepsia symptoms than to H. pylori infection.However furher studies are necessary to confirm these findings including a higher number of cases 1FD:Functional dyspepsia 2.HP: Helicobacter pylori Results: Case group vs Control Group
F Lopezkostner - One of the best experts on this subject based on the ideXlab platform.
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increasing crude and adjusted mortality rates for colorectal cancer in a developing South American Country
Colorectal Disease, 2013Co-Authors: A J Zarate, Faustino Alonso, Maria Luisa Garmendia, F LopezkostnerAbstract:Aim Colorectal cancer (CRC) is a major cause of cancer death worldwide. We examined temporal trends in death rates from colorectal cancer in Chile from 1983 to 2008. Method We analysed the mortality database in Chile from 1983 to 2008. Cases were selected using ICD-9/10 codes. We calculated mortality rates per 100 000 inhabitants according to sex, age group and type of cancer – colon (CC) or rectal (RC). The rates were adjusted by a direct method using the WHO-2000 standard population. Time trends were assessed with Prais–Winsten regression models. Results There were 26 250 deaths from CRC (75.7% for CC). There was a higher frequency of deaths from CC (57.6%) in women than in men, who had a higher frequency of deaths from RC (51.3%). The crude CC mortality rate increased by 116% (from 3.6 to 7.8), while the overall RC rate increased by 71% (from 1.4 to 2.4). After adjusting for age, a significant increase in mortality rate was found for CC (coefficient 0.09, 95% CI 0.08–0.11, P < 0.001) and RC (coefficient 0.02, 95% CI 0.009–0.04, P = 0.002) in men. In women, this increase was significant for CC (coefficient 0.03, 95% CI 0.005–0.05; P = 0.02), but not for RC (coefficient −0.007, 95% CI −0.02 to 0.005, P = 0.23). Conclusion The crude mortality rate from CRC has doubled in Chile in this period. After adjustment of mortality rates, it appears that much of this increase is due to the aging population. However, part of this increase could be explained by other factors.
Horacio W Rubio - One of the best experts on this subject based on the ideXlab platform.
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su1620 mast cells in the gastric antrum its relation with functional dyspepsia a multicenter study in a South American Country
Gastroenterology, 2012Co-Authors: Susana B Pignataro, Teresa Barcia, Esteban H Campitelli, Daniela Ibarra, Alicia Paszkiewich, Flavio O Pere, Santiago J Regnasco, Horacio W Rubio, Claudia Casco, Maria J JaroslavskyAbstract:INTRODUCTION:Mast cells might be involved in the pathogenesis of FD, but is still unclear how to evaluate their presence in the gastric mucosa,and their association with FD and H. pylori infection. AIM: to assess the presence of an increased number of mast cells in gastric mucosa (antrum) of patients with FD subtype postprandial distress, based on Rome III criteria, with and without HP infection. MATERIAL AND METHODS: an observational multicenter study, 53 patients were enrolled consecutively, 20(38%) male, mean age 52 years, who underwent an upper endoscopy to be compared with control group (n=56). For mast cells count, biopsy samples were taken from the antrum and they were detected by Giemsa stain, and HP status was defined as a positive urease test or histologic finding.Two blinded independent pathologists assessed the mast cells number, an a third one was called when in disagreement or when the difference of mast cells number was≥4.Statistical analysis: X2test was used to compare proportions, and the Mann-Whitney test to compare numerical variables in both groups.Odds ratios (OR)were calculated using logistic regression with a significance level of 0.05 in all cases. RESULTS:see Table I and II Forward Stepwise Multiple Logistic Regression was used to identify better predictors of mast cells> 6 among the following variables: age<45,sex male, H. pylori status and dyspepsia symptoms.This model included the age(OR=8,55; p=0,005) and dyspepsia(OR=7,19; p=0,013) CONCLUSION: an increased number of mast cells in the gastric antrum ,seems to be more related to age, to functional dyspepsia symptoms than to H. pylori infection.However furher studies are necessary to confirm these findings including a higher number of cases 1FD:Functional dyspepsia 2.HP: Helicobacter pylori Results: Case group vs Control Group