The Experts below are selected from a list of 40293 Experts worldwide ranked by ideXlab platform
I A Razak - One of the best experts on this subject based on the ideXlab platform.
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intercountry prevalences and practices of betel quid use in South Southeast and eastern asia regions and associated oral preneoplastic disorders an international collaborative Study by Asian betel quid consortium of South and east asia
International Journal of Cancer, 2011Co-Authors: Albert Minshan Ko, Saman Warnakulasuriya, Rosnah Binti Zain, Salah O Ibrahim, Wenhui Li, Shanshan Zhang, Budi Utomo, P S Rajapakse, Supun Amila Warusavithana, I A RazakAbstract:Health risks stemming from betel-quid (BQ) chewing are frequently overlooked by people. Updated epidemiological data on the increased BQ use among Asian populations using comparable data collection methods have not been widely available. To investigate the prevalence, patterns of practice and associated types of oral preneoplastic disorders, an intercountry Asian Betel-quid Consortium Study (the ABC Study) was conducted for Taiwan, Mainland China, Malaysia, Indonesia, Nepal and Sri Lanka. A random sample of 8,922 subjects was recruited, and the data were analyzed using survey-data modules adjusted for the complex survey design. Chewing rates among men (10.7-43.6) were significantly higher than women (1.8-34.9) in Taiwan, Mainland China, Nepal and Sri Lanka, while women's rates (29.5-46.8) were higher than that for men (9.8-12.0) in Malaysia and Indonesia. An emerging, higher proportion of new-users were identified for Hunan in Mainland China (11.1-24.7), where Hunan chewers have the unique practice of using the dried husk of areca fruit rather than the solid nut universally used by others. Men in the Eastern and South Asian Study communities were deemed likely to combine chewing with smoking and drinking (5.6-13.6). Indonesian women who chewed BQ exhibited the highest prevalence of oral lichen planus, oral submucous fibrosis and oral leukoplakia (9.1-17.3). Lower schooling, alcohol drinking and tobacco smoking were identified as being associated with BQ chewing. In conclusion, the ABC Study reveals the significant cultural and demographic differences contributing to practice patterns of BQ usage and the great health risks that such practices pose in the Asian region.
Reena Das - One of the best experts on this subject based on the ideXlab platform.
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deciphering molecular heterogeneity of indian families with hereditary spherocytosis using targeted next generation sequencing first South Asian Study
British Journal of Haematology, 2020Co-Authors: Anu Aggarwal, Manu Jamwal, Prashant Sharma, Man Updesh Singh Sachdeva, Deepak Bansal, Pankaj Malhotra, Reena DasAbstract:Defects in various erythrocyte membrane proteins genes (ankyrin, band-3, β- and α-spectrin and protein 4·2) can cause hereditary spherocytosis (HS). This molecular heterogeneity of HS, together with co-inherited genetic modifiers, results in marked phenotypic variability among patients. We studied the molecular spectrum and genotype-phenotype correlations in 73 families (with 113 patients) with HS. Deleterious variants including nonsense (42%), deletions (18%), splice site (20%), missense (10%) and duplication/insertion (10%) were found in 47 patients. The variants detected included sporadic and dominantly-inherited defects in ANK1 (53·2%), SPTB (36·2%) and SLC4A1 (4·2%). Compound heterozygous variants in SPTA1 (6·4%) showed autosomal recessive inheritance. Alpha-spectrin variants were associated with severe anaemia and splenectomy alleviated symptoms. Co-inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency was found in 15%. G6PD variants (n = 5) led to greater transfusion requirements (1-8 times) in males with HS. Homozygosity (41%) for the promoter variant of UGT1A1 (Gilbert syndrome) led to a significantly higher mean bilirubin level (126·54 µmol/l) with a higher frequency of cholelithiasis (30%) (P < 0·001). This first-ever South Asian Study on the molecular spectrum of HS found ANK1 and SPTB genes variants to be the commonest with inheritance being sporadic/dominant. Next-generation sequencing provided a relatively sensitive and rapid tool for molecular diagnosis with a diagnostic yield of 64·4%.
Albert Minshan Ko - One of the best experts on this subject based on the ideXlab platform.
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intercountry prevalences and practices of betel quid use in South Southeast and eastern asia regions and associated oral preneoplastic disorders an international collaborative Study by Asian betel quid consortium of South and east asia
International Journal of Cancer, 2011Co-Authors: Albert Minshan Ko, Saman Warnakulasuriya, Rosnah Binti Zain, Salah O Ibrahim, Wenhui Li, Shanshan Zhang, Budi Utomo, P S Rajapakse, Supun Amila Warusavithana, I A RazakAbstract:Health risks stemming from betel-quid (BQ) chewing are frequently overlooked by people. Updated epidemiological data on the increased BQ use among Asian populations using comparable data collection methods have not been widely available. To investigate the prevalence, patterns of practice and associated types of oral preneoplastic disorders, an intercountry Asian Betel-quid Consortium Study (the ABC Study) was conducted for Taiwan, Mainland China, Malaysia, Indonesia, Nepal and Sri Lanka. A random sample of 8,922 subjects was recruited, and the data were analyzed using survey-data modules adjusted for the complex survey design. Chewing rates among men (10.7-43.6) were significantly higher than women (1.8-34.9) in Taiwan, Mainland China, Nepal and Sri Lanka, while women's rates (29.5-46.8) were higher than that for men (9.8-12.0) in Malaysia and Indonesia. An emerging, higher proportion of new-users were identified for Hunan in Mainland China (11.1-24.7), where Hunan chewers have the unique practice of using the dried husk of areca fruit rather than the solid nut universally used by others. Men in the Eastern and South Asian Study communities were deemed likely to combine chewing with smoking and drinking (5.6-13.6). Indonesian women who chewed BQ exhibited the highest prevalence of oral lichen planus, oral submucous fibrosis and oral leukoplakia (9.1-17.3). Lower schooling, alcohol drinking and tobacco smoking were identified as being associated with BQ chewing. In conclusion, the ABC Study reveals the significant cultural and demographic differences contributing to practice patterns of BQ usage and the great health risks that such practices pose in the Asian region.
Anu Aggarwal - One of the best experts on this subject based on the ideXlab platform.
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deciphering molecular heterogeneity of indian families with hereditary spherocytosis using targeted next generation sequencing first South Asian Study
British Journal of Haematology, 2020Co-Authors: Anu Aggarwal, Manu Jamwal, Prashant Sharma, Man Updesh Singh Sachdeva, Deepak Bansal, Pankaj Malhotra, Reena DasAbstract:Defects in various erythrocyte membrane proteins genes (ankyrin, band-3, β- and α-spectrin and protein 4·2) can cause hereditary spherocytosis (HS). This molecular heterogeneity of HS, together with co-inherited genetic modifiers, results in marked phenotypic variability among patients. We studied the molecular spectrum and genotype-phenotype correlations in 73 families (with 113 patients) with HS. Deleterious variants including nonsense (42%), deletions (18%), splice site (20%), missense (10%) and duplication/insertion (10%) were found in 47 patients. The variants detected included sporadic and dominantly-inherited defects in ANK1 (53·2%), SPTB (36·2%) and SLC4A1 (4·2%). Compound heterozygous variants in SPTA1 (6·4%) showed autosomal recessive inheritance. Alpha-spectrin variants were associated with severe anaemia and splenectomy alleviated symptoms. Co-inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency was found in 15%. G6PD variants (n = 5) led to greater transfusion requirements (1-8 times) in males with HS. Homozygosity (41%) for the promoter variant of UGT1A1 (Gilbert syndrome) led to a significantly higher mean bilirubin level (126·54 µmol/l) with a higher frequency of cholelithiasis (30%) (P < 0·001). This first-ever South Asian Study on the molecular spectrum of HS found ANK1 and SPTB genes variants to be the commonest with inheritance being sporadic/dominant. Next-generation sequencing provided a relatively sensitive and rapid tool for molecular diagnosis with a diagnostic yield of 64·4%.
Wenhui Li - One of the best experts on this subject based on the ideXlab platform.
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intercountry prevalences and practices of betel quid use in South Southeast and eastern asia regions and associated oral preneoplastic disorders an international collaborative Study by Asian betel quid consortium of South and east asia
International Journal of Cancer, 2011Co-Authors: Albert Minshan Ko, Saman Warnakulasuriya, Rosnah Binti Zain, Salah O Ibrahim, Wenhui Li, Shanshan Zhang, Budi Utomo, P S Rajapakse, Supun Amila Warusavithana, I A RazakAbstract:Health risks stemming from betel-quid (BQ) chewing are frequently overlooked by people. Updated epidemiological data on the increased BQ use among Asian populations using comparable data collection methods have not been widely available. To investigate the prevalence, patterns of practice and associated types of oral preneoplastic disorders, an intercountry Asian Betel-quid Consortium Study (the ABC Study) was conducted for Taiwan, Mainland China, Malaysia, Indonesia, Nepal and Sri Lanka. A random sample of 8,922 subjects was recruited, and the data were analyzed using survey-data modules adjusted for the complex survey design. Chewing rates among men (10.7-43.6) were significantly higher than women (1.8-34.9) in Taiwan, Mainland China, Nepal and Sri Lanka, while women's rates (29.5-46.8) were higher than that for men (9.8-12.0) in Malaysia and Indonesia. An emerging, higher proportion of new-users were identified for Hunan in Mainland China (11.1-24.7), where Hunan chewers have the unique practice of using the dried husk of areca fruit rather than the solid nut universally used by others. Men in the Eastern and South Asian Study communities were deemed likely to combine chewing with smoking and drinking (5.6-13.6). Indonesian women who chewed BQ exhibited the highest prevalence of oral lichen planus, oral submucous fibrosis and oral leukoplakia (9.1-17.3). Lower schooling, alcohol drinking and tobacco smoking were identified as being associated with BQ chewing. In conclusion, the ABC Study reveals the significant cultural and demographic differences contributing to practice patterns of BQ usage and the great health risks that such practices pose in the Asian region.