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Karel Allegaert - One of the best experts on this subject based on the ideXlab platform.
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short term use of parenteral nutrition with a lipid Emulsion containing a mixture of Soybean Oil olive Oil medium chain triglycerides and fish Oil a randomized double blind study in preterm infants
Journal of Parenteral and Enteral Nutrition, 2012Co-Authors: Maissa Rayyan, Hugo Devlieger, Frank Jochum, Karel AllegaertAbstract:Background: For premature neonates needing parenteral nutrition (PN), a balanced lipid supply is crucial. The authors hypothesized that a lipid Emulsion containing medium-chain triglycerides (MCTs) and Soybean, olive, and fish Oils would be as safe and well tolerated as a Soybean Emulsion while beneficially influencing the fatty acid profile. Methods: Double-blind, controlled study in 53 neonates (<34 weeks’ gestation) randomized to receive at least 7 days of PN containing either an Emulsion of MCTs and Soybean, olive, and fish Oils or a Soybean Oil Emulsion. Target lipid dosage was 1.0 g fat/kg body weight [BW]/d on days 1–3, 2 g/kg BW/d on day 4, 3 g/kg BW/d on day 5, and 3.5 g/kg BW/d on days 6–14. Results: Test Emulsion vs control, mean ± SD: baseline triglyceride concentrations were 0.52 ± 0.16 vs 0.54 ± 0.19 mmol/L and increased similarly in both groups to 0.69 ± 0.38 vs 0.67 ± 0.36 on day 8 of treatment (P = .781 for change). A significantly higher decrease in total and direct bilirubin vs baseline was seen in the test group compared with the control group P < .05 between groups). In plasma and red blood cell phospholipids, eicosapentaenoic acid and docosahexaenoic acid were higher, and the n-6/n-3 fatty acid ratio was lower in the test group (P < .05 vs control). Conclusions: The lipid Emulsion, based on a mixture of MCTs and Soybean, olive, and fish Oils, was safe and well tolerated by preterm infants while beneficially modulating the fatty acid profile.
Virginie Colombjung - One of the best experts on this subject based on the ideXlab platform.
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a new intravenous fat Emulsion containing Soybean Oil medium chain triglycerides olive Oil and fish Oil a single center double blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition
Journal of Parenteral and Enteral Nutrition, 2010Co-Authors: Olivie Goule, H Antebi, Claude Wolf, C Talbotec, L G Alcindo, O Corriol, M Lamo, Virginie ColombjungAbstract:Background: SMOFlipid 20% is an intravenous lipid Emulsion (ILE) containing Soybean Oil, medium-chain triglycerides, olive Oil, and fish Oil developed to provide energy, essential fatty acids (FAs), and long-chain ω-3 FAs as a mixed Emulsion containing α-tocopherol. The aim was to assess the efficacy and safety of this new ILE in pediatric patients receiving home parenteral nutrition (HPN) compared with Soybean Oil Emulsion (SOE). Methods: This single-center, randomized, double-blind study included 28 children on HPN allocated to receive either SMOFlipid 20% (n = 15) or a standard SOE (Intralipid 20%, n = 13). ILE was administered 4 to 5 times per week (goal dose, 2.0 g/kg/d) within a parenteral nutrition regimen. Assessments, including safety and efficacy parameters, were performed on day 0 and after the last study infusion (day 29). Lipid peroxidation was determined by measurement of thiobarbituric acid reactive substances (TBARS). Results: There were no significant differences in laboratory safety para...
Johannes B Van Goudoever - One of the best experts on this subject based on the ideXlab platform.
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growth and fatty acid profiles of vlbw infants receiving a multicomponent lipid Emulsion from birth
Journal of Pediatric Gastroenterology and Nutrition, 2014Co-Authors: Hester Vlaardingerbroek, Marijn J Vermeulen, Virgilio P Carnielli, Frederic M Vaz, Chris H P Van Den Akker, Johannes B Van GoudoeverAbstract:OBJECTIVES Very-low-birth-weight (VLBW) infants are dependent on parenteral nutrition after birth. A parenteral lipid Emulsion with a multicomponent composition may improve growth and neurodevelopment and may prevent liver injury, which is often observed in association with long-term parenteral nutrition with pure Soybean Oil. Our aim was to evaluate the safety and efficacy of a multicomponent lipid Emulsion containing 30% Soybean Oil, 30% medium-chain triacylglycerol, 25% olive Oil, and 15% fish Oil compared with a conventional pure Soybean Oil Emulsion in VLBW infants. METHODS We conducted a double-blind randomized controlled trial in VLBW infants randomized to parenteral nutrition with the multicomponent (study group) or pure Soybean Oil Emulsion (control group) from birth at a dose of 2 to 3 g · kg(-1) · day(-1) until the infants were receiving full enteral nutrition. We assessed efficacy by growth rates and measuring plasma fatty acid profiles (representative subset). Safety was evaluated by assessing hematologic and biochemical parameters, potentially harmful phytosterol concentrations (same subset), and clinical neonatal outcome parameters. RESULTS Ninety-six infants were included (subsets n = 21). The multicomponent Emulsion was associated with higher weight and head circumference z scores during admission. Plasma eicosapentaenoic acid and docosahexaenoic acid concentrations were higher in the study group. The hematological, biochemical, and neonatal outcomes were not different between groups, whereas the plasma concentrations of phytosterols were higher in the control group. CONCLUSIONS The multicomponent lipid Emulsion was well tolerated and associated with improved growth and higher plasma fatty acid profiles in VLBW infants in comparison with the pure Soybean Oil Emulsion.
Enny D Freema - One of the best experts on this subject based on the ideXlab platform.
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constant flux crossflow filtration evaluation of surface modified fouling resistant membranes
Journal of Membrane Science, 2014Co-Authors: Daniel J Mille, Sirira Kasemse, Donald R Paul, Lu Wang, Enny D FreemaAbstract:The surfaces of polysulfone ultrafiltration membranes were modified with polydopamine and polydopamine-g-poly(ethylene glycol) hydrophilic coatings. Unmodified and modified membranes were challenged with a Soybean Oil Emulsion feed at six different permeate fluxes in constant flux crossflow filtration fouling studies. The threshold flux was determined for each membrane. Above the threshold flux, modified membranes generally exhibited lower transmembrane pressures than unmodified membranes. However, below the threshold flux, modified membranes had higher transmembrane pressures than unmodified membranes, likely due to a decrease in permeance resulting from the surface modification. To account for this difference in permeance, polydopamine-g-poly(ethylene glycol) modified membranes were compared to membranes with a thicker polydopamine coating and to an unmodified membrane with a smaller pore size than that used for the surface modified membranes; in this way, all three membranes had similar pure water permeances. In this case, the unmodified membrane exhibited a much higher transmembrane pressure during fouling than the modified membranes, so when membranes of the same permeance are compared, the surface modifications improved fouling resistance. Therefore, a potential strategy to achieve fouling resistance in a membrane of a desired flux and rejection is to modify the surface of a more permeable (and perhaps lower rejection) membrane, thereby making the resulting modified membrane fouling-resistant but leaving it with the desired flux and rejection characteristics.
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a crossflow filtration system for constant permeate flux membrane fouling characterization
Review of Scientific Instruments, 2013Co-Authors: Daniel J Mille, Donald R Paul, Enny D FreemaAbstract:Membrane fouling is often characterized using a crossflow filtration apparatus. Typically, the transmembrane pressure (TMP) difference is fixed, and the flux is allowed to decline as the membrane fouls and the resistance to mass transfer increases. However, as flux varies, so too does the rate at which foulants are brought to the membrane surface, so the observed fouling behavior is not solely the result of membrane/foulant interactions. Constant flux experiments, where the permeate flux is fixed and the TMP difference varies, minimize such variations in the hydrodynamic conditions at the membrane surface, but constant TMP difference experiments dominate the fouling literature because they are more straightforward to execute than constant flux experiments. Additionally, most industrial water purification membrane installations operate at constant flux rather than at constant TMP. Here, we describe the construction and operation of a constant flux crossflow fouling apparatus. System measurement accuracy was validated by comparison of pure water permeance measurements to values specified by the membrane manufacturer, reported elsewhere, and measured by another technique. Fouling experiments were performed with two membrane/foulant systems: polysulfone ultrafiltration membranes with a Soybean Oil Emulsion foulant and PVDF microfiltration membranes with a polystyrene latex bead suspension foulant. Automatic permeate flux control facilitated flux stepping experiments, which are commonly used to determine the threshold flux or critical flux of a membrane/foulant pair. Comparison of a flux stepping experiment with a literature report yielded good agreement.
Maissa Rayyan - One of the best experts on this subject based on the ideXlab platform.
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short term use of parenteral nutrition with a lipid Emulsion containing a mixture of Soybean Oil olive Oil medium chain triglycerides and fish Oil a randomized double blind study in preterm infants
Journal of Parenteral and Enteral Nutrition, 2012Co-Authors: Maissa Rayyan, Hugo Devlieger, Frank Jochum, Karel AllegaertAbstract:Background: For premature neonates needing parenteral nutrition (PN), a balanced lipid supply is crucial. The authors hypothesized that a lipid Emulsion containing medium-chain triglycerides (MCTs) and Soybean, olive, and fish Oils would be as safe and well tolerated as a Soybean Emulsion while beneficially influencing the fatty acid profile. Methods: Double-blind, controlled study in 53 neonates (<34 weeks’ gestation) randomized to receive at least 7 days of PN containing either an Emulsion of MCTs and Soybean, olive, and fish Oils or a Soybean Oil Emulsion. Target lipid dosage was 1.0 g fat/kg body weight [BW]/d on days 1–3, 2 g/kg BW/d on day 4, 3 g/kg BW/d on day 5, and 3.5 g/kg BW/d on days 6–14. Results: Test Emulsion vs control, mean ± SD: baseline triglyceride concentrations were 0.52 ± 0.16 vs 0.54 ± 0.19 mmol/L and increased similarly in both groups to 0.69 ± 0.38 vs 0.67 ± 0.36 on day 8 of treatment (P = .781 for change). A significantly higher decrease in total and direct bilirubin vs baseline was seen in the test group compared with the control group P < .05 between groups). In plasma and red blood cell phospholipids, eicosapentaenoic acid and docosahexaenoic acid were higher, and the n-6/n-3 fatty acid ratio was lower in the test group (P < .05 vs control). Conclusions: The lipid Emulsion, based on a mixture of MCTs and Soybean, olive, and fish Oils, was safe and well tolerated by preterm infants while beneficially modulating the fatty acid profile.