The Experts below are selected from a list of 213 Experts worldwide ranked by ideXlab platform
Haruyasu Yamaguchi - One of the best experts on this subject based on the ideXlab platform.
-
ORIGINAL ARTICLE: Computerized visuo-Spatial Memory Test as a supplementary screening Test for dementia: Computerized visuo-Spatial Memory Test
Psychogeriatrics, 2010Co-Authors: Yohko Maki, Hiroshi Yoshida, Haruyasu YamaguchiAbstract:Background: To prepare for a super-aging society, effective dementia screening Tests are required. The most salient deficit appearing from the early stages of dementia/Alzheimer's disease (AD) is a deterioration in Memory. The Hasegawa Dementia Scale-revised (HDS-R) and the Mini-Mental State Examination (MMSE) are widely used in Japan to screen for dementia. Both place an emphasis on Memory function, but neither examines visuo-Spatial Memory (VSM) function, even though VSM deficits are a sensitive marker for the detection of conversion to dementia. Furthermore, brief Tests of VSM that are appropriate for screening have not been standardized. Thus, in the present study, we devised a brief, computer-aided short-term VSM Test. Methods: Sixty-six aged people were evaluated. Using the Clinical Dementia Rating (CDR), it was found that 29 could be considered normal controls (NC; CDR 0), 10 had mild cognitive impairment (MCI; CDR 0.5), 15 had mild dementia (CDR 1), and 12 had moderate to severe dementia (CDR 2–3). The VSM Test estimated how many locations each subject could memorize. Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially. After the numbers on the circles on the screen had disappeared, the subjects were required to indicate the circles in ascending order. A touch panel screen was used for this Test to make it easier. The HDS-R was applied to subjects with MCI and dementia. Results: The mean (±SD) VSM score in subjects with MCI (5.70 ± 0.96) was significantly lower than that in NC subjects (6.69 ± 0.82), but significantly higher than that in subjects classified as CDR 1 (4.67 ± 0.87). There was no significant difference in VSM scores between subjects classified as CDR 1 and CDR 2–3 (3.80 ± 0.80). There was a moderate significant correlation between VSM and HDS-R scores. Conclusion: In the present study, the VSM Test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia. The software program for the VSM Test is distributed for free so that it can be widely used.
-
computerized visuo Spatial Memory Test as a supplementary screening Test for dementia
Psychogeriatrics, 2010Co-Authors: Yohko Maki, Hiroshi Yoshida, Haruyasu YamaguchiAbstract:BACKGROUND: To prepare for a super-aging society, effective dementia screening Tests are required. The most salient deficit appearing from the early stages of dementia/Alzheimer's disease (AD) is a deterioration in Memory. The Hasegawa Dementia Scale-revised (HDS-R) and the Mini-Mental State Examination (MMSE) are widely used in Japan to screen for dementia. Both place an emphasis on Memory function, but neither examines visuo-Spatial Memory (VSM) function, even though VSM deficits are a sensitive marker for the detection of conversion to dementia. Furthermore, brief Tests of VSM that are appropriate for screening have not been standardized. Thus, in the present study, we devised a brief, computer-aided short-term VSM Test. METHODS: Sixty-six aged people were evaluated. Using the Clinical Dementia Rating (CDR), it was found that 29 could be considered normal controls (NC; CDR 0), 10 had mild cognitive impairment (MCI; CDR 0.5), 15 had mild dementia (CDR 1), and 12 had moderate to severe dementia (CDR 2-3). The VSM Test estimated how many locations each subject could memorize. Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially. After the numbers on the circles on the screen had disappeared, the subjects were required to indicate the circles in ascending order. A touch panel screen was used for this Test to make it easier. The HDS-R was applied to subjects with MCI and dementia. RESULTS: The mean (+/-SD) VSM score in subjects with MCI (5.70 +/- 0.96) was significantly lower than that in NC subjects (6.69 +/- 0.82), but significantly higher than that in subjects classified as CDR 1 (4.67 +/- 0.87). There was no significant difference in VSM scores between subjects classified as CDR 1 and CDR 2-3 (3.80 +/- 0.80). There was a moderate significant correlation between VSM and HDS-R scores. CONCLUSION: In the present study, the VSM Test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia. The software program for the VSM Test is distributed for free so that it can be widely used.
-
original article computerized visuo Spatial Memory Test as a supplementary screening Test for dementia
Psychogeriatrics, 2010Co-Authors: Yohko Maki, Hiroshi Yoshida, Haruyasu YamaguchiAbstract:Background: To prepare for a super-aging society, effective dementia screening Tests are required. The most salient deficit appearing from the early stages of dementia/Alzheimer's disease (AD) is a deterioration in Memory. The Hasegawa Dementia Scale-revised (HDS-R) and the Mini-Mental State Examination (MMSE) are widely used in Japan to screen for dementia. Both place an emphasis on Memory function, but neither examines visuo-Spatial Memory (VSM) function, even though VSM deficits are a sensitive marker for the detection of conversion to dementia. Furthermore, brief Tests of VSM that are appropriate for screening have not been standardized. Thus, in the present study, we devised a brief, computer-aided short-term VSM Test. Methods: Sixty-six aged people were evaluated. Using the Clinical Dementia Rating (CDR), it was found that 29 could be considered normal controls (NC; CDR 0), 10 had mild cognitive impairment (MCI; CDR 0.5), 15 had mild dementia (CDR 1), and 12 had moderate to severe dementia (CDR 2–3). The VSM Test estimated how many locations each subject could memorize. Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially. After the numbers on the circles on the screen had disappeared, the subjects were required to indicate the circles in ascending order. A touch panel screen was used for this Test to make it easier. The HDS-R was applied to subjects with MCI and dementia. Results: The mean (±SD) VSM score in subjects with MCI (5.70 ± 0.96) was significantly lower than that in NC subjects (6.69 ± 0.82), but significantly higher than that in subjects classified as CDR 1 (4.67 ± 0.87). There was no significant difference in VSM scores between subjects classified as CDR 1 and CDR 2–3 (3.80 ± 0.80). There was a moderate significant correlation between VSM and HDS-R scores. Conclusion: In the present study, the VSM Test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia. The software program for the VSM Test is distributed for free so that it can be widely used.
Angela Maria Ribeiro - One of the best experts on this subject based on the ideXlab platform.
-
thiamine deficiency decreases glutamate uptake in the prefrontal cortex and impairs Spatial Memory performance in a water maze Test
Pharmacology Biochemistry and Behavior, 2006Co-Authors: Fabiana M Carvalho, Silvia R C Pereira, Rita G W Pires, Vany Perpetua Ferraz, Marco Aurelio Romanosilva, Ieda F Oliveirasilva, Angela Maria RibeiroAbstract:Using an animal model of Wernicke–Korsakoff syndrome, in which rats were submitted to a chronic ethanol treatment with or without a thiamine deficiency episode, the glutamate uptake in the prefrontal cortex and Spatial Memory aspects were studied. It was found that (i) thiamine deficiency, but not chronic ethanol consumption, induced a significant decrease of glutamate uptake; (ii) thiamine-deficient subjects showed an impaired performance in the water maze Spatial Memory Test though these animals were able to learn the task during the acquisition. In spite of the fact that thiamine deficiency affects both glutamate uptake and Spatial reference Memory, there was no significant correlation between these two data. The present results show that, although prefrontal cortex is considered by some authors a not vulnerable area to lesions caused by thiamine deficiency, this vitamin deficiency does cause a neurochemistry dysfunction in that region.
Pascual A Gargiulo - One of the best experts on this subject based on the ideXlab platform.
-
evaluating Spatial Memory function in mice a within subjects comparison between the water maze Test and its adaptation to dry land
Behavioural Brain Research, 2010Co-Authors: Llano L Lopez, Jonas Hauser, Joram Feldon, Pascual A GargiuloAbstract:The Morris water maze (WM) is a common Spatial Memory Test in rats. It has been adapted for evaluating genetic manipulations in mice. One major acknowledged problem of this cross-species translation is floating. We investigated here in mice the feasibility and practicality of an alternative paradigm—the cheeseboard (CB), which is a dry version of the WM, in a within-subject design allowing direct comparison with the conventional WM. Under identical task demands (reference or working Memory), mice learned in the CB as efficiently as in the WM. Furthermore, individual differences in learning rate correlated between the two reference Memory Tests conducted separately in the two mazes. However, no such correlation was found with respect to reference Memory retention or working Memory performance. This study demonstrated that the CB is an effective alternative to the WM as Spatial cognition Test. Additional Tests in the CB confirmed that the mice relied on extra maze cues in their Spatial search. We would recommend the CB as a valuable addition to, rather than a replacement of the WM in phenotyping transgenic mice, because the two apparatus might diverge in the ability to detect individual differences in various domains of mnemonic functions.
Yohko Maki - One of the best experts on this subject based on the ideXlab platform.
-
ORIGINAL ARTICLE: Computerized visuo-Spatial Memory Test as a supplementary screening Test for dementia: Computerized visuo-Spatial Memory Test
Psychogeriatrics, 2010Co-Authors: Yohko Maki, Hiroshi Yoshida, Haruyasu YamaguchiAbstract:Background: To prepare for a super-aging society, effective dementia screening Tests are required. The most salient deficit appearing from the early stages of dementia/Alzheimer's disease (AD) is a deterioration in Memory. The Hasegawa Dementia Scale-revised (HDS-R) and the Mini-Mental State Examination (MMSE) are widely used in Japan to screen for dementia. Both place an emphasis on Memory function, but neither examines visuo-Spatial Memory (VSM) function, even though VSM deficits are a sensitive marker for the detection of conversion to dementia. Furthermore, brief Tests of VSM that are appropriate for screening have not been standardized. Thus, in the present study, we devised a brief, computer-aided short-term VSM Test. Methods: Sixty-six aged people were evaluated. Using the Clinical Dementia Rating (CDR), it was found that 29 could be considered normal controls (NC; CDR 0), 10 had mild cognitive impairment (MCI; CDR 0.5), 15 had mild dementia (CDR 1), and 12 had moderate to severe dementia (CDR 2–3). The VSM Test estimated how many locations each subject could memorize. Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially. After the numbers on the circles on the screen had disappeared, the subjects were required to indicate the circles in ascending order. A touch panel screen was used for this Test to make it easier. The HDS-R was applied to subjects with MCI and dementia. Results: The mean (±SD) VSM score in subjects with MCI (5.70 ± 0.96) was significantly lower than that in NC subjects (6.69 ± 0.82), but significantly higher than that in subjects classified as CDR 1 (4.67 ± 0.87). There was no significant difference in VSM scores between subjects classified as CDR 1 and CDR 2–3 (3.80 ± 0.80). There was a moderate significant correlation between VSM and HDS-R scores. Conclusion: In the present study, the VSM Test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia. The software program for the VSM Test is distributed for free so that it can be widely used.
-
computerized visuo Spatial Memory Test as a supplementary screening Test for dementia
Psychogeriatrics, 2010Co-Authors: Yohko Maki, Hiroshi Yoshida, Haruyasu YamaguchiAbstract:BACKGROUND: To prepare for a super-aging society, effective dementia screening Tests are required. The most salient deficit appearing from the early stages of dementia/Alzheimer's disease (AD) is a deterioration in Memory. The Hasegawa Dementia Scale-revised (HDS-R) and the Mini-Mental State Examination (MMSE) are widely used in Japan to screen for dementia. Both place an emphasis on Memory function, but neither examines visuo-Spatial Memory (VSM) function, even though VSM deficits are a sensitive marker for the detection of conversion to dementia. Furthermore, brief Tests of VSM that are appropriate for screening have not been standardized. Thus, in the present study, we devised a brief, computer-aided short-term VSM Test. METHODS: Sixty-six aged people were evaluated. Using the Clinical Dementia Rating (CDR), it was found that 29 could be considered normal controls (NC; CDR 0), 10 had mild cognitive impairment (MCI; CDR 0.5), 15 had mild dementia (CDR 1), and 12 had moderate to severe dementia (CDR 2-3). The VSM Test estimated how many locations each subject could memorize. Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially. After the numbers on the circles on the screen had disappeared, the subjects were required to indicate the circles in ascending order. A touch panel screen was used for this Test to make it easier. The HDS-R was applied to subjects with MCI and dementia. RESULTS: The mean (+/-SD) VSM score in subjects with MCI (5.70 +/- 0.96) was significantly lower than that in NC subjects (6.69 +/- 0.82), but significantly higher than that in subjects classified as CDR 1 (4.67 +/- 0.87). There was no significant difference in VSM scores between subjects classified as CDR 1 and CDR 2-3 (3.80 +/- 0.80). There was a moderate significant correlation between VSM and HDS-R scores. CONCLUSION: In the present study, the VSM Test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia. The software program for the VSM Test is distributed for free so that it can be widely used.
-
original article computerized visuo Spatial Memory Test as a supplementary screening Test for dementia
Psychogeriatrics, 2010Co-Authors: Yohko Maki, Hiroshi Yoshida, Haruyasu YamaguchiAbstract:Background: To prepare for a super-aging society, effective dementia screening Tests are required. The most salient deficit appearing from the early stages of dementia/Alzheimer's disease (AD) is a deterioration in Memory. The Hasegawa Dementia Scale-revised (HDS-R) and the Mini-Mental State Examination (MMSE) are widely used in Japan to screen for dementia. Both place an emphasis on Memory function, but neither examines visuo-Spatial Memory (VSM) function, even though VSM deficits are a sensitive marker for the detection of conversion to dementia. Furthermore, brief Tests of VSM that are appropriate for screening have not been standardized. Thus, in the present study, we devised a brief, computer-aided short-term VSM Test. Methods: Sixty-six aged people were evaluated. Using the Clinical Dementia Rating (CDR), it was found that 29 could be considered normal controls (NC; CDR 0), 10 had mild cognitive impairment (MCI; CDR 0.5), 15 had mild dementia (CDR 1), and 12 had moderate to severe dementia (CDR 2–3). The VSM Test estimated how many locations each subject could memorize. Several numbered circles were shown on a monitor and subjects were required to memorize the location of these circles sequentially. After the numbers on the circles on the screen had disappeared, the subjects were required to indicate the circles in ascending order. A touch panel screen was used for this Test to make it easier. The HDS-R was applied to subjects with MCI and dementia. Results: The mean (±SD) VSM score in subjects with MCI (5.70 ± 0.96) was significantly lower than that in NC subjects (6.69 ± 0.82), but significantly higher than that in subjects classified as CDR 1 (4.67 ± 0.87). There was no significant difference in VSM scores between subjects classified as CDR 1 and CDR 2–3 (3.80 ± 0.80). There was a moderate significant correlation between VSM and HDS-R scores. Conclusion: In the present study, the VSM Test detected differences in VSM function among NC subjects and subjects with MCI and mild dementia. The software program for the VSM Test is distributed for free so that it can be widely used.
Jeanchristophe Cassel - One of the best experts on this subject based on the ideXlab platform.
-
the double h maze Test a novel simple water escape Memory task acquisition recall of recent and remote Memory and effects of systemic muscarinic or nmda receptor blockade during training
Behavioural Brain Research, 2011Co-Authors: Sarah Polbodetto, Helene Jeltschdavid, Lucas Lecourtier, Nathalia Rusnac, Celia Mamlamfook, Brigitte Cosquer, Karin Geiger, Jeanchristophe CasselAbstract:Abstract To explore Spatial cognition in rodents, research uses maze tasks, which differ in complexity, number of goals and pathways, behavioural flexibility, Memory duration, but also in the experimenter's control over the strategy developed to reach a goal (e.g., allocentric vs. egocentric). This study aimed at validating a novel Spatial Memory Test: the double-H maze Test. The transparent device made of an alley with two opposite arms at each extremity and two in its centre is flooded. An escape platform is submerged in one arm. For experiments 1–3, rats were released in unpredictable sequences from one of both central arms to favour an allocentric approach of the task. Experiment 1 (3 trials/day over 6 days) demonstrated classical learning curves and evidence for recent and nondegraded remote Memory performance. Experiment 2 (2 days, 3 trials/day) showed a dose-dependent alteration of task acquisition/consolidation by muscarinic or NMDA receptor blockade; these drug effects vanished with sustained training (experiment 3; 4 days, 3 trials/day). Experiment 4 oriented rats towards a procedural (egocentric) approach of the task. Memory was Tested in a misleading probe trial. Most rats immediately switched from response learning-based to place learning-based behaviour, but only when their initial view on environmental cues markedly differed between training and probe trials. Because this simple task enables the formation of a relatively stable Memory trace, it could be particularly adapted to study consolidation processes at a system level or/and the interplay between procedural and declarative-like Memory systems.