The Experts below are selected from a list of 25077 Experts worldwide ranked by ideXlab platform

Letson, Hayley L. - One of the best experts on this subject based on the ideXlab platform.

  • Specific Pathogen-Free Animals for civilian and military trauma: a cautionary note in the translation of new drug therapies
    'Ovid Technologies (Wolters Kluwer Health)', 2020
    Co-Authors: Dobson, Geoffrey P., Morris, Jodie L., Biros Erik, Letson, Hayley L.
    Abstract:

    Specific-pathogen free (SPF) Animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. The goal was to provide Animals with selected microbiota compatible with sustained health. Sixty years later, SPF status has become a variable itself in biomedical research. Alterations in the gut microbiome–host relationship can profoundly influence basic physiology, immune/inflammatory function, susceptibility to infection and disease, and behavior. In addition, it can influence the translational success of a drug or technology from animal models to humans. We discuss this aspect of SPF status in animal models used for military or civilian trauma and shock research. Currently, there is a broad spectrum of SPF exclusion and inclusion criteria which vary from one supplier or animal husbandry facility. If translation to humans is the end-game of trauma research, we recommend replicating a gut microbiome similar to the wild-type for optimal success. We further suggest that at the end of each publication a URL access be provided on Animal Microbial/Pathogen Exclusion Status that a study was based upon. This may help address the differences in results within a single laboratory or between laboratories around the world and improve translation success

Dobson, Geoffrey P. - One of the best experts on this subject based on the ideXlab platform.

  • Specific Pathogen-Free Animals for civilian and military trauma: a cautionary note in the translation of new drug therapies
    'Ovid Technologies (Wolters Kluwer Health)', 2020
    Co-Authors: Dobson, Geoffrey P., Morris, Jodie L., Biros Erik, Letson, Hayley L.
    Abstract:

    Specific-pathogen free (SPF) Animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. The goal was to provide Animals with selected microbiota compatible with sustained health. Sixty years later, SPF status has become a variable itself in biomedical research. Alterations in the gut microbiome–host relationship can profoundly influence basic physiology, immune/inflammatory function, susceptibility to infection and disease, and behavior. In addition, it can influence the translational success of a drug or technology from animal models to humans. We discuss this aspect of SPF status in animal models used for military or civilian trauma and shock research. Currently, there is a broad spectrum of SPF exclusion and inclusion criteria which vary from one supplier or animal husbandry facility. If translation to humans is the end-game of trauma research, we recommend replicating a gut microbiome similar to the wild-type for optimal success. We further suggest that at the end of each publication a URL access be provided on Animal Microbial/Pathogen Exclusion Status that a study was based upon. This may help address the differences in results within a single laboratory or between laboratories around the world and improve translation success

Biros Erik - One of the best experts on this subject based on the ideXlab platform.

  • Specific Pathogen-Free Animals for civilian and military trauma: a cautionary note in the translation of new drug therapies
    'Ovid Technologies (Wolters Kluwer Health)', 2020
    Co-Authors: Dobson, Geoffrey P., Morris, Jodie L., Biros Erik, Letson, Hayley L.
    Abstract:

    Specific-pathogen free (SPF) Animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. The goal was to provide Animals with selected microbiota compatible with sustained health. Sixty years later, SPF status has become a variable itself in biomedical research. Alterations in the gut microbiome–host relationship can profoundly influence basic physiology, immune/inflammatory function, susceptibility to infection and disease, and behavior. In addition, it can influence the translational success of a drug or technology from animal models to humans. We discuss this aspect of SPF status in animal models used for military or civilian trauma and shock research. Currently, there is a broad spectrum of SPF exclusion and inclusion criteria which vary from one supplier or animal husbandry facility. If translation to humans is the end-game of trauma research, we recommend replicating a gut microbiome similar to the wild-type for optimal success. We further suggest that at the end of each publication a URL access be provided on Animal Microbial/Pathogen Exclusion Status that a study was based upon. This may help address the differences in results within a single laboratory or between laboratories around the world and improve translation success

Morris, Jodie L. - One of the best experts on this subject based on the ideXlab platform.

  • Specific Pathogen-Free Animals for civilian and military trauma: a cautionary note in the translation of new drug therapies
    'Ovid Technologies (Wolters Kluwer Health)', 2020
    Co-Authors: Dobson, Geoffrey P., Morris, Jodie L., Biros Erik, Letson, Hayley L.
    Abstract:

    Specific-pathogen free (SPF) Animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. The goal was to provide Animals with selected microbiota compatible with sustained health. Sixty years later, SPF status has become a variable itself in biomedical research. Alterations in the gut microbiome–host relationship can profoundly influence basic physiology, immune/inflammatory function, susceptibility to infection and disease, and behavior. In addition, it can influence the translational success of a drug or technology from animal models to humans. We discuss this aspect of SPF status in animal models used for military or civilian trauma and shock research. Currently, there is a broad spectrum of SPF exclusion and inclusion criteria which vary from one supplier or animal husbandry facility. If translation to humans is the end-game of trauma research, we recommend replicating a gut microbiome similar to the wild-type for optimal success. We further suggest that at the end of each publication a URL access be provided on Animal Microbial/Pathogen Exclusion Status that a study was based upon. This may help address the differences in results within a single laboratory or between laboratories around the world and improve translation success

Michael J Owen - One of the best experts on this subject based on the ideXlab platform.

  • t cell receptor alpha beta deficient mice fail to develop colitis in the absence of a microbial environment
    American Journal of Pathology, 1997
    Co-Authors: Lee Dianda, Andrew M Hanby, N A Wright, A Sebesteny, Adrian Hayday, Michael J Owen
    Abstract:

    Mice with null mutations in cytokine or T cell receptor (TCR) genes develop intestinal inflammation. In the case of interleukin-2-/- and interleukin-10-/- mice it has been demonstrated that normal intestinal bacterial flora can cause gut pathology. TCR-alpha-/- mice not only develop colitis but also produce a strong antibody response to self-antigens, such as double-stranded DNA. It is therefore important to establish whether the intestinal inflammation develops spontaneously or is induced by luminal antigens. To address this issue, a germ-free colony of TCR-alpha-/- mice was derived and compared with TCR-alpha-/- mice kept in conventional Specific-Pathogen-Free conditions. Although Specific-Pathogen-Free Animals developed colitis with a high level of penetrance, there was no evidence of intestinal pathology in germ-free Animals. Furthermore, intestinal inflammation was not seen in TCR-alpha-/- mice colonized with a limited bacterial flora consisting of Lactobacillus plantarum, Streptococcus faecalis, S. faecium, and/or Escherichia coli. We conclude that intestinal inflammation in TCR-alpha-/- mice does not occur spontaneously nor does it result from the presence of bacteria, per se, but rather it is initiated by a Specific organism or group of organisms normally present in the gut flora that have yet to be identified.