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Pham Nguyen Son - One of the best experts on this subject based on the ideXlab platform.

  • Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study.
    Critical care research and practice, 2020
    Co-Authors: Pham Dang Hai, Le Lan Phuong, Nguyen Manh Dung, Le Thi Viet Hoa, Van Quyen, Nguyen Xuan Chinh, Vu Duy Minh, Pham Nguyen Son
    Abstract:

    Introduction. Left ventricular dysfunction is quite common in septic shock. Speckle-Tracking Echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional Echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using Speckle-Tracking Echocardiography. Methods. From May 2017 to December 2018, patients aged ≥18 years admitted to the intensive care unit with the diagnosis of sepsis and septic shock based on the sepsis-3 definition were included. Patients with other causes of cardiac dysfunction were excluded. Transthoracic Echocardiography was performed for all the patients within 24 hours of diagnosis. Left ventricular systolic function was assessed using conventional Echocardiography and Speckle-Tracking Echocardiography. Results. Patients with septic shock (n = 90) (study group) and 37 matched patients with sepsis but no septic shock (control group) were included. Left ventricular ejection fraction (LVEF) by conventional Echocardiography showed no significant difference between two groups (58.2 ± 9.9 vs. 58.6 ± 8.3, ). The global longitudinal strain (GLS) by STE was significantly reduced in patients with septic shock compared with that in the control (−14.6 ± 3.3 vs. −17.1 ± 3.3, ). Based on the cutoff value of GLS ≥ −15% for the definition of subclinical left ventricular systolic dysfunction, this dysfunction was detected in 50 patients with septic shock (55.6%) and in 6 patients in the control group (16.2%) ( ). Conclusions. Speckle-Tracking Echocardiography can detect early subclinical left ventricular systolic dysfunction via the left ventricular global longitudinal strain compared with conventional echocardiographic parameters in patients with septic shock.

Patricia A. Pellikka - One of the best experts on this subject based on the ideXlab platform.

  • Echocardiographic Assessment of Left Ventricular Systolic Function: An Overview of Contemporary Techniques, Including Speckle-Tracking Echocardiography
    Mayo Clinic proceedings, 2019
    Co-Authors: Sushil A. Luis, Jonathan Chan, Patricia A. Pellikka
    Abstract:

    Assessment of left ventricular systolic function has a central role in the evaluation of cardiac disease. Accurate assessment is essential to guide management and prognosis. Numerous echocardiographic techniques are used in the assessment, each with its own advantages and disadvantages. This review is based on a literature search of the PubMed, MEDLINE, EMBASE, and Scopus databases from inception through December 30, 2017, using the terms strain Echocardiography, tissue Doppler strain, and Speckle-Tracking Echocardiography. We provide the internist with a contemporary overview of current echocardiographic techniques used in the evaluation of left ventricular systolic function. In particular, we focus on the role of Speckle-Tracking Echocardiography, including its utility in the detection of subclinical left ventricular dysfunction and the associated prognostic implications.

  • Prognosis of Light Chain Amyloidosis With Preserved LVEF: Added Value of 2D Speckle-Tracking Echocardiography to the Current Prognostic Staging System
    JACC. Cardiovascular imaging, 2016
    Co-Authors: Sergio Barros-gomes, Patricia A. Pellikka, Brittney Williams, Lara F. Nhola, Martha Grogan, Joseph F. Maalouf, Angela Dispenzieri, Hector R. Villarraga
    Abstract:

    AbstractObjectives: This study evaluated whether 2-dimensional Speckle-Tracking Echocardiography (2D-STE) has incremental value for prognosis over traditional clinical, echocardiographic, and serol...

  • TWO DIMENSIONAL Speckle Tracking Echocardiography PREDICTS PRECLINICAL CARDIOTOXICITY IN BREAST CANCER PATIENTS
    Journal of the American College of Cardiology, 2014
    Co-Authors: Nicole P. Sandhu, Patricia A. Pellikka, Jocelyn N. Spoon, Joerg Herrmann, Hector R. Villarraga
    Abstract:

    Changes in two dimensional Speckle Tracking Echocardiography (2D-STE) may identify women at risk for cardiotoxicity during breast cancer treatment prior to left ventricular ejection fraction (LVEF) changes. Cardiotoxicity is defined as a drop in LVEF to < 50% or an absolute decrease of 10% on a

  • Speckle Tracking Echocardiography in acute myocarditis
    The international journal of cardiovascular imaging, 2012
    Co-Authors: Ju Feng Hsiao, Yuki Koshino, Crystal R. Bonnichsen, Fletcher A. Miller, Patricia A. Pellikka, Leslie T. Cooper, Hector R. Villarraga
    Abstract:

    To evaluate 2-dimensional Speckle Tracking Echocardiography as a diagnostic and prognostic tool in patients with acute myocarditis. In this retrospective cohort study, 45 patients (age, 39 ± 15 years; 32 male) with suspected acute myocarditis and 83 healthy controls (age, 39 ± 13 years; 27 male) underwent 2-dimensional Speckle Tracking Echocardiography. Main outcome measures were circumferential and longitudinal strain and strain rate as prognostic and diagnostic markers. Patients with myocarditis had lower circumferential strain (-13.3 ± 5.6 % vs. -22.3 ± 4 %), circumferential strain rate (-0.9 ± 0.3 vs. -1.4 ± 0.3 s(-1)), longitudinal strain (-11.7 ± 4 % vs. -17.7 ± 1.9 %), and longitudinal strain rate (-0.7 ± 0.2 vs. -1.0 ± 0.1 s(-1)) (all P < .001). For diagnostic purposes, longitudinal strain had the greatest area under the curve, 0.93 (optimal cutoff value, -15.1 %; sensitivity, 78 %; specificity, 93 %). Future events were defined as cardiac death, heart transplant, placement of left ventricular assist device or implantable cardioverter-defibrillator, pulmonary edema-related respiratory failure, cardiogenic shock, and rehospitalization due to cardiac events. For every 1 % decline in longitudinal or circumferential strain, the hazard ratios (95 % CIs) were 1.26 (1.10-1.47) and 1.34 (1.14-1.63), respectively; for every 0.1 s(-1) decline in longitudinal or circumferential strain rate, the hazard ratios (95 % CIs) were 1.43 (1.09-1.89) and 1.52 (1.19-2.01), respectively (P < .01). Kaplan-Meier curve and log-rank test showed event-free survival significantly related to these 4 measurements. In acute myocarditis, left ventricular strain and strain rate may be promising diagnostic and prognostic tools, even in patients with preserved left ventricular ejection fraction. Most importantly, this imaging technique had a role in predicting deterioration and overall event-free survival.

Victor Novack - One of the best experts on this subject based on the ideXlab platform.

  • Detection of Myocardial Dysfunction in Septic Shock: A Speckle-Tracking Echocardiography Study.
    Anesthesia and analgesia, 2015
    Co-Authors: Sajid Shahul, Gaurav Gulati, Michele R. Hacker, Feroze Mahmood, Robert Canelli, Junaid Nizamuddin, Bilal Mahmood, Ariel Mueller, Brett A. Simon, Victor Novack
    Abstract:

    Patients with septic shock are at increased risk of myocardial dysfunction. However, the left ventricular ejection fraction (EF) typically remains preserved in septic shock. Strain measurement using Speckle-Tracking Echocardiography may quantify abnormalities in myocardial function not detected by conventional Echocardiography. To investigate whether septic shock results in greater strain changes than sepsis alone, we evaluated strain in patients with sepsis and septic shock.We prospectively identified 35 patients with septic shock and 15 with sepsis. These patients underwent serial transthoracic echocardiograms at enrollment and 24 hours later. Measurements included longitudinal, radial, and circumferential strain in addition to standard echocardiographic assessments of left ventricular function.Longitudinal strain worsened significantly over 24 hours in patients with septic shock (P < 0.0001) but did not change in patients with sepsis alone (P = 0.43). No significant changes in radial or circumferential strain or EF were observed in either group over the 24-hour measurement period. In patients with septic shock, the significant worsening in longitudinal strain persisted after adjustment for left ventricular end-diastolic volume and vasopressor use (P < 0.0001). In patients with sepsis, adjustment for left ventricular end-diastolic volume and vasopressor use did not alter the finding of no significant differences in longitudinal strain (P = 0.48) or EF (P = 0.96).In patients with septic shock, but not sepsis, myocardial strain imaging using Speckle-Tracking Echocardiography identified myocardial dysfunction in the absence of changes in EF. These data suggest that strain imaging may play a role in cardiovascular assessment during septic shock.

Pham Dang Hai - One of the best experts on this subject based on the ideXlab platform.

  • Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study.
    Critical care research and practice, 2020
    Co-Authors: Pham Dang Hai, Le Lan Phuong, Nguyen Manh Dung, Le Thi Viet Hoa, Van Quyen, Nguyen Xuan Chinh, Vu Duy Minh, Pham Nguyen Son
    Abstract:

    Introduction. Left ventricular dysfunction is quite common in septic shock. Speckle-Tracking Echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional Echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using Speckle-Tracking Echocardiography. Methods. From May 2017 to December 2018, patients aged ≥18 years admitted to the intensive care unit with the diagnosis of sepsis and septic shock based on the sepsis-3 definition were included. Patients with other causes of cardiac dysfunction were excluded. Transthoracic Echocardiography was performed for all the patients within 24 hours of diagnosis. Left ventricular systolic function was assessed using conventional Echocardiography and Speckle-Tracking Echocardiography. Results. Patients with septic shock (n = 90) (study group) and 37 matched patients with sepsis but no septic shock (control group) were included. Left ventricular ejection fraction (LVEF) by conventional Echocardiography showed no significant difference between two groups (58.2 ± 9.9 vs. 58.6 ± 8.3, ). The global longitudinal strain (GLS) by STE was significantly reduced in patients with septic shock compared with that in the control (−14.6 ± 3.3 vs. −17.1 ± 3.3, ). Based on the cutoff value of GLS ≥ −15% for the definition of subclinical left ventricular systolic dysfunction, this dysfunction was detected in 50 patients with septic shock (55.6%) and in 6 patients in the control group (16.2%) ( ). Conclusions. Speckle-Tracking Echocardiography can detect early subclinical left ventricular systolic dysfunction via the left ventricular global longitudinal strain compared with conventional echocardiographic parameters in patients with septic shock.

Jun Wang - One of the best experts on this subject based on the ideXlab platform.

  • GW24-e0656 Radial displacement by Speckle Tracking Echocardiography on locating the target coronary artery is much better compared to radial strain
    Heart, 2013
    Co-Authors: Zhao Hang, Xuedong Shen, Zhiqing Qiao, Jun Pu, Jun Wang, Ben He
    Abstract:

    Objectives The value of radial displacement (RD) by Speckle Tracking Echocardiography in locating target coronary artery disease has not been able to determine. We hypothesised that the myocardial RD by Speckle Tracking Echocardiography during rest status could be used in locating target coronary artery and would be better compared to radial strain (RS). Methods Study population composited of 31 patients with first ST elevated myocardial infarction after primary percutaneous coronary intervention (PCI). Men 26, mean age 63 ± 10 years. The time between onsets to treatment was 5.7 ± 2.0 hours. The lesion involved the left anterior descending artery (LAD) in 17 patients, left circumflex artery (LCX) in 4 patients and right coronary artery (RCA) 10 patients. Speckle Tracking Echocardiography was performed within 72 hours after PCI during rest status. Myocardial RDs and radial strain 17 myocardial segments were measured by an Echo-PAC computer workstation for automatic function imaging. Results The territorial coronary arteries had been successfully recanalised in all patients. The AUCs of RD to predict LAD, LCX and RCA were significantly greater compared to RS (0.85- 1.0 vs 0.6- 0.87 for LAD, 0.85–0.94 vs 0.79–0.81 for LCX and 0.86 vs 0.55). The sensitivity and specificity of RD in relative segments to predict LAD, LCX and RCA were higher compared to RS. The sensitivity and specificity of RD in anterior septum at the papillary muscle level and apical level to predict LAD were 100% and 93- 100%, respectively. The sensitivity and specificity of RD in inferior lateral wall at the basal level to predict LCX was 100% and 89%, respectively. The sensitivity and specificity of RD in inferior wall to predict RCA was 90% and 81%, respectively. Conclusions RD by Speckle Tracking Echocardiography is a novel index to locate target coronary artery and is much better compared to RS.

  • EVALUATION OF POST-SYSTOLIC INDEX BY Speckle-Tracking Echocardiography ON LOCATING THE TARGET CORONARY ARTERY
    Journal of the American College of Cardiology, 2013
    Co-Authors: Zhiqing Qiao, Xuedong Shen, Hang Zhao, Jun Wang
    Abstract:

    The value of post systolic index (PSI) by Speckle Tracking Echocardiography in locating target coronary artery disease has not been able to determine. Because of 30% of the normal myocardial segments with post systolic contractility, pathologic PSI only exists in patients with decreased systolic