The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
G Leyendecker - One of the best experts on this subject based on the ideXlab platform.
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utero tubal Sperm Transport and its impairment in endometriosis and adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Inka Wiegratz, Natascha Doebert, S Zangos, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
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Utero‐Tubal Sperm Transport and Its Impairment in Endometriosis and Adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Stephan Zangos, Inka Wiegratz, Natascha Doebert, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
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Oxytocin : a stimulator of directed Sperm Transport in humans
Reproductive biomedicine online, 2007Co-Authors: G Kunz, D Beil, P Huppert, G LeyendeckerAbstract:Rhythmic peristaltic contractions of the muscular wall of the non-pregnant uterus, as well as rapid Sperm Transport from the vagina to the Fallopian tubes, have long been documented by means of vaginal sonography and hysterosalpingoscintigraphy. Uterine peristaltic activity reaches a maximum before ovulation and is controlled via oestradiol secretion from the dominant follicle systemically and into the utero-ovarian countercurrent system; it is also enhanced by oxytocin. In this study, the effect of oxytocin and its receptor antagonist atosiban on uterine peristalsis and thus directed Sperm Transport during the mid and late follicular phases was examined. Atosiban did not show any effect either on frequency or on pattern of the peristaltic contractions. However, oxytocin significantly increased the rapid and directed Transport of radiolabelled particles representing Spermatozoa from the vagina into the Fallopian tube ipsilateral to the site of the dominant follicle (P = 0.02, 0.04 and 0.02 after 1, 16 and 32 min of documentation respectively). It seems reasonable to assume that oxytocin plays an important, although not critical, role in the mechanisms governing rapid Sperm ascension that, at least in humans, were developed to rapidly preserve an aliquot of Spermatozoa following intercourse.
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Sonographic evidence for the involvement of the utero-ovarian counter-current system in the ovarian control of directed uterine Sperm Transport
Human reproduction update, 1998Co-Authors: G Kunz, M. Herbertz, M. Noe, G LeyendeckerAbstract:Sperm Transport from the cervix into the tube is an important uterine function within the process of reproduction. This function is exerted by uterine peristalsis and is controlled by the dominant ovarian structure via a cascade of endocrine events. The uterine peristaltic activity involves only the stratum subvasculare of the myometrium, which exhibits a predominantly circular arrangement of muscular fibres that separate at the fundal level into the fibres of the cornua and continue into the circular muscles of the respective tubes. Since Spermatozoa are Transported preferentially into the tube ipsilateral to the dominant follicle, this asymmetric uterine function may be controlled by the ovary via direct effects utilizing the utero-ovarian counter-current system, in addition to the systemic circulation. To test this possibility the sonographic characteristics of the uterine vascular bed were studied during different phases of the menstrual cycle. Vaginal sonography with the measurement of Doppler flow characteristics of both uterine arteries and of the arterial anastomoses of the uterine and ovarian arteries (junctional vessels) in the cornual region of both sides of the uterus during the menstrual phase of regular-cycling women demonstrated significant lower resistance indices of the junctional vessels ipsilateral to the side of the dominant ovarian structure as compared with the corresponding arteries contralaterally. By the use of the perfusion mode technique, it could be observed that vascular perfusion of the fundal myometrium was significantly increased ipsilateral to the dominant follicle during the late follicular phase of the cycle. These results show that the endocrine control of the dominant ovarian structure over uterine function is not only exerted via the systemic circulation but also directly, most probably utilizing the utero-ovarian counter-current system.
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THE UTERINE PERISTALTIC PUMP Normal and Impeded Sperm Transport within the Female Genital Tract
Advances in experimental medicine and biology, 1997Co-Authors: G Kunz, D Beil, Deiniger H, A. Einspanier, G. Mall, G LeyendeckerAbstract:Abstract Rapid as well as sustained Sperm Transport from the cervical canal to the isthmical part of the fallopian tube is provided by cervico-fundal uterine peristaltic contractions that can be visualized by vaginal sonography. The peristaltic contractions increase in frequency and presumably also in intensity as the proliferative phase progresses. As shown by placement of labeled albumin macrospheres of Sperm size at the external cervical os and serial hysterosalpingoscintigraphy (HSSG) Sperm reach, following their vaginal deposition, the uterine cavity within minutes. In the early follicular phase a large proportion of the macrospheres remains at the site of application, while a smaller proportion enters the uterine cavity with even a smaller one reaching the isthmical part of the tubes. In the mid-follicular phase of the cycle with increased frequency and intensity of the uterine contractions the proportion of macrospheres entering the uterine cavity as well as the tubes has significantly increased. In the late follicular phase with maximum frequency and intensity of uterine peristalsis the proportion of macrospheres entering the tube increases further at the expense of those at the site of application as well as within the uterine cavity. The Transport of the macrospheres into the tube is preferentially directed into the tube ipsilateral to the dominant follicle, which becomes apparent in the mid-follicular phase as soon as a dominant follicle can be identified by ultrasound. Since the macrosphere are inert particles the directed Sperm Transport into the tube ipsilateral to the dominant follicle is not functionally related to a mechanism such as chemotaxis but is rather provided by uterine contraction of which the direction may be controlled by a specific myometrial architecture in combination with an asymmetric distribution of myometrial oestradiol receptors. Women with infertility and mostly mild endometriosis display on VSUP a uterine hyperperistalsis with nearly double the frequency of contractions during the early and mid- as well as midluteal phase in comparison to the fertile and healthy controls. During midcycle these women display a considerable uterine dysperistalsis in that the normally long and regular cervico-fundal contractions during this phase of the cycle have become more or less undirected and convulsive in character. Hyperperistalsis results in the Transport of inert particles from the cervix into the tubes within minutes already during the early follicular phase, and may therefore constitute the mechanical cause for the development of endometriosis in that it Transports detached endometrial cells and tissue fragments via the tubes into the peritoneal cavity. Moreover, dysperistalsis may contribute to the infertility in these patients since it results in a break down of Sperm Transport within the female genital tract.
G Kunz - One of the best experts on this subject based on the ideXlab platform.
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utero tubal Sperm Transport and its impairment in endometriosis and adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Inka Wiegratz, Natascha Doebert, S Zangos, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
-
Utero‐Tubal Sperm Transport and Its Impairment in Endometriosis and Adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Stephan Zangos, Inka Wiegratz, Natascha Doebert, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
-
Oxytocin : a stimulator of directed Sperm Transport in humans
Reproductive biomedicine online, 2007Co-Authors: G Kunz, D Beil, P Huppert, G LeyendeckerAbstract:Rhythmic peristaltic contractions of the muscular wall of the non-pregnant uterus, as well as rapid Sperm Transport from the vagina to the Fallopian tubes, have long been documented by means of vaginal sonography and hysterosalpingoscintigraphy. Uterine peristaltic activity reaches a maximum before ovulation and is controlled via oestradiol secretion from the dominant follicle systemically and into the utero-ovarian countercurrent system; it is also enhanced by oxytocin. In this study, the effect of oxytocin and its receptor antagonist atosiban on uterine peristalsis and thus directed Sperm Transport during the mid and late follicular phases was examined. Atosiban did not show any effect either on frequency or on pattern of the peristaltic contractions. However, oxytocin significantly increased the rapid and directed Transport of radiolabelled particles representing Spermatozoa from the vagina into the Fallopian tube ipsilateral to the site of the dominant follicle (P = 0.02, 0.04 and 0.02 after 1, 16 and 32 min of documentation respectively). It seems reasonable to assume that oxytocin plays an important, although not critical, role in the mechanisms governing rapid Sperm ascension that, at least in humans, were developed to rapidly preserve an aliquot of Spermatozoa following intercourse.
-
Sonographic evidence for the involvement of the utero-ovarian counter-current system in the ovarian control of directed uterine Sperm Transport
Human reproduction update, 1998Co-Authors: G Kunz, M. Herbertz, M. Noe, G LeyendeckerAbstract:Sperm Transport from the cervix into the tube is an important uterine function within the process of reproduction. This function is exerted by uterine peristalsis and is controlled by the dominant ovarian structure via a cascade of endocrine events. The uterine peristaltic activity involves only the stratum subvasculare of the myometrium, which exhibits a predominantly circular arrangement of muscular fibres that separate at the fundal level into the fibres of the cornua and continue into the circular muscles of the respective tubes. Since Spermatozoa are Transported preferentially into the tube ipsilateral to the dominant follicle, this asymmetric uterine function may be controlled by the ovary via direct effects utilizing the utero-ovarian counter-current system, in addition to the systemic circulation. To test this possibility the sonographic characteristics of the uterine vascular bed were studied during different phases of the menstrual cycle. Vaginal sonography with the measurement of Doppler flow characteristics of both uterine arteries and of the arterial anastomoses of the uterine and ovarian arteries (junctional vessels) in the cornual region of both sides of the uterus during the menstrual phase of regular-cycling women demonstrated significant lower resistance indices of the junctional vessels ipsilateral to the side of the dominant ovarian structure as compared with the corresponding arteries contralaterally. By the use of the perfusion mode technique, it could be observed that vascular perfusion of the fundal myometrium was significantly increased ipsilateral to the dominant follicle during the late follicular phase of the cycle. These results show that the endocrine control of the dominant ovarian structure over uterine function is not only exerted via the systemic circulation but also directly, most probably utilizing the utero-ovarian counter-current system.
-
THE UTERINE PERISTALTIC PUMP Normal and Impeded Sperm Transport within the Female Genital Tract
Advances in experimental medicine and biology, 1997Co-Authors: G Kunz, D Beil, Deiniger H, A. Einspanier, G. Mall, G LeyendeckerAbstract:Abstract Rapid as well as sustained Sperm Transport from the cervical canal to the isthmical part of the fallopian tube is provided by cervico-fundal uterine peristaltic contractions that can be visualized by vaginal sonography. The peristaltic contractions increase in frequency and presumably also in intensity as the proliferative phase progresses. As shown by placement of labeled albumin macrospheres of Sperm size at the external cervical os and serial hysterosalpingoscintigraphy (HSSG) Sperm reach, following their vaginal deposition, the uterine cavity within minutes. In the early follicular phase a large proportion of the macrospheres remains at the site of application, while a smaller proportion enters the uterine cavity with even a smaller one reaching the isthmical part of the tubes. In the mid-follicular phase of the cycle with increased frequency and intensity of the uterine contractions the proportion of macrospheres entering the uterine cavity as well as the tubes has significantly increased. In the late follicular phase with maximum frequency and intensity of uterine peristalsis the proportion of macrospheres entering the tube increases further at the expense of those at the site of application as well as within the uterine cavity. The Transport of the macrospheres into the tube is preferentially directed into the tube ipsilateral to the dominant follicle, which becomes apparent in the mid-follicular phase as soon as a dominant follicle can be identified by ultrasound. Since the macrosphere are inert particles the directed Sperm Transport into the tube ipsilateral to the dominant follicle is not functionally related to a mechanism such as chemotaxis but is rather provided by uterine contraction of which the direction may be controlled by a specific myometrial architecture in combination with an asymmetric distribution of myometrial oestradiol receptors. Women with infertility and mostly mild endometriosis display on VSUP a uterine hyperperistalsis with nearly double the frequency of contractions during the early and mid- as well as midluteal phase in comparison to the fertile and healthy controls. During midcycle these women display a considerable uterine dysperistalsis in that the normally long and regular cervico-fundal contractions during this phase of the cycle have become more or less undirected and convulsive in character. Hyperperistalsis results in the Transport of inert particles from the cervix into the tubes within minutes already during the early follicular phase, and may therefore constitute the mechanical cause for the development of endometriosis in that it Transports detached endometrial cells and tissue fragments via the tubes into the peritoneal cavity. Moreover, dysperistalsis may contribute to the infertility in these patients since it results in a break down of Sperm Transport within the female genital tract.
Stefan Kissler - One of the best experts on this subject based on the ideXlab platform.
-
utero tubal Sperm Transport and its impairment in endometriosis and adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Inka Wiegratz, Natascha Doebert, S Zangos, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
-
Utero‐Tubal Sperm Transport and Its Impairment in Endometriosis and Adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Stephan Zangos, Inka Wiegratz, Natascha Doebert, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
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impaired utero tubal Sperm Transport in adenomyosis and endometriosis a cause for infertility
International Congress Series, 2004Co-Authors: Stefan Kissler, J. Kohl, N. Hamscho, Manfred Kaufmann, Stephan Zangos, T. J. Vogl, F. Gruenwald, E. SiebzehnrueblAbstract:Abstract Background : Patients with minimal to mild endometriosis suffer from infertility. Hysterosalpingoscintigraphy (HSSG) is the only method to evaluate integrity of utero-tubal Sperm Transport capacity. Material and Methods : HSSG and magnetic resonance imaging (MRI) in the late follicular phase in 41 endometriosis patients were done to detect integrity of Sperm Transport by HSSG and adenomyosis by MRI of the uterus. Results : Eighty-five percent of patients reveal signs of adenomyosis when suffering from endometriosis. Hence, the percentage of a complete failure of Sperm Transport in adenomyosis (negative HSSG) is significantly increased, whereas Sperm Transport prevails in endometriosis when no signs of adenomyosis are detected. In diffuse adenomyosis, positive Sperm Transport can almost be excluded. Conclusions : Since adenomyosis and endometriosis show a high prevalence and Sperm Transport capacity is impaired especially in adenomyosis, the uterine component of the disease has to be regarded as the cause for infertility in minor to mild endometriosis.
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Uterine contractility and directed Sperm Transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurement.
Acta obstetricia et gynecologica Scandinavica, 2004Co-Authors: Stefan Kissler, E. Siebzehnruebl, J. Kohl, Anja Mueller, N. Hamscho, Regine Gaetje, Andre Ahr, Achim Rody, Manfred KaufmannAbstract:Background. Uterine peristalsis sustains Sperm Transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal Transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase. Methods. Twenty-one female subjects (mean age 28.4 years) without a gynecologic history were examined sequentially by HSSG and IUP on the same day to evaluate uterine contractility in relation to the utero-tubal Transport function. In HSSG, intact Transport function was visualized by the rapid uptake of 99 m -technetium-marked albumin aggregates through the female genital tract. In IUP, the frequency of uterine contractions (UC/min), amplitude of uterine contractions and basal pressure tone were detected via a intrauterine catheter. HSSG and IUP were embedded in cycle monitoring with measurement of LH and estradiol. Results. In HSSG, a positive Transport of inert particles wa...
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Uterine contractility and directed Sperm Transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurement.
Acta obstetricia et gynecologica Scandinavica, 2004Co-Authors: Stefan Kissler, E. Siebzehnruebl, J. Kohl, Anja Mueller, N. Hamscho, Regine Gaetje, Andre Ahr, Achim Rody, Manfred KaufmannAbstract:Uterine peristalsis sustains Sperm Transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal Transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase. Twenty-one female subjects (mean age 28.4 years) without a gynecologic history were examined sequentially by HSSG and IUP on the same day to evaluate uterine contractility in relation to the utero-tubal Transport function. In HSSG, intact Transport function was visualized by the rapid uptake of 99m-technetium-marked albumin aggregates through the female genital tract. In IUP, the frequency of uterine contractions (UC/min), amplitude of uterine contractions and basal pressure tone were detected via a intrauterine catheter. HSSG and IUP were embedded in cycle monitoring with measurement of LH and estradiol. In HSSG, a positive Transport of inert particles was assessed in 20 of 21 subjects, in 76% to the side of the dominant follicle or on both sides of the oviduct, and in 19% a strict contralateral Transport could be observed. In only one subject (5%), no Transport was assessed. The mean value of uterine contractions was 3.4 UC/min (SD +/- 0.7), the mean amplitude was 12.0 mmHg (SD +/- 4.25 mmHg). Basal pressure tone was 70.7 mmHg. There was a statistically significant correlation with estradiol levels: none of the subjects with less than 3 UC/min showed an estradiol level higher than 100 pg/mL; nearly every patient (one exception) with more than 3 UC/min had an estradiol level higher than 100 pg/mL (p < 0.0001, Fisher's exact test). Intact periovulatory utero-tubal Transport function can be documented by HSSG and is caused by directed uterine contractility, measured consecutively by IUP. Uterine contractility is influenced by rising estradiol levels. Directed uterine contractility and intact utero-tubal Transport function are considered necessary for intact Sperm Transport, mainly to the side bearing the dominant follicle to maximize fertility.
J. Kohl - One of the best experts on this subject based on the ideXlab platform.
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utero tubal Sperm Transport and its impairment in endometriosis and adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Inka Wiegratz, Natascha Doebert, S Zangos, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
-
Utero‐Tubal Sperm Transport and Its Impairment in Endometriosis and Adenomyosis
Annals of the New York Academy of Sciences, 2007Co-Authors: Stefan Kissler, G Kunz, L Wildt, J. Kohl, Regine Gaetje, Achim Rody, Stephan Zangos, Inka Wiegratz, Natascha Doebert, G LeyendeckerAbstract:The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, Sperm is Transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse (dyspareunia), and abnormal uterine bleeding. Besides, endometriosis is often associated with female infertility and exhibits a massive impairment in the physiology of uterine contractility that can be documented by the in vivo examination method of hysterosalpingoscintigraphy (HSSG). In addition, endometriosis is associated in 80-90% of subjects with adenomyosis and our data clearly indicate that Sperm Transport is disturbed by hyperperistalsis when at least one focus of adenomyosis can be detected via magnetic resonance imaging (MRI) and turns into dysperistalsis (a complete failure in Sperm Transport capacity) when diffuse adenomyosis affecting all myometrial uterine muscle layers is detected. Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup.
-
impaired utero tubal Sperm Transport in adenomyosis and endometriosis a cause for infertility
International Congress Series, 2004Co-Authors: Stefan Kissler, J. Kohl, N. Hamscho, Manfred Kaufmann, Stephan Zangos, T. J. Vogl, F. Gruenwald, E. SiebzehnrueblAbstract:Abstract Background : Patients with minimal to mild endometriosis suffer from infertility. Hysterosalpingoscintigraphy (HSSG) is the only method to evaluate integrity of utero-tubal Sperm Transport capacity. Material and Methods : HSSG and magnetic resonance imaging (MRI) in the late follicular phase in 41 endometriosis patients were done to detect integrity of Sperm Transport by HSSG and adenomyosis by MRI of the uterus. Results : Eighty-five percent of patients reveal signs of adenomyosis when suffering from endometriosis. Hence, the percentage of a complete failure of Sperm Transport in adenomyosis (negative HSSG) is significantly increased, whereas Sperm Transport prevails in endometriosis when no signs of adenomyosis are detected. In diffuse adenomyosis, positive Sperm Transport can almost be excluded. Conclusions : Since adenomyosis and endometriosis show a high prevalence and Sperm Transport capacity is impaired especially in adenomyosis, the uterine component of the disease has to be regarded as the cause for infertility in minor to mild endometriosis.
-
Uterine contractility and directed Sperm Transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurement.
Acta obstetricia et gynecologica Scandinavica, 2004Co-Authors: Stefan Kissler, E. Siebzehnruebl, J. Kohl, Anja Mueller, N. Hamscho, Regine Gaetje, Andre Ahr, Achim Rody, Manfred KaufmannAbstract:Background. Uterine peristalsis sustains Sperm Transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal Transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase. Methods. Twenty-one female subjects (mean age 28.4 years) without a gynecologic history were examined sequentially by HSSG and IUP on the same day to evaluate uterine contractility in relation to the utero-tubal Transport function. In HSSG, intact Transport function was visualized by the rapid uptake of 99 m -technetium-marked albumin aggregates through the female genital tract. In IUP, the frequency of uterine contractions (UC/min), amplitude of uterine contractions and basal pressure tone were detected via a intrauterine catheter. HSSG and IUP were embedded in cycle monitoring with measurement of LH and estradiol. Results. In HSSG, a positive Transport of inert particles wa...
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Uterine contractility and directed Sperm Transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurement.
Acta obstetricia et gynecologica Scandinavica, 2004Co-Authors: Stefan Kissler, E. Siebzehnruebl, J. Kohl, Anja Mueller, N. Hamscho, Regine Gaetje, Andre Ahr, Achim Rody, Manfred KaufmannAbstract:Uterine peristalsis sustains Sperm Transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal Transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase. Twenty-one female subjects (mean age 28.4 years) without a gynecologic history were examined sequentially by HSSG and IUP on the same day to evaluate uterine contractility in relation to the utero-tubal Transport function. In HSSG, intact Transport function was visualized by the rapid uptake of 99m-technetium-marked albumin aggregates through the female genital tract. In IUP, the frequency of uterine contractions (UC/min), amplitude of uterine contractions and basal pressure tone were detected via a intrauterine catheter. HSSG and IUP were embedded in cycle monitoring with measurement of LH and estradiol. In HSSG, a positive Transport of inert particles was assessed in 20 of 21 subjects, in 76% to the side of the dominant follicle or on both sides of the oviduct, and in 19% a strict contralateral Transport could be observed. In only one subject (5%), no Transport was assessed. The mean value of uterine contractions was 3.4 UC/min (SD +/- 0.7), the mean amplitude was 12.0 mmHg (SD +/- 4.25 mmHg). Basal pressure tone was 70.7 mmHg. There was a statistically significant correlation with estradiol levels: none of the subjects with less than 3 UC/min showed an estradiol level higher than 100 pg/mL; nearly every patient (one exception) with more than 3 UC/min had an estradiol level higher than 100 pg/mL (p < 0.0001, Fisher's exact test). Intact periovulatory utero-tubal Transport function can be documented by HSSG and is caused by directed uterine contractility, measured consecutively by IUP. Uterine contractility is influenced by rising estradiol levels. Directed uterine contractility and intact utero-tubal Transport function are considered necessary for intact Sperm Transport, mainly to the side bearing the dominant follicle to maximize fertility.
Manfred Kaufmann - One of the best experts on this subject based on the ideXlab platform.
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impaired utero tubal Sperm Transport in adenomyosis and endometriosis a cause for infertility
International Congress Series, 2004Co-Authors: Stefan Kissler, J. Kohl, N. Hamscho, Manfred Kaufmann, Stephan Zangos, T. J. Vogl, F. Gruenwald, E. SiebzehnrueblAbstract:Abstract Background : Patients with minimal to mild endometriosis suffer from infertility. Hysterosalpingoscintigraphy (HSSG) is the only method to evaluate integrity of utero-tubal Sperm Transport capacity. Material and Methods : HSSG and magnetic resonance imaging (MRI) in the late follicular phase in 41 endometriosis patients were done to detect integrity of Sperm Transport by HSSG and adenomyosis by MRI of the uterus. Results : Eighty-five percent of patients reveal signs of adenomyosis when suffering from endometriosis. Hence, the percentage of a complete failure of Sperm Transport in adenomyosis (negative HSSG) is significantly increased, whereas Sperm Transport prevails in endometriosis when no signs of adenomyosis are detected. In diffuse adenomyosis, positive Sperm Transport can almost be excluded. Conclusions : Since adenomyosis and endometriosis show a high prevalence and Sperm Transport capacity is impaired especially in adenomyosis, the uterine component of the disease has to be regarded as the cause for infertility in minor to mild endometriosis.
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Uterine contractility and directed Sperm Transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurement.
Acta obstetricia et gynecologica Scandinavica, 2004Co-Authors: Stefan Kissler, E. Siebzehnruebl, J. Kohl, Anja Mueller, N. Hamscho, Regine Gaetje, Andre Ahr, Achim Rody, Manfred KaufmannAbstract:Background. Uterine peristalsis sustains Sperm Transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal Transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase. Methods. Twenty-one female subjects (mean age 28.4 years) without a gynecologic history were examined sequentially by HSSG and IUP on the same day to evaluate uterine contractility in relation to the utero-tubal Transport function. In HSSG, intact Transport function was visualized by the rapid uptake of 99 m -technetium-marked albumin aggregates through the female genital tract. In IUP, the frequency of uterine contractions (UC/min), amplitude of uterine contractions and basal pressure tone were detected via a intrauterine catheter. HSSG and IUP were embedded in cycle monitoring with measurement of LH and estradiol. Results. In HSSG, a positive Transport of inert particles wa...
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Uterine contractility and directed Sperm Transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurement.
Acta obstetricia et gynecologica Scandinavica, 2004Co-Authors: Stefan Kissler, E. Siebzehnruebl, J. Kohl, Anja Mueller, N. Hamscho, Regine Gaetje, Andre Ahr, Achim Rody, Manfred KaufmannAbstract:Uterine peristalsis sustains Sperm Transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal Transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase. Twenty-one female subjects (mean age 28.4 years) without a gynecologic history were examined sequentially by HSSG and IUP on the same day to evaluate uterine contractility in relation to the utero-tubal Transport function. In HSSG, intact Transport function was visualized by the rapid uptake of 99m-technetium-marked albumin aggregates through the female genital tract. In IUP, the frequency of uterine contractions (UC/min), amplitude of uterine contractions and basal pressure tone were detected via a intrauterine catheter. HSSG and IUP were embedded in cycle monitoring with measurement of LH and estradiol. In HSSG, a positive Transport of inert particles was assessed in 20 of 21 subjects, in 76% to the side of the dominant follicle or on both sides of the oviduct, and in 19% a strict contralateral Transport could be observed. In only one subject (5%), no Transport was assessed. The mean value of uterine contractions was 3.4 UC/min (SD +/- 0.7), the mean amplitude was 12.0 mmHg (SD +/- 4.25 mmHg). Basal pressure tone was 70.7 mmHg. There was a statistically significant correlation with estradiol levels: none of the subjects with less than 3 UC/min showed an estradiol level higher than 100 pg/mL; nearly every patient (one exception) with more than 3 UC/min had an estradiol level higher than 100 pg/mL (p < 0.0001, Fisher's exact test). Intact periovulatory utero-tubal Transport function can be documented by HSSG and is caused by directed uterine contractility, measured consecutively by IUP. Uterine contractility is influenced by rising estradiol levels. Directed uterine contractility and intact utero-tubal Transport function are considered necessary for intact Sperm Transport, mainly to the side bearing the dominant follicle to maximize fertility.
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Impaired utero-tubal Sperm Transport in adenomyosis and endometriosis—a cause for infertility
International Congress Series, 2004Co-Authors: Stefan Kissler, J. Kohl, N. Hamscho, Manfred Kaufmann, Stephan Zangos, T. J. Vogl, F. Gruenwald, E. SiebzehnrueblAbstract:Abstract Background : Patients with minimal to mild endometriosis suffer from infertility. Hysterosalpingoscintigraphy (HSSG) is the only method to evaluate integrity of utero-tubal Sperm Transport capacity. Material and Methods : HSSG and magnetic resonance imaging (MRI) in the late follicular phase in 41 endometriosis patients were done to detect integrity of Sperm Transport by HSSG and adenomyosis by MRI of the uterus. Results : Eighty-five percent of patients reveal signs of adenomyosis when suffering from endometriosis. Hence, the percentage of a complete failure of Sperm Transport in adenomyosis (negative HSSG) is significantly increased, whereas Sperm Transport prevails in endometriosis when no signs of adenomyosis are detected. In diffuse adenomyosis, positive Sperm Transport can almost be excluded. Conclusions : Since adenomyosis and endometriosis show a high prevalence and Sperm Transport capacity is impaired especially in adenomyosis, the uterine component of the disease has to be regarded as the cause for infertility in minor to mild endometriosis.
