The Experts below are selected from a list of 342 Experts worldwide ranked by ideXlab platform
Ali Noorafshan - One of the best experts on this subject based on the ideXlab platform.
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AMELIORATIVE EFFECTS OF CURCUMIN ON THE Spermatozoon TAIL LENGTH, Count, MOTILITY AND TESTOSTERONE SERUM LEVEL IN METRONIDAZOLE-TREATED MICE
Prague medical report, 2011Co-Authors: Saied Karbalay-doust, Ali NoorafshanAbstract:Metronidazole (MTZ) is used as an antiparasitic drug. Curcumin is considered as anti-oxidant and anti-inflammatory agent. The ameliorative effects of curcumin on MTZ induced toxicity on mice Spermatozoon tail length, Count, motility and testosterone level were investigated. MTZ was administered in 500 and 165 (high and therapeutic doses) mg/kg/day, with and without curcumin (100 mg/kg/day). After 16 days the above parameters were assessed. Spermatozoon Count and motility and serum testosterone level MTZ-treated (500 and 165) mice were reduced. In the mice treated with MTZ+curcumin these parameters decreased but in a lesser extent than the MTZ-treated animals. Mid-piece and total lengths of the Spermatozoon tail in control animals were 31.6±9.0 µm and 100.3±15.0 µm and in the mice treated with high doses (500) of MTZ were reduced. The mid-piece and total Spermatozoon tail length has been decreased in a lesser extent in the mice treated with high dose MTZ+curcumin than the mice treated with high dose MTZ (p
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ameliorative effects of curcumin on the Spermatozoon tail length Count motility and testosterone serum level in metronidazole treated mice
Prague medical report, 2011Co-Authors: Saied Karbalaydoust, Ali NoorafshanAbstract:Metronidazole (MTZ) is used as an antiparasitic drug. Curcumin is considered as anti-oxidant and anti-inflammatory agent. The ameliorative effects of curcumin on MTZ induced toxicity on mice Spermatozoon tail length, Count, motility and testosterone level were investigated. MTZ was administered in 500 and 165 (high and therapeutic doses) mg/kg/day, with and without curcumin (100 mg/kg/day). After 16 days the above parameters were assessed. Spermatozoon Count and motility and serum testosterone level MTZ-treated (500 and 165) mice were reduced. In the mice treated with MTZ+curcumin these parameters decreased but in a lesser extent than the MTZ-treated animals. Mid-piece and total lengths of the Spermatozoon tail in control animals were 31.6 ± 9.0 μm and 100.3 ± 15.0 μm and in the mice treated with high doses (500) of MTZ were reduced. The mid-piece and total Spermatozoon tail length has been decreased in a lesser extent in the mice treated with high dose MTZ+curcumin than the mice treated with high dose MTZ (p<0.01). But the length was not changed in animals treated with therapeutic dose of MTZ. It means curcumin treated animals had ~52% and ~39% average increase in mid-piece and total lengths in comparison with the MTZ-treated (500) animals. Stereological estimation of the sperm tail length, including sampling of spermatozoa and also Counting of the intersections of their tails with the stereological grids was a rapid technique and took only 5-10 minutes. It can be concluded that curcumin has an ameliorative effect on the Spermatozoon, testosterone level and tail length in MTZ-treated mice.
Saied Karbalaydoust - One of the best experts on this subject based on the ideXlab platform.
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ameliorative effects of curcumin on the Spermatozoon tail length Count motility and testosterone serum level in metronidazole treated mice
Prague medical report, 2011Co-Authors: Saied Karbalaydoust, Ali NoorafshanAbstract:Metronidazole (MTZ) is used as an antiparasitic drug. Curcumin is considered as anti-oxidant and anti-inflammatory agent. The ameliorative effects of curcumin on MTZ induced toxicity on mice Spermatozoon tail length, Count, motility and testosterone level were investigated. MTZ was administered in 500 and 165 (high and therapeutic doses) mg/kg/day, with and without curcumin (100 mg/kg/day). After 16 days the above parameters were assessed. Spermatozoon Count and motility and serum testosterone level MTZ-treated (500 and 165) mice were reduced. In the mice treated with MTZ+curcumin these parameters decreased but in a lesser extent than the MTZ-treated animals. Mid-piece and total lengths of the Spermatozoon tail in control animals were 31.6 ± 9.0 μm and 100.3 ± 15.0 μm and in the mice treated with high doses (500) of MTZ were reduced. The mid-piece and total Spermatozoon tail length has been decreased in a lesser extent in the mice treated with high dose MTZ+curcumin than the mice treated with high dose MTZ (p<0.01). But the length was not changed in animals treated with therapeutic dose of MTZ. It means curcumin treated animals had ~52% and ~39% average increase in mid-piece and total lengths in comparison with the MTZ-treated (500) animals. Stereological estimation of the sperm tail length, including sampling of spermatozoa and also Counting of the intersections of their tails with the stereological grids was a rapid technique and took only 5-10 minutes. It can be concluded that curcumin has an ameliorative effect on the Spermatozoon, testosterone level and tail length in MTZ-treated mice.
Saied Karbalay-doust - One of the best experts on this subject based on the ideXlab platform.
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AMELIORATIVE EFFECTS OF CURCUMIN ON THE Spermatozoon TAIL LENGTH, Count, MOTILITY AND TESTOSTERONE SERUM LEVEL IN METRONIDAZOLE-TREATED MICE
Prague medical report, 2011Co-Authors: Saied Karbalay-doust, Ali NoorafshanAbstract:Metronidazole (MTZ) is used as an antiparasitic drug. Curcumin is considered as anti-oxidant and anti-inflammatory agent. The ameliorative effects of curcumin on MTZ induced toxicity on mice Spermatozoon tail length, Count, motility and testosterone level were investigated. MTZ was administered in 500 and 165 (high and therapeutic doses) mg/kg/day, with and without curcumin (100 mg/kg/day). After 16 days the above parameters were assessed. Spermatozoon Count and motility and serum testosterone level MTZ-treated (500 and 165) mice were reduced. In the mice treated with MTZ+curcumin these parameters decreased but in a lesser extent than the MTZ-treated animals. Mid-piece and total lengths of the Spermatozoon tail in control animals were 31.6±9.0 µm and 100.3±15.0 µm and in the mice treated with high doses (500) of MTZ were reduced. The mid-piece and total Spermatozoon tail length has been decreased in a lesser extent in the mice treated with high dose MTZ+curcumin than the mice treated with high dose MTZ (p
Ş. Güniz Küçükgüzel - One of the best experts on this subject based on the ideXlab platform.
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Effect of etodolac hydrazone, a new compound synthesised from etodolac, on Spermatozoon quality, testicular lipid peroxidation, apoptosis and Spermatozoon DNA integrity
Andrologia, 2015Co-Authors: Serpil Sarıözkan, P. Çıkla-süzgün, Fazile Canturk, Abdurrauf Yuce, Gaffari Turk, Mehmet Güvenç, Ş. Güniz KüçükgüzelAbstract:: The aim of this study was to investigate the effect of etodolac hydrazone (EH), a new compound synthesised from etodolac, on Spermatozoon quality, testicular lipid peroxidation, apoptosis and Spermatozoon DNA integrity in rats. Group 1 (n = 8) received 1 ml dimethyl sulfoxide (DMSO) daily (Control); group 2 (n = 8) was treated with 5 mg kg(-1) day(-1) EH, dissolved in 1 ml DMSO (EH-5); and group 3 (n = 8) was treated with 10 mg kg(-1) day(-1) EH, dissolved in 1 ml DMSO (EH-10). All administrations were performed by gavage and maintained for 8 weeks. Both doses of EH administration caused significant decreases in absolute and relative weights of testis, whole epididymis, right cauda epididymis, and Spermatozoon motility, Spermatozoon Count in comparison with the control group. Only 10 mg kg(-1) day(-1) EH administration caused significant decreases in absolute and relative weights of seminal vesicles and serum testosterone level, and significant increases in testicular lipid peroxidation level, and numbers of TUNEL+ apoptotic germ cells and spermatozoa with damaged DNA along with some histopathological damages when compared to the control group. However, body and ventral prostate weight, and testicular antioxidant markers (glutathione, glutathione-peroxidase and catalase), were unaffected significantly by both doses of EH administration. In conclusion, two different doses of EH, in particular its high dose, damage to testicular spermatogenic cells and Spermatozoon DNA and, it decreases Spermatozoon motility, Count and testosterone level in healthy rats.
Serpil Sarıözkan - One of the best experts on this subject based on the ideXlab platform.
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Effect of etodolac hydrazone, a new compound synthesised from etodolac, on Spermatozoon quality, testicular lipid peroxidation, apoptosis and Spermatozoon DNA integrity
Andrologia, 2015Co-Authors: Serpil Sarıözkan, P. Çıkla-süzgün, Fazile Canturk, Abdurrauf Yuce, Gaffari Turk, Mehmet Güvenç, Ş. Güniz KüçükgüzelAbstract:: The aim of this study was to investigate the effect of etodolac hydrazone (EH), a new compound synthesised from etodolac, on Spermatozoon quality, testicular lipid peroxidation, apoptosis and Spermatozoon DNA integrity in rats. Group 1 (n = 8) received 1 ml dimethyl sulfoxide (DMSO) daily (Control); group 2 (n = 8) was treated with 5 mg kg(-1) day(-1) EH, dissolved in 1 ml DMSO (EH-5); and group 3 (n = 8) was treated with 10 mg kg(-1) day(-1) EH, dissolved in 1 ml DMSO (EH-10). All administrations were performed by gavage and maintained for 8 weeks. Both doses of EH administration caused significant decreases in absolute and relative weights of testis, whole epididymis, right cauda epididymis, and Spermatozoon motility, Spermatozoon Count in comparison with the control group. Only 10 mg kg(-1) day(-1) EH administration caused significant decreases in absolute and relative weights of seminal vesicles and serum testosterone level, and significant increases in testicular lipid peroxidation level, and numbers of TUNEL+ apoptotic germ cells and spermatozoa with damaged DNA along with some histopathological damages when compared to the control group. However, body and ventral prostate weight, and testicular antioxidant markers (glutathione, glutathione-peroxidase and catalase), were unaffected significantly by both doses of EH administration. In conclusion, two different doses of EH, in particular its high dose, damage to testicular spermatogenic cells and Spermatozoon DNA and, it decreases Spermatozoon motility, Count and testosterone level in healthy rats.