The Experts below are selected from a list of 114 Experts worldwide ranked by ideXlab platform

Joseph M Croffie - One of the best experts on this subject based on the ideXlab platform.

  • quality of life in pediatric patients with unremitting constipation pre and post malone antegrade continence enema mace procedure
    Journal of Pediatric Surgery, 2013
    Co-Authors: Aileen F Har, Frederick J Rescorla, Joseph M Croffie
    Abstract:

    Abstract Objective The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure. Methods Patients, ages 5 to 18years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as Spinal Cord Disorders were excluded from the study. The patient's parent/guardian completed the PedsQL TM Generic Core Scales QOL survey prior to the operation, 6months, and 12months after the procedure. Results A total of 15 consecutive patients meeting protocol criteria were recruited within a period of 20months. The mean age at the MACE procedure was 9.8years (range 7.0–11.1). 5 patients were female. The mean QOL score pre-MACE was 64.1. At 6months post-MACE the mean overall QOL score was 90.2, and it was 92.0 at 12months. All 15 patients at the 6month follow up had significant improvement in their QOL (p=1.9×10 −7 ) and all subcategories of QOL were significantly improved as well. Conclusions A MACE procedure is of benefit to otherwise normal pediatric patients who have unremitting functional constipation with failure of medical treatment. Our patients had a significant improvement in all QOL categories and overall QOL.

  • quality of life in pediatric patients with unremitting constipation pre and post malone antegrade continence enema mace procedure
    Gastroenterology, 2011
    Co-Authors: Aileen F Har, Frederick J Rescorla, Joseph M Croffie
    Abstract:

    Objective: The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure. Methods: Patients, ages 5 to 18 years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as Spinal Cord Disorders were excluded from the study. The patient's parent/guardian completed the PedsQL TM Generic Core Scales QOL survey prior to the operation, 6 months, and 12 months after

Aileen F Har - One of the best experts on this subject based on the ideXlab platform.

  • quality of life in pediatric patients with unremitting constipation pre and post malone antegrade continence enema mace procedure
    Journal of Pediatric Surgery, 2013
    Co-Authors: Aileen F Har, Frederick J Rescorla, Joseph M Croffie
    Abstract:

    Abstract Objective The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure. Methods Patients, ages 5 to 18years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as Spinal Cord Disorders were excluded from the study. The patient's parent/guardian completed the PedsQL TM Generic Core Scales QOL survey prior to the operation, 6months, and 12months after the procedure. Results A total of 15 consecutive patients meeting protocol criteria were recruited within a period of 20months. The mean age at the MACE procedure was 9.8years (range 7.0–11.1). 5 patients were female. The mean QOL score pre-MACE was 64.1. At 6months post-MACE the mean overall QOL score was 90.2, and it was 92.0 at 12months. All 15 patients at the 6month follow up had significant improvement in their QOL (p=1.9×10 −7 ) and all subcategories of QOL were significantly improved as well. Conclusions A MACE procedure is of benefit to otherwise normal pediatric patients who have unremitting functional constipation with failure of medical treatment. Our patients had a significant improvement in all QOL categories and overall QOL.

  • quality of life in pediatric patients with unremitting constipation pre and post malone antegrade continence enema mace procedure
    Gastroenterology, 2011
    Co-Authors: Aileen F Har, Frederick J Rescorla, Joseph M Croffie
    Abstract:

    Objective: The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure. Methods: Patients, ages 5 to 18 years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as Spinal Cord Disorders were excluded from the study. The patient's parent/guardian completed the PedsQL TM Generic Core Scales QOL survey prior to the operation, 6 months, and 12 months after

Frederick J Rescorla - One of the best experts on this subject based on the ideXlab platform.

  • quality of life in pediatric patients with unremitting constipation pre and post malone antegrade continence enema mace procedure
    Journal of Pediatric Surgery, 2013
    Co-Authors: Aileen F Har, Frederick J Rescorla, Joseph M Croffie
    Abstract:

    Abstract Objective The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure. Methods Patients, ages 5 to 18years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as Spinal Cord Disorders were excluded from the study. The patient's parent/guardian completed the PedsQL TM Generic Core Scales QOL survey prior to the operation, 6months, and 12months after the procedure. Results A total of 15 consecutive patients meeting protocol criteria were recruited within a period of 20months. The mean age at the MACE procedure was 9.8years (range 7.0–11.1). 5 patients were female. The mean QOL score pre-MACE was 64.1. At 6months post-MACE the mean overall QOL score was 90.2, and it was 92.0 at 12months. All 15 patients at the 6month follow up had significant improvement in their QOL (p=1.9×10 −7 ) and all subcategories of QOL were significantly improved as well. Conclusions A MACE procedure is of benefit to otherwise normal pediatric patients who have unremitting functional constipation with failure of medical treatment. Our patients had a significant improvement in all QOL categories and overall QOL.

  • quality of life in pediatric patients with unremitting constipation pre and post malone antegrade continence enema mace procedure
    Gastroenterology, 2011
    Co-Authors: Aileen F Har, Frederick J Rescorla, Joseph M Croffie
    Abstract:

    Objective: The primary aim of this study was to determine if there is a change in the quality of life in pediatric patients with unremitting functional constipation and/or encopresis after undergoing a MACE procedure. Methods: Patients, ages 5 to 18 years with unremitting constipation and a normal evaluation, including anorectal manometry and colonic manometry, who opted to undergo a MACE procedure were contacted to participate in the study. Patients with congenital anorectal malformations as well as Spinal Cord Disorders were excluded from the study. The patient's parent/guardian completed the PedsQL TM Generic Core Scales QOL survey prior to the operation, 6 months, and 12 months after

Mark H Tuszynski - One of the best experts on this subject based on the ideXlab platform.

  • generation and post injury integration of human Spinal Cord neural stem cells
    Nature Methods, 2018
    Co-Authors: Hiromi Kumamaru, Ken Kadoya, Andrew F Adler, Yoshio Takashima, Lori Graham, Giovanni Coppola, Mark H Tuszynski
    Abstract:

    Spinal Cord neural stem cells (NSCs) have great potential to reconstitute damaged Spinal neural circuitry, but they have yet to be generated in vitro. We now report the derivation of Spinal Cord NSCs from human pluripotent stem cells (hPSCs). Our observations show that these Spinal Cord NSCs differentiate into a diverse population of Spinal Cord neurons occupying multiple positions along the dorso-ventral axis, and can be maintained for prolonged time periods. Grafts into injured Spinal Cords were rich with excitatory neurons, extended large numbers of axons over long distances, innervated their target structures, and enabled robust corticoSpinal regeneration. The grafts synaptically integrated into multiple host intraSpinal and supraSpinal systems, including the corticoSpinal projection, and improved functional outcomes after injury. hPSC-derived Spinal Cord NSCs could enable a broad range of biomedical applications for in vitro disease modeling and constitute an improved clinically translatable cell source for ‘replacement’ strategies in several Spinal Cord Disorders.

Shamik Bhattacharyya - One of the best experts on this subject based on the ideXlab platform.

  • Spinal Cord Disorders myelopathy
    The American Journal of Medicine, 2018
    Co-Authors: Shamik Bhattacharyya
    Abstract:

    Myelopathy is a clinical diagnosis based on symptoms and physical examination findings. Laboratories and imaging, particularly with magnetic resonance imaging, can suggest a cause. Compressive myelopathy from degenerative disease of the vertebral column is the most common cause of myelopathy in older adults and should be screened for first in most cases. There are many other causes of myelopathy, including infectious, immune-mediated, nutritional, vascular, and neoplastic etiologies.