The Experts below are selected from a list of 993 Experts worldwide ranked by ideXlab platform
Junichi Takanashi - One of the best experts on this subject based on the ideXlab platform.
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differences in the time course of Splenial and white matter lesions in clinically mild encephalitis encephalopathy with a reversible Splenial lesion mers
Journal of the Neurological Sciences, 2010Co-Authors: Junichi Takanashi, Atsushi Imamura, Fumio Hayakawa, Hitoshi TeradaAbstract:Two patients with clinically mild encephalitis/encephalopathy with a reversible Splenial lesion (MERS) exhibiting lesions in the white matter and entire corpus callosum (type 2) are reported. The time course differed between the Splenial lesion and other lesions in the white matter and corpus callosum other than the splenium; the latter disappeared earlier than the former. These findings strongly suggest that MERS type 2 resolves completely through MERS type 1 exhibiting an isolated Splenial lesion, and MERS types 1 and 2 have the same pathophysiology. The possible prior white matter lesions in patients with MERS type 1 may explain the neurological symptoms or EEG abnormalities.
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a Splenial lesion with transiently reduced diffusion in clinically mild encephalitis is not always reversible a case report
Brain & Development, 2009Co-Authors: Yuji Hashimoto, Junichi Takanashi, Keiko Kaiho, Katsunori Fujii, Toshiyuki Okubo, Setsuo Ota, Yoichi KohnoAbstract:The MR imaging finding of a reversible Splenial lesion with transiently reduced diffusion has been reported in patients with clinically mild encephalitis/encephalopathy, leading to a new clinical-radiological syndrome, clinically mild encephalitis/encephalopathy with a reversible Splenial lesion. We recently experienced a 3-year-old boy with clinically mild encephalitis with a Splenial lesion exhibiting transient reduced diffusion on admission. He recovered completely with no particular treatment within 2 weeks. Though the Splenial lesion decreased in size, it was detected for over 5 months in T2-weighted imaging. It is suggested that a Splenial lesion with transiently reduced diffusion in clinically mild encephalitis/encephalopathy is not always reversible, and could result in gliosis.
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delirious behavior in influenza is associated with a reversible Splenial lesion
Brain & Development, 2009Co-Authors: Junichi Takanashi, Hiroko Tada, Haruo Kuroki, James A BarkovichAbstract:Delirious behavior is one of the main clinical features in patients with clinically mild encephalitis/encephalopathy with a reversible Splenial lesion. On the other hand, it has been reported that more than 10% of patients with influenza in Japan develop delirious behavior. Magnetic resonance imaging (MRI) studies in patients with influenza-associated delirious behavior were examined to determine how often a reversible Splenial lesion is associated with this symptom. All patients who presented to Kameda Medical Center between November 2007 and March 2008 with delirious behavior associated with influenza were studied using MRI and EEG. Of the 370 patients with influenza, 11 had delirious behavior, lasting for less than 12 h. MRI revealed a reversible Splenial lesion with homogenously reduced diffusion in 5 patients. Transient EEG abnormalities (occipital slow waves during wakefulness) were observed in 4 of the 9 patients examined. A reversible Splenial lesion with reduced diffusion should be considered as an underlying condition in patients with delirious behavior associated with influenza.
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widening spectrum of a reversible Splenial lesion with transiently reduced diffusion
American Journal of Neuroradiology, 2006Co-Authors: Junichi Takanashi, Hiroko Tada, A J Barkovich, Takashi Shiihara, Masao Kawatani, Hirokazu Tsukahara, Masahiro Kikuchi, Masayuki MaedaAbstract:Four patients with encephalitis/encephalopathy and parenchymal lesions accompanying reversible Splenial lesions were retrospectively evaluated. In 3 patients, reversible lesions with transiently reduced diffusion were seen in the splenium and symmetrically in the peripheral frontoparietal white matter, clinical signs and symptoms were mild, and recovery was complete. These and previous observations suggest a less severe course and outcome for patients with reversible lesions isolated to the splenium or to the splenium and peripheral frontoparietal white matter.
Hitoshi Terada - One of the best experts on this subject based on the ideXlab platform.
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differences in the time course of Splenial and white matter lesions in clinically mild encephalitis encephalopathy with a reversible Splenial lesion mers
Journal of the Neurological Sciences, 2010Co-Authors: Junichi Takanashi, Atsushi Imamura, Fumio Hayakawa, Hitoshi TeradaAbstract:Two patients with clinically mild encephalitis/encephalopathy with a reversible Splenial lesion (MERS) exhibiting lesions in the white matter and entire corpus callosum (type 2) are reported. The time course differed between the Splenial lesion and other lesions in the white matter and corpus callosum other than the splenium; the latter disappeared earlier than the former. These findings strongly suggest that MERS type 2 resolves completely through MERS type 1 exhibiting an isolated Splenial lesion, and MERS types 1 and 2 have the same pathophysiology. The possible prior white matter lesions in patients with MERS type 1 may explain the neurological symptoms or EEG abnormalities.
Andrew J Prendergast - One of the best experts on this subject based on the ideXlab platform.
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rotavirus associated mild encephalopathy with a reversible Splenial lesion mers case report and review of the literature
BMC Infectious Diseases, 2015Co-Authors: Konstantinos Karampatsas, Christina Spyridou, Ian R Morrison, C Y W Tong, Andrew J PrendergastAbstract:Rotavirus is the most common cause of severe gastroenteritis in children under the age of 5 years worldwide. It is well recognised that rotavirus can cause signs and symptoms beyond the gastrointestinal tract, including neurological manifestations such as encephalopathy. Mild encephalopathy with a reversible Splenial lesion (MERS) is a clinico-radiological syndrome that has been associated with rotavirus. We report a case of a 4-year-old boy with clinically mild encephalopathy, who had an isolated Splenial lesion in the corpus callosum on neuroimaging, and rotavirus RNA detected in faeces. We use this case as an opportunity to review the literature on rotavirus-associated MERS. A previously healthy 4-year-old boy presented with a 2-day history of vomiting, diarrhoea, and fever, complicated by reduced level of consciousness. Magnetic resonance imaging of the brain showed a marked hyperintensity in the splenium of the corpus callosum on T2 and diffusion-weighted images. Rotavirus genome was detected by polymerase chain reaction in a stool specimen, but not in the cerebrospinal fluid. The genotype was identified as G1P8. His clinical condition improved with gradual resolution of his symptoms. No neurological complications were evident upon discharge and the patient had no recurring symptoms or significant residual defects when followed up 2 months later. MERS is a novel clinic-radiological syndrome first described in Japan. A transient Splenial lesion with reduced diffusion that appears as a high signal intensity in diffusion-weighted MRI is the main diagnostic feature. Rotavirus is one of the most common agents associated with MERS, although to our knowledge only one previous case has been reported from Europe. The majority of patients appear to achieve full recovery following rotavirus-associated MERS, irrespective of treatment. This case, together with other published reports, supports the hypothesis that rotavirus-associated MERS is unlikely to be the result of direct viral invasion of the CNS. It has been suggested that MERS may be caused by intra-myelinic axonal oedema or local inflammatory cell infiltration; however, the pathogenesis remains incompletely understood.
Yoichi Kohno - One of the best experts on this subject based on the ideXlab platform.
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a Splenial lesion with transiently reduced diffusion in clinically mild encephalitis is not always reversible a case report
Brain & Development, 2009Co-Authors: Yuji Hashimoto, Junichi Takanashi, Keiko Kaiho, Katsunori Fujii, Toshiyuki Okubo, Setsuo Ota, Yoichi KohnoAbstract:The MR imaging finding of a reversible Splenial lesion with transiently reduced diffusion has been reported in patients with clinically mild encephalitis/encephalopathy, leading to a new clinical-radiological syndrome, clinically mild encephalitis/encephalopathy with a reversible Splenial lesion. We recently experienced a 3-year-old boy with clinically mild encephalitis with a Splenial lesion exhibiting transient reduced diffusion on admission. He recovered completely with no particular treatment within 2 weeks. Though the Splenial lesion decreased in size, it was detected for over 5 months in T2-weighted imaging. It is suggested that a Splenial lesion with transiently reduced diffusion in clinically mild encephalitis/encephalopathy is not always reversible, and could result in gliosis.
Zhengyan Zhao - One of the best experts on this subject based on the ideXlab platform.
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mild encephalitis encephalopathy with a reversible Splenial lesion mers associated with bacteria meningitis caused by listeria monocytogenes a case report
Medicine, 2018Co-Authors: Feng Gao, Zhefeng Yuan, Lihua Jiang, Zhezhi Xia, Zhengyan ZhaoAbstract:Rationale Mild encephalitis/encephalopathy with a reversible Splenial lesion is a clinico-radiological syndrome mainly triggered by viral infection. Bacteria, like listeria monocytogenes, are relatively rare pathogens. Patient concerns A two and a half years old girl with a 3-day history of fever and vomiting, complicated by a sudden seizure. She was in a coma after seizure. Diagnoses Listeria monocytogenes was detected in cerebrospinal fluid cultures. Serum IL-6 remarkably elevated, and hyponatremia appeared on day 2 of hospitalization. Magnetic resonance imaging of the brain performed on day 3 of hospitalization showed right subdural effusion and a lesion in the central portion of the splenium of the corpus callosum. Interventions We administered antimicrobial therapy, intravenous mannitol and hypertonic fluid therapy. Outcomes Her neurological symptoms improved gradually. The lesion in the splenium of the corpus callosum completely disappeared on magnetic resonance imaging on day 10 of hospitalization. Lessons We diagnosed this case as mild encephalitis/encephalopathy with a reversible Splenial lesion caused by listeria monocytogenes. The patient recovered completely clinically and on imaging, without any specific immunomodulatory treatment. It also indicated IL-6 may play a role in the forms of hyponatremia in mild encephalitis/encephalopathy with a reversible Splenial lesion.
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mild encephalitis encephalopathy with a reversible Splenial lesion mers associated with bacteria meningitis caused by listeria monocytogenes a case report
Medicine, 2018Co-Authors: Jialu Xu, Zhefeng Yuan, Lihua Jiang, Zhengyan ZhaoAbstract:AbstractRationale:Mild encephalitis/encephalopathy with a reversible Splenial lesion is a clinico-radiological syndrome mainly triggered by viral infection. Bacteria, like listeria monocytogenes, are relatively rare pathogens.Patient concerns:A two and a half years old girl with a 3-day history of f
