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Xiguang Zhang - One of the best experts on this subject based on the ideXlab platform.
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a predatory bivalved euarthropod from the cambrian Stage 3 xiaoshiba lagerstatte south china
Scientific Reports, 2016Co-Authors: Jie Yang, Javier Ortegahernandez, Xiguang ZhangAbstract:Bivalved euarthropods represent a conspicuous component of exceptionally-preserved fossil biotas throughout the Lower Palaeozoic. However, most of these taxa are known from isolated valves and thus there is a limited understanding of their morphological organization and palaeoecology in the context of early animal-dominated communities. The bivalved euarthropod Clypecaris serrata sp. nov., recovered from the Cambrian (Stage 3) Hongjingshao Formation in Kunming, southern China, is characterized by having a robust first pair of raptorial appendages that bear well-developed ventral-facing spines, paired dorsal spines on the trunk and posteriorly oriented serrations on the anteroventral margins of both valves. The raptorial limbs of C. serrata were adapted for grasping prey employing a descending stroke for transporting it close the mouth, whereas the backwards-facing marginal serrations of the bivalved carapace may have helped to secure the food items during feeding. The new taxon offers novel insights on the morphology of the enigmatic genus Clypecaris and indicates that the possession of paired dorsal spines is a diagnostic trait of the Family Clypecarididae within upper stem-group Euarthropoda. C. serrata evinces functional adaptations for an active predatory lifestyle within the context of Cambrian bivalved euarthropods and contributes towards the better understanding of feeding diversity in early ecosystems.
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articulated wiwaxia from the cambrian Stage 3 xiaoshiba lagerstatte
Scientific Reports, 2015Co-Authors: Jie Yang, Martin R Smith, Xiguang ZhangAbstract:Wiwaxia is a bizarre metazoan that has been interpreted as a primitive mollusc and as a polychaete annelid worm. Extensive material from the Burgess Shale provides a detailed picture of its morphology and ontogeny, but the fossil record outside this lagerstatte is scarce, and complete wiwaxiids are particularly rare. Here we report small articulated specimens of Wiwaxia foliosa sp. nov. from the Xiaoshiba fauna (Cambrian Stage 3, Hongjingshao Formation, Kunming, south China). Although spines are absent, the fossils' sclerites – like those of W. corrugata – are symmetrically arranged in five distinct zones. They form rows across the body, and were individually added and shed throughout growth to retain an approximately symmetrical body shape. Their development pattern suggests a molluscan affinity. The basic body plan of wiwaxiids is fundamentally conserved across two continents through Cambrian Stages 3–5 – revealing morphological stasis in the wake of the Cambrian explosion.
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articulated wiwaxia from the cambrian Stage 3 xiaoshiba lagerstatte
Scientific Reports, 2015Co-Authors: Jie Yang, Martin R Smith, Xiguang ZhangAbstract:Wiwaxia is a bizarre metazoan that has been interpreted as a primitive mollusc and as a polychaete annelid worm. Extensive material from the Burgess Shale provides a detailed picture of its morphology and ontogeny, but the fossil record outside this lagerstatte is scarce, and complete wiwaxiids are particularly rare. Here we report small articulated specimens of Wiwaxia foliosa sp. nov. from the Xiaoshiba fauna (Cambrian Stage 3, Hongjingshao Formation, Kunming, south China). Although spines are absent, the fossils' sclerites – like those of W. corrugata – are symmetrically arranged in five distinct zones. They form rows across the body, and were individually added and shed throughout growth to retain an approximately symmetrical body shape. Their development pattern suggests a molluscan affinity. The basic body plan of wiwaxiids is fundamentally conserved across two continents through Cambrian Stages 3–5 – revealing morphological stasis in the wake of the Cambrian explosion.
Jie Yang - One of the best experts on this subject based on the ideXlab platform.
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a predatory bivalved euarthropod from the cambrian Stage 3 xiaoshiba lagerstatte south china
Scientific Reports, 2016Co-Authors: Jie Yang, Javier Ortegahernandez, Xiguang ZhangAbstract:Bivalved euarthropods represent a conspicuous component of exceptionally-preserved fossil biotas throughout the Lower Palaeozoic. However, most of these taxa are known from isolated valves and thus there is a limited understanding of their morphological organization and palaeoecology in the context of early animal-dominated communities. The bivalved euarthropod Clypecaris serrata sp. nov., recovered from the Cambrian (Stage 3) Hongjingshao Formation in Kunming, southern China, is characterized by having a robust first pair of raptorial appendages that bear well-developed ventral-facing spines, paired dorsal spines on the trunk and posteriorly oriented serrations on the anteroventral margins of both valves. The raptorial limbs of C. serrata were adapted for grasping prey employing a descending stroke for transporting it close the mouth, whereas the backwards-facing marginal serrations of the bivalved carapace may have helped to secure the food items during feeding. The new taxon offers novel insights on the morphology of the enigmatic genus Clypecaris and indicates that the possession of paired dorsal spines is a diagnostic trait of the Family Clypecarididae within upper stem-group Euarthropoda. C. serrata evinces functional adaptations for an active predatory lifestyle within the context of Cambrian bivalved euarthropods and contributes towards the better understanding of feeding diversity in early ecosystems.
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articulated wiwaxia from the cambrian Stage 3 xiaoshiba lagerstatte
Scientific Reports, 2015Co-Authors: Jie Yang, Martin R Smith, Xiguang ZhangAbstract:Wiwaxia is a bizarre metazoan that has been interpreted as a primitive mollusc and as a polychaete annelid worm. Extensive material from the Burgess Shale provides a detailed picture of its morphology and ontogeny, but the fossil record outside this lagerstatte is scarce, and complete wiwaxiids are particularly rare. Here we report small articulated specimens of Wiwaxia foliosa sp. nov. from the Xiaoshiba fauna (Cambrian Stage 3, Hongjingshao Formation, Kunming, south China). Although spines are absent, the fossils' sclerites – like those of W. corrugata – are symmetrically arranged in five distinct zones. They form rows across the body, and were individually added and shed throughout growth to retain an approximately symmetrical body shape. Their development pattern suggests a molluscan affinity. The basic body plan of wiwaxiids is fundamentally conserved across two continents through Cambrian Stages 3–5 – revealing morphological stasis in the wake of the Cambrian explosion.
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articulated wiwaxia from the cambrian Stage 3 xiaoshiba lagerstatte
Scientific Reports, 2015Co-Authors: Jie Yang, Martin R Smith, Xiguang ZhangAbstract:Wiwaxia is a bizarre metazoan that has been interpreted as a primitive mollusc and as a polychaete annelid worm. Extensive material from the Burgess Shale provides a detailed picture of its morphology and ontogeny, but the fossil record outside this lagerstatte is scarce, and complete wiwaxiids are particularly rare. Here we report small articulated specimens of Wiwaxia foliosa sp. nov. from the Xiaoshiba fauna (Cambrian Stage 3, Hongjingshao Formation, Kunming, south China). Although spines are absent, the fossils' sclerites – like those of W. corrugata – are symmetrically arranged in five distinct zones. They form rows across the body, and were individually added and shed throughout growth to retain an approximately symmetrical body shape. Their development pattern suggests a molluscan affinity. The basic body plan of wiwaxiids is fundamentally conserved across two continents through Cambrian Stages 3–5 – revealing morphological stasis in the wake of the Cambrian explosion.
Craig Russo - One of the best experts on this subject based on the ideXlab platform.
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prospective cohort study of nephrogenic systemic fibrosis in patients with Stage 3 5 chronic kidney disease undergoing mri with injected gadobenate dimeglumine or gadoteridol
American Journal of Roentgenology, 2015Co-Authors: Gilles Soulez, Desiree E Morgan, Franz J. Wippold, Martin P Smith, Daniel C Bloomgarden, Neil M Rofsky, Hani H Abujudeh, Richard J Lichtenstein, Mark L Schiebler, Craig RussoAbstract:OBJECTIVE. The purpose of this study was to determine the incidence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) and moderate-to-severe impairment of kidney function who had not previously been exposed to gadolinium-based contrast agents (GBCAs) or referred to undergo contrast-enhanced MRI with gadobenate dimeglumine or gadoteridol. SUBJECTS AND METHODS. Two multicenter prospective cohort studies evaluated the incidence of unconfounded NSF in patients with Stage 3 CKD (estimated glomerular filtration rate [eGFR] in cohort 1, 30–59 mL/min/1.73 m2) or Stage 4 or 5 CKD (eGFR in cohort 2, < 30 mL/min/1.73 m2) after injection of gadobenate dimeglumine (study A) or gadoteridol (study B). A third study (study C) determined the incidence of NSF in patients with Stage 4 or 5 CKD who had not received a GBCA in the 10 years before enrollment. Monitoring for signs and symptoms suggestive of NSF was performed via telephone at 1, 3, 6, and 18 months, with clinic visits occurring ...
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prospective cohort study of nephrogenic systemic fibrosis in patients with Stage 3 5 chronic kidney disease undergoing mri with injected gadobenate dimeglumine or gadoteridol
American Journal of Roentgenology, 2015Co-Authors: Gilles Soulez, Desiree E Morgan, Franz J. Wippold, Martin P Smith, Daniel C Bloomgarden, Neil M Rofsky, Hani H Abujudeh, Richard J Lichtenstein, Mark L Schiebler, Craig RussoAbstract:OBJECTIVE. The purpose of this study was to determine the incidence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) and moderate-to-severe impairment of kidney function who had not previously been exposed to gadolinium-based contrast agents (GBCAs) or referred to undergo contrast-enhanced MRI with gadobenate dimeglumine or gadoteridol. SUBJECTS AND METHODS. Two multicenter prospective cohort studies evaluated the incidence of unconfounded NSF in patients with Stage 3 CKD (estimated glomerular filtration rate [eGFR] in cohort 1, 30–59 mL/min/1.73 m2) or Stage 4 or 5 CKD (eGFR in cohort 2, < 30 mL/min/1.73 m2) after injection of gadobenate dimeglumine (study A) or gadoteridol (study B). A third study (study C) determined the incidence of NSF in patients with Stage 4 or 5 CKD who had not received a GBCA in the 10 years before enrollment. Monitoring for signs and symptoms suggestive of NSF was performed via telephone at 1, 3, 6, and 18 months, with clinic visits occurring ...
Anna K L Reyners - One of the best experts on this subject based on the ideXlab platform.
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engot ov44 first study a randomized double blind adaptive phase iii study of standard of care soc platinum based therapy dostarlimab followed by niraparib dostarlimab maintenance as first line 1l treatment of Stage 3 or 4 ovarian cancer oc
Journal of Clinical Oncology, 2020Co-Authors: Anneclaire Hardybessard, Kathleen N. Moore, Mansoor Raza Mirza, Diane Provencher, B Asselain, Andres Redondo, Jacobus Pfisterer, Sandro Pignata, D Cibula, Anna K L ReynersAbstract:TPS6101Background: Despite surgery and CT (paclitaxel + carboplatin ± bevacizumab [bev]), 5-year survival rates remain low for patients (pts) with FIGO Stage 3 or 4 OC. Niraparib is a poly (ADP-rib...
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engot ov44 first study a randomized double blind adaptive phase iii study of platinum based therapy with dostarlimab tsr 042 niraparib versus standard of care soc platinum based therapy as first line treatment of Stage 3 4 non mucinous epithelial ova
Journal of Clinical Oncology, 2019Co-Authors: Anneclaire Hardybessard, Kathleen N. Moore, Mansoor Raza Mirza, Diane Provencher, B Asselain, Andres Redondo, Jacobus Pfisterer, Sandro Pignata, D Cibula, Anna K L ReynersAbstract:TPS5600Background: Despite surgery and SOC therapy (paclitaxel and carboplatin ± bevacizumab[bev]), 5-year survival rates remain low for patients (pts) with FIGO Stage 3/4 OC. Niraparib (ZEJULA) is...
Ma Yao - One of the best experts on this subject based on the ideXlab platform.
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Ergocalciferol versus calcitriol for controlling chronic kidney disease mineral bone disorder in Stage 3 to 5 CKD: A randomized controlled trial
EUROPEAN JOURNAL OF PHARMACOLOGY, 2016Co-Authors: Zhang Dongliang, Yin Daoxin, Wang Liyan, Ma YaoAbstract:To compare the efficacy and safety of ergocalciferol and calcitriol in Stage 3 to 5 chronic kidney disease (CKD) patients, a randomized, prospective, controlled, open-labeled study was designed. 204 patients were enrolled into the present study with following-up duration of 33.2 +/- 3.8 months. Patients in Group VitD2 (n = 104) and Group aVitD3 (n = 100) were treated by ergocalciferol and calcitriol, respectively. The 25-hydroxyvitamin D levels of group VitD2 increased significantly from 15.14 +/- 7.46 to 3732 +/- 10.49 ng/ml (P < 0.001, t= - 19.692) and increased more (P < 0.001, t= - 14.982) than those of group aVitD3, which increased from 14.90 +/- 6.15 to 18.08 +/- 7.55 ng/ml. Maintenance target levels of serum calcium, phosphorus, and intact parathyroid hormone as the primary outcome measure did not show significant difference in frequencies between two groups. In summary, treatment of CKD-mineral and bone disorders in CKD patients at Stages 3 to 5 using ergocalciferol has a similar long-term efficacy and safety profile as calcitriol. (C) 2016 Elsevier B.V. All rights reserved.Beijing Natural Science Foundation [7132091]; Beijing Municipal Science and Technology Commission Funds [Z121107001012138]; Capital Health Research and Development Project [2011-2002-02]SCI(E)PubMedARTICLEzhangdongliang@pkuih.edu.cn127-13378
