The Experts below are selected from a list of 3759 Experts worldwide ranked by ideXlab platform
Kazuhiko Arimori - One of the best experts on this subject based on the ideXlab platform.
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potent inhibition by Star Fruit of human cytochrome p450 3a cyp3a activity
Drug Metabolism and Disposition, 2004Co-Authors: Muneaki Hidaka, Tetsuya Ogikubo, Tomomi Iwakiri, Hirofumi Kodama, Keishi Yamasaki, Kenichi Fujita, Manabu Okumura, Kazuhiko ArimoriAbstract:There has been very limited information on the capacities of tropical Fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical Fruits on midazolam 1′-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical Fruits such as common papaw, dragon Fruit, kiwi Fruit, mango, passion Fruit, pomegranate, rambutan, and Star Fruit were tested. We also examined the inhibition of CYP3A activity by grapeFruit (white) and Valencia orange as controls. The juice of Star Fruit showed the most potent inhibition of CYP3A. The addition of a Star Fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1′-hydroxylase activity (residual activity of 0.1%). In the case of grape-Fruit, the residual activity was 14.7%. The inhibition depended on the amount of Fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from Star Fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the Star Fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of Star Fruit juice to be inhibitors of human CYP3A activity in vitro.
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potent inhibition by Star Fruit of human cytochrome p450 3a cyp3a activity
Drug Metabolism and Disposition, 2004Co-Authors: Muneaki Hidaka, Tetsuya Ogikubo, Tomomi Iwakiri, Hirofumi Kodama, Keishi Yamasaki, Kenichi Fujita, Manabu Okumura, Kazuhiko ArimoriAbstract:There has been very limited information on the capacities of tropical Fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical Fruits on midazolam 1′-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical Fruits such as common papaw, dragon Fruit, kiwi Fruit, mango, passion Fruit, pomegranate, rambutan, and Star Fruit were tested. We also examined the inhibition of CYP3A activity by grapeFruit (white) and Valencia orange as controls. The juice of Star Fruit showed the most potent inhibition of CYP3A. The addition of a Star Fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1′-hydroxylase activity (residual activity of 0.1%). In the case of grape-Fruit, the residual activity was 14.7%. The inhibition depended on the amount of Fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from Star Fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the Star Fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of Star Fruit juice to be inhibitors of human CYP3A activity in vitro.
Haihui Xie - One of the best experts on this subject based on the ideXlab platform.
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carotenoid derived flavor precursors from averrhoa carambola fresh Fruit
Molecules, 2019Co-Authors: Xuchao Jia, Dan Yang, Yue Yang, Haihui XieAbstract:The Fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as Star Fruit or carambola, is popular in tropical and subtropical regions. Carotenoid-derived components, mainly C13- and C15-norisoprenoids, contribute greatly to the flavor of Star Fruit. Previously reported norisoprenoids were tentatively identified by GC-MS analysis after enzymatic hydrolysis. To gain accurate information about glycosidically bound flavor precursors in Star Fruit, a phytochemical study was conducted, which led to the isolation of 16 carotenoid derivatives—One new C13-norisoprenoid glucoside, (5R,6S,7E,9R)-5,6,9-trihydroxy-7-megastigmene 9-O-β-d-glucoside (1); one new C15-norisoprenoid, (6S,7E,10S)-Δ9,15-10-hydroxyabscisic alcohol (11); and 14 known ones, of which 12 were in glucoside form. The structures of the two new compounds were elucidated on the basis of extensive spectroscopic data analysis and chemical reaction. Compound 11 was a rare C15-norisoprenoid with a double bond between C-9 and C-15, and its possible biogenetic pathway was proposed. The known compounds were identified by comparison of their mass and nuclear magnetic resonance (NMR) data with those reported in the literature. The structure identification of one new (1) and seven known (3–7, 9, and 10) C13-norisoprenoid glucosides from the genus Averrhoa for the first time enriches the knowledge of carotenoid-derived flavor precursors in Star Fruit.
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Carotenoid-Derived Flavor Precursors from Averrhoa carambola Fresh Fruit
MDPI AG, 2019Co-Authors: Xuchao Jia, Dan Yang, Yue Yang, Haihui XieAbstract:The Fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as Star Fruit or carambola, is popular in tropical and subtropical regions. Carotenoid-derived components, mainly C13- and C15-norisoprenoids, contribute greatly to the flavor of Star Fruit. Previously reported norisoprenoids were tentatively identified by GC-MS analysis after enzymatic hydrolysis. To gain accurate information about glycosidically bound flavor precursors in Star Fruit, a phytochemical study was conducted, which led to the isolation of 16 carotenoid derivatives—One new C13-norisoprenoid glucoside, (5R,6S,7E,9R)-5,6,9-trihydroxy-7-megastigmene 9-O-β-d-glucoside (1); one new C15-norisoprenoid, (6S,7E,10S)-Δ9,15-10-hydroxyabscisic alcohol (11); and 14 known ones, of which 12 were in glucoside form. The structures of the two new compounds were elucidated on the basis of extensive spectroscopic data analysis and chemical reaction. Compound 11 was a rare C15-norisoprenoid with a double bond between C-9 and C-15, and its possible biogenetic pathway was proposed. The known compounds were identified by comparison of their mass and nuclear magnetic resonance (NMR) data with those reported in the literature. The structure identification of one new (1) and seven known (3–7, 9, and 10) C13-norisoprenoid glucosides from the genus Averrhoa for the first time enriches the knowledge of carotenoid-derived flavor precursors in Star Fruit
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flavonoids isolated from the fresh sweet Fruit of averrhoa carambola commonly known as Star Fruit
Phytochemistry, 2018Co-Authors: Xuchao Jia, Haihui Xie, Yueming Jiang, Xiaoyi WeiAbstract:Abstract Thirteen flavonoids were isolated from the fresh sweet Fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as Star Fruit, and their structures were determined by spectroscopic and chemical methods. 8-Carboxymethyl-(+)-epicatechin methyl ester, pinobanksin 3-O-β- d -glucoside, and carambolasides M–Q were undescribed structures. (+)-Epicatechin, aromadendrin 3-O-β- d -glucoside, helicioside A, taxifolin 3′-O-β- d -glucoside, galangin 3-O-rutinoside, and isorhamnetin 3-O-rutinoside were reported from this species for the first time. Pinobanksin 3-O-β- d -glucoside and carambolasides M–Q showed more potent 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activity (IC50 = 5.3–2.3 μM) than l -ascorbic acid (10.5 μM). Further, (+)-epicatechin, pinobanksin 3-O-β- d -glucoside, isorhamnetin 3-O-rutinoside, and carambolasides O–Q exhibited weak porcine pancreatic lipase inhibitory activity.
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Heptyl vicianoside and methyl caramboside from sour Star Fruit
2018Co-Authors: Dan Yang, Xuchao Jia, Haihui XieAbstract:Two new alkyl glycosides, heptyl vicianoside (1) and methyl 2-O-β-d-fucopyranosyl-α-l-arabinofuranoside (methyl caramboside, 4), were isolated from the sour Fruit of Averrhoa carambola L. (Oxalidaceae), along with octyl vicianoside (2), cis-3-hexenyl rutinoside (3), and methyl α-d-fructofuranoside (5). Their structures were determined by spectroscopic and chemical methods. Compounds 2, 3, and 5 were obtained from the genus Averrhoa for the first time. All the compounds were evaluated for in vitro α-glucosidase, pancreatic lipase, and acetylcholinesterase inhibitory activities, but none of them were potent.
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further dihydrochalcone c glycosides from the Fruit of averrhoa carambola
Lwt - Food Science and Technology, 2016Co-Authors: Dan Yang, Haihui Xie, Xuchao Jia, Xiaoyi WeiAbstract:Abstract Further study on the chemical constituents present in the Fruit of Averrhoa carambola L. (Oxalidaceae), commonly called Star Fruit or carambola, led to the isolation of six new dihydrochalcone C -glycosides, carambolasides E∼J ( 1 ∼ 6 ). Their structures were determined by spectroscopic and chemical methods, including low temperature nuclear magnetic resonance (NMR). Compounds 1 ∼ 6 and two alkaline hydrolysates, 5a and 6a , exhibited more potent 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical cation (ABTS + ) scavenging activity with IC 50 values ranging from 4.52 to 2.54 μM than l -ascorbic acid (14.21 μM). However, they were inactive in scavenging 1,1-diphenyl-2-picrylhydrazyl radical (DPPH ) and in ferric reducing antioxidant power (FRAP).
Muneaki Hidaka - One of the best experts on this subject based on the ideXlab platform.
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potent inhibition by Star Fruit of human cytochrome p450 3a cyp3a activity
Drug Metabolism and Disposition, 2004Co-Authors: Muneaki Hidaka, Tetsuya Ogikubo, Tomomi Iwakiri, Hirofumi Kodama, Keishi Yamasaki, Kenichi Fujita, Manabu Okumura, Kazuhiko ArimoriAbstract:There has been very limited information on the capacities of tropical Fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical Fruits on midazolam 1′-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical Fruits such as common papaw, dragon Fruit, kiwi Fruit, mango, passion Fruit, pomegranate, rambutan, and Star Fruit were tested. We also examined the inhibition of CYP3A activity by grapeFruit (white) and Valencia orange as controls. The juice of Star Fruit showed the most potent inhibition of CYP3A. The addition of a Star Fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1′-hydroxylase activity (residual activity of 0.1%). In the case of grape-Fruit, the residual activity was 14.7%. The inhibition depended on the amount of Fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from Star Fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the Star Fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of Star Fruit juice to be inhibitors of human CYP3A activity in vitro.
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potent inhibition by Star Fruit of human cytochrome p450 3a cyp3a activity
Drug Metabolism and Disposition, 2004Co-Authors: Muneaki Hidaka, Tetsuya Ogikubo, Tomomi Iwakiri, Hirofumi Kodama, Keishi Yamasaki, Kenichi Fujita, Manabu Okumura, Kazuhiko ArimoriAbstract:There has been very limited information on the capacities of tropical Fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical Fruits on midazolam 1′-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical Fruits such as common papaw, dragon Fruit, kiwi Fruit, mango, passion Fruit, pomegranate, rambutan, and Star Fruit were tested. We also examined the inhibition of CYP3A activity by grapeFruit (white) and Valencia orange as controls. The juice of Star Fruit showed the most potent inhibition of CYP3A. The addition of a Star Fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1′-hydroxylase activity (residual activity of 0.1%). In the case of grape-Fruit, the residual activity was 14.7%. The inhibition depended on the amount of Fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from Star Fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the Star Fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of Star Fruit juice to be inhibitors of human CYP3A activity in vitro.
Xuchao Jia - One of the best experts on this subject based on the ideXlab platform.
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carotenoid derived flavor precursors from averrhoa carambola fresh Fruit
Molecules, 2019Co-Authors: Xuchao Jia, Dan Yang, Yue Yang, Haihui XieAbstract:The Fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as Star Fruit or carambola, is popular in tropical and subtropical regions. Carotenoid-derived components, mainly C13- and C15-norisoprenoids, contribute greatly to the flavor of Star Fruit. Previously reported norisoprenoids were tentatively identified by GC-MS analysis after enzymatic hydrolysis. To gain accurate information about glycosidically bound flavor precursors in Star Fruit, a phytochemical study was conducted, which led to the isolation of 16 carotenoid derivatives—One new C13-norisoprenoid glucoside, (5R,6S,7E,9R)-5,6,9-trihydroxy-7-megastigmene 9-O-β-d-glucoside (1); one new C15-norisoprenoid, (6S,7E,10S)-Δ9,15-10-hydroxyabscisic alcohol (11); and 14 known ones, of which 12 were in glucoside form. The structures of the two new compounds were elucidated on the basis of extensive spectroscopic data analysis and chemical reaction. Compound 11 was a rare C15-norisoprenoid with a double bond between C-9 and C-15, and its possible biogenetic pathway was proposed. The known compounds were identified by comparison of their mass and nuclear magnetic resonance (NMR) data with those reported in the literature. The structure identification of one new (1) and seven known (3–7, 9, and 10) C13-norisoprenoid glucosides from the genus Averrhoa for the first time enriches the knowledge of carotenoid-derived flavor precursors in Star Fruit.
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Carotenoid-Derived Flavor Precursors from Averrhoa carambola Fresh Fruit
MDPI AG, 2019Co-Authors: Xuchao Jia, Dan Yang, Yue Yang, Haihui XieAbstract:The Fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as Star Fruit or carambola, is popular in tropical and subtropical regions. Carotenoid-derived components, mainly C13- and C15-norisoprenoids, contribute greatly to the flavor of Star Fruit. Previously reported norisoprenoids were tentatively identified by GC-MS analysis after enzymatic hydrolysis. To gain accurate information about glycosidically bound flavor precursors in Star Fruit, a phytochemical study was conducted, which led to the isolation of 16 carotenoid derivatives—One new C13-norisoprenoid glucoside, (5R,6S,7E,9R)-5,6,9-trihydroxy-7-megastigmene 9-O-β-d-glucoside (1); one new C15-norisoprenoid, (6S,7E,10S)-Δ9,15-10-hydroxyabscisic alcohol (11); and 14 known ones, of which 12 were in glucoside form. The structures of the two new compounds were elucidated on the basis of extensive spectroscopic data analysis and chemical reaction. Compound 11 was a rare C15-norisoprenoid with a double bond between C-9 and C-15, and its possible biogenetic pathway was proposed. The known compounds were identified by comparison of their mass and nuclear magnetic resonance (NMR) data with those reported in the literature. The structure identification of one new (1) and seven known (3–7, 9, and 10) C13-norisoprenoid glucosides from the genus Averrhoa for the first time enriches the knowledge of carotenoid-derived flavor precursors in Star Fruit
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flavonoids isolated from the fresh sweet Fruit of averrhoa carambola commonly known as Star Fruit
Phytochemistry, 2018Co-Authors: Xuchao Jia, Haihui Xie, Yueming Jiang, Xiaoyi WeiAbstract:Abstract Thirteen flavonoids were isolated from the fresh sweet Fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as Star Fruit, and their structures were determined by spectroscopic and chemical methods. 8-Carboxymethyl-(+)-epicatechin methyl ester, pinobanksin 3-O-β- d -glucoside, and carambolasides M–Q were undescribed structures. (+)-Epicatechin, aromadendrin 3-O-β- d -glucoside, helicioside A, taxifolin 3′-O-β- d -glucoside, galangin 3-O-rutinoside, and isorhamnetin 3-O-rutinoside were reported from this species for the first time. Pinobanksin 3-O-β- d -glucoside and carambolasides M–Q showed more potent 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activity (IC50 = 5.3–2.3 μM) than l -ascorbic acid (10.5 μM). Further, (+)-epicatechin, pinobanksin 3-O-β- d -glucoside, isorhamnetin 3-O-rutinoside, and carambolasides O–Q exhibited weak porcine pancreatic lipase inhibitory activity.
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Heptyl vicianoside and methyl caramboside from sour Star Fruit
2018Co-Authors: Dan Yang, Xuchao Jia, Haihui XieAbstract:Two new alkyl glycosides, heptyl vicianoside (1) and methyl 2-O-β-d-fucopyranosyl-α-l-arabinofuranoside (methyl caramboside, 4), were isolated from the sour Fruit of Averrhoa carambola L. (Oxalidaceae), along with octyl vicianoside (2), cis-3-hexenyl rutinoside (3), and methyl α-d-fructofuranoside (5). Their structures were determined by spectroscopic and chemical methods. Compounds 2, 3, and 5 were obtained from the genus Averrhoa for the first time. All the compounds were evaluated for in vitro α-glucosidase, pancreatic lipase, and acetylcholinesterase inhibitory activities, but none of them were potent.
-
further dihydrochalcone c glycosides from the Fruit of averrhoa carambola
Lwt - Food Science and Technology, 2016Co-Authors: Dan Yang, Haihui Xie, Xuchao Jia, Xiaoyi WeiAbstract:Abstract Further study on the chemical constituents present in the Fruit of Averrhoa carambola L. (Oxalidaceae), commonly called Star Fruit or carambola, led to the isolation of six new dihydrochalcone C -glycosides, carambolasides E∼J ( 1 ∼ 6 ). Their structures were determined by spectroscopic and chemical methods, including low temperature nuclear magnetic resonance (NMR). Compounds 1 ∼ 6 and two alkaline hydrolysates, 5a and 6a , exhibited more potent 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical cation (ABTS + ) scavenging activity with IC 50 values ranging from 4.52 to 2.54 μM than l -ascorbic acid (14.21 μM). However, they were inactive in scavenging 1,1-diphenyl-2-picrylhydrazyl radical (DPPH ) and in ferric reducing antioxidant power (FRAP).
Keishi Yamasaki - One of the best experts on this subject based on the ideXlab platform.
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potent inhibition by Star Fruit of human cytochrome p450 3a cyp3a activity
Drug Metabolism and Disposition, 2004Co-Authors: Muneaki Hidaka, Tetsuya Ogikubo, Tomomi Iwakiri, Hirofumi Kodama, Keishi Yamasaki, Kenichi Fujita, Manabu Okumura, Kazuhiko ArimoriAbstract:There has been very limited information on the capacities of tropical Fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical Fruits on midazolam 1′-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical Fruits such as common papaw, dragon Fruit, kiwi Fruit, mango, passion Fruit, pomegranate, rambutan, and Star Fruit were tested. We also examined the inhibition of CYP3A activity by grapeFruit (white) and Valencia orange as controls. The juice of Star Fruit showed the most potent inhibition of CYP3A. The addition of a Star Fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1′-hydroxylase activity (residual activity of 0.1%). In the case of grape-Fruit, the residual activity was 14.7%. The inhibition depended on the amount of Fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from Star Fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the Star Fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of Star Fruit juice to be inhibitors of human CYP3A activity in vitro.
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potent inhibition by Star Fruit of human cytochrome p450 3a cyp3a activity
Drug Metabolism and Disposition, 2004Co-Authors: Muneaki Hidaka, Tetsuya Ogikubo, Tomomi Iwakiri, Hirofumi Kodama, Keishi Yamasaki, Kenichi Fujita, Manabu Okumura, Kazuhiko ArimoriAbstract:There has been very limited information on the capacities of tropical Fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical Fruits on midazolam 1′-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical Fruits such as common papaw, dragon Fruit, kiwi Fruit, mango, passion Fruit, pomegranate, rambutan, and Star Fruit were tested. We also examined the inhibition of CYP3A activity by grapeFruit (white) and Valencia orange as controls. The juice of Star Fruit showed the most potent inhibition of CYP3A. The addition of a Star Fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1′-hydroxylase activity (residual activity of 0.1%). In the case of grape-Fruit, the residual activity was 14.7%. The inhibition depended on the amount of Fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from Star Fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the Star Fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of Star Fruit juice to be inhibitors of human CYP3A activity in vitro.
