The Experts below are selected from a list of 17856 Experts worldwide ranked by ideXlab platform
J Y Petit - One of the best experts on this subject based on the ideXlab platform.
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effects of tumour necrosis factor α synthesis inhibitors on rat trinitrobenzene Sulphonic Acid induced chronic colitis
European Journal of Pharmacology, 2001Co-Authors: Christine Bobindubigeon, Xavier Collin, Nicole Grimaud, Jeanmichel Robert, Guillaume Le Baut, J Y PetitAbstract:The fact that tumour necrosis factor-alpha (TNF-alpha) is clearly involved in the pathogenesis of intestinal bowel disease, especially Crohn's disease, suggests that TNF-alpha synthesis inhibitors could be beneficial for treatment. The present study assessed the effect of chronic oral gavage of two in vitro TNF-alpha synthesis inhibitors, JM 34 maleate or [N-(4,6-dimethylpyridin-2-yl)-furane-2-carboxamide)] maleate and XC 21 or (N-betapicolyl-tetrafluorophtalimide), on colonic inflammation in trinitrobenzene Sulphonic Acid-induced colitis in rats. Rats received JM 34 maleate (100 mg/kg) and XC 21 (50 mg/kg) 1 h before colitis induction and then daily for 8 days by oral gavage. The colon was removed on day 8 and processed for clinical score, myeloperoxidase activity, and soluble TNF-alpha release. Treatment with XC 21, as well as dexamethasone and sulphasalazine, reduced colonic damage and decreased (except with dexamethasone) the incidence of diarrhoea. JM 34 maleate failed to improve the clinical signs of chronic colitis. After trinitrobenzene Sulphonic Acid-induced colitis, myeloperoxidase activity and TNF-alpha colonic mucosal production were substantially increased compared to the control (saline instillation). Both of these inflammatory indicators were then significantly decreased (P< or =0.05) after the four chronic treatments (JM 34 maleate, XC 21, sulphasalazine, and dexamethasone). XC 21 appeared to be as efficient as sulphasalazine in improving colonic inflammation.
V Theodorou - One of the best experts on this subject based on the ideXlab platform.
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colonic responses to lactobacillus farciminis treatment in trinitrobenzene Sulphonic Acid induced colitis in rats
Scandinavian Journal of Gastroenterology, 2004Co-Authors: Florence Lamine, Helene Eutamene, Jean Fioramonti, L Bueno, V TheodorouAbstract:Background: It has recently been shown that Lactobacillus farciminis treatment exerts an anti-inflammatory effect in trinitrobenzene Sulphonic Acid (TNBS)-induced colitis partly through a nitric oxide release by this strain. The aim of this study was to evaluate whether L. farciminis treatment shares also the general mechanisms of action involved in the beneficial effect of probiotics in the colonic inflammatory process. Methods: Rats received L. farciminis for 15 days before and 4 days after intracolonic administration of TNBS or vehicle. The following parameters were evaluated: macroscopic damage of colonic mucosa, myeloperoxidase activity, cytokine mucosal levels, bacterial profile in colonic content and mucosa, bacterial translocation and colonic paracellular permeability. Results: In the absence of TNBS, L. farciminis treatment reduced colonic paracellular permeability and increased the IL-10 level in the colonic wall. TNBS administration induced colonic macroscopic damage, associated with an increas...
Yucel Aritas - One of the best experts on this subject based on the ideXlab platform.
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melatonin reduces bacterial translocation and apoptosis in trinitrobenzene Sulphonic Acid induced colitis of rats
World Journal of Gastroenterology, 2008Co-Authors: Alper Akcan, Can Kucuk, Erdogan Sozuer, Duygu Esel, Hizir Akyildiz, Hulya Akgun, Sabahattin Muhtaroglu, Yucel AritasAbstract:AIM: To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS: Rats were randomly assigned to three groups: groupI: control, group II: experimental colitis, group III: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-α, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced incidence of bacterial translocation to the liver, spleen, mesenteric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin significantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene Sulphonic Acid- treated rats (16.11 ± 2.46 vs 32.97 ± 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on bacterial translocation and apoptosis.
Annamraju Kasi Viswanath - One of the best experts on this subject based on the ideXlab platform.
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comparative studies of chemically synthesized polyaniline and poly o toluidine doped with p toluene Sulphonic Acid
European Polymer Journal, 2004Co-Authors: Milind V Kulkarni, Annamraju Kasi ViswanathAbstract:Abstract Polyaniline and poly( o -toluidine) doped with p -toluene Sulphonic Acid ( p -TSA) were synthesized by in situ chemical polymerization method using ammonium per sulphate as an oxidizing agent. This is a novel polymerization process for the direct synthesis of emeraldine salt phase of the polymer. The polymers were characterized by using UV–Vis and FT-IR spectroscopy, SEM, elemental analyzer, TGA/DSC and conductivity measurements. Thermal analysis shows that poly( o -toluidine) is less thermally stable compared to polyaniline. The less conductivity in poly( o -toluidine) is due to the cumulative steric as well as electronic effect of the bulky methyl substituent present on the benzene ring. High temperature conductivity measurements show ‘thermal activated behavior’.
Xinli Liang - One of the best experts on this subject based on the ideXlab platform.
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the protective and healing effects of si shen wan in trinitrobenzene Sulphonic Acid induced colitis
Journal of Ethnopharmacology, 2012Co-Authors: Duanyong Liu, Yongmei Guan, Haimei Zhao, Dongmei Yan, Wenting Tong, Panting Wan, Weifeng Zhu, Hongning Liu, Xinli LiangAbstract:Abstract Ethnopharmacological relevance Si Shen Wan is a traditional Chinese herbal medicine formula for the treatment of diseases with diarrhea, such as ulcerative colitis, allergic colitis and chronic colitis. To investigate the protective and healing effects of Si Shen Wan in the experimental colitis induced by trinitrobenzene Sulphonic Acid, and to furture explore its mechanism of action. Materials and methods Rats with colitis treated with Si Shen Wan for 10 days. Colon wet weight, colon organ coefficient, colonic damage score and pathological change after trinitrobenzene Sulphonic Acid challenge were determined. The levels of MPO, MDA, GSH-PX, SOD and the expression of IL-4 and IL-10 mRNA in the colon were also measured. Results After treatment, colon wet weight, colon organ coefficient and colonic damage score were lower than that in the control group (p Conclusions It is a potential path that protective effect of Si Shen Wan on impaired colonic mucosa rats with experimental colitis was accomplished by down-regulating the level of MDA and MPO, and up-regulating the level of SOD and the IL-4 and IL-10 mRNA expression in the colon mucosa.
