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Shaokang Guan - One of the best experts on this subject based on the ideXlab platform.

  • Enhanced in Vitro and in Vivo Performance of Mg-Zn-Y-Nd Alloy Achieved with APTES Pretreatment for Drug-Eluting Vascular Stent Application
    ACS Applied Materials and Interfaces, 2016
    Co-Authors: Jing Liu, Qiuping Shi, Ting Fei Xi, Xingang Wang, Pei Wang, Bo Zheng, Ming Chen, Bin Zhang, Shaokang Guan
    Abstract:

    Bioabsorbable magnesium alloys are becoming prominent as temporary functional implants, as they avoid the risks generated by permanent metallic implants such as persiStent inflammation and late restenosis. Nevertheless, the overfast corrosion of Mg alloys under physiological conditions hinders their wider Application as medical implant materials. Here we investigate a simple one-step process to introduce a cross-linked 3-amino-propyltrimethoxysilane (APTES) silane physical barrier layer on the surface of Mg–Zn–Y–Nd alloys prior to electrostatic spraying with rapamycin-eluting poly(lactic-co-glycolic acid) (PLGA) layer. Surface microstructure was characterized by scanning electron microscope and Fourier transform infrared spectroscopy. Nanoscratch test verified the superior adhesion strength of PLGA coating in the group pretreated with APTES. Electrochemical tests combined with long-term immersion results suggested that the preferable in vitro anticorrosion behavior could be achieved by dense APTES barrier...

  • multifunctional mgf2 polydopamine coating on mg alloy for vascular Stent Application
    Journal of Materials Science & Technology, 2015
    Co-Authors: Xiaoli Liu, Shaokang Guan, Yufeng Zheng, Jing Liu, Zhen Zhen, Yudong Zheng, Yan Cheng
    Abstract:

    Mg alloy is of great potential in the Application of vascular Stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation. Besides, in order to accelerate the re-endothelialization of Mg-based Stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells (ECs). To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg–Zn–Y‒Nd alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid (HF) then in dopamine tris–Hydrochloric acid (tris–HCl) solution. The coating was uniform and thin, which consisted of two layers—the upper was polydopamine (PDA) layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF-PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells (VSMCs), which was preferable for re-endothelialization. The results suggest that HF-PDA-treated Mg–Zn–Y‒Nd alloy has great potential in the Application of vascular Stent and the surface coating method is of great Application value in biodegradable Mg alloy Stent due to its simplicity and effectiveness.

  • Multifunctional MgF2/Polydopamine Coating on Mg Alloy for Vascular Stent Application
    Journal of Materials Science & Technology, 2015
    Co-Authors: Xiaoli Liu, Shaokang Guan, Yufeng Zheng, Jing Liu, Zhen Zhen, Yudong Zheng, Yan Cheng
    Abstract:

    Mg alloy is of great potential in the Application of vascular Stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation. Besides, in order to accelerate the re-endothelialization of Mg-based Stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells (ECs). To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg–Zn–Y‒Nd alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid (HF) then in dopamine tris–Hydrochloric acid (tris–HCl) solution. The coating was uniform and thin, which consisted of two layers—the upper was polydopamine (PDA) layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF-PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells (VSMCs), which was preferable for re-endothelialization. The results suggest that HF-PDA-treated Mg–Zn–Y‒Nd alloy has great potential in the Application of vascular Stent and the surface coating method is of great Application value in biodegradable Mg alloy Stent due to its simplicity and effectiveness.

  • Effect of different processings on mechanical property and corrosion behavior in simulated body fluid of Mg-Zn-Y-Nd alloy for cardiovascular Stent Application
    Frontiers of Materials Science, 2014
    Co-Authors: Shijie Zhu, Liguo Wang, Qian Liu, Ya-feng Qian, Bin Sun, Shaokang Guan
    Abstract:

    The biomagnesium alloys have been considered to be one of the most potential biodegradable metal materials due to its good mechanical compatibility, biological compatibility, biological security and biodegradable characteristics. However, the two major problems of high degradation rates in physiological environment and low mechanical properties prevent the development of biomagnesium alloys. In the present work, the samples of Mg-Zn-Y-Nd alloy were prepared by cyclic extrusion compression (CEC) and equal channel angular pressing (ECAP). The microstructures, mechanical properties of alloy and its corrosion behavior in simulated body fluid (SBF) were evaluated. The results reveal that Mg-Zn-Y-Nd alloy consists of equiaxial fine grain structure with the homogeneous distribution of micrometer size and nano-sized second phase, which was caused by the dynamic recrystallization during the ECAP and CEC. The corrosion resistance of alloy was improved. The tensile and corrosion resistance were improved, especially the processed alloy exhibit uniform corrosion performances and decreased corrosion rate. This will provide theoretical ground for Mg-Zn-Y-Nd alloy as vascular Stent Application.

  • Corrosion protection of Mg-Zn-Y-Nd alloy by flower-like nanostructured TiO2 film for vascular Stent Application
    Journal of Chemical Technology & Biotechnology, 2013
    Co-Authors: Shusen Hou, Shijie Zhu, Liguo Wang, Qi Ding, Shaokang Guan
    Abstract:

    BACKGROUND The high in vivo corrosion rate of magnesium alloy vascular Stents is a primary problem. Smooth TiO2 film has excellent antithrombotic properties and could improve the corrosion resistance of magnesium alloy Stents. Research into special nanostructured TiO2 film, which may provide improved biocompatibility and act as a drug carrier, has seldom been reported in vascular Stent Applications. RESULTS Flower-like nanostructured TiO2 film was prepared on Mg-Zn-Y-Nd alloy substrate by an improved solvothermal method. Aqueous NH4F solution and hydrofluoric acid were added to ethanol solvent to adjust the hydrolysis rate of titanium butoxide, and thus the TiO2 nanostructure size. This reaction system was suitable for magnesium alloy due to its non-corrosive characteristic. Under properly chosen hydrolysis conditions, compact TiO2 film consisting of continuous flower-like nanostructures was obtained on substrate, with single sheet thickness of 50–100 nm. The charge transfer resistance of Mg-Zn-Y-Nd alloy in simulated body fluids was increased about 40 times by the nanostructured TiO2 film. CONCLUSIONS Through a solvothermal synthesis process, nanostructured TiO2 film can be prepared on the surface of Mg-Zn-Y-Nd alloy. Corrosion resistance of Mg-Zn-Y-Nd alloy in simulated body fluids can be improved by protection with the TiO2 film. © 2013 Society of Chemical Industry

Prashant N. Kumta - One of the best experts on this subject based on the ideXlab platform.

  • Effect of lithium and aluminum on the mechanical properties, in vivo and in vitro degradation and toxicity of multi-phase ultra-high ductility Mg-Li-Al-Zn quaternary alloys for vascular Stent Application
    ACS Biomaterials Science & Engineering, 2020
    Co-Authors: Daoli Zhao, Z. Dong, Shauna Chen, William R Heineman, Boeun Lee, Abhijit Roy, Raymon Yao, Prashant N. Kumta
    Abstract:

    Magnesium alloys are the most widely studied biodegradable metals for biodegradable vascular Stent Application. Two major issues with current magnesium alloy based Stents are the low ductility and ...

  • A feasibility study of biodegradable magnesium-aluminum-zinc-calcium-manganese (AZXM) alloys for tracheal Stent Application.
    Journal of Biomaterials Applications, 2019
    Co-Authors: Boeun Lee, Partha Saha, Prashant N. Kumta
    Abstract:

    Airway obstruction conditions are relatively rarely observed in clinical settings but nevertheless, extremely challenging to handle, especially when observed in pediatric patients. Several surgical procedures, including tracheal resection, end-to-end tracheal anastomosis, and tracheoplasty, have been developed and practised of late, to treat airway obstruction. However, the clinical outcome is typically not satisfactory due to airway restenosis conditions that develop following surgery. Various types of Stents are currently available for airway Stenting ranging from non-degradable silicone tubes and bio-inert metallic Stents (bare or coated with polymer matrix) to hybrid silicone tubes strengthened by metallic cores, but none of the Stents provides the satisfactory long-term effectiveness. Therefore, there is a significant clinical need for a biodegradable airway Stent that would maintain airway patency and totally degrade over time after meeting the desired objectives. The present study aims to investigate biodegradable magnesium-aluminum-zinc-calcium-manganese (AZXM) alloy as a potential tracheal Stent. The new AZXM alloy was fabricated by partially replacing aliminum in commercial AZ31 alloy with calcium. The present study demonstrates that calcium preferentially segregates along the grain boundaries as intermetallic phases (Mg2Ca) and is homogeneously distributed in the magnesium matrix. The extruded AZXM alloy showed less pitting, higher corrosion resistance in Hank's Balanced Salt Solution (HBSS) compared to the as-cast and solution-treated AZXM alloys and exhibited optimized mechanical properties. In vitro cytotoxicity evaluation using human trachea epithelial cells demonstrated excellent cyto-compatibility of AZXM alloys compared to pure Mg and commercial AZ31 validated by a very preliminary rabbit in vivo tracheal model study. Preliminary results show that the approach to use biodegradable AZXM alloys as a tracheal Stent is indeed promising, although further alloy processing is required to improve the ductility needed followed by a more exhaustive in vivo study to demonstrate full viability for Stent Applications.

  • a feasibility study of biodegradable magnesium aluminum zinc calcium manganese azxm alloys for tracheal Stent Application
    Journal of Biomaterials Applications, 2019
    Co-Authors: Boeun Lee, Partha Saha, Prashant N. Kumta
    Abstract:

    Airway obstruction conditions are relatively rarely observed in clinical settings but nevertheless, extremely challenging to handle, especially when observed in pediatric patients. Several surgical...

  • in vitro and in vivo evaluation of multiphase ultrahigh ductility mg li zn alloys for cardiovascular Stent Application
    ACS Biomaterials Science & Engineering, 2017
    Co-Authors: Jingyao Wu, Z. Dong, John Ohodnicki, Shauna Chen, Daoli Zhao, William R Heineman, Prashant N. Kumta
    Abstract:

    Magnesium alloys have been extensively studied as a novel biodegradable metallic material for cardiovascular Stent Application. However, the ductility limitation of magnesium alloy has been a key issue for biodegradable Stents Applications. In this study, two different multiphase ultrahigh ductility Mg–Li–Zn alloys, LZ61 and LZ91, are fabricated in the form of extruded rods and evaluated both in vitro and in vivo. The microstructure, mechanical properties and in vitro degradation are evaluated as well as in vitro cytotoxicity. The in vivo degradation, tissue response, and systematic toxicity are evaluated in a mouse subcutaneous model. Measurements show that LZ61 and LZ91 exhibit more than 40% elongation at fracture without significantly compromising the strength. Both in vitro and in vivo degradation showed low degradation rates for LZ61 but high degradation rate for the LZ91 alloy. Excellent biocompatibility is observed both in vivo and in vitro for LZ61 and LZ91. In summary, this study successfully dem...

Rong Fan - One of the best experts on this subject based on the ideXlab platform.

  • A promising biodegradable magnesium alloy suitable for clinical vascular Stent Application
    Scientific Reports, 2017
    Co-Authors: Lin Mao, Xiaobo Zhang, Li Shen, Jiahui Chen, Minsuk Kwak, Rong Fan, Lei Zhang, Jia Pei, Guangyin Yuan
    Abstract:

    We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular Stent Application by integrating the advantages of traditional medical stainless steel and polymer. This alloy exhibits high yield strength and elongation of 276 ± 6 MPa and 34.3 ± 3.4% respectively. The JDBM-2 with a stable degradation surface results in a highly homogeneous degradation mechanism and long-term structural and mechanical durability. In vitro cytotoxicity test of the Mg extract via human vascular endothelial cells (HUVECs) indicates that the corrosion products are well tolerated by the tested cells and potentially negligible toxic effect on arterial vessel walls. This alloy also exhibits compromised foreign body response (FBR) determined by human peripheral blood derived macrophage adhesion, foreign body giant cell (FBGC) formation and inflammatory cytokine and chemokine secretion. Finally, vascular Stents manufactured from the JDBM-2 were implanted into rabbits for long-term evaluation. The results confirm excellent tissue compatibility and up to 6-month structural and mechanical integrity of the Stent in vivo. Thus, the JDBM-2 Stent with up to 6-month structural and mechanical integrity and excellent tissue compatibility represents a major breakthrough in this field and a promising alternative to traditional medical stainless steel and polymer for the clinical Application.

  • enhanced bioactivity of mg nd zn zr alloy achieved with nanoscale mgf2 surface for vascular Stent Application
    ACS Applied Materials & Interfaces, 2015
    Co-Authors: Lin Mao, Li Shen, Jiahui Chen, Minsuk Kwak, Rong Fan, Lei Zhang, Jia Pei, Guangyin Yuan, Qiong Xue
    Abstract:

    Magnesium (Mg) alloys have revolutionized the Application of temporary load-bearing implants as they meet both engineering and medical requirements. However, rapid degradation of Mg alloys under physiological conditions remains the major obstacle hindering the wider use of Mg-based implants. Here we developed a simple method of preparing a nanoscale MgF2 film on Mg–Nd–Zn–Zr (denoted as JDBM) alloy, aiming to reduce the corrosion rate as well as improve the biological response. The corrosion rate of JDBM alloy exposed to artificial plasma is reduced by ∼20% from 0.337 ± 0.021 to 0.269 ± 0.043 mm·y–1 due to the protective effect of the MgF2 film with a uniform and dense physical structure. The in vitro cytocompatibility test of MgF2-coated JDBM using human umbilical vein endothelial cells indicates enhanced viability, growth, and proliferation as compared to the naked substrate, and the MgF2 film with a nanoscale flakelike feature of ∼200–300 nm presents a much more favorable environment for endothelial cel...

Yan Cheng - One of the best experts on this subject based on the ideXlab platform.

  • in vitro and in vivo studies on two step alkali fluoride treated mg zn y nd alloy for vascular Stent Application enhancement in corrosion resistance and biocompatibility
    ACS Biomaterials Science & Engineering, 2019
    Co-Authors: Pei Wang, Jing Liu, Shi Shen, Xujiang Luo, Pan Xiong, Shuang Gao, Jianglong Yan, Yan Cheng
    Abstract:

    Bioabsorbable magnesium alloys are becoming prominent materials for cardiovascular Stents, as their desirable mechanical properties and favorable biosafety. However, the rapid corrosion of magnesium alloys under physiological conditions hinders their wider Application as medical implant materials. Fluoride chemical conversion treatment is an effective and simple technique to improve the corrosion resistance for magnesium alloys. Despite previous literature reporting on fluoride chemical conversion treatment with hydrofluoric acid (HF) in different conditions, some defects are still present on the surface of the coating. In this study, we report on a two-step alkali-fluoride treatment of magnesium alloy by effectively removing the second phase in the substrate surface and form a dense and flawless magnesium fluoride (MgF2) coating to endow the magnesium alloy greater corrosion resistance. The results showed that the serious pitting corrosion caused by galvanic corrosion could be effectively prevented after...

  • multifunctional mgf2 polydopamine coating on mg alloy for vascular Stent Application
    Journal of Materials Science & Technology, 2015
    Co-Authors: Xiaoli Liu, Shaokang Guan, Yufeng Zheng, Jing Liu, Zhen Zhen, Yudong Zheng, Yan Cheng
    Abstract:

    Mg alloy is of great potential in the Application of vascular Stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation. Besides, in order to accelerate the re-endothelialization of Mg-based Stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells (ECs). To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg–Zn–Y‒Nd alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid (HF) then in dopamine tris–Hydrochloric acid (tris–HCl) solution. The coating was uniform and thin, which consisted of two layers—the upper was polydopamine (PDA) layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF-PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells (VSMCs), which was preferable for re-endothelialization. The results suggest that HF-PDA-treated Mg–Zn–Y‒Nd alloy has great potential in the Application of vascular Stent and the surface coating method is of great Application value in biodegradable Mg alloy Stent due to its simplicity and effectiveness.

  • Multifunctional MgF2/Polydopamine Coating on Mg Alloy for Vascular Stent Application
    Journal of Materials Science & Technology, 2015
    Co-Authors: Xiaoli Liu, Shaokang Guan, Yufeng Zheng, Jing Liu, Zhen Zhen, Yudong Zheng, Yan Cheng
    Abstract:

    Mg alloy is of great potential in the Application of vascular Stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation. Besides, in order to accelerate the re-endothelialization of Mg-based Stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells (ECs). To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg–Zn–Y‒Nd alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid (HF) then in dopamine tris–Hydrochloric acid (tris–HCl) solution. The coating was uniform and thin, which consisted of two layers—the upper was polydopamine (PDA) layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF-PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells (VSMCs), which was preferable for re-endothelialization. The results suggest that HF-PDA-treated Mg–Zn–Y‒Nd alloy has great potential in the Application of vascular Stent and the surface coating method is of great Application value in biodegradable Mg alloy Stent due to its simplicity and effectiveness.

Jing Liu - One of the best experts on this subject based on the ideXlab platform.

  • in vitro and in vivo studies on two step alkali fluoride treated mg zn y nd alloy for vascular Stent Application enhancement in corrosion resistance and biocompatibility
    ACS Biomaterials Science & Engineering, 2019
    Co-Authors: Pei Wang, Jing Liu, Shi Shen, Xujiang Luo, Pan Xiong, Shuang Gao, Jianglong Yan, Yan Cheng
    Abstract:

    Bioabsorbable magnesium alloys are becoming prominent materials for cardiovascular Stents, as their desirable mechanical properties and favorable biosafety. However, the rapid corrosion of magnesium alloys under physiological conditions hinders their wider Application as medical implant materials. Fluoride chemical conversion treatment is an effective and simple technique to improve the corrosion resistance for magnesium alloys. Despite previous literature reporting on fluoride chemical conversion treatment with hydrofluoric acid (HF) in different conditions, some defects are still present on the surface of the coating. In this study, we report on a two-step alkali-fluoride treatment of magnesium alloy by effectively removing the second phase in the substrate surface and form a dense and flawless magnesium fluoride (MgF2) coating to endow the magnesium alloy greater corrosion resistance. The results showed that the serious pitting corrosion caused by galvanic corrosion could be effectively prevented after...

  • Enhanced in Vitro and in Vivo Performance of Mg-Zn-Y-Nd Alloy Achieved with APTES Pretreatment for Drug-Eluting Vascular Stent Application
    ACS Applied Materials and Interfaces, 2016
    Co-Authors: Jing Liu, Qiuping Shi, Ting Fei Xi, Xingang Wang, Pei Wang, Bo Zheng, Ming Chen, Bin Zhang, Shaokang Guan
    Abstract:

    Bioabsorbable magnesium alloys are becoming prominent as temporary functional implants, as they avoid the risks generated by permanent metallic implants such as persiStent inflammation and late restenosis. Nevertheless, the overfast corrosion of Mg alloys under physiological conditions hinders their wider Application as medical implant materials. Here we investigate a simple one-step process to introduce a cross-linked 3-amino-propyltrimethoxysilane (APTES) silane physical barrier layer on the surface of Mg–Zn–Y–Nd alloys prior to electrostatic spraying with rapamycin-eluting poly(lactic-co-glycolic acid) (PLGA) layer. Surface microstructure was characterized by scanning electron microscope and Fourier transform infrared spectroscopy. Nanoscratch test verified the superior adhesion strength of PLGA coating in the group pretreated with APTES. Electrochemical tests combined with long-term immersion results suggested that the preferable in vitro anticorrosion behavior could be achieved by dense APTES barrier...

  • multifunctional mgf2 polydopamine coating on mg alloy for vascular Stent Application
    Journal of Materials Science & Technology, 2015
    Co-Authors: Xiaoli Liu, Shaokang Guan, Yufeng Zheng, Jing Liu, Zhen Zhen, Yudong Zheng, Yan Cheng
    Abstract:

    Mg alloy is of great potential in the Application of vascular Stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation. Besides, in order to accelerate the re-endothelialization of Mg-based Stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells (ECs). To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg–Zn–Y‒Nd alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid (HF) then in dopamine tris–Hydrochloric acid (tris–HCl) solution. The coating was uniform and thin, which consisted of two layers—the upper was polydopamine (PDA) layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF-PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells (VSMCs), which was preferable for re-endothelialization. The results suggest that HF-PDA-treated Mg–Zn–Y‒Nd alloy has great potential in the Application of vascular Stent and the surface coating method is of great Application value in biodegradable Mg alloy Stent due to its simplicity and effectiveness.

  • Multifunctional MgF2/Polydopamine Coating on Mg Alloy for Vascular Stent Application
    Journal of Materials Science & Technology, 2015
    Co-Authors: Xiaoli Liu, Shaokang Guan, Yufeng Zheng, Jing Liu, Zhen Zhen, Yudong Zheng, Yan Cheng
    Abstract:

    Mg alloy is of great potential in the Application of vascular Stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation. Besides, in order to accelerate the re-endothelialization of Mg-based Stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells (ECs). To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg–Zn–Y‒Nd alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid (HF) then in dopamine tris–Hydrochloric acid (tris–HCl) solution. The coating was uniform and thin, which consisted of two layers—the upper was polydopamine (PDA) layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF-PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells (VSMCs), which was preferable for re-endothelialization. The results suggest that HF-PDA-treated Mg–Zn–Y‒Nd alloy has great potential in the Application of vascular Stent and the surface coating method is of great Application value in biodegradable Mg alloy Stent due to its simplicity and effectiveness.