The Experts below are selected from a list of 9843 Experts worldwide ranked by ideXlab platform
Sergio Paoletti - One of the best experts on this subject based on the ideXlab platform.
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terminal Sterilization of bisgma tegdma thermoset materials and their bioactive surfaces by supercritical co2
Biomacromolecules, 2012Co-Authors: Ivan Donati, Monica Benincasa, Mariepierre Foulc, Gianluca Turco, Dario Solinas, Ireneo Kikic, Mila Toppazzini, Sara Spilimbergo, Sergio PaolettiAbstract:The development of biomaterials endowed with bioactive features relies on a simultaneous insight into a proper terminal Sterilization Process. FDA recommendations on sterility of biomaterials are very strict: a sterility assurance level (SAL) of 10–6 must be guaranteed for biomaterials to be used in human implants. In the present work, we have explored the potential of supercritical CO2 (scCO2) in the presence of H2O2 as a low-temperature Sterilization Process for thermoset materials and their bioactive surfaces. Different conditions allowing for terminal Sterilization have been screened and a treatment time–amount of H2O2 relationship proposed. The selected terminal Sterilization conditions did not notably modify the mechanical properties of the thermoset nor of their fiber-reinforced composites. This was confirmed by μCT analyses performed prior to and after the treatment. On the contrary, terminal Sterilization in the presence of H2O2 induced a slight decrease in the surface hardness. The treatment of ...
Patricia Antonoplos - One of the best experts on this subject based on the ideXlab platform.
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Inactivation of human immunodeficiency virus type 1, hepatitis A virus, respiratory syncytial virus, vaccinia virus, herpes simplex virus type 1, and poliovirus type 2 by hydrogen peroxide gas plasma Sterilization
American Journal of Infection Control, 1998Co-Authors: C Roberts, Patricia AntonoplosAbstract:Background: Studies were conducted to determine the capability of a hydrogen peroxide gas plasma Sterilization Process to inactivate several types of viruses. Six test agents were used: HIV type 1, human hepatitis A virus, respiratory syncytial virus, vaccinia, herpes simplex virus type 1, and poliovirus type 2. Methods: The test viruses were suspended in cell culture medium and dried on the bottom of sterile glass petri dishes. The inoculated dishes were Processed in the hydrogen peroxide gas plasma system for half the normal Sterilization cycle time. Four inoculated carriers for each virus were used in two separate half cycles. Infectivity of the test viruses and cytotoxicity to the indicator cell lines were assayed. Results: The hydrogen peroxide gas plasma Sterilization Process produced inactivation of the six viral test agents under these experimental conditions. The reduction in viral titers ranged from 2.5 log10to 5.5 log10, a 99.68% to 99.999% decrease. Conclusions: These results clearly demonstrate the virucidal effectiveness of the hydrogen peroxide gas plasma Sterilization Process against both lipid and nonlipid viruses.
Ivan Donati - One of the best experts on this subject based on the ideXlab platform.
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terminal Sterilization of bisgma tegdma thermoset materials and their bioactive surfaces by supercritical co2
Biomacromolecules, 2012Co-Authors: Ivan Donati, Monica Benincasa, Mariepierre Foulc, Gianluca Turco, Dario Solinas, Ireneo Kikic, Mila Toppazzini, Sara Spilimbergo, Sergio PaolettiAbstract:The development of biomaterials endowed with bioactive features relies on a simultaneous insight into a proper terminal Sterilization Process. FDA recommendations on sterility of biomaterials are very strict: a sterility assurance level (SAL) of 10–6 must be guaranteed for biomaterials to be used in human implants. In the present work, we have explored the potential of supercritical CO2 (scCO2) in the presence of H2O2 as a low-temperature Sterilization Process for thermoset materials and their bioactive surfaces. Different conditions allowing for terminal Sterilization have been screened and a treatment time–amount of H2O2 relationship proposed. The selected terminal Sterilization conditions did not notably modify the mechanical properties of the thermoset nor of their fiber-reinforced composites. This was confirmed by μCT analyses performed prior to and after the treatment. On the contrary, terminal Sterilization in the presence of H2O2 induced a slight decrease in the surface hardness. The treatment of ...
Christopher J Doona - One of the best experts on this subject based on the ideXlab platform.
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electromagnetics heat transfer and thermokinetics in microwave Sterilization
Aiche Journal, 2001Co-Authors: Hua Zhang, Ashim K Datta, I A Taub, Christopher J DoonaAbstract:Sterilization of solid foods using microwave power was studied using numerical modeling and specialized experimental verification. Maxwell's equations and the heat conduction equation were coupled using two separate finite-element programs and specially written modules to couple the programs. Spatial distributions of thermal-time, representing Sterilization, were calculated from time-temperature history and first-order kinetics. Experimentally, concentrations of marker compounds formed during heating were measured and taken as indices of thermal-time. Experimental data on marker formation combined with numerical calculations provide an accurate and comprehensive picture of the Sterilization Process and represent a major step in establishing the efficacy of microwave Sterilization Processing. Unlike conventional Sterilization, heating patterns can change qualitatively with geometry (shape and size) and properties (composition) of the food material, but optimal heating is possible by choosing suitable combinations of these factors. Combined with marker yield measurements, the numerical model can give comprehensive descriptions of the spatial time-temperature history, and thus can be used to verify the Sterilization Process.
C Roberts - One of the best experts on this subject based on the ideXlab platform.
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Inactivation of human immunodeficiency virus type 1, hepatitis A virus, respiratory syncytial virus, vaccinia virus, herpes simplex virus type 1, and poliovirus type 2 by hydrogen peroxide gas plasma Sterilization
American Journal of Infection Control, 1998Co-Authors: C Roberts, Patricia AntonoplosAbstract:Background: Studies were conducted to determine the capability of a hydrogen peroxide gas plasma Sterilization Process to inactivate several types of viruses. Six test agents were used: HIV type 1, human hepatitis A virus, respiratory syncytial virus, vaccinia, herpes simplex virus type 1, and poliovirus type 2. Methods: The test viruses were suspended in cell culture medium and dried on the bottom of sterile glass petri dishes. The inoculated dishes were Processed in the hydrogen peroxide gas plasma system for half the normal Sterilization cycle time. Four inoculated carriers for each virus were used in two separate half cycles. Infectivity of the test viruses and cytotoxicity to the indicator cell lines were assayed. Results: The hydrogen peroxide gas plasma Sterilization Process produced inactivation of the six viral test agents under these experimental conditions. The reduction in viral titers ranged from 2.5 log10to 5.5 log10, a 99.68% to 99.999% decrease. Conclusions: These results clearly demonstrate the virucidal effectiveness of the hydrogen peroxide gas plasma Sterilization Process against both lipid and nonlipid viruses.