The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Bradley J Catalone - One of the best experts on this subject based on the ideXlab platform.
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elevating the standard of endoscope processing terminal sterilization of duodenoscopes using a hydrogen peroxide ozone sterilizer
American Journal of Infection Control, 2019Co-Authors: Vanessa Molloysimard, Jeanluc Lemyre, Karine Martel, Bradley J CataloneAbstract:Background The health care community is increasingly aware of the processing challenges and infection risks associated with duodenoscopes owing to published reports of outbreaks and regulatory recalls. Studies have demonstrated that the current practices are inadequate for consistently producing patient-ready endoscopes. Alternatively, terminal sterilization would offer a greater margin of safety and potentially reduce the risk of patient infection. The purpose of this study was to evaluate the efficacy of a hydrogen peroxide–ozone sterilizer with regulatory clearance for terminal sterilization of duodenoscopes. Methods and Results Validation studies were performed under laboratory simulated-use and clinical in-use conditions. The overkill method study demonstrated a reduction of at least 6-log of Geobacillus stearothermophilus spores at half-cycle, providing a sterility assurance level of 10−6. In addition, the sterilizer achieved a 6-log reduction of G stearothermophilus in the presence of inorganic and organic soils in a simulated-use study. The clinical in-use study confirmed that the sterilizer achieved sterilization of patient-soiled duodenoscopes under actual use conditions. Conclusions Simulated-use and clinical in-use studies demonstrated the efficacy of a hydrogen peroxide–ozone sterilizer for terminal sterilization of duodenoscopes. This offers health care facilities a viable alternative for duodenoscope processing to enhance patient safety as part of a comprehensive infection control strategy.
Vanessa Molloysimard - One of the best experts on this subject based on the ideXlab platform.
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elevating the standard of endoscope processing terminal sterilization of duodenoscopes using a hydrogen peroxide ozone sterilizer
American Journal of Infection Control, 2019Co-Authors: Vanessa Molloysimard, Jeanluc Lemyre, Karine Martel, Bradley J CataloneAbstract:Background The health care community is increasingly aware of the processing challenges and infection risks associated with duodenoscopes owing to published reports of outbreaks and regulatory recalls. Studies have demonstrated that the current practices are inadequate for consistently producing patient-ready endoscopes. Alternatively, terminal sterilization would offer a greater margin of safety and potentially reduce the risk of patient infection. The purpose of this study was to evaluate the efficacy of a hydrogen peroxide–ozone sterilizer with regulatory clearance for terminal sterilization of duodenoscopes. Methods and Results Validation studies were performed under laboratory simulated-use and clinical in-use conditions. The overkill method study demonstrated a reduction of at least 6-log of Geobacillus stearothermophilus spores at half-cycle, providing a sterility assurance level of 10−6. In addition, the sterilizer achieved a 6-log reduction of G stearothermophilus in the presence of inorganic and organic soils in a simulated-use study. The clinical in-use study confirmed that the sterilizer achieved sterilization of patient-soiled duodenoscopes under actual use conditions. Conclusions Simulated-use and clinical in-use studies demonstrated the efficacy of a hydrogen peroxide–ozone sterilizer for terminal sterilization of duodenoscopes. This offers health care facilities a viable alternative for duodenoscope processing to enhance patient safety as part of a comprehensive infection control strategy.
B Kirk - One of the best experts on this subject based on the ideXlab platform.
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failure of non vacuum steam sterilization processes for dental handpieces
Journal of Hospital Infection, 2017Co-Authors: Sandra Winter, David F Lappin, G Mcdonagh, Andrew Smith, B KirkAbstract:Summary Background Dental handpieces are used in critical and semi-critical operative interventions. Although some dental professional bodies recommend that dental handpieces are sterilized between patient use there is a lack of clarity and understanding of the effectiveness of different steam sterilization processes. The internal mechanisms of dental handpieces contain narrow lumens (0.8–2.3 mm) which can impede the removal of air and ingress of saturated steam required to achieve sterilization conditions. Aim To identify the extent of sterilization failure in dental handpieces using a non-vacuum process. Methods In-vitro and in-vivo investigations were conducted on widely used UK bench-top steam Sterilizers and three different types of dental handpieces. The sterilization process was monitored inside the lumens of dental handpieces using thermometric (TM; dataloggers), chemical indicator (CI), and biological indicator (BI) methods. Findings All three methods of assessing achievement of sterility within dental handpieces that had been exposed to non-vacuum sterilization conditions demonstrated a significant number of failures [CI: 8/3024 (fails/no. of tests); BI: 15/3024; TM: 56/56] compared to vacuum sterilization conditions (CI: 2/1944; BI: 0/1944; TM: 0/36). The dental handpiece most likely to fail sterilization in the non-vacuum process was the surgical handpiece. Non-vacuum Sterilizers located in general dental practice had a higher rate of sterilization failure (CI: 25/1620; BI: 32/1620; TM: 56/56) with no failures in vacuum process. Conclusion Non-vacuum downward/gravity displacement, type N steam Sterilizers are an unreliable method for sterilization of dental handpieces in general dental practice. The handpiece most likely to fail sterilization is the type most frequently used for surgical interventions.
Karine Martel - One of the best experts on this subject based on the ideXlab platform.
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elevating the standard of endoscope processing terminal sterilization of duodenoscopes using a hydrogen peroxide ozone sterilizer
American Journal of Infection Control, 2019Co-Authors: Vanessa Molloysimard, Jeanluc Lemyre, Karine Martel, Bradley J CataloneAbstract:Background The health care community is increasingly aware of the processing challenges and infection risks associated with duodenoscopes owing to published reports of outbreaks and regulatory recalls. Studies have demonstrated that the current practices are inadequate for consistently producing patient-ready endoscopes. Alternatively, terminal sterilization would offer a greater margin of safety and potentially reduce the risk of patient infection. The purpose of this study was to evaluate the efficacy of a hydrogen peroxide–ozone sterilizer with regulatory clearance for terminal sterilization of duodenoscopes. Methods and Results Validation studies were performed under laboratory simulated-use and clinical in-use conditions. The overkill method study demonstrated a reduction of at least 6-log of Geobacillus stearothermophilus spores at half-cycle, providing a sterility assurance level of 10−6. In addition, the sterilizer achieved a 6-log reduction of G stearothermophilus in the presence of inorganic and organic soils in a simulated-use study. The clinical in-use study confirmed that the sterilizer achieved sterilization of patient-soiled duodenoscopes under actual use conditions. Conclusions Simulated-use and clinical in-use studies demonstrated the efficacy of a hydrogen peroxide–ozone sterilizer for terminal sterilization of duodenoscopes. This offers health care facilities a viable alternative for duodenoscope processing to enhance patient safety as part of a comprehensive infection control strategy.
Jeanluc Lemyre - One of the best experts on this subject based on the ideXlab platform.
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elevating the standard of endoscope processing terminal sterilization of duodenoscopes using a hydrogen peroxide ozone sterilizer
American Journal of Infection Control, 2019Co-Authors: Vanessa Molloysimard, Jeanluc Lemyre, Karine Martel, Bradley J CataloneAbstract:Background The health care community is increasingly aware of the processing challenges and infection risks associated with duodenoscopes owing to published reports of outbreaks and regulatory recalls. Studies have demonstrated that the current practices are inadequate for consistently producing patient-ready endoscopes. Alternatively, terminal sterilization would offer a greater margin of safety and potentially reduce the risk of patient infection. The purpose of this study was to evaluate the efficacy of a hydrogen peroxide–ozone sterilizer with regulatory clearance for terminal sterilization of duodenoscopes. Methods and Results Validation studies were performed under laboratory simulated-use and clinical in-use conditions. The overkill method study demonstrated a reduction of at least 6-log of Geobacillus stearothermophilus spores at half-cycle, providing a sterility assurance level of 10−6. In addition, the sterilizer achieved a 6-log reduction of G stearothermophilus in the presence of inorganic and organic soils in a simulated-use study. The clinical in-use study confirmed that the sterilizer achieved sterilization of patient-soiled duodenoscopes under actual use conditions. Conclusions Simulated-use and clinical in-use studies demonstrated the efficacy of a hydrogen peroxide–ozone sterilizer for terminal sterilization of duodenoscopes. This offers health care facilities a viable alternative for duodenoscope processing to enhance patient safety as part of a comprehensive infection control strategy.