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Demetrius Albanes - One of the best experts on this subject based on the ideXlab platform.

  • associations between prediagnostic concentrations of circulating sex Steroid Hormones and esophageal gastric cardia adenocarcinoma among men
    Journal of the National Cancer Institute, 2019
    Co-Authors: Jessica L Petrick, Paula L Hyland, Patrick Caro, Roni T Falk, Ruth M Pfeiffe, Sanford M Dawsey, Christia C Abne, Philip R Taylo, Stephanie J Weinstei, Demetrius Albanes
    Abstract:

    Background Esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are characterized by a strong male predominance. Concentrations of sex Steroid Hormones have been hypothesized to explain this sex disparity. However, no prospective population-based study has examined sex Steroid Hormones in relation to EA/GCA risk. Thus, we investigated whether prediagnostic circulating sex Steroid hormone concentrations were associated with EA/GCA in a nested case-control study drawn from participants in three prospective cohort studies. Methods Using gas chromatography-mass spectrometry (GC-MS) and electrochemiluminescence immunoassay, we quantitated sex Steroid Hormones and sex hormone binding globulin, respectively, in serum from 259 EA/GCA male case participants and 259 matched male control participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and Cancer Prevention Study II Nutrition Cohort. Multivariable conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between circulating Hormones and EA/GCA risk. All statistical tests were two-sided. Results Higher concentrations of dehydroepiandrosterone (DHEA) were associated with a 38% decreased risk of EA/GCA (OR per unit increase in log2 DHEA = 0.62, 95% CI = 0.47 to 0.82, Ptrend = .001). Higher estradiol concentrations were associated with a 34% reduced risk of EA/GCA (OR = 0.66, 95% CI = 0.45 to 0.98, Ptrend = .05), and the association with free estradiol was similar. No other associations between baseline hormone concentrations and future EA/GCA risk were observed. Conclusions This study provides the first evidence that higher concentrations of circulating DHEA, estradiol, and free estradiol may be associated with lower risks of EA/GCA in men.

  • Association of serum α-tocopherol with sex Steroid Hormones and interactions with smoking: implications for prostate cancer risk
    Cancer Causes & Control, 2011
    Co-Authors: Alison M. Mondul, Sabine Rohrmann, Manning Feinleib, William G Nelson, Andy Menke, Elizabeth A. Platz, Demetrius Albanes
    Abstract:

    Background Vitamin E may protect against prostate cancer, possibly only in smokers and, we hypothesize, through altered sex Steroid Hormones. A controlled trial in smokers showed that sex hormone levels were inversely associated with baseline serum α-tocopherol and decreased in response to vitamin E supplementation. The vitamin E-hormone relation is understudied in non-smokers. Methods Serum sex Steroid Hormones and α-tocopherol were measured for 1,457 men in NHANES III. Multivariable-adjusted geometric mean hormone concentrations by α-tocopherol quintile were estimated. Results We observed lower mean testosterone, estradiol, and SHBG concentrations with increasing serum α-tocopherol (Q1 = 5.5 and Q5 = 4.6 ng/ml, p - trend  =  0.0007 ; Q1 = 37.8 and Q5 = 33.1 pg/ml, p - trend  = 0.02; Q1 = 38.8 and Q5 = 30.6 pg/ml, p - trend  =  0.05, respectively). Interactions between serum α-tocopherol and exposure to cigarette smoke for total testosterone, total estradiol, and SHBG were found with the inverse relation observed only among smokers. Conclusions Results from this nationally representative, cross-sectional study indicate an inverse association between serum α-tocopherol and circulating testosterone, estradiol, and SHBG, but only in men who smoked. Our findings support vitamin E selectively influencing sex Hormones in smokers and afford possible mechanisms through which vitamin E may impact prostate cancer risk.

  • quantitative trait loci predicting circulating sex Steroid Hormones in men from the nci breast and prostate cancer cohort consortium bpc3
    Human Molecular Genetics, 2009
    Co-Authors: Demetrius Albanes, Ruth M. Pfeiffer, Jiyoung Ahn, Fredrick R Schumacher, Sonja I Berndt, Gerald L Andriole, Eva Ardanaz, Heiner Boeing, Bas Buenodemesquita
    Abstract:

    Twin studies suggest a heritable component to circulating sex Steroid Hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex Steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3α-androstanediol-glucuronide (N = 4767) and 17β-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 × 10−21), consistent with previous studies, and testosterone (P = 7.54 × 10−15), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 × 10−6) and SRD5A2 with 3α-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 × 10−6). Genetic variation in genes in the sex Steroid hormone pathway is associated with differences in circulating SHBG and sex Steroid Hormones.

Luca Gianaroli - One of the best experts on this subject based on the ideXlab platform.

  • Sex Steroid Hormones and Reproductive Disorders
    Reproductive Sciences, 2011
    Co-Authors: Bart C. J. M. Fauser, Joop S. E. Laven, Basil C. Tarlatzis, Kelle H. Moley, Hilary O. D. Critchley, Robert N. Taylor, Sarah L. Berga, Paul G. Mermelstein, Paul Devroey, Luca Gianaroli
    Abstract:

    The role of sex Steroid Hormones in reproductive function in women is well established. However, in the last two decades it has been shown that receptors for estrogens, progesterone and androgens are expressed in non reproductive tissue /organs (bone, brain, cardiovascular system) playing a role in their function. Therefore, it is critical to evaluate the impact of sex Steroid Hormones in the pathophysiology of some diseases (osteoporosis, Alzheimer, atherosclerosis). In particular, women with primary ovarian insufficiency, polycystic ovary syndrome, endometriosis and climacteric syndrome may have more health problems and therefore an hormonal treatment may be crucial for these women.

Jens Neunzig - One of the best experts on this subject based on the ideXlab platform.

  • the role of sulfated Steroid Hormones in reproductive processes
    The Journal of Steroid Biochemistry and Molecular Biology, 2017
    Co-Authors: Joachim Geyer, Katharina Bakhaus, Rita Bernhardt, Carina Blaschka, Y Dezhkam, Daniela Fietz, Gary Grosser, Katja Hartmann, Michaela F Hartmann, Jens Neunzig
    Abstract:

    Sulfated Steroid Hormones, such as dehydroepiandrosterone sulfate or estrone-3-sulfate, have long been regarded as inactive metabolites as they cannot activate classical Steroid receptors. Some of them are present in the blood circulation at quite high concentrations, but generally sulfated Steroids exhibit low membrane permeation due to their hydrophilic properties. However, sulfated Steroid Hormones can actively be imported into specific target cells via uptake carriers, such as the sodium-dependent organic anion transporter SOAT, and, after hydrolysis by the Steroid sulfatase (so-called sulfatase pathway), contribute to the overall regulation of Steroid responsive organs. To investigate the biological significance of sulfated Steroid Hormones for reproductive processes in humans and animals, the research group "Sulfated Steroids in Reproduction" was established by the German Research Foundation DFG (FOR1369). Projects of this group deal with transport of sulfated Steroids, sulfation of free Steroids, desulfation by the Steroid sulfatase, effects of sulfated Steroids on Steroid biosynthesis and membrane receptors as well as MS-based profiling of sulfated Steroids in biological samples. This review and concept paper presents key findings from all these projects and provides a broad overview over the current research on sulfated Steroid Hormones in the field of reproduction.

Philip R Taylo - One of the best experts on this subject based on the ideXlab platform.

  • associations between prediagnostic concentrations of circulating sex Steroid Hormones and esophageal gastric cardia adenocarcinoma among men
    Journal of the National Cancer Institute, 2019
    Co-Authors: Jessica L Petrick, Paula L Hyland, Patrick Caro, Roni T Falk, Ruth M Pfeiffe, Sanford M Dawsey, Christia C Abne, Philip R Taylo, Stephanie J Weinstei, Demetrius Albanes
    Abstract:

    Background Esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are characterized by a strong male predominance. Concentrations of sex Steroid Hormones have been hypothesized to explain this sex disparity. However, no prospective population-based study has examined sex Steroid Hormones in relation to EA/GCA risk. Thus, we investigated whether prediagnostic circulating sex Steroid hormone concentrations were associated with EA/GCA in a nested case-control study drawn from participants in three prospective cohort studies. Methods Using gas chromatography-mass spectrometry (GC-MS) and electrochemiluminescence immunoassay, we quantitated sex Steroid Hormones and sex hormone binding globulin, respectively, in serum from 259 EA/GCA male case participants and 259 matched male control participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and Cancer Prevention Study II Nutrition Cohort. Multivariable conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between circulating Hormones and EA/GCA risk. All statistical tests were two-sided. Results Higher concentrations of dehydroepiandrosterone (DHEA) were associated with a 38% decreased risk of EA/GCA (OR per unit increase in log2 DHEA = 0.62, 95% CI = 0.47 to 0.82, Ptrend = .001). Higher estradiol concentrations were associated with a 34% reduced risk of EA/GCA (OR = 0.66, 95% CI = 0.45 to 0.98, Ptrend = .05), and the association with free estradiol was similar. No other associations between baseline hormone concentrations and future EA/GCA risk were observed. Conclusions This study provides the first evidence that higher concentrations of circulating DHEA, estradiol, and free estradiol may be associated with lower risks of EA/GCA in men.

  • association between circulating levels of sex Steroid Hormones and esophageal adenocarcinoma in the finbar study
    PLOS ONE, 2018
    Co-Authors: Jessica L Petrick, Shanno Wood, Paula L Hyland, Patrick Caro, Roni T Falk, Ruth M Pfeiffe, Sanford M Dawsey, Christia C Abne, Philip R Taylo, Chantal Guillemette
    Abstract:

    Background Esophageal adenocarcinoma (EA) is characterized by a strong male predominance. Sex Steroid Hormones have been hypothesized to underlie this sex disparity, but no population-based study to date has examined this potential association. Methods Using mass spectrometry and ELISA, we quantitated sex Steroid Hormones and sex hormone binding globulin, respectively, in plasma from males– 172 EA cases and 185 controls–within the Factors Influencing the Barrett/Adenocarcinoma Relationship (FINBAR) Study, a case-control investigation conducted in Northern Ireland and Ireland. Multivariable adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between circulating Hormones and EA. Results Higher androgen:estrogen ratio metrics were associated with increased odds of EA (e.g., testosterone:estradiol ratio ORQ4 v. Q1 = 2.58, 95%CI = 1.23–5.43; Ptrend = 0.009). All estrogens and androgens were associated with significant decreased odds of EA. When restricted to individuals with minimal to no decrease in body mass index, the size of association for the androgen:estrogen ratio was not greatly altered. Conclusions This first study of sex Steroid Hormones and EA provides tentative evidence that androgen:estrogen balance may be a factor related to EA. Replication of these findings in prospective studies is needed to enhance confidence in the causality of this effect.

  • sex Steroid Hormones in relation to barrett s esophagus an analysis of the finbar study
    Journal of Andrology, 2017
    Co-Authors: Michael Cook, Shanno Wood, Paula L Hyland, Patrick Caro, Jennife Drahos, Roni T Falk, Ruth M Pfeiffe, Sanford M Dawsey, Christia C Abne, Philip R Taylo
    Abstract:

    Previously, we observed strong positive associations between circulating concentrations of free testosterone and free dihydrotestosterone (DHT) in relation to Barrett's esophagus in a US male military population. To replicate these findings, we conducted a second study of sex Steroid Hormones and Barrett's esophagus in the Factors Influencing the Barrett/Adenocarcinoma Relationship (FINBAR) Study based in Northern Ireland and Ireland. We used mass spectrometry to quantitate EDTA plasma concentrations of nine sex Steroid Hormones and ELISA to quantitate sex hormone-binding globulin in 177 male Barrett's esophagus cases and 185 male general population controls within the FINBAR Study. Free testosterone, free DHT, and free estradiol were estimated using standard formulas. Multivariable logistic regression estimated odds ratios (OR) and 95% confidence intervals (95%CI) of associations between exposures and Barrett's esophagus. While plasma hormone and sex hormone-binding globulin concentrations were not associated with all cases of Barrett's esophagus, we did observe positive associations with estrogens in younger men (e.g. estrone + estradiol ORcontinuous per ½IQR  = 2.92, 95%CI:1.08, 7.89), and free androgens in men with higher waist-to-hip ratios (e.g. free testosterone ORcontinuous per ½IQR  = 2.71, 95%CI:1.06, 6.92). Stratification by body mass index, antireflux medications, and geographic location did not materially affect the results. This study found evidence for associations between circulating sex Steroid Hormones and Barrett's esophagus in younger men and men with higher waist-to-hip ratios. Further studies are necessary to elucidate whether sex Steroid Hormones are consistently associated with esophageal adenocarcinogenesis.

Annekatrin Lukanova - One of the best experts on this subject based on the ideXlab platform.