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Yu. L. Ilchenko - One of the best experts on this subject based on the ideXlab platform.

  • BURKITT’S Lymphoma WITH A PRIMARY LESION OF THE Stomach (CLINICAL OBSERVATION)
    SINAPS LLC, 2017
    Co-Authors: A. O. Kasimova, Yu. D. Udalov, V. V. Korenkov, Yu. L. Ilchenko
    Abstract:

    The article describes the case of the primary Stomach Lymphoma of the Stomach in a 29-year-old man. The literature data on the etiology, diagnosis and morphological characteristics of the primary Lymphomas of the Stomach are presented, the questions of treatment tactics, variants of cytostatic therapy schemes are touched upon.In the described clinical example, the patient’s medical history is given: from the age of 16 the chronic gastroduodenitis is diagnosed, the patient periodically took omeprazole with a positive effect, there is no evidence of infection with Hp and there is no eradication. In April 2016, he noted the deterioration of health in the form of the appearance of discomfort in the epigastric region. In April 2016, an EHDS was performed at the outpatient stage, where an antral tumor of the Stomach was detected, and a biopsy of the formation was taken. Histological examination of atypical cells was not revealed, and in connection with this, in May 2016, he was hospitalized at the A.M. Burnazyan for additional examination.The article presents  data  of laboratory  and instrumental examination,  the  results  of EGDS, CT of thoracic  and abdominal  cavities, cytological, immunohistochemical,  and cytogenetic studies.The patient  was given three courses of cytostatic  therapy. The first course of cytostatic  therapy was started  in June 2016, the patient  transferred it satisfactorily, in the post-cytostatic period there was a leukopenia of 2,5 thousand  cells/μl, against which the viral lesion of the tongue mucosa developed, and the therapy with virolex was performed with positive dynamics.The EGD control showed marked positive dynamics. The second and third courses were conducted in July-August 2016, treatment was satisfactory. In September 2016 he was discharged for dynamic observation by a hematologist.The article draws the attention of medical practitioners  to the fact that, in the absence of specific clinical manifestations, the basis for the diagnosis of Lymphoma in this clinical example is the timely conduct of an endoscopic study with histological, immunohistochemical and cytogenetic  study of the biopsy

Egyed Miklós - One of the best experts on this subject based on the ideXlab platform.

  • Pimer gastrointestinalis non-Hodgkin-Lymphoma két magyarországi régió beteganyaga alapján = Primary gastrointestinal non-Hodgkin’s Lymphoma in two Hungarian regions
    'Akademiai Kiado Zrt.', 2029
    Co-Authors: Kollár Balázs, Rajnics Péter, Hunyady Béla, Zeleznik Erika, Jakucs János, Egyed Miklós
    Abstract:

    A felnőttkori non-Hodgkin-Lymphoma előfordulása az elmúlt évtizedekben jelentősen nőtt. A betegcsoport nagyon heterogén, változatos klinikai és morfológiai megjelenéssel. A legjellemzőbb nodalis érintettség mellett gyakoriak az extranodalis formák, amelyek leggyakrabban a gastrointestinalis traktust, a központi idegrendszert és a bőrt érintik. A gastrointestinalis traktus non-Hodgkin-lymphomáinak kezelési stratégiája változott az elmúlt évtizedben, a kemoimmunoterápia háttérbe szorította a korábban jóval gyakrabban végzett sebészeti beavatkozásokat. Módszerek: A szerzők Kaposváron, a Kaposi Mór Oktató Kórházban és Gyulán, a Pándy Kálmán Megyei Kórházban kezelt 48, gastrointestinalis traktust érintő non-Hodgkin-lymphomás betegük adatait mutatják be. A betegek közül 27 nő és 21 férfi, átlagéletkoruk 67,8 év. A leggyakoribb lokalizáció a gyomor ( n = 26), a leggyakoribb szövettani típus diffúz nagy B-sejtes Lymphoma (DLBCL) volt. A betegek rizikófaktorait a nemzetközi prognosztikai index (IPI) alapján állapították meg. Negyvenhat beteg kapott kemoimmunoterápiás kezelést, 6 esetben érintett mezős sugárkezelés, 3 esetben Helicobacter pylori -eradikáció, 4 betegnél gyomorreszekció történt. Eredmények: Az összes beteg 68%-ában sikerült komplett, 13%-ában parciális remissziót elérni, 19% nonreszponder volt. A nemzetközi prognosztikai index alapján a betegek többsége az alacsony, illetve magas intermedier rizikócsoportba tartozott (IPI-átlag: 2,68). A tápcsatorna felső szakaszát érintő lymphomás betegek prognózisa volt a legjobb (IPI: 2,0), ugyanakkor a gyomorlymphomás betegeknél volt a legmagasabb a komplett remisszió aránya (73%). Következtetés: Kemoimmunoterápiával a betegek gyógyulási esélyei javultak az elmúlt évtizedben, a gastrointestinalis traktust érintő non-Hodgkin-lymphomák jelentős hányada meggyógyítható. Az IPI a legelfogadottabb mutató a non-Hodgkin-Lymphoma prognózisának megítélésére. A komplett remisszióba jutott betegek prognosztikai indexe volt a legalacsonyabb, de az IPI-n kívül egyéb tényezők is befolyásolhatják a kezelésre adott választ. | Over the past few decades, the occurrence of adult onset non-Hodgkin’s Lymphoma has significantly grown. The patient population involved is very heterogeneous, with different clinical and morphological manifestations. In addition to the most typical nodal involvement, extra-nodal manifestations are also frequent, affecting, most often, the gastrointestinal tract, the central nervous system and the skin. The treatment strategy for non-Hodgkin’s Lymphoma has changed over the past decade: chemo-immunotherapy has largely taken over surgical intervention, the dominant treatment option of the past. Methods: The authors present their experience with 48 patients with non-Hodgkin’s Lymphoma, affecting the gastrointestinal tract, treated in Kaposvár, in the Kaposi Mór Teaching Hospital and in Gyula, in the Pándy Kálmán County Hospital. Demography: 27 female, 21 male; mean age: 67.8 years. Localization, pathological classification and the international prognostic index (IPI) have been analysed and correlated with the clinical response to different therapeutic strategies. Results: The most frequently involved GI organ was the Stomach ( n = 26), with the dominant histological type of diffuse large B-cell Lymphoma. Fourty-six patients received chemo-immunotherapy, 6 received radiotherapy, 3 patients were primarily treated with Helicobacter pylori eradication therapy, and 4 patients were referred for Stomach resection. A complete remission was achieved in 68% of the patients, a partial remission in 13%, while 19% did not show clinical response. Based on the international prognostic index, the majority of the patients fulfilled criteria of low or high intermediate risk categories, with an IPI average of 2.68. Patients with upper gastrointestinal tract involvement carried the best prognosis (IPI: 2.0); at the same time, patients with Stomach Lymphoma achieved the highest rate of remission (73%). Conclusions: With chemo-immunotherapy the chances of a complete remission have significantly improved over the past decade, thus a significant portion of non-Hodgkin’s Lymphomas involving the gastrointestinal tract can be cured. IPI index represents the most recognised indicator for assessing the prognosis of non-Hodgkin’s Lymphoma. Patients who achieved complete remission had the lowest prognostic index in this cohort; nevertheless, numerous data indicate that factors other than the IPI can also have an impact on patients’ response to treatment

A. O. Kasimova - One of the best experts on this subject based on the ideXlab platform.

  • BURKITT’S Lymphoma WITH A PRIMARY LESION OF THE Stomach (CLINICAL OBSERVATION)
    SINAPS LLC, 2017
    Co-Authors: A. O. Kasimova, Yu. D. Udalov, V. V. Korenkov, Yu. L. Ilchenko
    Abstract:

    The article describes the case of the primary Stomach Lymphoma of the Stomach in a 29-year-old man. The literature data on the etiology, diagnosis and morphological characteristics of the primary Lymphomas of the Stomach are presented, the questions of treatment tactics, variants of cytostatic therapy schemes are touched upon.In the described clinical example, the patient’s medical history is given: from the age of 16 the chronic gastroduodenitis is diagnosed, the patient periodically took omeprazole with a positive effect, there is no evidence of infection with Hp and there is no eradication. In April 2016, he noted the deterioration of health in the form of the appearance of discomfort in the epigastric region. In April 2016, an EHDS was performed at the outpatient stage, where an antral tumor of the Stomach was detected, and a biopsy of the formation was taken. Histological examination of atypical cells was not revealed, and in connection with this, in May 2016, he was hospitalized at the A.M. Burnazyan for additional examination.The article presents  data  of laboratory  and instrumental examination,  the  results  of EGDS, CT of thoracic  and abdominal  cavities, cytological, immunohistochemical,  and cytogenetic studies.The patient  was given three courses of cytostatic  therapy. The first course of cytostatic  therapy was started  in June 2016, the patient  transferred it satisfactorily, in the post-cytostatic period there was a leukopenia of 2,5 thousand  cells/μl, against which the viral lesion of the tongue mucosa developed, and the therapy with virolex was performed with positive dynamics.The EGD control showed marked positive dynamics. The second and third courses were conducted in July-August 2016, treatment was satisfactory. In September 2016 he was discharged for dynamic observation by a hematologist.The article draws the attention of medical practitioners  to the fact that, in the absence of specific clinical manifestations, the basis for the diagnosis of Lymphoma in this clinical example is the timely conduct of an endoscopic study with histological, immunohistochemical and cytogenetic  study of the biopsy

V. V. Korenkov - One of the best experts on this subject based on the ideXlab platform.

  • BURKITT’S Lymphoma WITH A PRIMARY LESION OF THE Stomach (CLINICAL OBSERVATION)
    SINAPS LLC, 2017
    Co-Authors: A. O. Kasimova, Yu. D. Udalov, V. V. Korenkov, Yu. L. Ilchenko
    Abstract:

    The article describes the case of the primary Stomach Lymphoma of the Stomach in a 29-year-old man. The literature data on the etiology, diagnosis and morphological characteristics of the primary Lymphomas of the Stomach are presented, the questions of treatment tactics, variants of cytostatic therapy schemes are touched upon.In the described clinical example, the patient’s medical history is given: from the age of 16 the chronic gastroduodenitis is diagnosed, the patient periodically took omeprazole with a positive effect, there is no evidence of infection with Hp and there is no eradication. In April 2016, he noted the deterioration of health in the form of the appearance of discomfort in the epigastric region. In April 2016, an EHDS was performed at the outpatient stage, where an antral tumor of the Stomach was detected, and a biopsy of the formation was taken. Histological examination of atypical cells was not revealed, and in connection with this, in May 2016, he was hospitalized at the A.M. Burnazyan for additional examination.The article presents  data  of laboratory  and instrumental examination,  the  results  of EGDS, CT of thoracic  and abdominal  cavities, cytological, immunohistochemical,  and cytogenetic studies.The patient  was given three courses of cytostatic  therapy. The first course of cytostatic  therapy was started  in June 2016, the patient  transferred it satisfactorily, in the post-cytostatic period there was a leukopenia of 2,5 thousand  cells/μl, against which the viral lesion of the tongue mucosa developed, and the therapy with virolex was performed with positive dynamics.The EGD control showed marked positive dynamics. The second and third courses were conducted in July-August 2016, treatment was satisfactory. In September 2016 he was discharged for dynamic observation by a hematologist.The article draws the attention of medical practitioners  to the fact that, in the absence of specific clinical manifestations, the basis for the diagnosis of Lymphoma in this clinical example is the timely conduct of an endoscopic study with histological, immunohistochemical and cytogenetic  study of the biopsy

Yu. D. Udalov - One of the best experts on this subject based on the ideXlab platform.

  • BURKITT’S Lymphoma WITH A PRIMARY LESION OF THE Stomach (CLINICAL OBSERVATION)
    SINAPS LLC, 2017
    Co-Authors: A. O. Kasimova, Yu. D. Udalov, V. V. Korenkov, Yu. L. Ilchenko
    Abstract:

    The article describes the case of the primary Stomach Lymphoma of the Stomach in a 29-year-old man. The literature data on the etiology, diagnosis and morphological characteristics of the primary Lymphomas of the Stomach are presented, the questions of treatment tactics, variants of cytostatic therapy schemes are touched upon.In the described clinical example, the patient’s medical history is given: from the age of 16 the chronic gastroduodenitis is diagnosed, the patient periodically took omeprazole with a positive effect, there is no evidence of infection with Hp and there is no eradication. In April 2016, he noted the deterioration of health in the form of the appearance of discomfort in the epigastric region. In April 2016, an EHDS was performed at the outpatient stage, where an antral tumor of the Stomach was detected, and a biopsy of the formation was taken. Histological examination of atypical cells was not revealed, and in connection with this, in May 2016, he was hospitalized at the A.M. Burnazyan for additional examination.The article presents  data  of laboratory  and instrumental examination,  the  results  of EGDS, CT of thoracic  and abdominal  cavities, cytological, immunohistochemical,  and cytogenetic studies.The patient  was given three courses of cytostatic  therapy. The first course of cytostatic  therapy was started  in June 2016, the patient  transferred it satisfactorily, in the post-cytostatic period there was a leukopenia of 2,5 thousand  cells/μl, against which the viral lesion of the tongue mucosa developed, and the therapy with virolex was performed with positive dynamics.The EGD control showed marked positive dynamics. The second and third courses were conducted in July-August 2016, treatment was satisfactory. In September 2016 he was discharged for dynamic observation by a hematologist.The article draws the attention of medical practitioners  to the fact that, in the absence of specific clinical manifestations, the basis for the diagnosis of Lymphoma in this clinical example is the timely conduct of an endoscopic study with histological, immunohistochemical and cytogenetic  study of the biopsy