The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Tangyi Tsao - One of the best experts on this subject based on the ideXlab platform.
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solitary gastric peutz jeghers type Stomach Polyp mimicking a malignant gastric tumor
World Journal of Gastroenterology, 2012Co-Authors: Jikuen Yu, Tangyi TsaoAbstract:Most cases of Peutz-Jeghers type Polyps of the Stomach are associated with mucocutaneous pigmentation and multiple intestinal Polyposis. A solitary Peutz-Jeghers type Polyp of the Stomach is rare. We here report a case of a 71-year-old woman with a solitary Peutz-Jeghers type Polyp of the Stomach who presented with intolerable epigastric pain and weight loss of 5 kg over the prior two months. During the hospital treatment course for this patient, endoscopic examination revealed a bulging lesion with a central hole, mucosal ulceration, an asymmetrical wall thickness and a narrowing of the gastric lumen. A gastric biopsy further revealed ulceration with moderate dysplasia. The patient received endoscopic ultrasonography which showed a second subepithelial lesion that measured 4 cm × 3 cm. Computed tomography of the abdomen subsequently showed a thickened gastric wall with three visibly enlarged lymph nodes, all greater than 1 cm. The suspected diagnosis was malignant gastric cancer with lymph node metastases. The other lesion, which measured 2 cm × 2 cm × 1 cm was noted in the submucosa of the jejunum during surgery. The patient was treated using a subtotal gastrectomy and partial resection of the jejunal tumor. The final pathological report indicated a gastric Peutz-Jeghers type Polyp with proliferation of smooth muscle bundles in the submucosal layer, and hyperplastic glands in the mucosal layer and ectopic pancreas of the jejunum. This is the first reported clinical case of a solitary Peutz-Jeghers type Polyp of the Stomach accompanying a lymph node enlargement and ectopic pancreas in the jejunum that simulates Stomach cancer with lymph node metastases.
Jikuen Yu - One of the best experts on this subject based on the ideXlab platform.
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solitary gastric peutz jeghers type Stomach Polyp mimicking a malignant gastric tumor
World Journal of Gastroenterology, 2012Co-Authors: Jikuen Yu, Tangyi TsaoAbstract:Most cases of Peutz-Jeghers type Polyps of the Stomach are associated with mucocutaneous pigmentation and multiple intestinal Polyposis. A solitary Peutz-Jeghers type Polyp of the Stomach is rare. We here report a case of a 71-year-old woman with a solitary Peutz-Jeghers type Polyp of the Stomach who presented with intolerable epigastric pain and weight loss of 5 kg over the prior two months. During the hospital treatment course for this patient, endoscopic examination revealed a bulging lesion with a central hole, mucosal ulceration, an asymmetrical wall thickness and a narrowing of the gastric lumen. A gastric biopsy further revealed ulceration with moderate dysplasia. The patient received endoscopic ultrasonography which showed a second subepithelial lesion that measured 4 cm × 3 cm. Computed tomography of the abdomen subsequently showed a thickened gastric wall with three visibly enlarged lymph nodes, all greater than 1 cm. The suspected diagnosis was malignant gastric cancer with lymph node metastases. The other lesion, which measured 2 cm × 2 cm × 1 cm was noted in the submucosa of the jejunum during surgery. The patient was treated using a subtotal gastrectomy and partial resection of the jejunal tumor. The final pathological report indicated a gastric Peutz-Jeghers type Polyp with proliferation of smooth muscle bundles in the submucosal layer, and hyperplastic glands in the mucosal layer and ectopic pancreas of the jejunum. This is the first reported clinical case of a solitary Peutz-Jeghers type Polyp of the Stomach accompanying a lymph node enlargement and ectopic pancreas in the jejunum that simulates Stomach cancer with lymph node metastases.
Miyazaki I - One of the best experts on this subject based on the ideXlab platform.
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A study on 29 patients with cancers of the gastric remnant--a speculation on a remnant cancer-promoting factor from the aspect of tumor location
Nihon Geka Gakkai zasshi, 1990Co-Authors: Takeo Kosaka, Kamata T, Takashi Fujimura, Hajime Hasegawa, Yutaka Yonemura, Koichi Miwa, Miyazaki IAbstract:We reviewed 29 patients who developed carcinomas of the gastric remnant more than 10 years after the initial gastrectomy. The median age was 59 years (29-75), with a male-to-female ratio of 3.8:1. The reason for previous operation was Stomach ulcer in 16 patients, chronic gastritis in 2, Stomach Polyp in 2, duodenal ulcer in 5 and Stomach cancer in 4 patients. Regarding the type of the original operations, Billroth's operation I (B-I) was performed for 10 patients, Billroth's II (B-II) for 18 and Roux-en Y operation for one. The site of tumor was classified into three groups, stoma (gastroenterostomy), stump (gastric cut-end except stoma) and others (the site except stoma and stump). The patients reconstructed with B-II developed significantly more carcinomas in the stoma than those reconstructed with B-I, with the incidence of 10/18 and 0/10, respectively (p less than 0.05). The interval between the initial operation and the second one was significantly longer in patients with stomal cancer than in those with stump cancer (p less than 0.05). There were no significant difference in the frequency and degree of histologic change, such as intestinal metaplasia or glandular cystification in noncancerous areas, between the B-I and B-II patients. This study suggested that cancers of the gastric remnant, especially those developed in the stoma after B-II were different from the other remnant cancers in terms of carcinogenesis or cancer promotion, and that they were probably induced by duodenogastric reflux to the gastrojejunostomized area.
Knezević A - One of the best experts on this subject based on the ideXlab platform.
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Diseases of the upper segment of the gastrointestinal tract and Helicobacter pylori infection
Medicinski Pregled, 1997Co-Authors: Zivanović M, Mrdja Z, Zivanović B, Ljiljana Hadnadjev, Trbojević S, Dragomir Damjanov, Somer L, Majoros J, Zora Petrovic, Knezević AAbstract:Helicobacter pylori infection is the most frequent infection in humans. It is assumed that over 50% of total world population suffer from this infection. Chronic gastritis is the most usual consequence of this infection. Development of peptic ulcer appears in case of 10 to 20 percent of infected people with the increased risk of malignancy. In the group of 819 examined patients at the Clinic for gastroenterology and hepatology of the Institute for internal diseases, the presence of helicobacter pylori was confirmed in case of 69.18% of patients. The infection was equally observed in both sexes and its frequency was higher with the increase of age, reaching its peak in the sixth decade of life (75.24%). The highest frequency was found in patients with duodenal ulcer (84.85%) and hyperplastic Stomach Polyp (81.82%) and lowest in case of resected Stomach (56.52%). We also establish the dependence of the type and degree of pathohistological changes and the Helicobacter pylori infection.
Sakae Homma - One of the best experts on this subject based on the ideXlab platform.
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The role of positron emission tomography in the detection of incidental gastrointestinal tract lesions in patients examined for lung cancer
The journal of the Japanese Respiratory Society, 2010Co-Authors: Kazutoshi Isobe, Yoshinobu Hata, Shinji Sakaguchi, Yujiro Takai, Kazutoshi Shibuya, Keigo Takagi, Sakae HommaAbstract:The purpose of this study was to clarify the clinical characteristics of lung cancer patients with abnormal accumulation in the gastrointestinal tract by fluoro-2-deoxyglucose positron emission tomography (PET). Of the 968 consecutive patients with primary lung cancer who underwent PET from October 2005 through September 2009, 26 patients had local abnormal accumulation in the gastrointestinal tract. We retrospectively compared the localization of abnormal accumulation in the gastrointestinal tract, standardized uptake value (SUV) max (1 hour), and the final clinical diagnosis. The site of abnormal accumulation was the esophagus in 1 case, the Stomach in 8 and the small intestine to large intestine in 17. In 15 out of 26 (57%) cases with true PET positive results, there was esophageal cancer in 1 case, gastric cancer in 2, gastrointestinal stromal tumor in 1, colon cancer in 8, and 1 each of metastasis to the Stomach, small intestine and large intestine from lung cancer. In 11 cases with false PET-positive results, there was a Stomach Polyp in 1 case, gastritis in 3, colon Polyp in 1, diverticulitis in 1 and normal physiologic accumulation in 5. There were no differences in mean SUV max among malignant lesions, benign lesions, and normal physiologic accumulation. We should perform endoscopy of the digestive tract to detect malignant lesions with high incidence rates when PET shows localalized abnormal accumulation in the gastrointestinal, tract in patients with lung cancer.