The Experts below are selected from a list of 1131 Experts worldwide ranked by ideXlab platform

Liviu Feller - One of the best experts on this subject based on the ideXlab platform.

  • Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review
    International journal of dentistry, 2016
    Co-Authors: Razia A.g. Khammissa, J. Fourie, R. Chandran, Johan Lemmer, Liviu Feller
    Abstract:

    In immunocompromised subjects, Epstein-Barr virus (EBV) infection of terminally differentiated oral keratinocytes may result in subclinical productive infection of the virus in the Stratum Spinosum and in the Stratum granulosum with shedding of infectious virions into the oral fluid in the desquamating cells. In a minority of cases this productive infection with dysregulation of the cell cycle of terminally differentiated epithelial cells may manifest as oral hairy leukoplakia. This is a white, hyperkeratotic, benign lesion of low morbidity, affecting primarily the lateral border of the tongue. Factors that determine whether productive EBV replication within the oral epithelium will cause oral hairy leukoplakia include the fitness of local immune responses, the profile of EBV gene expression, and local environmental factors.

G J Atkins - One of the best experts on this subject based on the ideXlab platform.

  • detection of epstein barr virus dna in tongue tissues from aids autopsies without clinical evidence of oral hairy leukoplakia
    Journal of Oral Pathology & Medicine, 1995
    Co-Authors: M J E M R Mabruk, Stephen Flint, Mary Toner, N Leonard, O Shells, David C Coleman, G J Atkins
    Abstract:

    Epstein-Barr virus (EBV) DNA was detected by in situ hybridization at 3 sites of 30 samples taken from clinically normal lateral border of tongue mucosa from 15 AIDS autopsies and in none of 20 samples from 10 controls. The first positive case showed a thin layer of parakeratosis correlated with positive signals for EBV in one area and an adjacent area without obvious parakeratosis was also positive for EBV. These findings were present on both sides of the tongue. The second case was unilaterally positive for EBV and parakeratosis was absent. The hybridization signals were localised to koilocyte-like cells in the Stratum Spinosum, as in oral hairy leukoplakia (OHL). These observations suggest that the in situ hybridization technique can detect very early or subclinical OHL, and supports the role of EBV in the pathogenesis of this lesion.

Razia A.g. Khammissa - One of the best experts on this subject based on the ideXlab platform.

  • Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review
    International journal of dentistry, 2016
    Co-Authors: Razia A.g. Khammissa, J. Fourie, R. Chandran, Johan Lemmer, Liviu Feller
    Abstract:

    In immunocompromised subjects, Epstein-Barr virus (EBV) infection of terminally differentiated oral keratinocytes may result in subclinical productive infection of the virus in the Stratum Spinosum and in the Stratum granulosum with shedding of infectious virions into the oral fluid in the desquamating cells. In a minority of cases this productive infection with dysregulation of the cell cycle of terminally differentiated epithelial cells may manifest as oral hairy leukoplakia. This is a white, hyperkeratotic, benign lesion of low morbidity, affecting primarily the lateral border of the tongue. Factors that determine whether productive EBV replication within the oral epithelium will cause oral hairy leukoplakia include the fitness of local immune responses, the profile of EBV gene expression, and local environmental factors.

Robert W Nordhausen - One of the best experts on this subject based on the ideXlab platform.

  • spirochetes isolated from dairy cattle with papillomatous digital dermatitis and interdigital dermatitis
    Veterinary Microbiology, 1995
    Co-Authors: Richard L Walker, Deryck H Read, K J Loretz, Robert W Nordhausen
    Abstract:

    Two groups of spirochetes were isolated from papillomatous digital dermatitis (PDD) lesions in dairy cattle. The two groups could be readily differentiated on the basis of morphologic and immunologic characteristics and enzymatic activity. A spirochete isolated from an interdigital dermatitis (IDD) lesion appeared morphologically and antigenically similar to spirochetes in one of the PDD groups and exhibited an identical enzyme activity pattern. The two groups of PDD spirochetes had characteristics most consistent with the genus Treponema. The PDD and IDD isolates differed morphologically from previously described bovine Treponema spp. Although spirochetes have been observed to be one of the predominant bacterial morphotypes in PDD and IDD and are found invading the Stratum Spinosum and dermal papillae in PDD lesions, the significance of these spirochetes in the etiopathogenesis of PDD and IDD is presently unknown.

Anoj Kumar Baliarsinha - One of the best experts on this subject based on the ideXlab platform.

  • Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation
    Indian Journal of Endocrinology and Metabolism, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at Stratum Spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.

  • Pigmentation in vitamin B12 deficiency masquerading Addison′s pigmentation: A rare presentation
    Wolters Kluwer Medknow Publications, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at Stratum Spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis