Stress Resistance

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Md Sakhawat Hossain - One of the best experts on this subject based on the ideXlab platform.

  • dietary nucleotide administration influences growth immune responses and oxidative Stress Resistance of juvenile red sea bream pagrus major
    Aquaculture, 2016
    Co-Authors: Shunsuke Koshio, Manabu Ishikawa, Md Sakhawat Hossain, Saichiro Yokoyama, Nadia Mahjabin Sony
    Abstract:

    Abstract A 56- day feeding trial was carried out to determine effects of purified nucleotide mixture for red sea bream ( Pagrus major ). Five dietary level of purified nucleotide mixture containing equal portion of inosine 5′ monophosphate (IMP), adenosine 5′ monophosphate (AMP), guanosine 5′ monophosphate (GMP), uridine 5′ monophosphate (UMP) and cytidine 5′ monophosphate (CMP) were supplemented to the basal diet (control, D1) at 0.5 (D2), 1.0 (D3), 1.5 (D4), 2.0 (D5) and 2.5 (D6) g kg − 1 . Triplicate groups of fish (initial weight: 2.6 g) were stocked in 100-L polycarbonate circular tanks at a density of 18 fish per tank under the flow-through system, and were fed the respective test diets twice daily to satiation level. After feeding trial, significantly higher growth performances, survival (%) and feed utilization were observed in fish fed with 1.5% mixed nucleotide supplemented diet (D4). Growth performance parameters were not differed significantly among diet groups D3 and D4. Feed conversion ratio, protein efficiency ratio and survival were not differed among diets D2 to D5. All the growth and feed utilization parameters were significantly lower in D1 and D6. In case of oxidative Stress parameters fish fed nucleotide supplemented diets showed best condition because of the least oxidative Stressed condition as well as the highest tolerance against oxidation. Stress Resistance against low salinity exposure (LT 50 ), significantly increased with nucleotide supplementation and was highest in D4. Total serum protein, serum lysozyme activity and total peroxidase content tended to be higher (P > 0.05) in nucleotide supplemented group. Catalase activity reduced (P  − 1 mixed nucleotides to promote growth, immune responses and Stress Resistance of juvenile red sea bream.

Andrew Dillin - One of the best experts on this subject based on the ideXlab platform.

  • four glial cells regulate er Stress Resistance and longevity via neuropeptide signaling in c elegans
    Science, 2020
    Co-Authors: Ashley E Frakes, Melissa G Metcalf, Sarah U Tronnes, Raz Barziv, Jenni Durieux, Holly K Gildea, Nazineen Kandahari, Samira Monshietehadi, Andrew Dillin
    Abstract:

    The ability of the nervous system to sense cellular Stress and coordinate protein homeostasis is essential for organismal health. Unfortunately, Stress responses that mitigate disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (UPRER), become defunct with age. In this work, we expressed the constitutively active UPRER transcription factor, XBP-1s, in a subset of astrocyte-like glia, which extended the life span in Caenorhabditis elegans Glial XBP-1s initiated a robust cell nonautonomous activation of the UPRER in distal cells and rendered animals more resistant to protein aggregation and chronic ER Stress. Mutants deficient in neuropeptide processing and secretion suppressed glial cell nonautonomous induction of the UPRER and life-span extension. Thus, astrocyte-like glial cells play a role in regulating organismal ER Stress Resistance and longevity.

  • xbp 1 is a cell nonautonomous regulator of Stress Resistance and longevity
    Cell, 2013
    Co-Authors: Rebecca C Taylor, Andrew Dillin
    Abstract:

    Summary The ability to ensure proteostasis is critical for maintaining proper cell function and organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum unfolded protein response (UPR ER ) in aging of C. elegans and found that age-onset loss of ER proteostasis could be reversed by expression of a constitutively active form of XBP-1, XBP-1s. Neuronally derived XBP-1s was sufficient to rescue Stress Resistance, increase longevity, and activate the UPR ER in distal, non-neuronal cell types through a cell-nonautonomous mechanism. Loss of UPR ER signaling components in distal cells blocked cell-nonautonomous signaling from the nervous system, thereby blocking increased longevity of the entire animal. Reduction of small clear vesicle (SCV) release blocked nonautonomous signaling downstream of xbp-1s , suggesting that the release of neurotransmitters is required for this intertissue signaling event. Our findings point toward a secreted ER Stress signal (SERSS) that promotes ER Stress Resistance and longevity. PaperFlick

  • xbp 1 is a cell nonautonomous regulator of Stress Resistance and longevity
    Cell, 2013
    Co-Authors: Rebecca C Taylor, Andrew Dillin
    Abstract:

    The ability to ensure proteostasis is critical for maintaining proper cell function and organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum unfolded protein response (UPR(ER)) in aging of C. elegans and found that age-onset loss of ER proteostasis could be reversed by expression of a constitutively active form of XBP-1, XBP-1s. Neuronally derived XBP-1s was sufficient to rescue Stress Resistance, increase longevity, and activate the UPR(ER) in distal, non-neuronal cell types through a cell-nonautonomous mechanism. Loss of UPR(ER) signaling components in distal cells blocked cell-nonautonomous signaling from the nervous system, thereby blocking increased longevity of the entire animal. Reduction of small clear vesicle (SCV) release blocked nonautonomous signaling downstream of xbp-1s, suggesting that the release of neurotransmitters is required for this intertissue signaling event. Our findings point toward a secreted ER Stress signal (SERSS) that promotes ER Stress Resistance and longevity.

  • daf 16 employs the chromatin remodeller swi snf to promote Stress Resistance and longevity
    Nature Cell Biology, 2013
    Co-Authors: Christian G Riedel, Andrew Dillin, Robert H Dowen, Guinevere F Lourenco, Natalia V Kirienko, Thomas Heimbucher, Jason A West, Sarah K Bowman, Robert E Kingston, John M Asara
    Abstract:

    Organisms are constantly challenged by Stresses and privations and require adaptive responses for their survival. The transcription factor DAF-16/FOXO is central nexus in these responses, but despite its importance little is known about how it regulates its target genes. Proteomic identification of DAF-16/FOXO binding partners in Caenorhabditis elegans and their subsequent functional evaluation by RNA interference (RNAi) revealed several candidate DAF-16/FOXO cofactors, most notably the chromatin remodeller SWI/SNF. DAF-16/FOXO and SWI/SNF form a complex and globally colocalize at DAF-16/FOXO target promoters. We show that specifically for gene-activation, DAF-16/FOXO depends on SWI/SNF, facilitating SWI/SNF recruitment to target promoters, in order to activate transcription by presumed remodelling of local chromatin. For the animal, this translates into an essential role of SWI/SNF for DAF-16/FOXO-mediated processes, i.e. dauer formation, Stress Resistance, and the promotion of longevity. Thus we give insight into the mechanisms of DAF-16/FOXO-mediated transcriptional regulation and establish a critical link between ATP-dependent chromatin remodelling and lifespan regulation.

Nadia Mahjabin Sony - One of the best experts on this subject based on the ideXlab platform.

  • dietary nucleotide administration influences growth immune responses and oxidative Stress Resistance of juvenile red sea bream pagrus major
    Aquaculture, 2016
    Co-Authors: Shunsuke Koshio, Manabu Ishikawa, Md Sakhawat Hossain, Saichiro Yokoyama, Nadia Mahjabin Sony
    Abstract:

    Abstract A 56- day feeding trial was carried out to determine effects of purified nucleotide mixture for red sea bream ( Pagrus major ). Five dietary level of purified nucleotide mixture containing equal portion of inosine 5′ monophosphate (IMP), adenosine 5′ monophosphate (AMP), guanosine 5′ monophosphate (GMP), uridine 5′ monophosphate (UMP) and cytidine 5′ monophosphate (CMP) were supplemented to the basal diet (control, D1) at 0.5 (D2), 1.0 (D3), 1.5 (D4), 2.0 (D5) and 2.5 (D6) g kg − 1 . Triplicate groups of fish (initial weight: 2.6 g) were stocked in 100-L polycarbonate circular tanks at a density of 18 fish per tank under the flow-through system, and were fed the respective test diets twice daily to satiation level. After feeding trial, significantly higher growth performances, survival (%) and feed utilization were observed in fish fed with 1.5% mixed nucleotide supplemented diet (D4). Growth performance parameters were not differed significantly among diet groups D3 and D4. Feed conversion ratio, protein efficiency ratio and survival were not differed among diets D2 to D5. All the growth and feed utilization parameters were significantly lower in D1 and D6. In case of oxidative Stress parameters fish fed nucleotide supplemented diets showed best condition because of the least oxidative Stressed condition as well as the highest tolerance against oxidation. Stress Resistance against low salinity exposure (LT 50 ), significantly increased with nucleotide supplementation and was highest in D4. Total serum protein, serum lysozyme activity and total peroxidase content tended to be higher (P > 0.05) in nucleotide supplemented group. Catalase activity reduced (P  − 1 mixed nucleotides to promote growth, immune responses and Stress Resistance of juvenile red sea bream.

Seyed Hossein Hoseinifar - One of the best experts on this subject based on the ideXlab platform.

  • the effects of lactobacillus acidophilus as feed supplement on skin mucosal immune parameters intestinal microbiota Stress Resistance and growth performance of black swordtail xiphophorus helleri
    Fish & Shellfish Immunology, 2015
    Co-Authors: Seyed Hossein Hoseinifar, Zahra Roosta, Abdolmajid Hajimoradloo, Farzaneh Vakili
    Abstract:

    Abstract The present study evaluates the effects of different levels of dietary Lactobacillus acidophilus as feed supplement on intestinal microbiota, skin mucus immune parameters and salinity Stress Resistance as well as growth performance of black swordtail ( Xiphophorus helleri ). One-thousand and eight hundred healthy black swordtail larvae (0.03 ± 0.001 g) were randomly distributed in 12 tanks (100 L) at a density of 150 fish per aquaria and fed different levels of dietary L. acidophilus (0, 1.5 × 10 8 , 3 × 10 8 and 6 × 10 8  CFU g −1 ) for 10 weeks. At the end of trial, there were significant differences among antibacterial activity of skin mucus in probiotic fed fish and control group ( P L. acidophilus fed fish ( P P L. acidophilus significantly elevated black swordtail Resistance against salinity Stress (i.e survival %) ( P L. acidophilus improved weight gain, SGR, FCR compared to fish fed unsupplemented diet ( P L. acidophilus on mucosal immune parameters, intestinal microbiota, Stress Resistance and growth parameters of black swordtail and the appropriate inclusion is 6 × 10 8  CFU g −1 .

  • effects of dietary fructo oligosaccharide supplementation on the growth performance haemato immunological parameters gut microbiota and Stress Resistance of common carp cyprinus carpio fry
    British Journal of Nutrition, 2014
    Co-Authors: Seyed Hossein Hoseinifar, Narges Soleimani, Einar Ringo
    Abstract:

    The present study was conducted to investigate the effects of dietary fructo-oligosaccharide (FOS) (0, 1, 2 and 3 %) supplementation on the growth performance, haemato-immunological parameters, cultivable autochthonous (non-adherent) intestinal microbiota and Stress Resistance of common carp ( Cyprinus carpio ) fry (3·23 ( sem 0·14) g). These parameters were measured after feeding the carp fry with the experimental diets for 7 weeks. Dietary FOS supplementation had no significant effects on the growth performance and food intake of carp fry compared with the control treatment. It also had no significant effects on the following haematological parameters: erythrocyte count; leucocyte counts (WBC); haematocrit; Hb; mean corpuscular volume; mean corpuscular Hb content; mean corpuscular Hb concentration. However, WBC and respiratory burst activity were significantly affected by dietary FOS supplementation. Evaluation of the cultivable autochthonous intestinal microbiota revealed a significant increase in the levels of total viable heterotrophic aerobic bacteria and lactic acid bacteria in fish fed diets supplemented with 2 and 3 % FOS. Furthermore, dietary FOS supplementation significantly increased the survival rate and Stress Resistance of carp fry compared with the control treatment. These results encourage conducting further research on the administration of FOS and other prebiotics in carp fry studies.

  • dietary galactooligosaccharide affects intestinal microbiota Stress Resistance and performance of caspian roach rutilus rutilus fry
    Fish & Shellfish Immunology, 2013
    Co-Authors: Seyed Hossein Hoseinifar, Mohsen Khalili, Hosseinali Khoshbavar Rostami, Angeles M Esteban
    Abstract:

    The aim of this study was to assess the effects of galactooligosaccharide (GOS), on the growth performance, Stress Resistance and intestinal microbiota of Caspian roach (Rutilus rutilus) fry. Specimens (1.36 ± 0.03 g) were fed either a basal control diet (0% GOS, non-supplemented) or the basal diet supplemented with 1% and 2% of GOS. After 7 weeks of the feeding trials, growth factors (final weight, weight gain, specific growth rate, condition factor and food conversion ratio) as well as body composition, Resistance to salinity Stress and autochthonous intestinal microbiota were assessed. Results demonstrated that at the end of the trial growth factors (final weight, weight gain, SGR, FCR) were significantly higher in 2% GOS fed fish (P 0.05). Nevertheless, autochthonous lactic acid bacteria levels were significantly elevated in fish fed 2% dietary GOS (P < 0.05). These results confirm that GOS improves growth performance, Stress Resistance and modulates intestinal microbiota by increasing lactic acid bacteria of Caspian roach fry, a very important fish species in the Caspian Sea.

Ana M Gonzalezparamas - One of the best experts on this subject based on the ideXlab platform.

  • epicatechin modulates Stress Resistance in c elegans via insulin igf 1 signaling pathway
    PLOS ONE, 2019
    Co-Authors: Begona Ayudaduran, Montserrat Dueñas, Susana Gonzalezmanzano, Antonio Mirandavizuete, Celestino Santosbuelga, Ana M Gonzalezparamas
    Abstract:

    : The nematode Caenorhabditis elegans has been used to examine the influence of epicatechin (EC), an abundant flavonoid in the human diet, in some Stress biomarkers (ROS production, lipid peroxidation and protein carbonylation). Furthermore, the ability of EC to modulate the expression of some key genes in the insulin/IGF-1 signaling pathway (IIS), involved in longevity and oxidative or heat shock Stress response, has also been explored. The final aim was to contribute to the elucidation of the mechanisms involved in the biological effects of flavonoids. The results showed that EC-treated wild-type C. elegans exhibited increased survival and reduced oxidative damage of biomolecules when submitted to thermal Stress. EC treatment led to a moderate elevation in ROS levels, which might activate endogenous mechanisms of defense protecting against oxidative insult. The enhanced Stress Resistance induced by EC was found to be mediated through the IIS pathway, since assays in daf-2, age-1, akt-1, akt-2, sgk-1, daf-16, skn-1 and hsf-1 loss of function mutant strains failed to show any heat-resistant phenotype against thermal Stress when treated with EC. Consistently, EC treatment upregulated the expression of some Stress Resistance associated genes, such as gst-4, hsp-16.2 and hsp-70, which are downstream regulated by the IIS pathway.