The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Hyone-myong Eun - One of the best experts on this subject based on the ideXlab platform.
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Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species
Parasitology research, 2009Co-Authors: Stéphane Bonneau, Laurence Maynard, Krzysztof Tomczuk, Dawid J. Kok, Hyone-myong EunAbstract:In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin–praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n = 6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
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Anthelmintic efficacies of a tablet formula of ivermectin–praziquantel on horses experimentally infected with three Strongylus species
Parasitology Research, 2009Co-Authors: Stéphane Bonneau, Laurence Maynard, Krzysztof Tomczuk, Dawid Kok, Hyone-myong EunAbstract:In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin–praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris , Strongylus equinus , and Strongylus edentatus . The horses were randomly allocated to three groups ( n = 6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris , 100% and 81.4% on S. equinus , and equally 100% on S. edentatus . However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris -induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
K. Szczepaniak - One of the best experts on this subject based on the ideXlab platform.
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The Strongylidae belonging to Strongylus genus in horses from southeastern Poland
Parasitology Research, 2012Co-Authors: M. B. Studzińska, K. Tomczuk, M. Demkowska-kutrzepa, K. SzczepaniakAbstract:Postmortem parasitic examinations of the large intestines of 725 slaughtered horses from individual farmers in southeastern Poland were carried out. The examinations were carried out monthly since February 2006 until January 2007 (except for August 2007 because of a technological stoppage in the slaughterhouse). The examinations included the intensiveness and extensiveness of the infestation of the Strongylidae belonging to the Strongylus genus. The Strongylidae were found in 26.5 % of the examined horses. Strongylus vulgaris was the most dominant nematode and had a 22.8 % prevalence, Strongylus edentatus was carried by 18.3 % of the horses. Strongylus equinus was identified only in 1.7 % of the examined horses. Our findings revealed that combined infestation of S. vulgaris and S. edentatus occurred in 100 (52.1 %) of the 725 horses infected by the Strongylidae. The present results indicate that the lowest prevalence of strongyle species except for S. equinus was found in January, February, and March. However, it is difficult to draw a conclusion because of an extremely low extensiveness of infestation. The results indicate that the prevalence of the Strongylidae in horses from southeastern Poland is limited.
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REVIEW The Strongylidae belonging to Strongylus genus in horses from southeastern Poland
2012Co-Authors: M. B. Studzińska, K. Tomczuk, M. Demkowska-kutrzepa, K. SzczepaniakAbstract:Abstract Postmortem parasitic examinations of the large intestines of 725 slaughtered horses from individual farmers in southeastern Poland were carried out. The examinations were carried out monthly since February 2006 until January 2007 (except for August 2007 because of a technological stoppage in the slaughterhouse). The examinations included the intensiveness and extensiveness of the infestation of the Strongylidae belonging to the Strongylus genus. The Strongylidae were found in 26.5 % of the examined horses. Strongylus vulgariswas the most dominant nematode and had a 22.8 % prevalence, Strongylus edentatus was carried by 18.3 % of the horses. Strongylus equinus was identified only in 1.7 % of the examined horses. Our findings revealed that combined infestation of S. vulgaris and S. edentatus occurred in 100 (52.1%) of the 725 horses infected by the Strongylidae. The present results indicate that the lowest prevalence of strongyle species except for S. equinus was found in January, February, and March. However, it is difficult to draw a conclusion because of an extremely low extensiveness of infestation. The results indicate that the prevalence of the Strongylidae in horses from southeastern Poland is limited
Olivier Sparagano - One of the best experts on this subject based on the ideXlab platform.
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New Method for Simultaneous Species-Specific Identification of Equine Strongyles (Nematoda, Strongylida) by Reverse Line Blot Hybridization
Journal of clinical microbiology, 2007Co-Authors: Donato Traversa, Thomas R. Klei, Raffaella Iorio, Jakub Gawor, Domenico Otranto, Olivier SparaganoAbstract:The ability of a reverse line blot (RLB) assay to identify 13 common species of equine small strongyles (cyathostomins) and to discriminate them from three Strongylus spp. (large strongyles) was demonstrated. The assay relied on the specific hybridization of PCR-amplified intergenic spacer DNA fragments of the nuclear ribosomal DNA to membrane-bound species-specific probes. All cyathostomins examined were unequivocally identified and simultaneously discriminated from each other and from three large strongyles (Strongylus edentatus, Strongylus equinus, and Strongylus vulgaris). This assay will enable the accurate and rapid identification of equine cyathostomins irrespective of their life cycle stage, opening important avenues for a better understanding of their biology and epidemiology and of the pathogenesis of cyathostomin-associated disease. In particular, this RLB method promises to be a powerful diagnostic tool to determine the roles of individual species in the pathogenesis of mixed infections and to elucidate some aspects of cyathostominosis. Also, it could represent a basic step toward the development of a rapid and simple molecular test for the early detection of drug-resistant genotypes of horse strongyle species.
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New method for simultaneous species-specific identification of equine strongyles (nematoda, strongylida) by reverse line blot hybridization
'American Society for Microbiology', 2007Co-Authors: Traversa D, T. R. Klei, Iorio R, Gawor J, Otranto D, Olivier SparaganoAbstract:The ability of a reverse line blot (RLB) assay to identify 13 common species of equine small strongyles (cyathostomins) and to discriminate them from three Strongylus spp. (large strongyles) was demonstrated. The assay relied on the specific hybridization of PCR-amplified intergenic spacer DNA fragments of the nuclear ribosomal DNA to membrane-bound species-specific probes. All cyathostomins examined were unequivocally identified and simultaneously discriminated from each other and from three large strongyles (Strongylus edentatus, Strongylus equinus, and Strongylus vulgaris). This assay will enable the accurate and rapid identification of equine cyathostomins irrespective of their life cycle stage, opening important avenues for a better understanding of their biology and epidemiology and of the pathogenesis of cyathostomin-associated disease. In particular, this RLB method promises to be a powerful diagnostic tool to determine the roles of individual species in the pathogenesis of mixed infections and to elucidate some aspects of cyathostominosis. Also, it could represent a basic step toward the development of a rapid and simple molecular test for the early detection of drug-resistant genotypes of horse strongyle species
Stéphane Bonneau - One of the best experts on this subject based on the ideXlab platform.
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Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species
Parasitology research, 2009Co-Authors: Stéphane Bonneau, Laurence Maynard, Krzysztof Tomczuk, Dawid J. Kok, Hyone-myong EunAbstract:In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin–praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n = 6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
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Anthelmintic efficacies of a tablet formula of ivermectin–praziquantel on horses experimentally infected with three Strongylus species
Parasitology Research, 2009Co-Authors: Stéphane Bonneau, Laurence Maynard, Krzysztof Tomczuk, Dawid Kok, Hyone-myong EunAbstract:In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin–praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris , Strongylus equinus , and Strongylus edentatus . The horses were randomly allocated to three groups ( n = 6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris , 100% and 81.4% on S. equinus , and equally 100% on S. edentatus . However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris -induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
M. B. Studzińska - One of the best experts on this subject based on the ideXlab platform.
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The Strongylidae belonging to Strongylus genus in horses from southeastern Poland
Parasitology Research, 2012Co-Authors: M. B. Studzińska, K. Tomczuk, M. Demkowska-kutrzepa, K. SzczepaniakAbstract:Postmortem parasitic examinations of the large intestines of 725 slaughtered horses from individual farmers in southeastern Poland were carried out. The examinations were carried out monthly since February 2006 until January 2007 (except for August 2007 because of a technological stoppage in the slaughterhouse). The examinations included the intensiveness and extensiveness of the infestation of the Strongylidae belonging to the Strongylus genus. The Strongylidae were found in 26.5 % of the examined horses. Strongylus vulgaris was the most dominant nematode and had a 22.8 % prevalence, Strongylus edentatus was carried by 18.3 % of the horses. Strongylus equinus was identified only in 1.7 % of the examined horses. Our findings revealed that combined infestation of S. vulgaris and S. edentatus occurred in 100 (52.1 %) of the 725 horses infected by the Strongylidae. The present results indicate that the lowest prevalence of strongyle species except for S. equinus was found in January, February, and March. However, it is difficult to draw a conclusion because of an extremely low extensiveness of infestation. The results indicate that the prevalence of the Strongylidae in horses from southeastern Poland is limited.
