The Experts below are selected from a list of 2391 Experts worldwide ranked by ideXlab platform
Jurriaan Ton - One of the best experts on this subject based on the ideXlab platform.
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Chemical priming of immunity without costs to Plant growth
The New phytologist, 2018Co-Authors: Will Buswell, Roland E. Schwarzenbacher, Estrella Luna, Matthew A. Sellwood, Beining Chen, Victor Flors, Pierre Pétriacq, Jurriaan TonAbstract:- β-aminobutyric acid (BABA) induces broad-spectrum disease resistance, but also represses Plant growth, which has limited its exploitation in crop protection. BABA perception relies on binding to the aspartyl-tRNA synthetase (AspRS) IBI1, which primes the enzyme for secondary defense activity. This study aimed to identify structural BABA analogues that induce resistance without Stunting Plant growth. - Using site-directed mutagenesis, we demonstrate that the (L)-aspartic acid-binding domain of IBI1 is critical for BABA perception. Based on interaction models of this domain, we screened a small library of structural BABA analogues for growth repression and induced resistance against biotrophic Hyaloperonospora arabidopsidis (Hpa). - A range of resistance-inducing compounds were identified, of which (R)-β-homoserine (RBH) was the most effective. Surprisingly, RBH acted through different pathways than BABA. RBH-induced resistance (RBH-IR) against Hpa functioned independently salicylic acid, partially relied on camalexin, and was associated with augmented cell wall defense. RBH-IR against necrotrophic Plectosphaerella cucumerina acted via priming of ethylene and jasmonic acid defenses. RBH-IR was also effective in tomato against Botrytis cinerea. Metabolic profiling revealed that RBH, unlike BABA, does not majorly affect Plant metabolism. - RBH primes distinct defense pathways against biotrophic and necrotrophic pathogens without Stunting Plant growth, signifying strong potential for exploitation in crop protection.
Will Buswell - One of the best experts on this subject based on the ideXlab platform.
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Chemical priming of immunity without costs to Plant growth
The New phytologist, 2018Co-Authors: Will Buswell, Roland E. Schwarzenbacher, Estrella Luna, Matthew A. Sellwood, Beining Chen, Victor Flors, Pierre Pétriacq, Jurriaan TonAbstract:- β-aminobutyric acid (BABA) induces broad-spectrum disease resistance, but also represses Plant growth, which has limited its exploitation in crop protection. BABA perception relies on binding to the aspartyl-tRNA synthetase (AspRS) IBI1, which primes the enzyme for secondary defense activity. This study aimed to identify structural BABA analogues that induce resistance without Stunting Plant growth. - Using site-directed mutagenesis, we demonstrate that the (L)-aspartic acid-binding domain of IBI1 is critical for BABA perception. Based on interaction models of this domain, we screened a small library of structural BABA analogues for growth repression and induced resistance against biotrophic Hyaloperonospora arabidopsidis (Hpa). - A range of resistance-inducing compounds were identified, of which (R)-β-homoserine (RBH) was the most effective. Surprisingly, RBH acted through different pathways than BABA. RBH-induced resistance (RBH-IR) against Hpa functioned independently salicylic acid, partially relied on camalexin, and was associated with augmented cell wall defense. RBH-IR against necrotrophic Plectosphaerella cucumerina acted via priming of ethylene and jasmonic acid defenses. RBH-IR was also effective in tomato against Botrytis cinerea. Metabolic profiling revealed that RBH, unlike BABA, does not majorly affect Plant metabolism. - RBH primes distinct defense pathways against biotrophic and necrotrophic pathogens without Stunting Plant growth, signifying strong potential for exploitation in crop protection.
Roland E. Schwarzenbacher - One of the best experts on this subject based on the ideXlab platform.
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Chemical priming of immunity without costs to Plant growth
The New phytologist, 2018Co-Authors: Will Buswell, Roland E. Schwarzenbacher, Estrella Luna, Matthew A. Sellwood, Beining Chen, Victor Flors, Pierre Pétriacq, Jurriaan TonAbstract:- β-aminobutyric acid (BABA) induces broad-spectrum disease resistance, but also represses Plant growth, which has limited its exploitation in crop protection. BABA perception relies on binding to the aspartyl-tRNA synthetase (AspRS) IBI1, which primes the enzyme for secondary defense activity. This study aimed to identify structural BABA analogues that induce resistance without Stunting Plant growth. - Using site-directed mutagenesis, we demonstrate that the (L)-aspartic acid-binding domain of IBI1 is critical for BABA perception. Based on interaction models of this domain, we screened a small library of structural BABA analogues for growth repression and induced resistance against biotrophic Hyaloperonospora arabidopsidis (Hpa). - A range of resistance-inducing compounds were identified, of which (R)-β-homoserine (RBH) was the most effective. Surprisingly, RBH acted through different pathways than BABA. RBH-induced resistance (RBH-IR) against Hpa functioned independently salicylic acid, partially relied on camalexin, and was associated with augmented cell wall defense. RBH-IR against necrotrophic Plectosphaerella cucumerina acted via priming of ethylene and jasmonic acid defenses. RBH-IR was also effective in tomato against Botrytis cinerea. Metabolic profiling revealed that RBH, unlike BABA, does not majorly affect Plant metabolism. - RBH primes distinct defense pathways against biotrophic and necrotrophic pathogens without Stunting Plant growth, signifying strong potential for exploitation in crop protection.
Estrella Luna - One of the best experts on this subject based on the ideXlab platform.
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Chemical priming of immunity without costs to Plant growth
The New phytologist, 2018Co-Authors: Will Buswell, Roland E. Schwarzenbacher, Estrella Luna, Matthew A. Sellwood, Beining Chen, Victor Flors, Pierre Pétriacq, Jurriaan TonAbstract:- β-aminobutyric acid (BABA) induces broad-spectrum disease resistance, but also represses Plant growth, which has limited its exploitation in crop protection. BABA perception relies on binding to the aspartyl-tRNA synthetase (AspRS) IBI1, which primes the enzyme for secondary defense activity. This study aimed to identify structural BABA analogues that induce resistance without Stunting Plant growth. - Using site-directed mutagenesis, we demonstrate that the (L)-aspartic acid-binding domain of IBI1 is critical for BABA perception. Based on interaction models of this domain, we screened a small library of structural BABA analogues for growth repression and induced resistance against biotrophic Hyaloperonospora arabidopsidis (Hpa). - A range of resistance-inducing compounds were identified, of which (R)-β-homoserine (RBH) was the most effective. Surprisingly, RBH acted through different pathways than BABA. RBH-induced resistance (RBH-IR) against Hpa functioned independently salicylic acid, partially relied on camalexin, and was associated with augmented cell wall defense. RBH-IR against necrotrophic Plectosphaerella cucumerina acted via priming of ethylene and jasmonic acid defenses. RBH-IR was also effective in tomato against Botrytis cinerea. Metabolic profiling revealed that RBH, unlike BABA, does not majorly affect Plant metabolism. - RBH primes distinct defense pathways against biotrophic and necrotrophic pathogens without Stunting Plant growth, signifying strong potential for exploitation in crop protection.
Matthew A. Sellwood - One of the best experts on this subject based on the ideXlab platform.
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Chemical priming of immunity without costs to Plant growth
The New phytologist, 2018Co-Authors: Will Buswell, Roland E. Schwarzenbacher, Estrella Luna, Matthew A. Sellwood, Beining Chen, Victor Flors, Pierre Pétriacq, Jurriaan TonAbstract:- β-aminobutyric acid (BABA) induces broad-spectrum disease resistance, but also represses Plant growth, which has limited its exploitation in crop protection. BABA perception relies on binding to the aspartyl-tRNA synthetase (AspRS) IBI1, which primes the enzyme for secondary defense activity. This study aimed to identify structural BABA analogues that induce resistance without Stunting Plant growth. - Using site-directed mutagenesis, we demonstrate that the (L)-aspartic acid-binding domain of IBI1 is critical for BABA perception. Based on interaction models of this domain, we screened a small library of structural BABA analogues for growth repression and induced resistance against biotrophic Hyaloperonospora arabidopsidis (Hpa). - A range of resistance-inducing compounds were identified, of which (R)-β-homoserine (RBH) was the most effective. Surprisingly, RBH acted through different pathways than BABA. RBH-induced resistance (RBH-IR) against Hpa functioned independently salicylic acid, partially relied on camalexin, and was associated with augmented cell wall defense. RBH-IR against necrotrophic Plectosphaerella cucumerina acted via priming of ethylene and jasmonic acid defenses. RBH-IR was also effective in tomato against Botrytis cinerea. Metabolic profiling revealed that RBH, unlike BABA, does not majorly affect Plant metabolism. - RBH primes distinct defense pathways against biotrophic and necrotrophic pathogens without Stunting Plant growth, signifying strong potential for exploitation in crop protection.
