The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Fumiaki Shono - One of the best experts on this subject based on the ideXlab platform.
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A research to develop a predicting system of mammalian Subacute Toxicity (1) prediction of Subacute Toxicity using the biological parameters of acute toxicities
Chemosphere, 1996Co-Authors: Takaaki Yamaguchi, Hiroshi Nishimura, Tomoyuki Watanabe, Shoji Saito, Masashi Yabuki, Kunio Shiba, Naohiko Isobe, Fumio Kishida, Michiko Kumano, Fumiaki ShonoAbstract:Abstract Predicting equations of Subacute Toxicity were developed by analyzing rat acute and Subacute Toxicity data of 56 chemicals of various structures. Minimum or 10% effect level in acute or Subacute Toxicity was estimated as a “biological parameter”. Good regression equations were established between the geometrical means (“combined parameters' of any two of the parameters of acute and Subacute toxicities and introduction of log P to the equations improved the correlations with a statistically significant multiple regression coefficient. The lowest predicted effect level of the Subacute Toxicity, which is selected from the data calculated by the above several correlations, can predict the upper limit of the no observed effect level.
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A research to develop a predicting system of mammalian Subacute Toxicity. (2) Single dose detailed Toxicity studies
Chemosphere, 1996Co-Authors: Takaaki Yamaguchi, Hiroshi Nishimura, Tomoyuki Watanabe, Shoji Saito, Masashi Yabuki, Naohiko Isobe, Fumiaki Shono, Hiroshi Sako, Haruhiko Adachi, Kunio ShibaAbstract:Abstract “Single dose detailed Toxicity study” in rats was conducted with 6 chemical substances to establish a predicting system of Subacute Toxicity of non-congeneric industrial chemicals. In the detailed examinations, new and previously reported biological parameters were developed and utilized for the establishment and confirmation of the correlations for both qualitative and quantitative prediction of target organs and effects in repeated dose Toxicity studies of non-congeners; the new parameters were concerned with liver, kidneys and blood and the established relating equations for prediction had a correlation coefficient of 0. 83 (liver), 0.49 (kidneys) and 0. 94 (blood), while the old parameters effectively confirmed the previous correlations. The serial changes in the study gave a biological explanation to the established relationships between acute and Subacute toxicities in terms of extrapolation.
Takaaki Yamaguchi - One of the best experts on this subject based on the ideXlab platform.
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A research to develop a predicting system of mammalian Subacute Toxicity (1) prediction of Subacute Toxicity using the biological parameters of acute toxicities
Chemosphere, 1996Co-Authors: Takaaki Yamaguchi, Hiroshi Nishimura, Tomoyuki Watanabe, Shoji Saito, Masashi Yabuki, Kunio Shiba, Naohiko Isobe, Fumio Kishida, Michiko Kumano, Fumiaki ShonoAbstract:Abstract Predicting equations of Subacute Toxicity were developed by analyzing rat acute and Subacute Toxicity data of 56 chemicals of various structures. Minimum or 10% effect level in acute or Subacute Toxicity was estimated as a “biological parameter”. Good regression equations were established between the geometrical means (“combined parameters' of any two of the parameters of acute and Subacute toxicities and introduction of log P to the equations improved the correlations with a statistically significant multiple regression coefficient. The lowest predicted effect level of the Subacute Toxicity, which is selected from the data calculated by the above several correlations, can predict the upper limit of the no observed effect level.
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A research to develop a predicting system of mammalian Subacute Toxicity. (2) Single dose detailed Toxicity studies
Chemosphere, 1996Co-Authors: Takaaki Yamaguchi, Hiroshi Nishimura, Tomoyuki Watanabe, Shoji Saito, Masashi Yabuki, Naohiko Isobe, Fumiaki Shono, Hiroshi Sako, Haruhiko Adachi, Kunio ShibaAbstract:Abstract “Single dose detailed Toxicity study” in rats was conducted with 6 chemical substances to establish a predicting system of Subacute Toxicity of non-congeneric industrial chemicals. In the detailed examinations, new and previously reported biological parameters were developed and utilized for the establishment and confirmation of the correlations for both qualitative and quantitative prediction of target organs and effects in repeated dose Toxicity studies of non-congeners; the new parameters were concerned with liver, kidneys and blood and the established relating equations for prediction had a correlation coefficient of 0. 83 (liver), 0.49 (kidneys) and 0. 94 (blood), while the old parameters effectively confirmed the previous correlations. The serial changes in the study gave a biological explanation to the established relationships between acute and Subacute toxicities in terms of extrapolation.
Kunio Shiba - One of the best experts on this subject based on the ideXlab platform.
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A research to develop a predicting system of mammalian Subacute Toxicity (1) prediction of Subacute Toxicity using the biological parameters of acute toxicities
Chemosphere, 1996Co-Authors: Takaaki Yamaguchi, Hiroshi Nishimura, Tomoyuki Watanabe, Shoji Saito, Masashi Yabuki, Kunio Shiba, Naohiko Isobe, Fumio Kishida, Michiko Kumano, Fumiaki ShonoAbstract:Abstract Predicting equations of Subacute Toxicity were developed by analyzing rat acute and Subacute Toxicity data of 56 chemicals of various structures. Minimum or 10% effect level in acute or Subacute Toxicity was estimated as a “biological parameter”. Good regression equations were established between the geometrical means (“combined parameters' of any two of the parameters of acute and Subacute toxicities and introduction of log P to the equations improved the correlations with a statistically significant multiple regression coefficient. The lowest predicted effect level of the Subacute Toxicity, which is selected from the data calculated by the above several correlations, can predict the upper limit of the no observed effect level.
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A research to develop a predicting system of mammalian Subacute Toxicity. (2) Single dose detailed Toxicity studies
Chemosphere, 1996Co-Authors: Takaaki Yamaguchi, Hiroshi Nishimura, Tomoyuki Watanabe, Shoji Saito, Masashi Yabuki, Naohiko Isobe, Fumiaki Shono, Hiroshi Sako, Haruhiko Adachi, Kunio ShibaAbstract:Abstract “Single dose detailed Toxicity study” in rats was conducted with 6 chemical substances to establish a predicting system of Subacute Toxicity of non-congeneric industrial chemicals. In the detailed examinations, new and previously reported biological parameters were developed and utilized for the establishment and confirmation of the correlations for both qualitative and quantitative prediction of target organs and effects in repeated dose Toxicity studies of non-congeners; the new parameters were concerned with liver, kidneys and blood and the established relating equations for prediction had a correlation coefficient of 0. 83 (liver), 0.49 (kidneys) and 0. 94 (blood), while the old parameters effectively confirmed the previous correlations. The serial changes in the study gave a biological explanation to the established relationships between acute and Subacute toxicities in terms of extrapolation.
Almir Gonçalves Wanderley - One of the best experts on this subject based on the ideXlab platform.
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Acute and Subacute Toxicity of Schinus terebinthifolius bark extract.
Journal of Ethnopharmacology, 2009Co-Authors: L.b. Lima, Carlos F.b. Vasconcelos, Hélida M. L. Maranhão, V.r. Leite, Pablo De Ataide Ferreira, B.a. Andrade, E.l. Araújo, Haroudo Satiro Xavier, Simone S.l. Lafayette, Almir Gonçalves WanderleyAbstract:Abstract Ethnopharmacological relevance Schinus terebinthifolius Raddi (Anacardiaceae) has long been used in traditional Brazilian medicine, especially to treat inflammatory and haemostatic diseases. Aim of the study The objective of this study was to evaluate the acute and Subacute Toxicity (45 days) of Schinus terebinthifolius via the oral route in Wistar rats of both sexes. Materials and methods For the acute Toxicity test, the dried extract of Schinus terebinthifolius bark was administered in doses from 0.625 to 5.0 g/kg ( n = 5/group/sex) and in the Subacute Toxicity test the following doses were used: 0.25, 0.625 and 1.5625 g/kg/day ( n = 13/group/sex), for 45 consecutive days. Results In the acute Toxicity test, Schinus terebinthifolius did not produce any toxic signs or deaths. The Subacute treatment with Schinus terebinthifolius did not alter either the body weight gain or the food and water consumption. The hematological and biochemical analysis did not show significant differences in any of the parameters examined in female or male groups, except in two male groups, in which the treatment with Schinus terebinthifolius (0.25 and 0.625 g/kg) induced an increase of mean corpuscular volume values (2.9 and 2.6%, respectively). These variations are within the physiological limits described for the specie and does not have clinical relevance. Conclusion The acute and Subacute administration of the dried extract of Schinus terebinthifolius bark did not produced toxic effects in Wistar rats.
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acute and Subacute Toxicity of the carapa guianensis aublet meliaceae seed oil
Journal of Ethnopharmacology, 2008Co-Authors: Joao Henrique Costasilva, Simone S.l. Lafayette, C R Lima, Erick J R Silva, Alice Valenca Araujo, Maria Do Carmo C A Fraga, Ribeiro A E Ribeiro, A C Arruda, Almir Gonçalves WanderleyAbstract:Carapa guianensis (Meliaceae), known as Andiroba in Brazil, has been used by Amazon Rainforest indigenous communities for treatment of coughs, convulsions, skin diseases, arthritis, rheumatism, ear infections, to heal wounds and bruises and as an insect repellent. Carapa guianensis seed oil (SO) was evaluated for its acute and Subacute Toxicity (30 days) by the oral route in Wistar rats. In the acute Toxicity test, SO (0.625-5.0g/kg, n=5/sex) did not produce any hazardous symptoms or deaths. The Subacute treatment with SO (0.375, 0.75 and 1.5g/kg, n=10/group) failed to change body weight gain, food and water consumption. Hematological analysis showed no significant differences in any of the parameters examined. However, in the biochemical parameters, there was an increase in the alanine aminotransferase (ALT) serum level (29%) in the group SO 1.5g/kg. In addition, absolute and relative liver weights were increased at the doses of 0.75g/kg (23.4 and 19.1%) and 1.5g/kg (18.7 and 33.1%). In conclusion, acute and Subacute administration of Carapa guianensis seed oil did not produce toxic effects in male Wistar rats. However, the increase in the ALT serum level and in both absolute and relative liver weights may indicate a possible hepatic Toxicity.
Xiangliang Yang - One of the best experts on this subject based on the ideXlab platform.
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acute and Subacute Toxicity studies on triptolide and triptolide loaded polymeric micelles following intravenous administration in rodents
Food and Chemical Toxicology, 2013Co-Authors: Yinsheng Qiu, Waikei Lam, Xiangliang YangAbstract:Except its anti-tumour effects, triptolide (TP) also shows multiple pharmacological side activities, such as immune-suppressive and male anti-fertility. To increase the therapeutic index of TP, a novel polymeric micelle system containing TP (TP-PM) has been developed to treat tumour. Our previous studies have demonstrated the good anti-tumour efficacy of TP-PM. This paper investigated the acute Toxicity in mice and Subacute Toxicity in rats of TP-PM and TP. Results demonstrated that the LD50 for TP-PM and TP administered intravenously were 1.06 mg/kg and 0.83 mg/kg in mice, respectively. In Subacute Toxicity study, TP-PM and TP were administered intravenously at the dose levels of 0.1 mg/kg and 0.3 mg/kg for 14 d. Compared to the control, there was significant decrease in the serum AST activities, the testis ACP activities, thymus index, testis index, and significant increase in spleen index, and obvious histopathological changes in rats treated with TP, however, the toxicities of TP-PM on liver, kidney, testis and spleen are slighter than TP. Compared to TP, TP-PM significantly increased the ACP activity of the testis and decreased the MDA level in serum. So, the polymeric micelles may be a novel drug delivery carrier of TP for reducing the toxicities of TP.
