The Experts below are selected from a list of 5199 Experts worldwide ranked by ideXlab platform
Nesko Neskovic - One of the best experts on this subject based on the ideXlab platform.
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subacute and Subchronic Toxicity of avalon mixture bentazone dicamba to rats
Environmental Toxicology and Pharmacology, 2015Co-Authors: Dragica Brkic, Ilona Szakonynepasics, Slavica Gasic, Ivana Teodorovic, Božidar Raskovic, Nenad Brkic, Nesko NeskovicAbstract:Abstract Subacute and Subchronic Toxicity of the herbicide Avalon ® , a mixture of bentazone and dicamba, were tested on rats. Avalon ® was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
Dragica Brkic - One of the best experts on this subject based on the ideXlab platform.
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subacute and Subchronic Toxicity of avalon mixture bentazone dicamba to rats
Environmental Toxicology and Pharmacology, 2015Co-Authors: Dragica Brkic, Ilona Szakonynepasics, Slavica Gasic, Ivana Teodorovic, Božidar Raskovic, Nenad Brkic, Nesko NeskovicAbstract:Abstract Subacute and Subchronic Toxicity of the herbicide Avalon ® , a mixture of bentazone and dicamba, were tested on rats. Avalon ® was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
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Subacute and Subchronic Toxicity of Avalon(®) mixture (bentazone+dicamba) to rats.
Environmental Toxicology and Pharmacology, 2015Co-Authors: Dragica Brkic, Slavica Gasic, Ivana Teodorovic, Ilona Szakonyne-pasics, Božidar Rašković, Nenad Brkić, Neško NeškovićAbstract:Abstract Subacute and Subchronic Toxicity of the herbicide Avalon ® , a mixture of bentazone and dicamba, were tested on rats. Avalon ® was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
Birhanu Tesfaye - One of the best experts on this subject based on the ideXlab platform.
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Antihyperglycemic and Subchronic Toxicity study of Moringa stenopetala leaves in mice
2014Co-Authors: Tesemma Sileshi, Eyasu Makonnen, Asfaw Debella, Birhanu TesfayeAbstract:Objective: To evaluate the antihyperglycemic activity and Subchronic Toxicity of an extract of Moringa stenopetala (M. stenopetala) leaves in mice. Methods: Antihyperglycemic activities of various solvent subfractions and chromatographic fractions were investigated in alloxan induced diabetic mice. All fractions were administered intragastrically using oral gavage at a dose of 500 mg/kg. For the Subchronic Toxicity investigation of the 70% ethanol extract of M. stenopetala leaves, a daily dose of 300 or 600 mg/kg body weight was administered to mice over 96 d. Some hematological and plasma biochemical parameters were measured as indices of organ specific Toxicity. Preliminary phytochemical screening and antioxidant activity investigation was done using thin layer chromatography method. Results: Among the solvent subfractions of the 70% ethanol extract tested only butanol subfraction exhibited significant reduction of blood glucose level (P
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antihyperglycemic and Subchronic Toxicity study of moringa stenopetala leaves in mice
2014Co-Authors: Tesemma Sileshi, Eyasu Makonnen, Asfaw Debella, Birhanu TesfayeAbstract:Objective: To evaluate the antihyperglycemic activity and Subchronic Toxicity of an extract of Moringa stenopetala (M. stenopetala) leaves in mice. Methods: Antihyperglycemic activities of various solvent subfractions and chromatographic fractions were investigated in alloxan induced diabetic mice. All fractions were administered intragastrically using oral gavage at a dose of 500 mg/kg. For the Subchronic Toxicity investigation of the 70% ethanol extract of M. stenopetala leaves, a daily dose of 300 or 600 mg/kg body weight was administered to mice over 96 d. Some hematological and plasma biochemical parameters were measured as indices of organ specific Toxicity. Preliminary phytochemical screening and antioxidant activity investigation was done using thin layer chromatography method. Results: Among the solvent subfractions of the 70% ethanol extract tested only butanol subfraction exhibited significant reduction of blood glucose level (P<0.05) at 2 h (53.44%) and 4.5 h (46.34%) in diabetic mice and it was further fractionated chromatographically. This resulted in isolation of three chromatographic fractions (fraction 1, 2, and 3) which exhibited maximal blood glucose reduction (P<0.01) at 6 h (77.2%), at 4.5 h (69.1%) and at 4.5 h (71.96%) after administration. Furthermore, these fractions exhibited comparable antioxidant activity, and preliminary phytochemical screening indicated the presence of phenolic compounds which may be phenolic glycoside in all fractions. The Subchronic Toxicity study of the 70% ethanol extract of M. stenopetala leaves revealed that there were no significant differences in body weight, between controls and treated mice. Hematological analysis showed no differences in most parameters examined. Furthermore, it did not significantly affect plasma creatinine, urea, cholesterol, triglycerides and CA125 levels. It also did not significantly affect the plasma T3, T4 and THS level. It, however, caused a significant dose-dependent increases in aspartate aminotransferase and alkaline phosphatase. The plasma alanine aminotransferase increased in a dose dependent manner, though not significant. Conclusions: The present study revealed that the crude ethanol extract and solvent-solvent fractions as well as chromatographic fractions have antihyperglycemic effect. Furthermore, the crude ethanol extract have some effect on liver of the mice on Subchronic administration. Therefore, further study should be done to identify the active principal compound responsible for antihyperglycemic effect and to rule out the safety in other animal model.
Paulo Roberto Dalsenter - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Subchronic Toxicity of the hydroethanolic extract of tropaeolum majus in wistar rats
Journal of Ethnopharmacology, 2012Co-Authors: Caroline Gomes, Arquimedes Gasparotto, Ana Carolina Lourenco, Erica Barbosa Liuti, Aline Oliveira Duque, Fabiola Nihi, Tatiane Camacho Mendes, Emerson Luiz Botelho Lourenço, Paulo Roberto DalsenterAbstract:Abstract Ethnopharmacological relevance The use of medicinal plants for the treatment of diseases usually comes from the belief that they present low Toxicity due their natural origin. However, it is necessary a toxicological and pharmacological evaluation for these plants. Tropaeolum majus is a medicinal plant used in popular medicine to treat several diseases, including cardiovascular disorders, urinary tract infections and asthma. Even though several studies proved its therapeutic effects, there are few toxicological studies with this species. Aim of the study The present study was carried out to evaluate the Subchronic Toxicity of the hydroethanolic extract obtained from leaves of T. majus (HETM) in Wistar rats. Material and methods Male and female Wistar rats received three doses of HETM (75, 375 and 750 mg/kg) for 28 days. After the treatments biochemical, hematological and histopathological parameters were analyzed. Results No significant alterations in the animal's body weight gain, relative organs weight, serum biochemical analysis, hematological or histopathological analyses of liver, kidneys and spleen were observed. Conclusions These results demonstrate the absence of Subchronic Toxicity due to oral treatment with HETM for 28 days in Wistar rats. However, other toxicological studies are necessary to evaluate the total safety of this plant.
Ivana Teodorovic - One of the best experts on this subject based on the ideXlab platform.
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subacute and Subchronic Toxicity of avalon mixture bentazone dicamba to rats
Environmental Toxicology and Pharmacology, 2015Co-Authors: Dragica Brkic, Ilona Szakonynepasics, Slavica Gasic, Ivana Teodorovic, Božidar Raskovic, Nenad Brkic, Nesko NeskovicAbstract:Abstract Subacute and Subchronic Toxicity of the herbicide Avalon ® , a mixture of bentazone and dicamba, were tested on rats. Avalon ® was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
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Subacute and Subchronic Toxicity of Avalon(®) mixture (bentazone+dicamba) to rats.
Environmental Toxicology and Pharmacology, 2015Co-Authors: Dragica Brkic, Slavica Gasic, Ivana Teodorovic, Ilona Szakonyne-pasics, Božidar Rašković, Nenad Brkić, Neško NeškovićAbstract:Abstract Subacute and Subchronic Toxicity of the herbicide Avalon ® , a mixture of bentazone and dicamba, were tested on rats. Avalon ® was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
