The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
Roger Williams - One of the best experts on this subject based on the ideXlab platform.
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Subclinical Seizure activity and prophylactic phenytoin infusion in acute liver failure a controlled clinical trial
Hepatology, 2000Co-Authors: A J Ellis, Julia Wendon, Roger WilliamsAbstract:Subclinical Seizure activity in the patient with encephalopathy and on ventilation with acute liver failure (ALF) is a poorly recognized entity. Its importance lies in the likely exacerbation of cerebral hypoxia and the contribution of such Seizure activity to the development of cerebral edema. The aim of the present study was to document the frequency of Subclinical Seizure activity in a cohort of patients with ALF by using a cerebral function and activity monitor that allows continuous recording of electroencephalogram activity at the bedside and to determine whether the prophylactic administration of the antiepileptic agent phenytoin would reduce its occurrence. Forty-two patients were enrolled in a controlled clinical trial: 20 patients were given phenytoin and 22 acted as controls. Subclinical Seizure activity was recorded in 3 and 10 patients, respectively, of the treated and control groups. Pupillary abnormalities indicative of Seizure activity and/or raised intracranial pressure (ICP) were also seen less frequently in the phenytoin-treated group compared with the controls (5 and 11 patients, respectively). Autopsy examinations available in 19 patients showed signs of cerebral edema in only 2 (22%) of the phenytoin-treated patients compared with 7 (70%) of the controls (P <.033). Based on these findings, we recommend that patients with ALF, on reaching the stage of grade III or IV encephalopathy, should be routinely monitored for Subclinical Seizure activity. In this study, prophylaxis with phenytoin reduced the frequency of such Seizure activity and its effects, and proved to be safe with the regimen used.
A J Ellis - One of the best experts on this subject based on the ideXlab platform.
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Subclinical Seizure activity and prophylactic phenytoin infusion in acute liver failure a controlled clinical trial
Hepatology, 2000Co-Authors: A J Ellis, Julia Wendon, Roger WilliamsAbstract:Subclinical Seizure activity in the patient with encephalopathy and on ventilation with acute liver failure (ALF) is a poorly recognized entity. Its importance lies in the likely exacerbation of cerebral hypoxia and the contribution of such Seizure activity to the development of cerebral edema. The aim of the present study was to document the frequency of Subclinical Seizure activity in a cohort of patients with ALF by using a cerebral function and activity monitor that allows continuous recording of electroencephalogram activity at the bedside and to determine whether the prophylactic administration of the antiepileptic agent phenytoin would reduce its occurrence. Forty-two patients were enrolled in a controlled clinical trial: 20 patients were given phenytoin and 22 acted as controls. Subclinical Seizure activity was recorded in 3 and 10 patients, respectively, of the treated and control groups. Pupillary abnormalities indicative of Seizure activity and/or raised intracranial pressure (ICP) were also seen less frequently in the phenytoin-treated group compared with the controls (5 and 11 patients, respectively). Autopsy examinations available in 19 patients showed signs of cerebral edema in only 2 (22%) of the phenytoin-treated patients compared with 7 (70%) of the controls (P <.033). Based on these findings, we recommend that patients with ALF, on reaching the stage of grade III or IV encephalopathy, should be routinely monitored for Subclinical Seizure activity. In this study, prophylaxis with phenytoin reduced the frequency of such Seizure activity and its effects, and proved to be safe with the regimen used.
Jiri Raboch - One of the best experts on this subject based on the ideXlab platform.
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Subclinical Epileptiform Process in Patients with Unipolar Depression and Its Indirect Psychophysiological Manifestations
2013Co-Authors: Petr Bob, Denisa Jasova, Jiri RabochAbstract:Background: According to recent clinical findings epileptiform activity in temporolimbic structures may cause depressive and other psychiatric symptoms that may occur independently of any Seizure in patient’s history. In addition in these patients Subclinical Seizure-like activity with indirect clinical manifestations likely may occur in a form of various forms of cognitive, affective, memory, sensory, behavioral and somatic symptoms (the so-called complex partial Seizure-like symptoms). A typical characteristic of epileptiform changes is increased neural synchrony related to spreading of epileptiform activity between hemispheres even in Subclinical conditions i.e. without Seizures. These findings suggest a hypothesis that measures reflecting a level of synchronization and information transfer between hemispheres could reflect spreading of epileptiform activity and might be related to complex partial Seizure-like symptoms. Methods and Findings: Suitable data for such analysis may provide various physiological signals reflecting brain laterality, as for example bilateral electrodermal activity (EDA) that is closely related to limbic modulation influences. With this purpose we have performed measurement and analysis of bilateral EDA and compared the results with psychometric measures of complex partial Seizure-like symptoms, depression and actually experienced stress in 44 patients with unipolar depression and 35 healthy controls. The results in unipolar depressive patients show that during rest conditions the patients with higher level of complex partial Seizure like symptoms (CPSI) display increased level of EDA transinformation (PTI
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Subclinical epileptiform process in patients with unipolar depression and its indirect psychophysiological manifestations.
Public Library of Science (PLoS), 2024Co-Authors: Petr Bob, Denisa Jasova, Jiri RabochAbstract:BACKGROUND: According to recent clinical findings epileptiform activity in temporolimbic structures may cause depressive and other psychiatric symptoms that may occur independently of any Seizure in patient's history. In addition in these patients Subclinical Seizure-like activity with indirect clinical manifestations likely may occur in a form of various forms of cognitive, affective, memory, sensory, behavioral and somatic symptoms (the so-called complex partial Seizure-like symptoms). A typical characteristic of epileptiform changes is increased neural synchrony related to spreading of epileptiform activity between hemispheres even in Subclinical conditions i.e. without Seizures. These findings suggest a hypothesis that measures reflecting a level of synchronization and information transfer between hemispheres could reflect spreading of epileptiform activity and might be related to complex partial Seizure-like symptoms. METHODS AND FINDINGS: Suitable data for such analysis may provide various physiological signals reflecting brain laterality, as for example bilateral electrodermal activity (EDA) that is closely related to limbic modulation influences. With this purpose we have performed measurement and analysis of bilateral EDA and compared the results with psychometric measures of complex partial Seizure-like symptoms, depression and actually experienced stress in 44 patients with unipolar depression and 35 healthy controls. The results in unipolar depressive patients show that during rest conditions the patients with higher level of complex partial Seizure like symptoms (CPSI) display increased level of EDA transinformation (PTI) calculated between left and right EDA records (Spearman correlation between CPSI and PTI is r = 0.43, p = 0.004). CONCLUSIONS: The result may present potentially useful clinical finding suggesting that increased EDA transinformation (PTI) could indirectly indicate increased neural synchrony as a possible indicator of epileptiform activity in unipolar depressive patients treated by serotoninergic antidepresants
Peng Yen-yi - One of the best experts on this subject based on the ideXlab platform.
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Reversible dementia: Subclinical Seizure in early-onset dementia
'Wiley', 2017Co-Authors: Tjong Elysia, Mchugh William, Peng Yen-yiAbstract:We report a case of early-onset dementia with Subclinical Seizures. Aggressive Seizure control improved the patient's cognition. Commonly, an EEG is only performed following overt behavioral Seizures. Therefore, Subclinical Seizures tend to be underdiagnosed. Serial or extended EEG should be seriously considered in patients with early-onset dementia
Yenyi Peng - One of the best experts on this subject based on the ideXlab platform.
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reversible dementia Subclinical Seizure in early onset dementia
Clinical Case Reports, 2017Co-Authors: Elysia Tjong, William Mchugh, Yenyi PengAbstract:Key Clinical Message We report a case of early-onset dementia with Subclinical Seizures. Aggressive Seizure control improved the patient's cognition. Commonly, an EEG is only performed following overt behavioral Seizures. Therefore, Subclinical Seizures tend to be underdiagnosed. Serial or extended EEG should be seriously considered in patients with early-onset dementia.
