The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Barbara Brotschi - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat Necrosis in neonates with hypoxic ischaemic encephalopathy registered in the swiss national asphyxia and cooling register
BMC Pediatrics, 2015Co-Authors: Beate Grass, Lisa Weibel, Cornelia Hagmann, Barbara BrotschiAbstract:Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous Fat Necrosis (SCFN) is an adverse event occurring in neonates with HIE. We analyzed risk factors for SCFN regarding demographic factors, cooling methods and deviation from target temperature range during hypothermia therapy. Data of all neonates registered in the National Asphyxia and Cooling Register in Switzerland between 2011 and 2013 were analyzed. 2.8 % of all cooled neonates with HIE developed SCFN. Perinatal and neonatal characteristics did not differ between neonates with and without SCFN. Applied cooling methods did not correlate with the occurrence of SCFN. In neonates with SCFN 83.3 % of all noted temperatures were within the target temperature range versus 77.5 % in neonates without SCFN. Neonates with SCFN showed 3.6 % of all measured temperatures below target temperature range compared to 12.7 % in neonates without SCFN. Subcutaneous Fat Necrosis in the neonate with HIE undergoing TH is a potential adverse event that seems to occur independently from the whole-body cooling method applied and proportion of temperature measurements outside target temperature range. In this cohort, moderate overcooling associated with moderate hypothermia (33.0–34.0 °C) does not seem to be an independent risk factor for SCFN. There is no correlation between the severity of HIE and incidence of SCFN.
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Subcutaneous Fat Necrosis in neonates with hypoxic ischaemic encephalopathy registered in the swiss national asphyxia and cooling register
BMC Pediatrics, 2015Co-Authors: Beate Grass, Lisa Weibel, Cornelia Hagmann, Barbara BrotschiAbstract:Background Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous Fat Necrosis (SCFN) is an adverse event occurring in neonates with HIE.
Lisa Weibel - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat Necrosis in neonates with hypoxic ischaemic encephalopathy registered in the swiss national asphyxia and cooling register
BMC Pediatrics, 2015Co-Authors: Beate Grass, Lisa Weibel, Cornelia Hagmann, Barbara BrotschiAbstract:Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous Fat Necrosis (SCFN) is an adverse event occurring in neonates with HIE. We analyzed risk factors for SCFN regarding demographic factors, cooling methods and deviation from target temperature range during hypothermia therapy. Data of all neonates registered in the National Asphyxia and Cooling Register in Switzerland between 2011 and 2013 were analyzed. 2.8 % of all cooled neonates with HIE developed SCFN. Perinatal and neonatal characteristics did not differ between neonates with and without SCFN. Applied cooling methods did not correlate with the occurrence of SCFN. In neonates with SCFN 83.3 % of all noted temperatures were within the target temperature range versus 77.5 % in neonates without SCFN. Neonates with SCFN showed 3.6 % of all measured temperatures below target temperature range compared to 12.7 % in neonates without SCFN. Subcutaneous Fat Necrosis in the neonate with HIE undergoing TH is a potential adverse event that seems to occur independently from the whole-body cooling method applied and proportion of temperature measurements outside target temperature range. In this cohort, moderate overcooling associated with moderate hypothermia (33.0–34.0 °C) does not seem to be an independent risk factor for SCFN. There is no correlation between the severity of HIE and incidence of SCFN.
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Subcutaneous Fat Necrosis in neonates with hypoxic ischaemic encephalopathy registered in the swiss national asphyxia and cooling register
BMC Pediatrics, 2015Co-Authors: Beate Grass, Lisa Weibel, Cornelia Hagmann, Barbara BrotschiAbstract:Background Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous Fat Necrosis (SCFN) is an adverse event occurring in neonates with HIE.
Dean S Morrell - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat Necrosis in a newborn following icebag application for treatment of supraventricular tachycardia
Journal of Perinatology, 2006Co-Authors: S Diamantis, T Bastek, Pamela A Groben, Dean S MorrellAbstract:Cases of Subcutaneous Fat Necrosis of the newborn (SCFN) and neonatal cold panniculitis have been reported most often secondary to perinatal distress or hypothermia. We present a case of a newborn infant who developed erythematous, indurated plaques on both cheeks and right shoulder following ice pack application for supraventricular tachycardia. The distinction between SCFN and cold panniculitis is important as SCFN may have complications such as hypercalcemia, whereas cold panniculitis is not associated with such sequelae. Clinicians should be aware of the diagnostic similarities and differences between these two conditions because of differences in potential serious sequelae.
Beate Grass - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat Necrosis in neonates with hypoxic ischaemic encephalopathy registered in the swiss national asphyxia and cooling register
BMC Pediatrics, 2015Co-Authors: Beate Grass, Lisa Weibel, Cornelia Hagmann, Barbara BrotschiAbstract:Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous Fat Necrosis (SCFN) is an adverse event occurring in neonates with HIE. We analyzed risk factors for SCFN regarding demographic factors, cooling methods and deviation from target temperature range during hypothermia therapy. Data of all neonates registered in the National Asphyxia and Cooling Register in Switzerland between 2011 and 2013 were analyzed. 2.8 % of all cooled neonates with HIE developed SCFN. Perinatal and neonatal characteristics did not differ between neonates with and without SCFN. Applied cooling methods did not correlate with the occurrence of SCFN. In neonates with SCFN 83.3 % of all noted temperatures were within the target temperature range versus 77.5 % in neonates without SCFN. Neonates with SCFN showed 3.6 % of all measured temperatures below target temperature range compared to 12.7 % in neonates without SCFN. Subcutaneous Fat Necrosis in the neonate with HIE undergoing TH is a potential adverse event that seems to occur independently from the whole-body cooling method applied and proportion of temperature measurements outside target temperature range. In this cohort, moderate overcooling associated with moderate hypothermia (33.0–34.0 °C) does not seem to be an independent risk factor for SCFN. There is no correlation between the severity of HIE and incidence of SCFN.
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Subcutaneous Fat Necrosis in neonates with hypoxic ischaemic encephalopathy registered in the swiss national asphyxia and cooling register
BMC Pediatrics, 2015Co-Authors: Beate Grass, Lisa Weibel, Cornelia Hagmann, Barbara BrotschiAbstract:Background Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous Fat Necrosis (SCFN) is an adverse event occurring in neonates with HIE.
Salvino Marcello Vitaliti - One of the best experts on this subject based on the ideXlab platform.
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use of zoledronic acid in a neonate with Subcutaneous Fat Necrosis complicated with severe refractory hypercalcemia
American Journal of Perinatology, 2019Co-Authors: Maria Angela Militello, Giuliana Vitaliti, Francesca Finazzo, Paolo Manzoni, Salvino Marcello VitalitiAbstract:Objective Subcutaneous Fat Necrosis (SCFN) is a rare condition that may occur in the neonatal period. SCFN is an inflammatory disorder of the adipose tissue, usually found in full-term healthy infants who have a history of intrauterine or perinatal distress. It is usually a self-limited condition; however, in some cases, it can get complicated, leading to severe hypercalcemia that may be life-threatening. Study Design We report and describe a classic presentation of SCFN that led to severe hypercalcemia refractory to standard treatment. The diagnosis of SCFN was made based on the finding of Subcutaneous nodules and of hypercalcemia. The serum calcium level reached 16.6 mg/dL. Hypercalcemia was treated first with intravenous infusions of fluids and furosemide and then of methylprednisolone. This standard treatment was not effective; therefore, we administered a single low dose of zoledronic acid, which, in turn, was efficacious in ultimately managing the hypercalcemia. Conclusion Our case shows how a single low dose of zoledronic acid was safe and effective in managing severe hypercalcemia unresponsive to conventional treatment while minimizing the risk of hypocalcemic rebounds.
