The Experts below are selected from a list of 10920 Experts worldwide ranked by ideXlab platform
Bernard Moss - One of the best experts on this subject based on the ideXlab platform.
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colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions
Cell Host & Microbe, 2007Co-Authors: George C Katsafanas, Bernard MossAbstract:Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation factors eIF4E and eIF4G, and ribosomal proteins are concentrated in the same subdomains of cytoplasmic DNA factories. Furthermore, a cell coinfected with two recombinant vaccinia viruses expressing a virus core protein fused to cyan or yellow fluorescent protein displayed separate cyan and yellow factories, indicating that each factory formed from a single genome and was the site of transcription and translation as well as DNA replication. Hijacking of the host translation apparatus within the factory likely enhances the efficiency of virus replication and contributes to the suppression of host protein synthesis, thereby facilitating poxvirus Subjugation of the cell.
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colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions
Cell Host & Microbe, 2007Co-Authors: George C Katsafanas, Bernard MossAbstract:Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation factors eIF4E and eIF4G, and ribosomal proteins are concentrated in the same subdomains of cytoplasmic DNA factories. Furthermore, a cell coinfected with two recombinant vaccinia viruses expressing a virus core protein fused to cyan or yellow fluorescent protein displayed separate cyan and yellow factories, indicating that each factory formed from a single genome and was the site of transcription and translation as well as DNA replication. Hijacking of the host translation apparatus within the factory likely enhances the efficiency of virus replication and contributes to the suppression of host protein synthesis, thereby facilitating poxvirus Subjugation of the cell.
George C Katsafanas - One of the best experts on this subject based on the ideXlab platform.
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colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions
Cell Host & Microbe, 2007Co-Authors: George C Katsafanas, Bernard MossAbstract:Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation factors eIF4E and eIF4G, and ribosomal proteins are concentrated in the same subdomains of cytoplasmic DNA factories. Furthermore, a cell coinfected with two recombinant vaccinia viruses expressing a virus core protein fused to cyan or yellow fluorescent protein displayed separate cyan and yellow factories, indicating that each factory formed from a single genome and was the site of transcription and translation as well as DNA replication. Hijacking of the host translation apparatus within the factory likely enhances the efficiency of virus replication and contributes to the suppression of host protein synthesis, thereby facilitating poxvirus Subjugation of the cell.
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colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions
Cell Host & Microbe, 2007Co-Authors: George C Katsafanas, Bernard MossAbstract:Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation factors eIF4E and eIF4G, and ribosomal proteins are concentrated in the same subdomains of cytoplasmic DNA factories. Furthermore, a cell coinfected with two recombinant vaccinia viruses expressing a virus core protein fused to cyan or yellow fluorescent protein displayed separate cyan and yellow factories, indicating that each factory formed from a single genome and was the site of transcription and translation as well as DNA replication. Hijacking of the host translation apparatus within the factory likely enhances the efficiency of virus replication and contributes to the suppression of host protein synthesis, thereby facilitating poxvirus Subjugation of the cell.
Larissa Z Tiedens - One of the best experts on this subject based on the ideXlab platform.
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anger and advancement versus sadness and Subjugation the effect of negative emotion expressions on social status conferral
Research Papers in Economics, 2001Co-Authors: Larissa Z TiedensAbstract:Four studies examine status conferral (decisions about to whom positions of status and power should be given). All of the studies show that people confer more status to targets who express anger than to targets who express sadness. In the first study, participants watched a video of President Clinton expressing either anger or sadness when talking about the Monica Lewinsky scandal. Those who say the anger clip were more likely to believe that Clinton should remain president than those who saw the sad clip. In the second study, participants said they were more likely to vote for an unknown political candidate when they saw him deliver a speech about terrorism in an angry way than when they saw the same speech delivered in a sad way. The third study showed that a manager's ratings of how likely people in his department were to be promoted were positively correlated with co-works' ratings of the degree to which these workers expressed anger at work. In the final study, participants who viewed a job candidate describing himself as having felt angry about a negative event from his previous job assigned him a higher status position and a higher salary than when the job candidate said he felt sad about the event. Further, Studies 2,3,and 4 showed that anger expressions created impressions that the expressor was competent, and, these perceptions of competence mediated the relationship between emotion expression and status conferral.
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anger and advancement versus sadness and Subjugation the effect of negative emotion expressions on social status conferral
Journal of Personality and Social Psychology, 2001Co-Authors: Larissa Z TiedensAbstract:Four studies examined status conferral (decisions about who should be granted status). The studies show that people confer more status to targets who express anger than to targets who express sadness. In the 1st study, participants supported President Clinton more when they viewed him expressing anger about the Monica Lewinsky scandal than when they saw him expressing sadness about the scandal. This effect was replicated with an unknown politician in Study 2. The 3rd study showed that status conferral in a company was correlated with peers' ratings of the workers' anger. In the final study, participants assigned a higher status position and a higher salary to a job candidate who described himself as angry as opposed to sad. Furthermore, Studies 2-4 showed that anger expressions created the impression that the expresser was competent and that these perceptions mediated the relationship between emotional expressions and status conferral.
Saito Nicole - One of the best experts on this subject based on the ideXlab platform.
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Sovereignty, Statehood, and Subjugation: Native Hawaiian and Japanese American Discourse over Hawaiian Statehood
Chapman University Digital Commons, 2021Co-Authors: Saito NicoleAbstract:Although discourse over Hawaiian statehood has increasingly been described by scholars as a racial conflict between Japanese Americans and Native Hawaiians, there existed a broad spectrum of interactions between the two groups. Both communities were forced to confront the prejudices they had against each other while recognizing their shared experiences with discrimination, creating a paradoxical political culture of competition and solidarity up until the conclusion of World War Two. From 1946 to 1950, however, the country’s collective understanding of Japanese American citizenship began to shift with recognition of the community’s military service record and an increased proportion of veterans elected to Congress. This shift prioritized Japanese American interests in statehood, marginalizing Native Hawaiians. From 1950 to 1959, the indigenous people were forced to frame their opinions before Congress in two ways: by conforming to harmful racial stereotypes, or arguing their opinions based on Japanese American interests rather than their own. These constraints—along with the Red Scare and pre-existing, intra-communal class tensions—eventually silenced Native Hawaiians in statehood discourse, be they in support or opposed. As such, statehood discourse was defined not by an explicit racial conflict between Japanese Americans and Native Hawaiians, but by the empowered assertion of Japanese American identity contrasted with Native Hawaiians’ careful navigation of mainland prejudices and, eventually, their political silencing
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3rd Place Contest Entry: Sovereignty, Statehood, and Subjugation: Native Hawaiian and Japanese American Discourse over Hawaiian Statehood
Chapman University Digital Commons, 2021Co-Authors: Saito NicoleAbstract:This is Nicole Saito\u27s submission for the 2021 Kevin and Tam Ross Undergraduate Research Prize, which won first place. It contains her essay on using library resources, a three-page sample of her research project on the consequences that Japanese American advocacy for Hawaiian statehood had on Native Hawaiians, and her works cited list. Nicole is a junior at Chapman University, majoring in Political Science, History, and Economics. Her faculty mentor is Dr. Robert Slayton
Peter L Jennings - One of the best experts on this subject based on the ideXlab platform.
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government discourses on entrepreneurship issues of legitimization Subjugation and power
Entrepreneurship Theory and Practice, 2005Co-Authors: Lew Perren, Peter L JenningsAbstract:The belief in market-driven ideology and the assumption that new business ventures create jobs and foster innovation has embedded entrepreneurship into political discourse. Academics have analyzed government policies on entrepreneurship, but they have tended to share the same underlying beliefs in the function of entrepreneurs within the economic machine. This article explores selected dimensions of the impact of those beliefs by using critical discourse analysis to show how government websites around the world portray entrepreneurs and their role in society. Discourses of government power and self-legitimization are revealed that manifest themselves in a colonizing discourse of entrepreneurial Subjugation. The article concludes by challenging government rhetoric on entrepreneurship and questioning the motives underpinning the agenda of government involvement in supporting entrepreneurs.
