The Experts below are selected from a list of 441 Experts worldwide ranked by ideXlab platform
O. V. Ivanova - One of the best experts on this subject based on the ideXlab platform.
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Effect of Phensuccinal on Pancreatic b-Cells in Rats with Neonatally Induced Streptozotocin Diabetes Mellitus
Bulletin of Experimental Biology and Medicine, 2001Co-Authors: N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, O. V. IvanovaAbstract:The effect of phensuccinal, a low-toxic Succinic Acid Derivative, on the function of pancreatic β-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of β-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.
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Effect of phensuccinal on pancreatic beta-cells in rats with neonatally induced streptozotocin diabetes mellitus.
Bulletin of experimental biology and medicine, 2001Co-Authors: N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, O. V. IvanovaAbstract:The effect of phensuccinal, a low-toxic Succinic Acid Derivative, on the function of pancreatic beta-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of beta-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.
Cesare Daniele Venneri - One of the best experts on this subject based on the ideXlab platform.
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A facile chemoenzymatic approach to chiral non-racemic β-alkyl-γ-amino Acids and 2-alkylSuccinic Acids. A concise synthesis of (S)-(+)-Pregabalin
Tetrahedron: Asymmetry, 2008Co-Authors: Fulvia Felluga, Giuliana Pitacco, Ennio Valentin, Cesare Daniele VenneriAbstract:Abstract Both enantiomerically pure antipodes of GABA analogues were prepared as hydrochloride salts, by enzymatic kinetic resolution of their precursors ethyl 2-(nitromethyl)alkanoates. These latter compounds can be easily transformed into enantiomerically pure 2-alkylSuccinic Acids by a Nef reaction followed by oxidation. Interestingly, this reaction was particularly easy for the neopentyl Derivative ( S )-(+)- 7d , which underwent conversion into its corresponding Succinic Acid Derivative ( S )-(−)- 8d in buffered solution. The absolute configurations of the main compounds of interest involved are given, together with their CD spectra.
N. I. Gorbenko - One of the best experts on this subject based on the ideXlab platform.
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Effect of Phensuccinal on Pancreatic b-Cells in Rats with Neonatally Induced Streptozotocin Diabetes Mellitus
Bulletin of Experimental Biology and Medicine, 2001Co-Authors: N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, O. V. IvanovaAbstract:The effect of phensuccinal, a low-toxic Succinic Acid Derivative, on the function of pancreatic β-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of β-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.
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Effect of phensuccinal on pancreatic beta-cells in rats with neonatally induced streptozotocin diabetes mellitus.
Bulletin of experimental biology and medicine, 2001Co-Authors: N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, O. V. IvanovaAbstract:The effect of phensuccinal, a low-toxic Succinic Acid Derivative, on the function of pancreatic beta-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of beta-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.
Fulvia Felluga - One of the best experts on this subject based on the ideXlab platform.
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A facile chemoenzymatic approach to chiral non-racemic β-alkyl-γ-amino Acids and 2-alkylSuccinic Acids. A concise synthesis of (S)-(+)-Pregabalin
Tetrahedron: Asymmetry, 2008Co-Authors: Fulvia Felluga, Giuliana Pitacco, Ennio Valentin, Cesare Daniele VenneriAbstract:Abstract Both enantiomerically pure antipodes of GABA analogues were prepared as hydrochloride salts, by enzymatic kinetic resolution of their precursors ethyl 2-(nitromethyl)alkanoates. These latter compounds can be easily transformed into enantiomerically pure 2-alkylSuccinic Acids by a Nef reaction followed by oxidation. Interestingly, this reaction was particularly easy for the neopentyl Derivative ( S )-(+)- 7d , which underwent conversion into its corresponding Succinic Acid Derivative ( S )-(−)- 8d in buffered solution. The absolute configurations of the main compounds of interest involved are given, together with their CD spectra.
V. V. Poltorak - One of the best experts on this subject based on the ideXlab platform.
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Effect of Phensuccinal on Pancreatic b-Cells in Rats with Neonatally Induced Streptozotocin Diabetes Mellitus
Bulletin of Experimental Biology and Medicine, 2001Co-Authors: N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, O. V. IvanovaAbstract:The effect of phensuccinal, a low-toxic Succinic Acid Derivative, on the function of pancreatic β-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of β-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.
-
Effect of phensuccinal on pancreatic beta-cells in rats with neonatally induced streptozotocin diabetes mellitus.
Bulletin of experimental biology and medicine, 2001Co-Authors: N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, O. V. IvanovaAbstract:The effect of phensuccinal, a low-toxic Succinic Acid Derivative, on the function of pancreatic beta-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of beta-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.
