The Experts below are selected from a list of 549 Experts worldwide ranked by ideXlab platform
Hua Wang - One of the best experts on this subject based on the ideXlab platform.
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visible light enabled spirocyclization of alkynes leading to 3 sulfonyl and 3 sulfenyl azaspiro 4 5 trienones
Green Chemistry, 2017Co-Authors: Daoshan Yang, Chenglong He, Yulong Zhang, Hua WangAbstract:A mild and convenient visible-light-induced method has been developed for the construction of 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones through metal-free difunctionalization of alkynes with Sulfinic Acids or thiols at room temperature. The present protocol simply utilizes visible light as the safe and eco-friendly energy source, and inexpensive and non-toxic organic dyes (Eosin Y and Na2-Eosin Y) as photocatalysts providing various sulfur-containing azaspiro[4,5]trienones in moderate to good yields.
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visible light induced c h sulfenylation using Sulfinic Acids
Green Chemistry, 2017Co-Authors: Pengfei Sun, Daoshan Yang, Wei Wei, Min Jiang, Zuli Wang, Liyan Zhang, Hui Zhang, Zhenzhen Zhang, Yu Wang, Hua WangAbstract:The visible light and Eosin B-catalyzed direct sulfenylation of sp2 C–H bonds with Sulfinic Acids through a photoredox process has been demonstrated at room temperature under transition metal-free conditions for the first time. Diverse heteroaryl sulfides were obtained in moderate to good yields. This is the first example of the sulfenylation of sp2 C–H bonds using arylSulfinic Acids as odorless sulfur reagents under visible light-induced conditions. More interestingly, the reductive products could be obtained under visible light-induced oxidative conditions. This protocol demonstrates a new model for C–S bond formation, which serves as a novel approach toward the synthesis of heteroaryl sulfides.
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direct difunctionalization of alkynes with Sulfinic Acids and molecular iodine a simple and convenient approach to e β iodovinyl sulfones
ChemInform, 2015Co-Authors: Daoshan Yang, Huijun Jing, Hua WangAbstract:A wide range of the title compounds (III) is efficiently obtained from simple and easily available starting materials with excellent stereo- and regioselectivity and without use of any metal catalyst or additives.
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direct difunctionalization of alkynes with Sulfinic Acids and molecular iodine a simple and convenient approach to e β iodovinyl sulfones
RSC Advances, 2015Co-Authors: Daoshan Yang, Huijun Jing, Hua WangAbstract:A simple and convenient approach for the construction of β-iodovinyl sulfones has been developed via direct difunctionalization of alkynes with Sulfinic Acids and molecular iodine. The present reaction provides a highly efficient approach to a diverse range of substituted (E)-β-iodovinyl sulfones in moderate to good yields with excellent stereo- and regio-selectivities but no need for any metal catalyst or additives.
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catalyst free direct arylsulfonylation of n arylacrylamides with Sulfinic Acids a convenient and efficient route to sulfonated oxindoles
Green Chemistry, 2014Co-Authors: Wei Wei, Daoshan Yang, Jiangwei Wen, Jinmao You, Hua WangAbstract:A simple, efficient and catalyst-free procedure has been developed for the construction of sulfonated oxindoles via the direct arylsulfonylation of N-arylacrylamides with Sulfinic Acids. The present protocol, which simply utilizes cheap oxidants, readily-available starting materials, and catalyst-free conditions, provides an alternative and highly attractive approach to a series of sulfonated oxindoles with high atom efficiency and excellent functional group tolerance.
Lei Wang - One of the best experts on this subject based on the ideXlab platform.
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recent advances in exploring diverse decarbonylation decarboxylation and desulfitation coupling reactions for organic transformations
Synlett, 2016Co-Authors: Hongji Li, Pinhua Li, Tao Miao, Min Wang, Lei WangAbstract:Decarbonylation, decarboxylation and desulfitation reactions have been adopted as new strategies and applied in organic synthesis for their obvious advantages over traditional cross-coupling reactions involving organometallic reagents. In this account, we highlight our recent progress on the development of novel decarbonylative, decarboxylative and desulfitative coupling reactions to construct diverse hydrocarbons via transition-metal catalysis and visible-light photoredox catalysis. In addition, mechanistic investigations describe the decarboxylative process of α-keto Acids by trapping possible formed intermediates, and plausible reaction pathways are proposed. In another case, we demonstrate the successful desulfitative reactions of Sulfinic Acids and their sodium salts with other organic coupling partners. Among these, several reactions tolerate a range of functional groups whilst others even occur in aqueous solution. 1 Introduction 2 Palladium-Catalyzed Decarbonylative Arylation of Azoles with Arylamides 3 Transition-Metal-Catalyzed (-Mediated) Decarboxylation of Carboxylic Acids and their Derivatives 4 Visible-Light Photoredox-Catalyzed Decarboxylative Coupling Reactions 5 Transition-Metal-Catalyzed Desulfitative Coupling Reactions 6 Conclusion
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visible light initiated oxidative cyclization of phenyl propiolates with Sulfinic Acids to coumarin derivatives under metal free conditions
ChemInform, 2015Co-Authors: Wenchao Yang, Pinhua Li, Lei Wang, Shuai YangAbstract:A simple procedure is elaborated for the synthesis of coumarins by an eosin-catalyzed photooxidative cyclization of aryl 3-arylpropionates with Sulfinic Acids.
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visible light initiated oxidative cyclization of phenyl propiolates with Sulfinic Acids to coumarin derivatives under metal free conditions
Chemical Communications, 2015Co-Authors: Wenchao Yang, Pinhua Li, Lei Wang, Shuai YangAbstract:A visible-light initiated oxidative cyclization of phenyl propiolates with Sulfinic Acids has been developed. The arylsulfonylation of alkynes was performed at room temperature under metal-free conditions to generate coumarin derivatives with wide functional group tolerance, good yields and high regioselectivity.
Daoshan Yang - One of the best experts on this subject based on the ideXlab platform.
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visible light enabled spirocyclization of alkynes leading to 3 sulfonyl and 3 sulfenyl azaspiro 4 5 trienones
Green Chemistry, 2017Co-Authors: Daoshan Yang, Chenglong He, Yulong Zhang, Hua WangAbstract:A mild and convenient visible-light-induced method has been developed for the construction of 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones through metal-free difunctionalization of alkynes with Sulfinic Acids or thiols at room temperature. The present protocol simply utilizes visible light as the safe and eco-friendly energy source, and inexpensive and non-toxic organic dyes (Eosin Y and Na2-Eosin Y) as photocatalysts providing various sulfur-containing azaspiro[4,5]trienones in moderate to good yields.
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visible light induced c h sulfenylation using Sulfinic Acids
Green Chemistry, 2017Co-Authors: Pengfei Sun, Daoshan Yang, Wei Wei, Min Jiang, Zuli Wang, Liyan Zhang, Hui Zhang, Zhenzhen Zhang, Yu Wang, Hua WangAbstract:The visible light and Eosin B-catalyzed direct sulfenylation of sp2 C–H bonds with Sulfinic Acids through a photoredox process has been demonstrated at room temperature under transition metal-free conditions for the first time. Diverse heteroaryl sulfides were obtained in moderate to good yields. This is the first example of the sulfenylation of sp2 C–H bonds using arylSulfinic Acids as odorless sulfur reagents under visible light-induced conditions. More interestingly, the reductive products could be obtained under visible light-induced oxidative conditions. This protocol demonstrates a new model for C–S bond formation, which serves as a novel approach toward the synthesis of heteroaryl sulfides.
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direct difunctionalization of alkynes with Sulfinic Acids and molecular iodine a simple and convenient approach to e β iodovinyl sulfones
ChemInform, 2015Co-Authors: Daoshan Yang, Huijun Jing, Hua WangAbstract:A wide range of the title compounds (III) is efficiently obtained from simple and easily available starting materials with excellent stereo- and regioselectivity and without use of any metal catalyst or additives.
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direct difunctionalization of alkynes with Sulfinic Acids and molecular iodine a simple and convenient approach to e β iodovinyl sulfones
RSC Advances, 2015Co-Authors: Daoshan Yang, Huijun Jing, Hua WangAbstract:A simple and convenient approach for the construction of β-iodovinyl sulfones has been developed via direct difunctionalization of alkynes with Sulfinic Acids and molecular iodine. The present reaction provides a highly efficient approach to a diverse range of substituted (E)-β-iodovinyl sulfones in moderate to good yields with excellent stereo- and regio-selectivities but no need for any metal catalyst or additives.
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catalyst free direct arylsulfonylation of n arylacrylamides with Sulfinic Acids a convenient and efficient route to sulfonated oxindoles
Green Chemistry, 2014Co-Authors: Wei Wei, Daoshan Yang, Jiangwei Wen, Jinmao You, Hua WangAbstract:A simple, efficient and catalyst-free procedure has been developed for the construction of sulfonated oxindoles via the direct arylsulfonylation of N-arylacrylamides with Sulfinic Acids. The present protocol, which simply utilizes cheap oxidants, readily-available starting materials, and catalyst-free conditions, provides an alternative and highly attractive approach to a series of sulfonated oxindoles with high atom efficiency and excellent functional group tolerance.
Bing Han - One of the best experts on this subject based on the ideXlab platform.
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tert-Butyl nitrite-mediated vicinal sulfoximation of alkenes with Sulfinic Acids: a highly efficient approach toward α-sulfonyl ketoximes
Organic Chemistry Frontiers, 2017Co-Authors: Fei Chen, Neng-neng Zhou, Jun-long Zhan, Bing HanAbstract:A novel vicinal sulfoximation of alkenes was achieved under mild and metal-free conditions by using readily available Sulfinic Acids as the sulfonating agent and tert-butyl nitrite (TBN) as the radical initiator and the oxime source. Various structurally important α-sulfonyl ketoximes can be prepared from unactivated as well as activated alkenes in high efficiency by utilizing this protocol.
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tert butyl hydroperoxide tbhp initiated vicinal sulfonamination of alkynes a radical annulation toward 3 sulfonylindoles
Organic Letters, 2016Co-Authors: Fei Chen, Qiang Meng, Shangqing Han, Bing HanAbstract:A novel, efficient, and facile vicinal sulfonamination of alkynes by the reaction of accessible 2-alkynyl arylazides with Sulfinic Acids in the presence of tert-butyl hydroperoxide (TBHP) has been developed. This protocol utilizes Sulfinic Acids as the sulfonating reagent, azidos as the aminating reagent, and TBHP as the sulfonyl radical initiator. By using this protocol, a variety of potentially bioactive 3-sulfonylindoles were facilely synthesized via direct annulation.
Aiwen Lei - One of the best experts on this subject based on the ideXlab platform.
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Electrooxidative Tandem Cyclization of Activated Alkynes with Sulfinic Acids To Access Sulfonated Indenones
2017Co-Authors: Jiangwei Wen, Huamin Wang, Wenyan Shi, Fan Zhang, Dong Liu, Shan Tang, Xiao-min Lin, Aiwen LeiAbstract:An electrooxidative direct arylsulfonlylation of ynones with Sulfinic Acids via a radical tandem cyclization strategy has been developed for the construction of sulfonated indenones under oxidant-free conditions. This method provides a simple and efficient approach to prepare various sulfonylindenones in good to excellent yields, demonstrating the tremendous prospect of utilizing electrocatalysis in oxidative coupling. Notably, this reaction could be easily scaled up with good efficiency
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visible light induced oxidant free oxidative cross coupling for constructing allylic sulfones from olefins and Sulfinic Acids
Chemical Communications, 2016Co-Authors: Guoting Zhang, Aiwen Lei, Lingling Zhang, Yi Luo, Chenho TungAbstract:An oxidant-free dehydrogenative sulfonylation of α-methyl-styrene derivatives was developed for the construction of allylic sulfones by using eosin Y as a photosensitizer in conjunction with a cobaloxime catalyst. The process features a low-cost metal catalyst and atom economy, which provides an appealing strategy for future synthetic chemistry.
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Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes toward β‑Keto Sulfones
2013Co-Authors: Jian Zhang, Ganglu Zhao, Huamin Wang, Aiwen LeiAbstract:An unprecedented dioxygen-triggered oxidative radical process was explored using dioxygen as the solely terminal oxidant, realizing aerobic oxidaitve difunctionalization of terminal alkynes toward β-keto sulfones with high selectivity. Operando IR experiments revealed that pyridine not only acts as a base to successfully surpress ATRA (atom transfer radical addition) process, but also plays a vital role in reducing the activity of Sulfinic Acids