The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Toshio Tanaka - One of the best experts on this subject based on the ideXlab platform.
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the cyclic organoSulfur Compound zwiebelane a from onion allium cepa functions as an enhancer of polymyxin b in fungal vacuole disruption
Planta Medica, 2010Co-Authors: Baiyinlang Borjihan, Akira Ogita, Kenichi Fujita, Toshio TanakaAbstract:: Zwiebelane A (CIS-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl Sulfur Compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.
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enhancement of the fungicidal activity of amphotericin b by allicin an allyl Sulfur Compound from garlic against the yeast saccharomyces cerevisiae as a model system
Planta Medica, 2006Co-Authors: Akira Ogita, Kenichi Fujita, Makoto Taniguchi, Toshio TanakaAbstract:: Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-Sulfur Compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were visible as small discrete particles. Although allicin was ineffective in promoting AmB-induced plasma membrane disability, this Compound enhanced AmB-induced structural damage to the vacuolar membrane even at a non-lethal dose of the antibiotic. Allicin could also enhance the antifungal activity of AmB against the pathogenic fungus Candida albicans and against Aspergillus fumigatus. In contrast, allicin did not enhance the cytotoxic activity of AmB against cells of human promyelocytic leukemia (HL-60), a vacuole-less organism.
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synergistic fungicidal activity of cu2 and allicin an allyl Sulfur Compound from garlic and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in saccharomyces cerevisiae
Toxicology, 2005Co-Authors: Akira Ogita, Kenichi Fujita, Kiyoo Hirooka, Yoshihiro Yamamoto, Nobuo Tsutsui, Makoto Taniguchi, Toshio TanakaAbstract:Abstract Cu 2+ showed a dose-dependent fungicidal activity against Saccharomyces cerevisiae cells, and its lethal effect was extremely enhanced in the presence of allicin, an allyl Sulfur Compound from garlic. The fungicidal activity of Cu 2+ was unaffected or rather attenuated by other Sulfur-containing Compounds such as N -acetyl-cysteine, l -cysteine or dithiothreitol. Ca 2+ could absolutely protect against the lethal effect of Cu 2+ itself, but showed no protection against the fungicidal activity of Cu 2+ newly generated in combination with allicin. Cu 2+ accelerated an endogenous generation of reactive oxygen species (ROS) in S. cerevisiae cells at a lethal concentration, but such intracellular oxidative stress induction was not observed during cell death progression upon treatment with Cu 2+ and allicin. A surfactant, sodium N -lauroyl sarcosinate (SLS), enhanced the solubilization of a few proteins including alkyl hydroperoxide reductase 1 (AHP1) in intact cells, accounting for the absence of this protein in the extract from allicin-treated cells. Allicin-treated cells were rendered extremely sensitive to the subsequent Cu 2+ treatment as in the case of SLS-treated cells. Allicin-treated cells and SLS-treated cells similarly showed an increased sensitivity to exogenously added tert -butyl hydroperoxide ( t -BOOH), an organic peroxide that is detoxified by the action of AHP1. Our study suggests that allicin influences the mode of cell surface localization or the related function of AHP1 as a defense against phospholipid peroxidation by the external action of Cu 2+ .
J L G Fierro - One of the best experts on this subject based on the ideXlab platform.
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effectiveness of metal organic frameworks for removal of refractory organo Sulfur Compound present in liquid fuels
Fuel, 2011Co-Authors: Gema Blancobrieva, J M Camposmartin, Saeed M Alzahrani, J L G FierroAbstract:Abstract Adsorption of organo-Sulfur Compounds present in liquid fuels on metal–organic framework (MOF) Compounds is an efficient alternative to the conventional hydrodeSulfurization process. It has been demonstrated that the extent of dibenzothiophene (DBT) adsorption at temperatures close to ambient (304 K) is much higher on MOFs systems than on the benchmarked Y-type zeolite. In addition, the DBT adsorption capacity depends strongly on the MOF type as illustrated by the much higher extent of adsorption observed on the copper- (C300) and Al-containing (A100) MOF systems than on the Fe-containing (F300) MOF counterpart. With the aim to investigate the operation in consecutive cycles, the MOFs used in adsorption experiments were regenerated. In addition, the remaining S-containing Compounds were identified and quantified by photoelectron spectroscopy (XPS). Examination of S2p core-level spectrum of the adsorbed S-Compounds of regenerated MOFs pointed out that a fraction of these molecules become oxidized into S(VI) species.
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effectiveness of metal organic frameworks for removal of refractory organo Sulfur Compound present in liquid fuels
Fuel, 2011Co-Authors: Gema Blancobrieva, J M Camposmartin, Saeed M Alzahrani, J L G FierroAbstract:Abstract Adsorption of organo-Sulfur Compounds present in liquid fuels on metal–organic framework (MOF) Compounds is an efficient alternative to the conventional hydrodeSulfurization process. It has been demonstrated that the extent of dibenzothiophene (DBT) adsorption at temperatures close to ambient (304 K) is much higher on MOFs systems than on the benchmarked Y-type zeolite. In addition, the DBT adsorption capacity depends strongly on the MOF type as illustrated by the much higher extent of adsorption observed on the copper- (C300) and Al-containing (A100) MOF systems than on the Fe-containing (F300) MOF counterpart. With the aim to investigate the operation in consecutive cycles, the MOFs used in adsorption experiments were regenerated. In addition, the remaining S-containing Compounds were identified and quantified by photoelectron spectroscopy (XPS). Examination of S2p core-level spectrum of the adsorbed S-Compounds of regenerated MOFs pointed out that a fraction of these molecules become oxidized into S(VI) species.
Mark Dopson - One of the best experts on this subject based on the ideXlab platform.
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A Novel Inorganic Sulfur Compound Metabolizing Ferroplasma-Like Population Is Suggested to Mediate Extracellular Electron Transfer
Frontiers Media S.A., 2018Co-Authors: Domenico Simone, Daniela Palma, Elias Broman, Stephanie Turner, Mark DopsonAbstract:Mining and processing of metal sulfide ores produces waters containing metals and inorganic Sulfur Compounds such as tetrathionate and thiosulfate. If released untreated, these Sulfur Compounds can be oxidized to generate highly acidic wastewaters [termed ‘acid mine drainage (AMD)’] that cause severe environmental pollution. One potential method to remediate mining wastewaters is the maturing biotechnology of ‘microbial fuel cells’ that offers the sustainable removal of acid generating inorganic Sulfur Compounds alongside producing an electrical current. Microbial fuel cells exploit the ability of bacterial cells to transfer electrons to a mineral as the terminal electron acceptor during anaerobic respiration by replacing the mineral with a solid anode. In consequence, by substituting natural minerals with electrodes, microbial fuel cells also provide an excellent platform to understand environmental microbe–mineral interactions that are fundamental to element cycling. Previously, tetrathionate degradation coupled to the generation of an electrical current has been demonstrated and here we report a metagenomic and metatranscriptomic analysis of the microbial community. Reconstruction of inorganic Sulfur Compound metabolism suggested the substrate tetrathionate was metabolized by the Ferroplasma-like and Acidithiobacillus-like populations via multiple pathways. Characterized Ferroplasma species do not utilize inorganic Sulfur Compounds, suggesting a novel Ferroplasma-like population had been selected. Oxidation of intermediate sulfide, Sulfur, thiosulfate, and adenylyl-sulfate released electrons and the extracellular electron transfer to the anode was suggested to be dominated by candidate soluble electron shuttles produced by the Ferroplasma-like population. However, as the soluble electron shuttle Compounds also have alternative functions within the cell, it cannot be ruled out that acidophiles use novel, uncharacterized mechanisms to mediate extracellular electron transfer. Several populations within the community were suggested to metabolize intermediate inorganic Sulfur Compounds by multiple pathways, which highlights the potential for mutualistic or symbiotic relationships. This study provided the genetic base for acidophilic microbial fuel cells utilized for the remediation of inorganic Sulfur Compounds from AMD
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Table_2_A Novel Inorganic Sulfur Compound Metabolizing Ferroplasma-Like Population Is Suggested to Mediate Extracellular Electron Transfer.xlsx
2018Co-Authors: Domenico Simone, Daniela Palma, Elias Broman, Stephanie Turner, Mark DopsonAbstract:Mining and processing of metal sulfide ores produces waters containing metals and inorganic Sulfur Compounds such as tetrathionate and thiosulfate. If released untreated, these Sulfur Compounds can be oxidized to generate highly acidic wastewaters [termed ‘acid mine drainage (AMD)’] that cause severe environmental pollution. One potential method to remediate mining wastewaters is the maturing biotechnology of ‘microbial fuel cells’ that offers the sustainable removal of acid generating inorganic Sulfur Compounds alongside producing an electrical current. Microbial fuel cells exploit the ability of bacterial cells to transfer electrons to a mineral as the terminal electron acceptor during anaerobic respiration by replacing the mineral with a solid anode. In consequence, by substituting natural minerals with electrodes, microbial fuel cells also provide an excellent platform to understand environmental microbe–mineral interactions that are fundamental to element cycling. Previously, tetrathionate degradation coupled to the generation of an electrical current has been demonstrated and here we report a metagenomic and metatranscriptomic analysis of the microbial community. Reconstruction of inorganic Sulfur Compound metabolism suggested the substrate tetrathionate was metabolized by the Ferroplasma-like and Acidithiobacillus-like populations via multiple pathways. Characterized Ferroplasma species do not utilize inorganic Sulfur Compounds, suggesting a novel Ferroplasma-like population had been selected. Oxidation of intermediate sulfide, Sulfur, thiosulfate, and adenylyl-sulfate released electrons and the extracellular electron transfer to the anode was suggested to be dominated by candidate soluble electron shuttles produced by the Ferroplasma-like population. However, as the soluble electron shuttle Compounds also have alternative functions within the cell, it cannot be ruled out that acidophiles use novel, uncharacterized mechanisms to mediate extracellular electron transfer. Several populations within the community were suggested to metabolize intermediate inorganic Sulfur Compounds by multiple pathways, which highlights the potential for mutualistic or symbiotic relationships. This study provided the genetic base for acidophilic microbial fuel cells utilized for the remediation of inorganic Sulfur Compounds from AMD.
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Table_1_A Novel Inorganic Sulfur Compound Metabolizing Ferroplasma-Like Population Is Suggested to Mediate Extracellular Electron Transfer.docx
2018Co-Authors: Domenico Simone, Daniela Palma, Elias Broman, Stephanie Turner, Mark DopsonAbstract:Mining and processing of metal sulfide ores produces waters containing metals and inorganic Sulfur Compounds such as tetrathionate and thiosulfate. If released untreated, these Sulfur Compounds can be oxidized to generate highly acidic wastewaters [termed ‘acid mine drainage (AMD)’] that cause severe environmental pollution. One potential method to remediate mining wastewaters is the maturing biotechnology of ‘microbial fuel cells’ that offers the sustainable removal of acid generating inorganic Sulfur Compounds alongside producing an electrical current. Microbial fuel cells exploit the ability of bacterial cells to transfer electrons to a mineral as the terminal electron acceptor during anaerobic respiration by replacing the mineral with a solid anode. In consequence, by substituting natural minerals with electrodes, microbial fuel cells also provide an excellent platform to understand environmental microbe–mineral interactions that are fundamental to element cycling. Previously, tetrathionate degradation coupled to the generation of an electrical current has been demonstrated and here we report a metagenomic and metatranscriptomic analysis of the microbial community. Reconstruction of inorganic Sulfur Compound metabolism suggested the substrate tetrathionate was metabolized by the Ferroplasma-like and Acidithiobacillus-like populations via multiple pathways. Characterized Ferroplasma species do not utilize inorganic Sulfur Compounds, suggesting a novel Ferroplasma-like population had been selected. Oxidation of intermediate sulfide, Sulfur, thiosulfate, and adenylyl-sulfate released electrons and the extracellular electron transfer to the anode was suggested to be dominated by candidate soluble electron shuttles produced by the Ferroplasma-like population. However, as the soluble electron shuttle Compounds also have alternative functions within the cell, it cannot be ruled out that acidophiles use novel, uncharacterized mechanisms to mediate extracellular electron transfer. Several populations within the community were suggested to metabolize intermediate inorganic Sulfur Compounds by multiple pathways, which highlights the potential for mutualistic or symbiotic relationships. This study provided the genetic base for acidophilic microbial fuel cells utilized for the remediation of inorganic Sulfur Compounds from AMD.
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Electricity generation from an inorganic Sulfur Compound containing mining wastewater by acidophilic microorganisms
Research in microbiology, 2016Co-Authors: Stephan Christel, Pawel Roman, Zhen Lim Wong, Martijn F.m. Bijmans, Mark DopsonAbstract:Sulfide mineral processing often produces large quantities of wastewaters containing acid-generating inorganic Sulfur Compounds. If released untreated, these wastewaters can cause catastrophic environmental damage. In this study, microbial fuel cells were inoculated with acidophilic microorganisms to investigate whether inorganic Sulfur Compound oxidation can generate an electrical current. Cyclic voltammetry suggested that acidophilic microorganisms mediated electron transfer to the anode, and that electricity generation was catalyzed by microorganisms. A cation exchange membrane microbial fuel cell, fed with artificial wastewater containing tetrathionate as electron donor, reached a maximum whole cell voltage of 72 ± 9 mV. Stepwise replacement of the artificial anolyte with real mining process wastewater had no adverse effect on bioelectrochemical performance and generated a maximum voltage of 105 ± 42 mV. 16S rRNA gene sequencing of the microbial consortia resulted in sequences that aligned within the genera Thermoplasma, Ferroplasma, Leptospirillum, Sulfobacillus and Acidithiobacillus. This study opens up possibilities to bioremediate mining wastewater using microbial fuel cell technology.
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RNA transcript sequencing reveals inorganic Sulfur Compound oxidation pathways in the acidophile Acidithiobacillus ferrivorans
FEMS Microbiology Letters, 2016Co-Authors: Stephan Christel, Elizabeth L.j. Watkin, Jimmy Fridlund, Antoine Buetti-dinh, Moritz Buck, Mark DopsonAbstract:Acidithiobacillus ferrivorans is an acidophile implicated in low-temperature biomining for the recovery of metals from sulfide minerals. Acidithiobacillus ferrivorans obtains its energy from the ox ...
Akira Ogita - One of the best experts on this subject based on the ideXlab platform.
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the cyclic organoSulfur Compound zwiebelane a from onion allium cepa functions as an enhancer of polymyxin b in fungal vacuole disruption
Planta Medica, 2010Co-Authors: Baiyinlang Borjihan, Akira Ogita, Kenichi Fujita, Toshio TanakaAbstract:: Zwiebelane A (CIS-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl Sulfur Compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.
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enhancement of the fungicidal activity of amphotericin b by allicin an allyl Sulfur Compound from garlic against the yeast saccharomyces cerevisiae as a model system
Planta Medica, 2006Co-Authors: Akira Ogita, Kenichi Fujita, Makoto Taniguchi, Toshio TanakaAbstract:: Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-Sulfur Compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were visible as small discrete particles. Although allicin was ineffective in promoting AmB-induced plasma membrane disability, this Compound enhanced AmB-induced structural damage to the vacuolar membrane even at a non-lethal dose of the antibiotic. Allicin could also enhance the antifungal activity of AmB against the pathogenic fungus Candida albicans and against Aspergillus fumigatus. In contrast, allicin did not enhance the cytotoxic activity of AmB against cells of human promyelocytic leukemia (HL-60), a vacuole-less organism.
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synergistic fungicidal activity of cu2 and allicin an allyl Sulfur Compound from garlic and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in saccharomyces cerevisiae
Toxicology, 2005Co-Authors: Akira Ogita, Kenichi Fujita, Kiyoo Hirooka, Yoshihiro Yamamoto, Nobuo Tsutsui, Makoto Taniguchi, Toshio TanakaAbstract:Abstract Cu 2+ showed a dose-dependent fungicidal activity against Saccharomyces cerevisiae cells, and its lethal effect was extremely enhanced in the presence of allicin, an allyl Sulfur Compound from garlic. The fungicidal activity of Cu 2+ was unaffected or rather attenuated by other Sulfur-containing Compounds such as N -acetyl-cysteine, l -cysteine or dithiothreitol. Ca 2+ could absolutely protect against the lethal effect of Cu 2+ itself, but showed no protection against the fungicidal activity of Cu 2+ newly generated in combination with allicin. Cu 2+ accelerated an endogenous generation of reactive oxygen species (ROS) in S. cerevisiae cells at a lethal concentration, but such intracellular oxidative stress induction was not observed during cell death progression upon treatment with Cu 2+ and allicin. A surfactant, sodium N -lauroyl sarcosinate (SLS), enhanced the solubilization of a few proteins including alkyl hydroperoxide reductase 1 (AHP1) in intact cells, accounting for the absence of this protein in the extract from allicin-treated cells. Allicin-treated cells were rendered extremely sensitive to the subsequent Cu 2+ treatment as in the case of SLS-treated cells. Allicin-treated cells and SLS-treated cells similarly showed an increased sensitivity to exogenously added tert -butyl hydroperoxide ( t -BOOH), an organic peroxide that is detoxified by the action of AHP1. Our study suggests that allicin influences the mode of cell surface localization or the related function of AHP1 as a defense against phospholipid peroxidation by the external action of Cu 2+ .
Kenichi Fujita - One of the best experts on this subject based on the ideXlab platform.
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the cyclic organoSulfur Compound zwiebelane a from onion allium cepa functions as an enhancer of polymyxin b in fungal vacuole disruption
Planta Medica, 2010Co-Authors: Baiyinlang Borjihan, Akira Ogita, Kenichi Fujita, Toshio TanakaAbstract:: Zwiebelane A (CIS-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl Sulfur Compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.
-
enhancement of the fungicidal activity of amphotericin b by allicin an allyl Sulfur Compound from garlic against the yeast saccharomyces cerevisiae as a model system
Planta Medica, 2006Co-Authors: Akira Ogita, Kenichi Fujita, Makoto Taniguchi, Toshio TanakaAbstract:: Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-Sulfur Compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were visible as small discrete particles. Although allicin was ineffective in promoting AmB-induced plasma membrane disability, this Compound enhanced AmB-induced structural damage to the vacuolar membrane even at a non-lethal dose of the antibiotic. Allicin could also enhance the antifungal activity of AmB against the pathogenic fungus Candida albicans and against Aspergillus fumigatus. In contrast, allicin did not enhance the cytotoxic activity of AmB against cells of human promyelocytic leukemia (HL-60), a vacuole-less organism.
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synergistic fungicidal activity of cu2 and allicin an allyl Sulfur Compound from garlic and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in saccharomyces cerevisiae
Toxicology, 2005Co-Authors: Akira Ogita, Kenichi Fujita, Kiyoo Hirooka, Yoshihiro Yamamoto, Nobuo Tsutsui, Makoto Taniguchi, Toshio TanakaAbstract:Abstract Cu 2+ showed a dose-dependent fungicidal activity against Saccharomyces cerevisiae cells, and its lethal effect was extremely enhanced in the presence of allicin, an allyl Sulfur Compound from garlic. The fungicidal activity of Cu 2+ was unaffected or rather attenuated by other Sulfur-containing Compounds such as N -acetyl-cysteine, l -cysteine or dithiothreitol. Ca 2+ could absolutely protect against the lethal effect of Cu 2+ itself, but showed no protection against the fungicidal activity of Cu 2+ newly generated in combination with allicin. Cu 2+ accelerated an endogenous generation of reactive oxygen species (ROS) in S. cerevisiae cells at a lethal concentration, but such intracellular oxidative stress induction was not observed during cell death progression upon treatment with Cu 2+ and allicin. A surfactant, sodium N -lauroyl sarcosinate (SLS), enhanced the solubilization of a few proteins including alkyl hydroperoxide reductase 1 (AHP1) in intact cells, accounting for the absence of this protein in the extract from allicin-treated cells. Allicin-treated cells were rendered extremely sensitive to the subsequent Cu 2+ treatment as in the case of SLS-treated cells. Allicin-treated cells and SLS-treated cells similarly showed an increased sensitivity to exogenously added tert -butyl hydroperoxide ( t -BOOH), an organic peroxide that is detoxified by the action of AHP1. Our study suggests that allicin influences the mode of cell surface localization or the related function of AHP1 as a defense against phospholipid peroxidation by the external action of Cu 2+ .
