The Experts below are selected from a list of 16230 Experts worldwide ranked by ideXlab platform
Guy Chouinard - One of the best experts on this subject based on the ideXlab platform.
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severe cases of neuroleptic induced Supersensitivity psychosis diagnostic criteria for the disorder and its treatment
Schizophrenia Research, 1991Co-Authors: Guy ChouinardAbstract:Tardive dyskinesia is thought to result from neostriatal dopaminergic receptor Supersensitivity induced by chronic treatment with neuroleptics. Similarly, receptor Supersensitivity occurring in other dopaminergic regions of the brain could result in the development of Supersensitivity psychosis. As with tardive dyskinesia, severe forms of the disorder are rare. Ten such cases are described whose main characteristic is that psychotic symptoms can no longer be masked by increased dosages of neuroleptics. Diagnostic criteria for the disorder are proposed, and treatment with antiepileptic medication is described.
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Neuroleptic-induced Supersensitivity psychosis in patients with bipolar affective disorder.
Acta Psychiatrica Scandinavica, 1990Co-Authors: W. Steiner, M. Laporta, Guy ChouinardAbstract:Clinical syndromes thought to arise from neuroleptic-induced dopamine receptor Supersensitivity are well described in psychiatry. Tardive dyskinesia may arise from neostriatal Supersensitivity and Supersensitivity psychosis may arise from mesolimbic Supersensitivity in schizophrenics chronically treated with neuroleptics. The authors present 5 cases of Supersensitivity psychosis that developed in patients with bipolar affective disorder. The clinical syndrome is described and the implications for the long-term course of bipolar affective disorder are discussed.
Choongon Jang - One of the best experts on this subject based on the ideXlab platform.
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inhibition of baclofen on morphine induced hyperactivity reverse tolerance and postsynaptic dopamine receptor Supersensitivity
Pharmacological Research, 2001Co-Authors: Sanghee Woo, Hackseang Kim, Jaesuk Yun, Myung Koo Lee, Yeonhee Seong, Choongon JangAbstract:This study was performed to investigate the effect of tetrahydroisoxazolopyridine (THIP), a GABAA agonist, on the morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor Supersensitivity in mice. A single administration of morphine induced hyperactivity in mice. However, the morphine-induced hyperactivity was inhibited dose-dependently by the administration of THIP (0.2, 0.4 and 0.8 mg/kg, i.p.). In contrast, daily administration of morphine resulted in a reverse tolerance to the hyperactivity caused by morphine (10 mg/kg, s.c). THIP inhibited the development of reverse tolerance in the mice that had received the repeated same morphine (10 mg/kg, s.c.) doses. The postsynaptic dopamine receptor Supersensitivity, which was evidenced by the enhanced ambulatory activity after the administration of apomorphine (2 mg/kg, s.c), also developed in the reverse tolerant mice. THIP also inhibited the development of the postsynaptic dopamine receptor Supersensitivity induced by the chronic morphine administration. These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor Supersensitivity induced by morphine can be inhibited activating the GABAA receptors.
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inhibition by mk 801 of cocaine induced sensitization conditioned place preference and dopamine receptor Supersensitivity in mice
Brain Research Bulletin, 1996Co-Authors: Hackseang Kim, Wookyu Park, Choongon JangAbstract:Abstract Repeated administration of cocaine led to increases in ambulation-accelerating activity (sensitization) and conditioned place preference (CPP). Dopamine (DA)-receptor Supersensitivity was also developed in cocaine-induced sensitized and CPP mice. An N -methyl- d -aspartate (NMDA)-receptor antagonist, MK-801, blocked simultaneously developments of cocaine-induced behavioral sensitization, CPP, and DA-receptor Supersensitivity. Furthermore, MK-801 inhibited a apomorphine-induced striatal dopaminergic action: climbing behavior. These results suggest that the cocaine-induced dopaminergic behaviors such as sensitization to ambulatory activity and CPP may be produced via activation of the NMDA receptor. The development of postsynaptic DA-receptor Supersensitivity may be an underlying common mechanism that mediates cocaine-induced behavioral sensitization and CPP.
Hiroshi Yoshida - One of the best experts on this subject based on the ideXlab platform.
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Participation of protein synthesis in development of Supersensitivity in cultured rat vas deferens.
Japanese Journal of Pharmacology, 2019Co-Authors: Hiroshi Higuchi, Shuji Uchida, Miho Murata, Hiroshi YoshidaAbstract:Organ culture of rat vas deferens produced Supersensitivity to norepinephrine and acetylcholine in contractile response without change in α1-adrenergic and muscarinic acetylcholine receptors. The development of Supersensitivity was inhibited by low temperature and protein synthesis inhibitors. However, protein synthesis inhibitor had no significant effect on the receptors. These findings suggested that the Supersensitivity may be induced by synthesis of protein(s) which have a stimulatory effect in a process(es) after activation of receptor to contraction.
Hackseang Kim - One of the best experts on this subject based on the ideXlab platform.
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inhibition of baclofen on morphine induced hyperactivity reverse tolerance and postsynaptic dopamine receptor Supersensitivity
Pharmacological Research, 2001Co-Authors: Sanghee Woo, Hackseang Kim, Jaesuk Yun, Myung Koo Lee, Yeonhee Seong, Choongon JangAbstract:This study was performed to investigate the effect of tetrahydroisoxazolopyridine (THIP), a GABAA agonist, on the morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor Supersensitivity in mice. A single administration of morphine induced hyperactivity in mice. However, the morphine-induced hyperactivity was inhibited dose-dependently by the administration of THIP (0.2, 0.4 and 0.8 mg/kg, i.p.). In contrast, daily administration of morphine resulted in a reverse tolerance to the hyperactivity caused by morphine (10 mg/kg, s.c). THIP inhibited the development of reverse tolerance in the mice that had received the repeated same morphine (10 mg/kg, s.c.) doses. The postsynaptic dopamine receptor Supersensitivity, which was evidenced by the enhanced ambulatory activity after the administration of apomorphine (2 mg/kg, s.c), also developed in the reverse tolerant mice. THIP also inhibited the development of the postsynaptic dopamine receptor Supersensitivity induced by the chronic morphine administration. These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor Supersensitivity induced by morphine can be inhibited activating the GABAA receptors.
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inhibition by mk 801 of cocaine induced sensitization conditioned place preference and dopamine receptor Supersensitivity in mice
Brain Research Bulletin, 1996Co-Authors: Hackseang Kim, Wookyu Park, Choongon JangAbstract:Abstract Repeated administration of cocaine led to increases in ambulation-accelerating activity (sensitization) and conditioned place preference (CPP). Dopamine (DA)-receptor Supersensitivity was also developed in cocaine-induced sensitized and CPP mice. An N -methyl- d -aspartate (NMDA)-receptor antagonist, MK-801, blocked simultaneously developments of cocaine-induced behavioral sensitization, CPP, and DA-receptor Supersensitivity. Furthermore, MK-801 inhibited a apomorphine-induced striatal dopaminergic action: climbing behavior. These results suggest that the cocaine-induced dopaminergic behaviors such as sensitization to ambulatory activity and CPP may be produced via activation of the NMDA receptor. The development of postsynaptic DA-receptor Supersensitivity may be an underlying common mechanism that mediates cocaine-induced behavioral sensitization and CPP.
Allison Reid - One of the best experts on this subject based on the ideXlab platform.
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Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites
Naunyn-Schmiedeberg's Archives of Pharmacology, 1990Co-Authors: Jana Sawynok, Allison ReidAbstract:The present study was conducted (a) to determine if cross-Supersensitivity at spinal noradrenergic receptors could be demonstrated in antinociceptive tests following depletion of spinal cord 5-hydroxytryptamine (5HT) by the intrathecal (i.t.) and intracerebroventricular (i.c.v.) administration of 5,7-dihydroxytryptamine (5,7DHT), and (b) to compare the pattern of Supersensitivity at spinal 5HT receptors following these manipulations and 5,7DHT microinjected into the ventral raphe (VR) region and the nucleus raphe magnus (NRM). Both i.t. and i.c.v. administration of 5,7DHT produced a marked depletion of spinal cord 5HT (> 75%) and Supersensitivity to the i.t. injection of 5HT in the tail flick and hot plate tests. No Supersensitivity to the i.t. injection of noradrenaline (NA) was observed. Microinjection of 5,7DHT into the VR and NRM produced less depletion of spinal cord 5HT (40–57%), and Supersensitivity to the i.t. injection of 5HT was observed only in the hot plate test following microinjection of 5,7DHT into the VR. An increased incidence of signs of the 5HT behavioural syndrome, particularly tremor and Straub tail, was observed in all 5,7DHT-pretreated groups. These results indicate that cross-Supersensitivity to spinal NA receptors does not occur following depletion of spinal cord 5HT. In addition, responses mediated by 5HT receptors show a differential pattern of development of Supersensitivity. Thus, the 5HT behavioural syndrome (presumably mediated by 5HT_1A receptors) more readily reflects the development of Supersensitivity than the tail flick test (presumably mediated by 5HT_2 receptors), while the hot plate test (uncharacterized subtype) shows an intermediate development of Supersensitivity.
